Single-use bioreactor for high volume cell cultures

For optimizing cell culture efficiency, this advanced bioreactor revolutionizes your production with scalable single-use technology, providing unmatched mixing and mass transfer performance.

Cultures Cells and Expresses Proteins

The DynaDrive Single-Use Bioreactor, engineered by Thermo Fisher Scientific, revolutionizes the bioprocessing workflow for pharmaceutical manufacturers and biotechnology companies. Its innovative stir-tank design features a reengineered mixing impeller and sparging system that optimizes mixing dynamics and mass transfer, critical for demanding cell cultures. This bioreactor excels in applications such as monoclonal antibody production, recombinant proteins, and gene therapies, delivering scalability from 50 to 5,000 liters, making it adaptable for pilot-scale to commercial production.

Engineered for efficiency, the DynaDrive reduces seed-train turndown ratios with a 10:1 and 20:1 ratio for 50 L and 500 L reactors respectively, minimizing contamination risk. Equipped with load cells for precise measurement and constructed with robust Thermo Scientific Aegis 5-14 bioprocessing film, it ensures durability and high performance. The open-architecture design allows seamless integration with existing control systems, enhancing operational efficiency. Fully compliant with BioPhorum Operations Group (BPOG) guidelines for leachable and extractable safety, it supports rigorous regulatory standards crucial for life sciences applications, ensuring reliability in biopharmaceutical production environments.

Benefits

  • Enhances productivity with scalable volumes from pilot to commercial scale.
  • Minimizes contamination risk through reduced seed-train turndown ratios.
  • Facilitates efficient cell culture with optimized mixing and mass transfer.
  • Integrates easily with existing systems due to open-architecture design.
  • Complies with safety guidelines, ensuring reliability in regulated environments.

General


Applications
Cell and gene therapy,Biopharmaceuticals,Nutraceuticals,Protein expression
End products
Viral vectors,Monoclonal antibodies,Protein supplements,Vaccine components,Cell-based therapeutics,Gene therapies,Recombinant proteins
Steps before
Cell Culture Preparation,Media Preparation,Seed Train Development
Steps after
Harvesting,Protein Expression Analysis,Purification
Input ingredients
cell culture media,single-use bioprocess container,seed culture
Output ingredients
biomass,protein expression products
Market info
Thermo Fisher Scientific is renowned for providing innovative scientific instruments, laboratory equipment, and engineered-to-order solutions across various industries, esteemed for their high-quality products and expertise in life sciences, pharmaceuticals, and biotechnology sectors.

Technical Specifications


Capacity
500 L
Height (Metric)
3 m
Width (Metric)
81 cm
Length (Metric)
82 cm
Material
Stainless Steel
Power Input per Volume (PIV)
Optimized for modern cell culture processes
KLa Performance
Optimized for modern cell culture processes
Seed Train Process
10
Scalability
50 L to 5,000 L
Max Cell Density
>100 million cells/mL
Sparging Approach
Redesigned for optimization

Operating Characteristics


Working Mechanism
Revolutionary stir-tank design
Batch vs. continuous operation
Batch,fed batch,and perfusion cultures
Seed-train turndown ratio
10
Mixing Dynamics
Optimized for modern cell culture processes
Interoperability
Open-architecture approach with control systems
Cleaning Method
Leachable and extractable (L,E) evaluated

Material Compatibility


Density/particle size
0.5–2.5 g/cm³

Physical Characteristics


Tank shape and size
Stir-tank design,500 L capacity
Material
Stainless Steel
Height
9 ft. 9 in. / 3 m
Length
2 ft. 7 in. / 82 cm
Width
2 ft. 7 in. / 81 cm

Custom Options


Control System Integration
Interoperable with available control systems