Single-use bioreactor for high volume cell cultures
Scaling up cell culture processes from pilot-scale to commercial production can be challenging due to the risk of contamination and the need for efficient mixing and mass transfer in large volumes. Optimizing these parameters is crucial for ensuring consistent and high-density cell growth.
Optimize large-scale cell cultures with efficient mixing
The Thermo Scientific™ DynaDrive™ Single-Use Bioreactor (S.U.B.) is a state-of-the-art solution designed to meet the high demands of modern cell culture processes. It utilizes an innovative stir-tank design that ensures optimal mixing dynamics and mass transfer performance. This single-use bioreactor supports volumes of up to 5000 L, making it ideal for batch, fed-batch, and perfusion cultures. The DynaDrive S.U.B. features an ergonomically friendly hardware design, including a jacketed bioreactor with load cells for precise monitoring. It leverages a robust mixing impeller and optimized sparging for enhanced performance. The system’s open-architecture approach allows for interoperability with various control systems. It also employs Thermo Scientific’s Aegis 5-14 bioprocessing film, which undergoes rigorous leachable and extractable evaluations as per BioPhorum Operations Group (BPOG) guidelines.
Benefits
- Scalable from 50 L to 5000 L
- Reduces contamination risk with single-use design
- Optimized mixing for high-density cell cultures
- Compatible with various control systems
- Ergonomically friendly for ease of use