Single-use bioreactor for cell culture processes

Optimize your cell culture productivity with advanced mixing dynamics that support high cell density processing, perfect for scaling up from pilot to commercial production with reduced contamination risk.

Optimizes Cell Culture and Mixing Processes

The DynaDrive Single-Use Bioreactor from Thermo Scientific is designed to revolutionize biopharmaceutical manufacturing, offering unmatched flexibility for cell culture and mixing processes. Central to its operation is a stir tank design that efficiently accommodates batch, fed-batch, and perfusion processes. It supports biopharmaceutical applications including monoclonal antibodies and viral vectors for gene therapy, managing from pilot to commercial-scale production with capacities up to 5,000 liters. Ergonomically designed for ease of use, the bioreactor features an open-architecture system compatible with various control frameworks, ensuring seamless integration into existing production lines. Thermo Scientific’s robust Aegis 5-14 bioprocessing film is utilized for bioprocess containers, combining agility with durability. The system supports highly regulated environments, adhering to BPOG guidelines for leachables and extractables, and it offers streamlined seed train processes to minimize contamination risks. Furthermore, its design prioritizes efficiency with optimized mixing dynamics and an energy-efficient drive train, ensuring reliable operation at high cell densities.

Benefits

  • Enhances production scalability from pilot to commercial stages, ensuring seamless transition.
  • Reduces contamination risks with advanced seed train process optimization.
  • Integrates easily into existing systems with open-architecture compatibility.
  • Achieves higher cell concentrations efficiently, supporting demanding bioproduction needs.
  • Complies with stringent regulatory standards, ensuring safety and quality.

General


Applications
Biopharmaceuticals,Gene therapy products,Cell culture products
End products
Car-t cell therapies,Monoclonal antibodies,Viral vectors for gene therapy,Cellular immunotherapies,Recombinant proteins
Steps before
Cell Culture,Seed Train Preparation,Media Preparation
Steps after
Harvesting,Protein Purification,Downstream Processing
Input ingredients
cell culture media,cells,nutrients,oxygen
Output ingredients
bioproducts,protein,biomass
Market info
Thermo Fisher Scientific is renowned for providing innovative scientific instruments, laboratory equipment, and engineered-to-order solutions across various industries, esteemed for their high-quality products and expertise in life sciences, pharmaceuticals, and biotechnology sectors.

Technical Specifications


Capacity
500 L
Capacity (English)
132 gal
Height
9 ft. 9 in.
Height (Metric)
3 m
Length
2 ft. 7 in.
Length (Metric)
82 cm
Width
2 ft. 7 in.
Width (Metric)
81 cm
Material
Stainless Steel
Mixing Dynamics
Optimized for modern cell culture
Turndown Ratio
20
Power Input per Volume (PIV)
Optimized
KLa Performance
Optimized for modern processes
Cell Density
>100 million cells/mL

Operating Characteristics


Working mechanism
Stir-tank design
Integrated steps
Mixing and mass transfer optimization
Batch vs. continuous operation
Batch,fed batch,and perfusion cultures
Automation level
Interoperability with control systems
Cleaning method
CIP
Energy efficiency
Optimized PIV and kLa performance
Seed train process
10

Product type Characteristics


Usage
Batch,fed batch,and perfusion cultures

Physical Characteristics


Material
Stainless Steel
Machine footprint
2 ft. 7 in. x 2 ft. 7 in.

Custom Options


Control panel type
Open-architecture,interoperable
Integration possibilities
Interoperable with available control systems
Scale options
50 L,500 L,3000 L,5000 L
Sparging approach
Redesigned for optimized performance
Drive train integration
Integrated in BPC
Film material
Thermo Scientific Aegis 5-14 bioprocessing film