Controller for pilot and production scale bioreactors

Optimize your bioprocess with a robust, configurable controller designed to seamlessly integrate with pilot and production bioreactors, ensuring precise control and measurement for your cultivation processes.

Controls and Integrates Bioprocesses for Pilot and Production

The Pro-Control from Getinge is an adaptable bioprocess controller designed for pilot and production scale bioreactors. Featuring compatibility with DeltaV™, Siemens, and Allen Bradley PLCs, it ensures seamless integration within any facility. Ideal for producing monoclonal antibodies, CAR-T cell therapies, and lab-grown meat, it offers flexible configuration options tailored to specific process requirements. Capable of supporting single-use or sterilizable-in-place systems, Pro-Control manages operations from batch to continuous cultivation efficiently. It boasts a comprehensive set of sensors and actuators, ensuring precise measurement and control, while adhering to cGMP standards. The controller’s design optimizes both single-use and stainless-steel bioreactor applications, facilitating energy-efficient operations and streamlined cleaning.

Benefits

  • Enhances operational efficiency with seamless integration and automation.
  • Complies with cGMP and 21 CFR part 11 for strict regulatory environments.
  • Flexible configuration supports both single-use and sterilizable solutions, adapting to various production needs.
  • Improves process accuracy with advanced sensor technology for critical parameter monitoring.
  • Streamlines production changeovers, reducing downtime and enhancing productivity.

General


Applications
Media optimization,Microbial cultures,Nutraceuticals,Biopharmaceuticals,Cell and gene therapy,Cellular agriculture
End products
Car-t cell therapies,Probiotic cultures,Monoclonal antibodies,Lab-grown meat,Herbal supplements,Optimized cell culture media
Steps before
Media preparation,Cell inoculation,Sterilization of containers,Sensor calibration
Steps after
Sterilization in place,Batch harvesting,Downstream processing,Cleaning and disinfection
Input ingredients
single-use bioreactor ingredients,stainless steel bioreactor ingredients,gas,liquid,biomass,offgas measurements,pressure
Output ingredients
bioprocessed products,cell cultures,microbial cultures,optimized media,processed batches,fed-batch outputs,perfusion outputs,continuous cultivation products
Market info
Getinge is known for providing innovative healthcare and life sciences products, specializing in medical technology, infection control, surgical workflows, and critical care solutions. They maintain a strong reputation for quality and technological advancement in these sectors.

Technical Specifications


PH Sensor
Mettler Toledo INSUS pH sensor,Traditional Electrochemical
DO sensor
Mettler Toledo INSUS DO sensor,Traditional Polarographic
Temperature Range
0-150 °C,accuracy 0.1°C
Weight Measurement
Reactor load cells and balances
Additional I/O
Up to 8 Analog in and 4 Analog out,Up to 8 Digital in and 8 Digital out
Gas Control
Up to 8 MFC's with solenoid valves or up to 8 rotameters with solenoid valves
Liquid Control
Up to 4 internal fixed speed pumps,Up to 2 external variable speed pumps
Impeller Type
Marine Impeller,Rushton,Marine,Hydrofoil
Temperature Control
Lauda Temperature Control Unit (TCU),Cooling and heating jacket via bioreactor wall
Control Hardware and Software
Siemens,Allen Bradley,iFix,DeltaV™
Certifications
CE certified,GAMP compliant,21 CFR part 11 compatible
Communication,SCADA
Lucullus® PIMS,DeltaV™,iFix
Getinge OPC server available

Operating Characteristics


Integration with factory systems
DeltaV,Siemens PLC,Allen Bradley PLC,iFix
Automation level
Fully configurable,PLC / SCADA
Compatibility
Single-use and sterilizable-in-place applications
Process type
Batch,Fed-Batch,Perfusion,Continuous cultivation
Flexibility
Designed on wheels for SUPR,skid for stainless steel
Control hardware and software platform
Siemens,Allen Bradley,iFix,DeltaV
CIP/SIP
CIP 121°C / SIP 135°C


21 CFR part 11 compatible
Yes

Physical Characteristics


Machine footprint
Mobile on wheels or fixed on a skid
Tank sizes
50 to 5,000 L
Discharge method
N/A
Control panel type
Siemens or Allen Bradley
Compact footprint
Mobile design available

Custom Options


Control panel type
Integrated with DeltaV™,Siemens PLC,Allen Bradley PLC
Integration possibilities
iFix,DeltaV™,Siemens,Allen Bradley
Design flexibility
Wheeled design for SUPR,Skid design for stainless steel bioreactor