Single-use bioreactors for mammalian and insect cell cultivation
Optimize your bioprocesses with scalable, single-use bioreactors designed for efficient cell cultivation from lab to production scale, ensuring flexibility and reduced contamination risks in developing therapeutics like vaccines and monoclonal antibodies.
Cultivates and Monitors Cell and Gene Therapies
The BioBLU® c Single-Use Bioreactors from Eppendorf are rigid-walled, stirred-tank systems engineered to elevate cell cultivation processes with unmatched scalability and precision. These bioreactors are ideal for the pharmaceutical and biotech sectors, providing a solution for the cultivation of human and animal cells, including stem cells, microbial cells, and cell aggregates for applications like gene therapy and vaccine production. With a working volume range from 100 mL to 40 L, these bioreactors support scalable production needs.
They integrate seamlessly with Eppendorf’s benchtop bioreactor systems, ensuring ease of incorporation in existing laboratory setups. The bioreactors feature optical pH sensors and dissolved oxygen monitoring to maintain optimal environmental conditions, while non-invasive sensor technology minimizes contamination risk. Available with pitched-blade impellers designed for efficient mixing, these bioreactors deliver precise control over process variables. Compliance with stringent sterilization standards guarantees operational safety, while fully weldable and easy-to-connect tubing facilitates maintenance and system adjustments. Additionally, customization options allow for flexible adaptation to specific project requirements, supported by Eppendorf’s engineering expertise.
Benefits
- Enhances scalability and production efficiency with up to 400-fold cell expansion capability.
- Minimizes contamination risk using non-invasive sensor technology for critical parameter monitoring.
- Reduces labor with easy-to-connect tubing and seamless integration into existing systems.
- Ensures operational safety with stringent sterilization standards, reducing contamination concerns.
- Supports diverse bioprocess applications, from vaccine production to gene therapy, enhancing adaptability.
- Applications
- Vaccines,Viral vectors,Stem cells,Microbial cells,Cell therapy,Monoclonal antibodies,Biopharmaceuticals,Gene therapy,Cell aggregates,Human and animal cells
- End products
- Pluripotent stem cell-derived cardiomyocytes,Erythropoietin,Insulin,Chimeric antigen receptors,Influenza vaccine,Rituximab,Stem cell-derived neural cells,Adeno-associated viral vectors,Car-t therapy products,Hepatitis b vaccine
- Steps before
- Cell Culture Preparation,Media Preparation
- Steps after
- Harvesting,Dowstream Processing,Sterilization
- Input ingredients
- mammalian cells,insect cells,microbial cells,suspension cells,adherent cells,microcarriers,cell aggregates,Fibra-Cel Disks,culture medium
- Output ingredients
- cell culture,monoclonal antibodies,biologics,vaccines,modern food,stem cell cultivation,viral vectors,scale-up processes
- Market info
- Eppendorf is known for manufacturing high-quality laboratory equipment, including pipettes, centrifuges, and bioprocessing tools. Renowned for their precision and reliability, Eppendorf's products are widely used in scientific research and clinical laboratories worldwide.
- Bioreactor Type
- Single-Use
- Volume Range
- 100 mL – 40 L
- Cell Cultivation
- Human,Animal,Mammalian,Insect
- Cell Expansion
- 400-fold
- Impeller Type
- Pitched-Blade,8-Blade
- Sterilization Method
- Irradiated (>15 kGy β or >25 kGy X-ray)
- Sensing Technology
- Non-Invasive Optical pH
- Temperature Measurement
- Non-Invasive
- Compliance
- SAL level 10⁻⁶ for X-ray Irradiation
- Mixing Method
- Low-Shear
- Support Matrix
- Fibra-Cel® Disks
- Drive Type
- Sealed Magnetic
- Gas Sparger Type
- Microsparger / Macrosparger
- Construction Material
- Rigid-Walled
- Batch vs. continuous operation
- Batch
- Automation level
- Manual / PLC
- Exhaust Treatment
- Liquid-free exhaust condensation (Peltier) / Electric heater band
- Cleaning method
- Sterile (Irradiated by > 15 kGy (β) or > 25 kGy (X-ray))
- Non-invasive sensor technology
- Temperature,Dissolved oxygen (DO),pH
- Sterilization
- SAL-level 10-6for X-ray
- Impeller design
- Pitched-blade / 8-blade impeller
- Biological compatibility
- Compatible with human and animal cell cultures
- Corrosive resistance (e.g. acids)
- Resistant
- Cleanability
- Designed for easy cleaning
- Sterilization Compatibility
- Sterilized by irradiation (>15 kGy β or >25 kGy X-ray)
- SAL-level
- 10^-6
- Bioreactor Size
- 100 mL–40 L
- Impeller Type
- Pitched-blade / 8-blade
- Material Type
- Single-Use
- Container Shape
- Stirred-Tank
- Motor Type
- Sealed Magnetic Drive
- Tubing
- Weldable and Easy to Connect
- Sterilization Method
- X-ray,Beta Irradiation
- Exhaust Treatment
- Peltier / Electric Heater Band
- Sparger Type
- Microsparger / Macrosparger
- Port Type
- Pockets for pH,DO,temperature
- Drive System
- Sealed magnetic drive