Single-use fermentor for microbial fermentation
Scaling up microbial fermentation processes requires precise temperature control, sterility, and efficient mixing. Traditional stainless steel fermentors can be labor-intensive and slow to adapt, creating bottlenecks in commercial production.
Optimizes fermentation with enhanced temperature control
The HyPerforma™ Enhanced Single-Use Fermentor (eS.U.F.) from Thermo Fisher Scientific is a sophisticated solution designed to streamline microbial fermentation. Featuring an enhanced jacketing allowing a 35% increase in surface area, it improves temperature control capabilities by at least 21%. The fermentor includes a tank with sterile contact surfaces for efficient mixing, venting, sparging, and temperature sensing. Its unique mixing system ensures optimal cell viability and performance while maintaining sterility. The system supports a 5:1 turndown ratio, enabling operations with a low 60-L working volume. The compact design minimizes footprint and features a cable/tubing management system, simplified bag loading, and advanced foam sensors to mitigate exhaust filter failure. Additionally, it retains the traditional stirred-tank design with a specific height-to-diameter ratio of 3:1, making it scalable and reliable from process development to full-scale production.
Benefits
- Enhanced temperature control with 35% increased surface area
- Efficient mixing with unique overhead mixing system
- Compact design minimizes footprint
- 5:1 turndown ratio for flexible working volumes
- Advanced foam sensor prevents filter failure