Single-use fermentor for microbial fermentation

Enhance your microbial fermentation processes with a system designed for precise temperature control and efficient mixing, tailored for scalability from pilot to production stages.

Enhances Fermentation and Temperature Control

The HyPerforma™ Enhanced Single-Use Fermentor from Thermo Fisher Scientific integrates enhanced functionality into your microbial fermentation processes. With a 35% increase in jacketed surface area, this fermentor significantly optimizes temperature control by at least 21%. The proprietary mixing system, featuring three re-designed turbine impellers and a sparger configuration, ensures optimal sterility and mixing efficiency. Suitable for biopharmaceuticals and fine chemicals, it supports the production of monoclonal antibodies, insulin, and bioethanol. Operating with a 5:1 turndown ratio, it accommodates volumes as low as 60-L, ideal for batch and fed-batch operations. The fermentor is PLC-controlled for precise automation, ensuring seamless integration into existing production lines. Enhanced cable/tubing management and a minimized vessel footprint simplify installation and operation. Constructed from stainless steel, it offers robust chemical resistance, while the state-of-the-art foam sensor prevents exhaust filter failures, reducing downtime and maintenance.

Benefits

  • Enhances productivity with precise temperature control and efficient heat transfer.
  • Lowers operational costs through minimized downtime and maintenance requirements.
  • Improves product yield with optimized mixing and sterility.
  • Facilitates flexible production with scalable turndown ratios.
  • Integrates seamlessly into production lines with reduced equipment footprint.

General


Applications
Fine chemicals,Nutraceuticals,Biopharmaceuticals,Enzymes,Biofuel
End products
Lipase enzymes,Bioethanol,Insulin,Monoclonal antibodies,Dietary supplements
Steps before
Media preparation,Inoculum development,Substrate preparation
Steps after
Harvesting,Downstream processing,Purification
Input ingredients
microbial cultures,Pichia,Bacillus,batch cultures,fed-batch cultures
Output ingredients
enhanced single-use fermentation,optimum cell viability,production scalability,fermentation products
Market info
Thermo Fisher Scientific is renowned for providing innovative scientific instruments, laboratory equipment, and engineered-to-order solutions across various industries, esteemed for their high-quality products and expertise in life sciences, pharmaceuticals, and biotechnology sectors.

Technical Specifications


Capacity
300 L
Jacketed Tank
Yes
Voltage
220/240 V
Turndown Ratio
5
Height-to-Diameter Ratio
3
Enhanced Surface Area
35% increase
Temperature Control Improvement
21%
Working Volume
Minimum 60 L
Material
Stainless Steel
Mixing System
Overhead

Operating Characteristics


Batch vs. continuous operation
Batch / Inline Continuous
Automation level
Manual / PLC / SCADA
Energy efficiency
0.5–2 kWh/kg moisture
Cleaning method
CIP / Manual
Temperature control capability
Improved by 21%
Footprint
Minimized
Working volume
60-L to 300-L
Mixing system
Overhead mixing

Material Compatibility


Biological compatibility
Yes
Cleanability
Yes
Corrosive resistance (e.g. acids)
Yes

Product type Characteristics


Microbial Cultures
Pichia,Bacillus

Physical Characteristics


Tank capacity
300 L
Tank shape
Stirred-tank
Footprint
Minimized vessel footprint
Jacket type
Enhanced jacketed
Vessel Height-to-Diameter Ratio
3
Baffle inclusion
Yes
Impeller location
Top-driven
Access door
Front access

Custom Options


Mixing system type
Unique proprietary overhead
Bag loading
Simplified with front access door
Cable/tubing management
Enhanced organization