Industrial fermentors for large-scale bioprocessing

Enhance yield and consistency in fermentation processes with precise control over cultivation conditions, enabling seamless scale-up from pilot to full industrial production.

Cultivates and Ferments Biotech and Pharmaceutical Products

The BRS-100/150/200SJ, BRS-250/300/500SJ, BRS-1000SJ, and BRS-3000SJ Industrial Fermentors and Bioreactors from BRS Biotech are engineered for seamless integration into biotech and pharmaceutical production lines. These systems cater to the cultivation and fermentation of a wide range of products, including monoclonal antibodies, insulin, and specialized enzymes like phytase. Constructed from 316 stainless steel, they ensure corrosion resistance and durability, meeting stringent GMP and FDA standards.

The fermentors and bioreactors operate with single or double-sealed magnetic bearings to guarantee robust mixing and minimal contamination. Available volumes range from 100 to 60,000 liters, allowing for customizable scaling from pilot to industrial production. These units feature comprehensive automation, including advanced remote control capabilities via a SCADA system. Mass flow control, automatic air flow metering, and integrated sensors for optical density, methanol, ethanol, and redox levels provide precise process control.

Designed for minimal downtime, these systems include Clean-In-Place (CIP) functionality for efficient cleaning and quick turnaround for subsequent batches. BRS Biotech offers customization options such as tailored agitation speed, temperature control, and pressure settings, ensuring each system aligns with specific production requirements. Suitable for liquid, gas, and slurry product types, they support both batch and continuous operations, making them ideal for diverse applications in the production of biopharmaceuticals, nutraceuticals, and other high-value biotech products.

Benefits

  • Enhances production scalability with customizable volumes up to 60,000 liters.
  • Improves process precision with advanced remote control and integrated sensor systems.
  • Ensures rapid turnaround with Clean-In-Place functionality, minimizing contamination risks.
  • Reduces energy costs through efficient mass flow control and optimized motor settings.
  • Complies with GMP and FDA standards, ensuring reliable and safe pharmaceutical production.

General


Applications
Amino acids,Proteins,Vitamins,Supplements,Microbiological synthesis products,Nutraceuticals,Animal cells,Biopharmaceuticals,Enzymes,Food ingredients,Plant protection products,Pharmaceuticals
End products
Biopesticides,Xylanase enzyme,Insulin,E. coli recombinant proteins,Monoclonal antibodies,Probiotic capsules,Amino acid infusion solutions,Aspartic acid,Vitamin b12,Beta-glucanase enzyme,Alginate,Phytase enzyme,Glutamine supplement,Whey protein,Creatine supplement
Steps before
Cell culture preparation,Media preparation,Seed train,Inoculation
Steps after
Downstream processing,Purification,Concentration,Drying
Input ingredients
bacteria,yeast,fungi,animal cells,microorganisms,microalgae,macroalgae,substratum,medium,methanol,ethanol,acid,alkali,water,steam,air
Output ingredients
proteins,monoclonal antibodies (mAb),amino acids,enzymes,phytase,beta-gluconase,xylonase,probiotics,plant protection products
Market info

Technical Specifications


Available volumes
100/150/200/300/450/750/1000 l to 60,000 l
Material
316 Stainless Steel
Agitation
Single,double-sealed,or magnetic bearing
Control functions
Temperature,agitation speed,pH,DO,medium flow,antifoam/level,air flow (manual),pressure (manual)
Advanced Controls
MassFlowControl,air outlet filter heating,optical density sensor,cell suspension concentration monitoring sensor,methanol sensor,ethanol sensor,redox sensor,gas analyzer
SIP ports
For medium inlet system (acid,antifoam,alkali,substratum)
SCADA
Advanced remote control system
Total Volume
100/150/200,250/300/500,1000,3000 L
Working Volume
70/120/160,200/210/400,700,2100 L

Operating Characteristics


Automation level
Manual / PLC / SCADA
Batch vs. continuous operation
Batch
CIP/SIP
CIP 121°C / SIP 135°C
Platform-mounted design
Open frame construction
Central connection system
Steam,water,and air
Cell cultivation support
Bacteria,yeast,fungi,animal cells
Access level
Easy access for maintenance and operation
Photobioreactor capability
Aquatic organisms,micro– and macroalgae
Energy efficiency
0.5–2 kWh/kg moisture

Material Compatibility


Abrasion resistance
High
Biological compatibility
Yes
Cleanability
Easy to clean
Corrosive resistance (e.g. acids)
Yes
Density/particle size
Adjustable depending on application

Physical Characteristics


Material
316 Stainless Steel
Total Volume
100 L - 60,000 L
Working Volume
70 L - 2100 L
Construction Type
Open frame,platform-mounted
Agitation
Single,double-sealed or magnetic bearing
Available Volumes
100/150/200/300/450/750/1000 L and more

Custom Options


Control panel type
SCADA advance – advanced remote control system
Integration possibilities
Stand-alone or fully equipped lines for biotech and pharmaceutical plants
Agitation system
Single,double-sealed,or magnetic bearing
Volume range
100L to 60,000L and more
Frame construction
Open frame for easy maintenance and operation
Customization setup
Custom setup via questionnaire
Basic control functions
Temperature,agitation speed,pH,DO,medium flow,antifoam/level,air flow (manual),pressure (manual)
Advanced control functions
MassFlowControl,automatic air flow meter,optical density sensor,cell suspension concentration monitoring sensor
Sensor options
Methanol,ethanol,redox sensors
Material
316 Stainless Steel
Platform-mounted
Yes
Central connections
Steam,water,and air