Vertical-wheel bioreactor for cell therapy applications
For cell therapy manufacturing, scaling up from small-scale cell culture processes can present significant challenges, such as optimizing process parameters for different volumes and ensuring consistency. This necessitates solutions that offer control and scalability for various stages, including clinical trials.
Customizable control of cell culture parameters
The PBS-3 Vertical-Wheel bioreactor by PBS Biotech is a single-use bioreactor designed for cell therapy applications. It offers customizable control of process parameters through an intuitive touchscreen interface, making it suitable for clinical trials, including first-in-human studies. The PBS-3 can be configured for use with either single-use or reusable dissolved oxygen (DO) and pH sensors, and installation and operations qualification protocols are available for sale. It allows for process development in PBS Minis to scale up seamlessly to this 3-liter bioreactor, bridging the gap to larger-scale production. The single-use vessels come in both floored and floorless configurations, tailored to different cell culture needs—floored for cells grown on microcarriers and floorless for cell aggregates.
Benefits
- Single-use vessels and software qualified for clinical trials
- Touchscreen interface for intuitive control and reporting
- Configurable for single-use or reusable sensors
- Scalable from small-scale development to larger volumes
- Customizable programming of process controls and real-time monitoring