Vertical-wheel bioreactor for cell therapy applications

Elevate your cell culture process with a bioreactor designed for precise parameter control and seamless scale-up, ensuring the efficient production of therapeutic cells and exosome-based therapeutics.

Cultures and Scales Therapeutic Cells

The PBS-3 Vertical-Wheel Bioreactor from PBS Biotech is designed to optimize your cell therapy production processes. This single-use, stirred suspension bioreactor offers customizable process parameters, effectively addressing complex needs in therapeutic cell cultivation, such as mixing, monitoring, and sampling. It caters to applications including MSC, hiPSC, CAR-T, and NK cell therapies, and is suitable for biotech and pharmaceutical industries. The bioreactor is engineered to simplify the scale-up process from laboratory to clinical trials, ensuring smooth transition to larger volumes. Featuring real-time data monitoring and process control, it allows remote access for adjustments and alarms via a secure interface. The system supports the integration of single-use or reusable sensors for DO and pH, meeting FDA and GMP standards. Available as a compact, bench-top system, it fits effortlessly into research and development environments, making it a versatile addition to your cell therapy production line.

Benefits

  • Streamlines scale-up of therapeutic cell production from small to clinical volumes.
  • Enhances cell culture consistency with precise parameter control and monitoring.
  • Facilitates cost-effective operations with single-use vessels, eliminating cleaning requirements.
  • Ensures regulatory compliance with FDA and GMP standards.
  • Offers flexibility in process development through customizable and remote-access features.

General


Applications
Stem cells,Hipsc,Nk cells,Therapeutic cells,Cell therapy,Msc,Biopharmaceuticals,Exosomes,Car-t
End products
Car-t cell therapies,Nk cell therapies,Mesenchymal stem cell (msc) therapies,Induced pluripotent stem cell (ipsc) therapies,Exosome-based therapeutics
Steps before
Process Development,Small Scale Cell Culture Process Design
Steps after
Process Optimization,Data Analysis,Scale-Up to PBS-15 Bioreactor,Clinical Trials
Input ingredients
cell culture media,microcarriers,single cells,cell aggregates,sensors
Output ingredients
cultured cells,cellular products,data from process monitoring
Market info
PBS Biotech is known for manufacturing single-use, scalable bioreactor systems designed for cell therapy and biologics production, featuring their innovative Air-Wheel mixing technology for efficient and consistent results.

Technical Specifications


Single-Use or Reusable Sensors
Single-Use/Reusuable
Bioreactor Volume
3L
Touchscreen Interface
Intuitive
Process Customization
User-configurable
Real-time Monitoring
Available
Remote Monitoring Capability
Yes
Type of Bioreactor
Vertical-Wheel
Power Supply
120 V / 240 V
Compliance
21 CFR Part 11 cGMP
Bioreactor Installation
Bench-top
Hydrodynamic Performance
High
Process Scale-up Capability
Yes
Bioreactor Software
v4 Software,3.0 Upgrade

Operating Characteristics


Automation level
Touchscreen interface with customizable programming
CIP/SIP
Single-use vessels for easy cleaning and sterilization
Batch vs. continuous operation
Batch
Remote monitoring
Secure connection for process monitoring and adjustments
Process scale-up
Scalable from small-scale to larger 15L bioreactor
Sensor compatibility
Single-use or reusable DO and pH sensors
Data storage and access
21 CFR Part 11 compliant
Installation and operations qualification
Protocols available for sale

Physical Characteristics


Footprint
Lab Bench Compatible
Vessel Type
Single-Use / Reusable
Control Panel
Touchscreen Interface
Impeller Type
Floored / Floorless Vertical-Wheel
Volume Capacity
3L Scale-Up

Custom Options


Control panel type
Touchscreen