Biopharma cell centrifuge for gentle protein recovery
In biopharmaceutical production, ensuring the integrity of cell cultures during the separation process is crucial. Traditional separation methods can cause cell damage, leading to reduced yields and increased downstream processing challenges.
Gentle cell harvesting and efficient protein recovery
The Alfa Laval Culturefuge is a range of bottom-fed hermetic cell centrifuges designed for the gentle harvesting of mammalian cell cultures, microbial cells, and precipitated proteins. What makes the Culturefuge unique is its hollow spindle feed mechanism, which ensures gentle acceleration of the feed liquid to rotational speed, thereby minimizing cell lysis and preventing the release of unwanted intracellular proteins. This results in enhanced yields and optimized downstream operations. Offered in skid-mounted configurations, the Culturefuge systems include comprehensive features like an integrated electrical system with PLC, pneumatic unit, and piping for service and process liquids. They meet major pressure vessel specifications such as ASME and PED. Available in configurations suitable for capacities ranging from 200 to 20,000 liters per hour, the Culturefuge series can scale from pilot plants to full production. Additional options include superfine electro-polished contact surfaces and steam-sterilizable pumps for solid transport.
Benefits
- Enhanced protein yields through gentle cell processing
- Consistent product quality with fully hermetic design
- Easy scalability from pilot plant to full-scale production
- Complies with major regulatory standards for biopharma
- Automated CIP and SIP systems for maximum hygiene