Micro-line vial filling solution for biopharmaceuticals

Ensure batch consistency and sterility in fill-finish operations with a compact design capable of high-speed, aseptic filling of both liquids and powders, seamlessly integrating into your existing production line.

Fills, Stoppers, and Caps Vials Efficiently

The Hull i-Dositecno Micro-Line Vial Filling Systems from ATS Scientific Products address crucial challenges in biopharmaceutical production. These systems ensure precise and consistent filling, stoppering, and capping of vials, accommodating both liquid and powder products. Designed for applications such as vaccines, insulin, and diagnostic reagents, the systems support diverse end-product forms like eye drops and protein powders. With an output of up to 200 units per minute, the servo-driven motion-controlled design provides efficiency and accuracy, seamlessly integrating into your existing production line. Featuring compliance with cGMP and FDA standards, the Micro-Line equipment offers versatility with quick-change parts and aseptic filling systems to meet all production requirements. The systems are equipped with Siemens or Allen Bradley PLCs that facilitate easy automation and customization, ensuring optimal performance and minimal maintenance downtime.

Benefits

  • Enhances production efficiency with high-speed filling, achieving up to 200 units per minute.
  • Minimizes contamination risk through aseptic design and 100% non-destructive In-Process Weight Control.
  • Offers flexibility with easy changeover for multiple vial formats and product types.
  • Ensures compliance with cGMP, Annex 1, and FDA standards, meeting stringent regulatory requirements.
  • Reduces operational costs with low maintenance needs and durable construction materials.

General


Applications
Oral solutions,Powder fill,Biopharmaceuticals,Test kits,Diagnostic,Veterinary health products,Human injectables,Ophthalmic eye care solutions
End products
Protein powders,Vaccines,Pregnancy test kits,Insulin,Vitamin powder supplements,Monoclonal antibodies,Veterinary antibiotics,Cough syrups,Eye drops,Veterinary vaccines,Oral suspensions,Artificial tears,Diagnostic reagents
Steps before
Vial Washing,Sterilization,Depyrogenation,Pre-Fill Inspection
Steps after
Freeze Drying,Capping,External Vial Washing,Packing
Input ingredients
liquid,powder,bulk vials,ready-to-use (RTU) vials
Output ingredients
filled vials,stoppered vials,capped vials
Market info

Technical Specifications


Filling speed
50 or 200 units per minute (upm)
Filling volume
100µL to 500 mL
Automation
Servo-driven,PLC-controlled
Compliance
21 CFR Part 11
Batch consistency
Guaranteed
Container type
Vials
Materials
Polyoxymethylene Copolymer (POMc)
Filling nozzle options
One or two nozzles
Filling method
Peristaltic pump / ceramic/SS rotary piston
Cleanroom compatibility
Cleanroom ready
Control system
Siemens or Allen Bradley PLC
Changeover capability
Quick changeover with POMc parts
Filling type
Liquid or powder
Pick and place channels
Up to 2-channel

Operating Characteristics


Filling speed
50 or 200 upm
Automation level
PLC-controlled servo motors
Batch vs. continuous operation
Batch
Changeover time
Quick changeover with POMc parts
CIP/SIP
Available


GMP Compliance
cGMP,Annex 1
21 CFR Part 11
Integrated software
IQ/OQ Validation Packages
Available
GAMP
GAMP5

Physical Characteristics


Machine footprint
Compact design
Control panel type
Siemens or Allen Bradley PLC-controlled
No. of filling nozzles
1 or 2
Discharge method
Servo-driven star wheel transport
Transport type
Servo-driven star wheel
Material for change parts
Polyoxymethylene Copolymer (POMc)

Custom Options


Control panel type
Siemens or Allen Bradley PLC-controlled
Compact footprint
Yes
Filling nozzle configuration
One or two filling nozzles
Feeding system type
Tanks or bag holder inside machine
Integration possibilities
Compatible with vial washers,sterilization tunnels,freeze dryer systems,capping machines
Changeover materials
POMc (Polyoxymethylene Copolymer) or PEEK (Polyether ether ketone)
Filling options
Aseptic liquid dosing by peristaltic pump or ceramic/SS rotary piston,micro-dose,and solid powder filling by micro-auger
Output rate configuration
Automatically set via servo motors