Virus filtration systems for biologics processing

Ensure efficient virus retention in biopharmaceutical production by integrating modular filter holders and single-use flow paths designed for scalability and precise control.

Filters and Retains Viruses in Biopharmaceutical Products

The Viresolve®Pro Virus Filtration System with Magnus Holders from the Viresolve® line provides a robust solution for biopharmaceutical manufacturers seeking reliable viral clearance. It uses specialized virus filter holders and modular filter systems ideal for monoclonal antibodies (mAbs), therapeutic proteins, and mRNA-based vaccines production. The system effectively integrates prefiltration and virus retention processes to ensure consistent viral safety across various production scales, from pilot to large-scale operations. Featuring a single-use flow path design, it minimizes risk of contamination while simplifying changeovers. This system supports scalable operations and adapts to evolving process requirements, making it indispensable in modern biopharma manufacturing. Designed to comply with industry standards, it facilitates both manual and modular operation modes, ensuring versatility in cleaning and maintenance.

Benefits

  • Ensures comprehensive viral clearance to meet stringent biopharmaceutical safety standards.
  • Adapts to changing production needs with scalable configurations from pilot to large-scale operations.
  • Enhances operational efficiency with quick and easy system setup and changeovers.
  • Minimizes contamination risks with single-use flow path systems.
  • Supports compliance with industry regulations for safe and effective biopharma manufacturing.

General


Applications
Mab development,Protein biology,Biologics manufacturing,Biopharmaceuticals,Pharmaceutical manufacturing,Mrna development
End products
Biopharmaceutical formulations,Gene therapy products,Mrna-based vaccines,Monoclonal antibodies (mabs),Biologics such as enzyme replacement therapies,Viral vector vaccines,Therapeutic proteins
Steps before
Chromatography,Chemical Treatment
Steps after
Sterilization
Input ingredients
biologics feed streams,mAbs process feed,viral particles
Output ingredients
retained viruses,virus-free biologics,filtered biologics product
Market info
Merck is known for its focus on life sciences, healthcare, and performance materials, offering products like pharmaceuticals, biopharmaceuticals, and high-tech materials. It has a strong reputation for innovation and quality in these sectors.

Technical Specifications


Processing Efficiency
High
Scalability
6x scalability
Automation
Simple manual hydraulics
Footprint
Minimized holder footprint
Vertical Orientation
Yes
Flow Path
Single-use flow path
Setup Time
Fast setup
Holder Configuration
Modular format
Loading and Unloading
Quick and easy
Loading rods
Multiple lengths

Operating Characteristics


Scalability
1 to 30 Pod filters
Loading and unloading
Quick and easy
Module format
Modular for 6x scalability
System adaptability
Maximum adaptability with single-use flow paths
Footprint
Minimized with vertical orientation
Flow path design
Optimized single-use
Hydraulics
Simple manual
Integration capability
Flexible and easy-to-use filter holders

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Physical Characteristics


Machine footprint
Minimized holder footprint with vertical orientation
Loading and unloading
Quick and easy
Discharge method
No product contact
Holder design
Vertical orientation
Rod length
Multiple lengths for various sized installations
Construction
Robust construction
Modular format
Scalable within the same footprint
Flow path design
Optimized single-use
Configuration
Modular,allows as few as one filter

Custom Options


Modular format
6x scalability within the same footprint
Pod configuration
1 to 30 Pod filters
Holder type
Viresolve®Pro Magnus,Pro+,Shield H
Flexibility
Easy reconfiguration for scale up/down
Flow path design
Single-use for adaptability
Footprint
Minimized,vertical orientation
Rod length
Multiple lengths for various installations
Hydraulics
Simple manual
Flow path assembly
Optimally designed Flexware® assemblies
Installation adaptability
Fast setup of hardware