Sanitary shell & tube heat exchangers for pharmaceutical applications
Ensure sterility and precision in thermal management with these compact heat exchangers designed for stringent hygienic standards in pharma and biotech processes.
Cools and Condenses Water for Injection
The PUREX – WFI Cooler from Hydropure offers a compact, efficient solution for cooling and condensing Water for Injection, crucial in pharmaceutical and biotech production lines. This equipment employs a robust, sanitary shell and tube heat exchanger with the option of a double tubesheet design to prevent cross-contamination. Ideal for applications in producing high-purity end-products such as COVID-19 vaccines and monoclonal antibodies, it operates within a flow range of 0 to 50 m3/hr and pressures up to 100 bar. Automation integration allows seamless operation within your existing systems. The PUREX – WFI Cooler is constructed from corrosion-resistant materials like SS 316L and Hastelloy, ensuring durability and compliance with ASME BPE standards. It includes a Clean-in-Place (CIP) system for effortless maintenance and is fully customizable to meet specific processing needs.
Benefits
- Ensures high purity of Water for Injection, critical for pharmaceutical safety and efficacy.
- Prevents cross-contamination with double tubesheet design, safeguarding product integrity.
- Reduces operational costs through optimized heat exchange efficiency.
- Complies with stringent ASME BPE standards, ensuring regulatory compliance.
- Minimizes maintenance downtime with integrated Clean-in-Place system.
- Applications
- Fine chemicals,Biopharmaceuticals,High purity products,Water for injection,Pharmaceuticals
- End products
- Sterile injectable drugs,Cosmetic peptides,Insulin,Monoclonal antibodies,Covid-19 vaccines,High-performance liquid chromatography solvents,Buffered saline,Plasmid dna,Intravenous saline solutions,Enzyme replacement therapies
- Steps before
- Water Purification,Water for Injection Generation,Heat Transfer Preparation
- Steps after
- Temperature Control,Sterilization,Process Fluid Cooling,Packing
- Input ingredients
- water for injection,clean steam,process fluid,high purity product,multi-phase fluids,slurries,liquid/gas
- Output ingredients
- sub-cooled clean steam,temperature-controlled product,cooled or heated process fluid,condensed steam,cooled or heated product sampling,seal cooling,drained product
- Market info
- Flow Range
- 0 – 50 m3/hr
- Pressure Range
- 0 – 100 bar
- Material of Construction
- SS 316L,1.4435,Hastelloy®,Inconel®
- Finish
- 20µin (0.5µm) Ra,15µin (0.38µm) Ra with electropolish
- Flow Range
- 0 – 2.2 m3/hr
- Pressure Range
- 0 – 310 bar
- Construction
- All welded,seamless tube
- Clean-in-Place (CIP)
- Yes
- Materials of Construction
- Stainless Steel,Hastelloy®,Inconel®,Titanium
- ASME Compliance
- ASME BPE
- Single or Double Tubesheet
- Yes
- Brazing
- Nickel brazed
- Drainability
- Fully drainable on tube side
- Thermal Stress Resistance
- Highly resistant
- Custom Fittings
- Available
- Working Mechanism
- Shell,Tube / Tube-in-Tube
- Clean-in-Place Principles
- Available (CIP)
- Batch vs Continuous Operation
- Continuous
- Temperature Control
- 0 – 50 m3/hr
- Pressure Handling
- 0 – 310 bar
- Risk of Cross-Contamination
- None
- Corrosive resistance (e.g. acids)
- Yes
- Thermal fatigue resistance
- Yes
- Material options
- SS 316L,Hastelloy®,Inconel®,Titanium
- Cross-contamination prevention
- Single/Double Tubesheet
- Material of Construction
- SS 316L,1.4435,Hastelloy®,Inconel®,Titanium
- Design Type
- Shell,Tube,Tube-in-Tube
- Surface Finish
- 20µin (0.5µm) Ra,improved to 15µin (0.38µm) Ra with electropolishing
- Flow Range
- 0 – 50 m3/hr (Shell,Tube),0 – 2.2 m3/hr (Tube-in-Tube)
- Pressure Range
- 0 – 100 bar (Shell,Tube),0 – 310 bar (Tube-in-Tube)
- Tubesheet Type
- Single or Double
- Size Customization
- Customized design modifications available
- Integrated Custom Fittings
- NPT,tube stubs,or custom fittings
- Drainability
- Fully drainable on tube/product side
- Mounting
- Integrated threaded holes for mounting
- Flow Range
- 0 – 50 m3/hr / 0 – 2.2 m3/hr
- Pressure Range
- 0 – 100 bar / 0 – 310 bar
- Material Options
- SS 316L,1.4435,Hastelloy®,Inconel®,Titanium and other alloys
- Electropolishing
- Available
- Tubesheet Option
- Single or double
- Mounting
- Integrated threaded holes
- Fittings
- NPT,tube stubs,or custom fittings
- Design Modifications
- Custom design,special tube size or count,special baffle configurations
- Shell options
- Special shell diameter and length