Sanitary shell & tube heat exchangers for pharmaceutical applications

Ensure sterility and precision in thermal management with these compact heat exchangers designed for stringent hygienic standards in pharma and biotech processes.

Cools and Condenses Water for Injection

The PUREX – WFI Cooler from Hydropure offers a compact, efficient solution for cooling and condensing Water for Injection, crucial in pharmaceutical and biotech production lines. This equipment employs a robust, sanitary shell and tube heat exchanger with the option of a double tubesheet design to prevent cross-contamination. Ideal for applications in producing high-purity end-products such as COVID-19 vaccines and monoclonal antibodies, it operates within a flow range of 0 to 50 m3/hr and pressures up to 100 bar. Automation integration allows seamless operation within your existing systems. The PUREX – WFI Cooler is constructed from corrosion-resistant materials like SS 316L and Hastelloy, ensuring durability and compliance with ASME BPE standards. It includes a Clean-in-Place (CIP) system for effortless maintenance and is fully customizable to meet specific processing needs.

Benefits

  • Ensures high purity of Water for Injection, critical for pharmaceutical safety and efficacy.
  • Prevents cross-contamination with double tubesheet design, safeguarding product integrity.
  • Reduces operational costs through optimized heat exchange efficiency.
  • Complies with stringent ASME BPE standards, ensuring regulatory compliance.
  • Minimizes maintenance downtime with integrated Clean-in-Place system.

General


Applications
Fine chemicals,Biopharmaceuticals,High purity products,Water for injection,Pharmaceuticals
End products
Sterile injectable drugs,Cosmetic peptides,Insulin,Monoclonal antibodies,Covid-19 vaccines,High-performance liquid chromatography solvents,Buffered saline,Plasmid dna,Intravenous saline solutions,Enzyme replacement therapies
Steps before
Water Purification,Water for Injection Generation,Heat Transfer Preparation
Steps after
Temperature Control,Sterilization,Process Fluid Cooling,Packing
Input ingredients
water for injection,clean steam,process fluid,high purity product,multi-phase fluids,slurries,liquid/gas
Output ingredients
sub-cooled clean steam,temperature-controlled product,cooled or heated process fluid,condensed steam,cooled or heated product sampling,seal cooling,drained product
Market info

Technical Specifications


Flow Range
0 – 50 m3/hr
Pressure Range
0 – 100 bar
Material of Construction
SS 316L,1.4435,Hastelloy®,Inconel®
Finish
20µin (0.5µm) Ra,15µin (0.38µm) Ra with electropolish
Flow Range
0 – 2.2 m3/hr
Pressure Range
0 – 310 bar
Construction
All welded,seamless tube
Clean-in-Place (CIP)
Yes
Materials of Construction
Stainless Steel,Hastelloy®,Inconel®,Titanium
ASME Compliance
ASME BPE
Single or Double Tubesheet
Yes
Brazing
Nickel brazed
Drainability
Fully drainable on tube side
Thermal Stress Resistance
Highly resistant
Custom Fittings
Available

Operating Characteristics


Working Mechanism
Shell,Tube / Tube-in-Tube
Clean-in-Place Principles
Available (CIP)
Batch vs Continuous Operation
Continuous
Temperature Control
0 – 50 m3/hr
Pressure Handling
0 – 310 bar
Risk of Cross-Contamination
None

Material Compatibility


Corrosive resistance (e.g. acids)
Yes
Thermal fatigue resistance
Yes
Material options
SS 316L,Hastelloy®,Inconel®,Titanium
Cross-contamination prevention
Single/Double Tubesheet

Physical Characteristics


Material of Construction
SS 316L,1.4435,Hastelloy®,Inconel®,Titanium
Design Type
Shell,Tube,Tube-in-Tube
Surface Finish
20µin (0.5µm) Ra,improved to 15µin (0.38µm) Ra with electropolishing
Flow Range
0 – 50 m3/hr (Shell,Tube),0 – 2.2 m3/hr (Tube-in-Tube)
Pressure Range
0 – 100 bar (Shell,Tube),0 – 310 bar (Tube-in-Tube)
Tubesheet Type
Single or Double
Size Customization
Customized design modifications available
Integrated Custom Fittings
NPT,tube stubs,or custom fittings
Drainability
Fully drainable on tube/product side
Mounting
Integrated threaded holes for mounting

Custom Options


Flow Range
0 – 50 m3/hr / 0 – 2.2 m3/hr
Pressure Range
0 – 100 bar / 0 – 310 bar
Material Options
SS 316L,1.4435,Hastelloy®,Inconel®,Titanium and other alloys
Electropolishing
Available
Tubesheet Option
Single or double
Mounting
Integrated threaded holes
Fittings
NPT,tube stubs,or custom fittings
Design Modifications
Custom design,special tube size or count,special baffle configurations
Shell options
Special shell diameter and length