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The topical route is a convenient route for the self-administration of drugs. But turning a pharmaceutical formulation into an easy-to-use cream involves specialized cream manufacturing equipment. Topical dosage forms are essentially an emulsion of oil and water.  But the ratios can be changed to process it into lotions, ointments, and gels.

Which cream equipment do you need?

Homogenizer for creams

Homogenization (or pharmaceutical micronization) is the process of red...

Filling machine for creams

Liquid cosmetics have particular requirements when it comes to filling and capping containers. Mo...

High shear lab mixer for creams

Lab-scale mixers are vital in the design or small-batch production of a range of pharmaceuti...

Cosmetic cream filler

From thin liquid baby oils and perfumes to thicker lotions and creams for hair and skincare, cosmetic p...

Emulsifier for cosmetic creams

The process of making cream and lotion involves mixing of water phase and oil phase to create...

Sachet Machine

If you want to pack into eye-catching 4-side sealed sachets between 40x50 mm and 250x200 mm in size, investing ...

Pharmaceutical formulation and mixing tanks

Preparation lines for formulating pharmaceuticals include fixed and mobile tan...

Batch vacuum mixer for emulsion-based products

The production of creams or ointments can be either be a water in oil (w/o)...

Pilot ultrasonic extractor

In the herbal medicine industry, an ultrasonic extractor is a valid alternative to conventional e...

Pilot plant homogeniser

From food to pharma, homogenization is an essential step in the production process that provides unif...

Complete Cutting, Mixing, Emulsifying and Heating System

From laboratory scale to large volume food or cosmetic productio...

Continuous chocolate line with vertical ball mills

To mix and refine cocoa liquor, cocoa powder, sugar, and lecithin, sev...

Small batch filter press for oil seeds

Getting a high-quality oil filtration can be a challenging task,  with a filtration ...

Cold oil press for seeds

With a cold oil press, you can optimize the process of extracting oil from a wide variety of oil see...

Dispersing machine for emulsions and suspensions

Equipment operating under the rotor/stator principal is often employed wh...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Dispersing machine for very fine emulsions and suspensions

For continuous high performance mixing of solid and liquid ra...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Colloid mill

For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen.  ...

Cone mill machine

When your raw materials include agglomorated suspensions of grainy or crystalline solids and your process n...

Corundum disk mill

Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,mus...

Inline batch mixer for solids and liquids

Several issues often arise when your process requires batch-wise mixing of powde...

Continuous homogenizing system

Certain mixing tasks present unique challenges and manufacturers need equipment that is speci...

High accuracy homogenizing system

When extremely high accuracy is required in your recipe or formulation traditional mixing...

Horizontal kneader

For high viscosity products, better results and reduced process times can be achieved with kneading type r...

Vertical kneader

Production of highly viscous products with high solid content often benefits from kneading processes rather t...

Continuous kneader

Effective mixing of highly viscous products with extremely high solids content can be difficult and the re...

Batch dispersing machine

Equipment operating under the rotor/stator principal is often employed when more traditional methods...

Batch dispersing machine for abrasive products

For mixing and dispersing tasks that cannot be completed by conventional st...

Batch dispersing machine for bottom entry into vessels

When your process requires high performance mixing or dispersion b...

GMP homogenizing system

Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accur...

Cost-effective homogenizing and emulsifying system

Manufacturers need production mixing equipment that is capable, flexib...

Dust-free continuous homogenizing system

Producers in a wide variety of industries benefit from equipment that can continuo...

Dilution system for two or more liquids in one pass

Onsite dilution of liquid process ingredients has historically been a...

Small-scale laboratory dispersing machine

Developing and validating new processes requires reliable and highly versatile e...

Pilot dispersing machine for testing and scale-up

Innovators in process development need laboratory equipment that helps ...

In-line laboratory dispersing machine

Innovators in a wide variety of industries need laboratory equipment on which process...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

Jet flow agitator for high-viscosity media

Processes including homogenization, dispersing, suspension, emulsification and ...

Agitator for medium viscosity media

Mixing fluids of medium viscosity for many production processes requires an agitator wi...

Agitator for low viscosity media

Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale p...

High-pressure homogenizer

When processes call for homogenized emulsions with extremely fine particle sizes the traditional t...

High-speed unscrambler for large bottles

Large volume plastic bottling plants need high-speed unscramblers suitable for lar...

High-speed unscrambler for small bottles

Large-scale production of smaller volume bottled product needs a gentle, accurate ...

Low-speed unscrambler

Smaller plastic bottling lines need a lower cost, lower volume unscrambling machine that maintains gent...

Compact monoblock filler

Filling and capping bottles and pots for food, chemical and cosmetic...

Flowmeter filler

For larger production runs of food, non-food and cosmetics industries, where ...

In-line monoblock linear filler & capper

In many food, chemicals and cosmetic industry...

Multi-head capper

For the stand-alone capping of bottles of up to 2.5litre capacity you need ...

Servo controlled filler

For food and non-food liquid products that are high foam or have a hi...

Single head capper

For the stand-alone capping of bottles of up to 30 litre capacity for smal...

High pressure pilot homogenizer

Biotech and pharmaceutical development programs often requir...

High pressure industrial homogenizer

For any industrial pharmaceutical process that relies ...

High pressure electric laboratory homogenizer

It’s vital that small units for experimenta...

High pressure air powered laboratory homogenizer

Offering lab-scale to small pharmaceutica...

Pilot high pressure homogenizer

For maximum value, a high-pressure homogenizer that’s suita...

A two-component filling application tube filler

A wide variety of pharmaceutical, cosmetic...

Low speed tube filler

Increasing numbers of products in the pharmaceutical, cosmetic and food...

Medium speed tube filler and sealer

For scale-up filling of tube packaging for pharmaceutic...

Medium and high speed range automatic tube filler

When scaling up production of pharmaceu...

High speed automatic tube filler

For high-volume lines filling pharmaceutical, cosmetic or f...

Loading cassette for a tube filler

High performance tube-filling machines are used in the p...

Tube feeder for a small scale production tube filler

Low speed tube-filling machines are ...

Tube feeding unit for high volume and high speed tube filler

High performance tube-filli...

Tube unloader and feeder

The pharmaceutical and cosmetic industries utilise high speed tube f...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic produc...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are p...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pha...

Automatic cartoner for applications in pharma and cosmetics

For high capacity production...

High-capacity horizontal cartoner for pharma and cosmetics appliances

Cartoners take ca...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be place...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing ...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceutical...

Self-adhesive linear labeling machine for bottles

It is vital to have precise and long-lasting labels on bottles to avoid...

Manual metal tube sealing equipment

For small-batch productions that utilize metal tubes as containers for their products, ...

Up to four head automatic filling machine

Increasing consumer demand forces production lines, especially packaging, to inv...
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Stories about cream

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Raise the API content to 99%

Pharmaceutical creams are mostly used to treat skin issues such as rashes, stings, or fungal infections. Unlike cosmetic creams, medicated creams penetrate the epidermis and target cells in the lower layers of the skin.

Pharmaceutical creams must contain 99% pure active ingredients. However, APIs are applied in lower concentrations than in other formulations like tablets.

Mix the water and oil phases to produce a stable emulsion

The preparation of oil and water phases involves different cream manufacturing equipment. Oils are extracted and purified from biological materials using extraction technology. Water is filtered from contaminants and distilled.

The two come together in specialized mixing systems that suspend the liquids into an emulsion. A finer droplet renders a more stable emulsion and a smoother cream consistency.

Disperse the drugs and additives in the liquids before emulsification

The oil phase can be either a mineral oil or a silicone, enriched with emollients and lubricants. If the additives are in wax form, heating equipment is used to melt them into the oil base.

Excipients such as binders, thickeners, and stabilizers help the two phases to emulsify. But these agents are dispersed into the water phase. Active ingredients are dispersed into both phases depending on their reactive properties.

Find dispersing technology

Use high-shear mixing equipment to prevent lumps

Not all mixing technologies are suitable for manufacturing pharmaceutical creams. The mechanism needs to incorporate the drugs (typically in powder form) into the emulsion droplets. Failing to combine the materials homogeneously causes agglomerate in the formulation down the line.

High-shear mixers disperse the API and excipients uniformly in the oil and water phases. Similarly, the high rate of agitation lowers the interfacial tension between the phases, producing a more stable emulsion.

Add viscosity modifiers to retain a consistent texture in creams

Excipients are used to facilitate drug delivery. But, at the same time, molecules can coalesce into a microstructure forming large crystals.

Lubricants keep the fluidity of the formulation. But changing temperatures alter their behavior, and creams may feel greasy in warmer environments. Viscosity modifiers reduce the change of stickiness in lubricants to keep a consistent structure.

How to pack your creams and ointments

When filling topical formulations it is essential to get the amount of product in various consistencies per container just right and to be able to accommodate various container shapes and sizes. There are many factors that influence the decision for choosing a container to fill in topical dosage forms. Some of these factors are materials and visual appearance while others are specific to the usage of the product filled. The most common containers for filling creams are tubes and glass or plastic jars.

Tubes have narrow openings that protect the creams against contamination and preserve the product’s shelf life. Tubes are mostly made from low or high-density polyethylene and aluminum. They have various top shapes that can be applied. For example, triangular toppers allow to push out as much product as needed with precision. Push tops are also common for creams that need controlled amounts produced with each pump. Tubes can be of different diameters ranging from 16mm to 50mm and the capacity ranging from 5ml to 240ml. A filling machine, therefore, becomes a critical piece of equipment for any cream manufacturing plant.

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