Tell us about your production challenge

The topical route is a convenient route for the self-administration of drugs. But turning a pharmaceutical formulation into an easy-to-use cream involves specialized cream manufacturing equipment. Topical dosage forms are essentially an emulsion of oil and water.  But the ratios can be changed to process it into lotions, ointments, and gels.

Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Raise the API content to 99%

Pharmaceutical creams are mostly used to treat skin issues such as rashes, stings, or fungal infections. Unlike cosmetic creams, medicated creams penetrate the epidermis and target cells in the lower layers of the skin.

Pharmaceutical creams must contain 99% pure active ingredients. However, APIs are applied in lower concentrations than in other formulations like tablets.

Mix the water and oil phases to produce a stable emulsion

The preparation of oil and water phases involves different cream manufacturing equipment. Oils are extracted and purified from biological materials using extraction technology. Water is filtered from contaminants and distilled.

The two come together in specialized mixing systems that suspend the liquids into an emulsion. A finer droplet renders a more stable emulsion and a smoother cream consistency.

Find dispersing technology

Disperse the drugs and additives in the liquids before emulsification

The oil phase can be either a mineral oil or a silicone, enriched with emollients and lubricants. If the additives are in wax form, heating equipment is used to melt them into the oil base.

Excipients such as binders, thickeners, and stabilizers help the two phases to emulsify. But these agents are dispersed into the water phase. Active ingredients are dispersed into both phases depending on their reactive properties.

Find dispersing technology

Use high-shear mixing equipment to prevent lumps

Not all mixing technologies are suitable for manufacturing pharmaceutical creams. The mechanism needs to incorporate the drugs (typically in powder form) into the emulsion droplets. Failing to combine the materials homogeneously causes agglomerate in the formulation down the line.

High-shear mixers disperse the API and excipients uniformly in the oil and water phases. Similarly, the high rate of agitation lowers the interfacial tension between the phases, producing a more stable emulsion.

Add viscosity modifiers to retain a consistent texture in creams

Excipients are used to facilitate drug delivery. But, at the same time, molecules can coalesce into a microstructure forming large crystals.

Lubricants keep the fluidity of the formulation. But changing temperatures alter their behavior, and creams may feel greasy in warmer environments. Viscosity modifiers reduce the change of stickiness in lubricants to keep a consistent structure.

How to pack your creams and ointments

When filling topical formulations it is essential to get the amount of product in various consistencies per container just right and to be able to accommodate various container shapes and sizes. There are many factors that influence the decision for choosing a container to fill in topical dosage forms. Some of these factors are materials and visual appearance while others are specific to the usage of the product filled. The most common containers for filling creams are tubes and glass or plastic jars.

Tubes have narrow openings that protect the creams against contamination and preserve the product’s shelf life. Tubes are mostly made from low or high-density polyethylene and aluminum. They have various top shapes that can be applied. For example, triangular toppers allow to push out as much product as needed with precision. Push tops are also common for creams that need controlled amounts produced with each pump. Tubes can be of different diameters ranging from 16mm to 50mm and the capacity ranging from 5ml to 240ml. A filling machine, therefore, becomes a critical piece of equipment for any cream manufacturing plant.

Which cream technology do you need?

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Laboratory filling system for liquid and creamy products

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Wafer sheet cream application system

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Intermediate cream container for snack production

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Planetary stirrer for creamy and foamy masses

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Vertical mixer for creams and desserts

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Industrial cream whipping machine

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Vacuum mixer for liquid and cream processing

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Vacuum homogenizer for creams and ointments

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Undervacuum homogenizer for cosmetic and pharmaceutical creams

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Compact milk pasteurizer for milk, cream, and whey

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High pressure homogenization system for dairy and creams

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Small-scale milk pasteurizer with skimming centrifuge

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Vacuum homogenizer for cosmeto-pharma applications

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Vacuum homogenizer for cosmetics and pharmaceuticals

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Energy-saving cooling tumbler for industrial kitchens

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Stainless steel milk storage tank

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Centrifugal separators for liquid/liquid/solid separation

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Layered food production line

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Parfait production line equipment

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Pneumatic depositor for bakery batters and fillings

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Portable table top bakery depositor

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Automatic milk standardization unit

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Pasteurizer for dairy products

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Direct Uht processing system for dairy and plant-based beverages

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Automated milk standardization unit

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Indirect Uht processing for dairy products

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Dry and liquid ingredient batch mixer for bakery applications

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Self-priming centrifugal pump for entrained air handling

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High pressure homogenizer for dairy and food processing

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Ultra high temperature infusion plant for milk processing

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Ultra high temperature (uht) direct heating for infusion Esl plant

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Hygienic tanks for various processing needs

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Infusion Uht system for dairy and plant-based beverages

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Complete cutting, mixing, emulsifying and heating system

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Low temperature evaporator for heat-sensitive food products

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Curd making equipment for cheese production

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Continuous heat exchanger for soups and sauces

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Industrial premixing system for batch and inline processing

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High solids crossflow filter for wine filtration

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Lipstick moulding system

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Lipstick packaging fit tester

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Laboratory demoulding unit for lipstick samples

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Inline high shear mixer for low to medium viscosity liquids

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Multifunctional mixer for high volume batches

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Volumetric filling and capping solution for liquids and viscous products

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Horizontal element kieselgur filters

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Htst pasteurization system for liquid foods

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Centrifugal separators for dairy products

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Cip cleaning system for dairy industries

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Rotary filling and sealing for liquid to pasty products

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High speed cheese dosing and wrapping solution

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Filling and sealing pre-formed cups solution

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Homogenizers for high-pressure applications

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High-pressure homogenizers for dairy and beverage industries

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Beer production filtration system

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Open milk cooler with 2,000 liters capacity

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Vertical milk cooler for large-scale farms

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Industrial aseptic fillers for food processing

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Scraped surface sterilizers for food industry products

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Aseptic filler for bag-in-box packaging

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Industrial pasteurizer for dairy and beverage processing

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Inline system for personal care product production

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Caramel cooking solution

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Gravity filling systems for still beverages

Ensure precise and clean filling for still beverages with gravity systems that...

Pneumatic dosers for variable density products

Achieve precise dosing for liquid to dense products with versatile pneumati...

Inline high shear mixing unit for low to medium viscosity products

Achieve precise emulsification and size-reduction wi...

High-shear mixer for high viscosity products

Achieve consistent, homogeneous mixtures of high-viscosity products with a ve...

Ultra-high shear mixer for emulsification and homogenization

Optimize your production with ultra-high shear mixing, acce...

Aseptic fillers for liquid and viscous products

Ensure sterile and precise filling of liquid and viscous foods with adapta...

High-precision rotary weight filler for edible oils and sauces

Achieve exceptional filling precision with solutions desi...

Semi-automatic filler for bag-in-box packaging

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Chocolate processing unit for mixing and grinding

Achieve precise mixing and conching efficiency for premium chocolate an...

Automatic chocolate processing line

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Ball mill refiner for cocoa liquor and chocolate production

Optimize your cocoa and chocolate refinement with precise gr...

Scraped surface sterilizer for high viscosity liquid products

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Industrial cheese processing plants

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Cheese processing plant

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Cheese processing plant for hard and semi-hard cheese

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Cip cleaning systems for dairy processing plants

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Cheese vat for varied cheese types

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Cheese vat for diverse cheese production

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Depositing solutions for liquid and semi-liquid foods

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Full production line with depositing and ultrasonic cutting

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Linear filling and capping for stable bottles

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In-line external homogenizer for industrial fluid processing

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Rotary filler for preformed containers

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Label inspection for vertical products

Ensure label quality and accuracy with advanced inspection technology designed for p...

Conical mixer for dry, moist, and viscous materials

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Plate heat exchanger sterilizer for food products

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Aseptic tank module for liquid food storage

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Gasketed plate heat exchangers for hygienic applications

Ensure optimal hygiene and thermal efficiency in your processing...

Drum decanting unit for high viscosity liquids

Efficiently decant high viscosity liquids like solvent-based paints and ess...

High precision three-roller wraparound labeller

Achieve precise label placement on round containers effortlessly with a th...

Industrial melt tanks for butter and chocolate

Reduce manual labor and elevate safety in your production line with a melt ...

Rotary pressure sterilizer for canned food products

Streamline your canning operations with continuous high-speed sterili...

Volumetric piston filler for liquid and viscous products

Achieve precise volume control and enhance product integrity wit...

Hygienic centrifugal pump for beverage applications

Ensure gentle handling and efficient transfer of sensitive liquids wi...

Sustainable packaged compressor system

Enhance your production with a scalable compressor system designed for high efficien...

High shear mixer for dairy and personal care products

Achieve consistent emulsification and stable homogeneity with high ...

High shear test mixers for developing new products

Streamline product development with high shear test mixers, allowing y...

Very high pressure homogenizer compression block

Experience reliable performance at extreme pressures with a compression b...

Industrial homogenizer for dairy, beverage, and pharmaceutical applications

Enhance your production efficiency with a ...

Aseptic filling system for bag-in-box containers

Ensure sterility and precision in filling aseptic liquid products, with s...

Aseptic liquid dosing system

Ensure precise, sterile dosing of aseptic liquid products, enhancing product integrity and exte...

Compact plate evaporator for temperature-sensitive products

Ensure optimal heat transfer and minimal space usage with th...

Solid-wall bowl separators for milk & whey

Achieve precise skimming and standardizing of milk and whey with this advanced ...

Rotary piston fillers for pumpable products

Optimize high-speed production lines with precision filling for diverse liquid...

Industrial coating pan for food and pharmaceutical products

Optimize your production with precision mixing and coating, ...

Industrial mixers for hire

Optimize your production line with versatile mixers designed for precision blending, heating, and...

Emptying systems for high viscosity fluids and pastes

Efficiently empty high-viscosity fluids and pastes with precision, ...

Milk reception unit for dairy processing

Ensure precise measurement and streamlined handling of raw milk with an engineered...

Complete mixing solution for food, cosmetics, and chemical industries

Optimize your production line with a system that ...

Turnkey stainless steel tanks

Optimize your liquid processing with versatile stainless steel tanks designed for efficient st...

Industrial chiller systems for processing cooling

Optimize your production line with advanced chiller systems designed to...

Industrial depositor for automated recipe management

Effortlessly streamline your production with precise depositing cont...

Multi piston depositors for bakery production

For bakeries seeking precision in depositing and filling, these multi piston...

Aseptic filler for fruit juices and purees

Ensure product integrity and shelf stability with a versatile filler designed t...

Rotary cup filling and closing system

Maximize production efficiency with a system that offers precision filling and secure...

Forming, filling, and sealing system for liquid food products

Achieve precise portion control and versatile packaging wi...

Indirect Uht treatment for dairy products

Ensure your beverages achieve extended shelf life with consistent quality using ...

Direct Uht processing for heat-sensitive liquid products

Achieve optimal taste and nutritional value in liquid foods thro...

Spore and bacteria removal unit for dairy products

Ensure superior quality by precisely removing spores and bacteria from...

Industrial clarifier for dairy and plant-based products

Optimize your production line with cutting-edge clarification tec...

High shear mixer for dairy and beverage applications

When creating complex formulations like sauces or dairy spreads, ach...

Homogenizer for high-capacity food processing

Achieve superior emulsification and suspension handling with this high-press...

Evaporator for dairy products

Need efficient moisture removal in diverse dairy and food applications? This falling film evap...

Aseptic tank with blending function for liquid food storage

Achieve seamless integration of aseptic buffering and in-lin...

Ultra-high temperature processor for premium liquid foods

Achieve superior product quality and flexibility with advanced...

Uht processing unit for dairy products

Optimize your liquid food production with continuous, high-capacity UHT treatment th...

Industrial homogenizer for dairy and beverage applications

Enhance product quality and reduce operational costs with a h...

High-pressure homogenizer for dairy and beverage products

Achieve optimal product consistency and extend shelf life with...

Ingredient dissolver for small batches

Efficiently dissolve water-soluble powders and concentrates up to 200 cP with precis...

Industrial plate heat exchanger for food processing

Ensure consistent product quality with precise temperature control an...

Storage tank for food liquid storage

Ensure seamless liquid product handling with precision-engineered storage tanks design...

Filling system for tetra wedge aseptic packages

Optimize your production line with a reliable filling system designed to e...

Semi-automatic capping solution for small to medium operations

Streamline and personalize your capping processes with ve...

Cleaning in place system for dairy processing plants

Streamline cleaning efficiency and ensure product quality in your da...

Milk pasteurizer system

Ensure your dairy and plant-based beverages achieve optimal safety and quality with precise temperatu...

Pilot plant homogenizer for immiscible liquids

Streamline your R&D with precise homogenization, allowing you to test ...

Multipurpose ultra high temperature (uht) pilot plants

Optimize liquid food production with a versatile pilot unit design...

Plate juice pasteurizer system

Ensure optimal pasteurization with precise temperature control and high heat recovery, reduci...

Combi ultra high temperature (uht) processing plant for dairy and beverages

Achieve precise heat treatment for diverse...

Sanitary gasketed plate heat exchangers for clean applications

Ensure product purity and maintain hygienic standards wit...

High pressure homogenizer for food and beverage processing

Optimize your production line with a versatile high-pressure ...

Clean in place (cip) system for industrial cleaning

Ensure optimal hygiene and production efficiency with a system that s...

Centrifugal atomizer for precise spray drying

Achieve precise control over particle size and moisture content with centrif...

Process tanks for mixing, cooking, and cooling applications

Efficiently tackle viscous product challenges with advanced ...

External washing and drying system for sealed vials

Ensure contamination-free packaging of liquid vials with this precise...

Milk pre-cooling systems for dairy farms

Optimize dairy production with advanced milk pre-cooling systems that significantl...

Instant milk cooling systems for dairy farms

Optimize your dairy operations by instantly cooling milk with systems designe...

Remote monitoring app for milk coolers

Ensure milk quality and streamline operations with a remote monitoring app that prov...

Flexible R&D wet agitator mill for cosmetics

Using nanoparticles in cosmetics requires precise control over material break...

Agitator bead mill for API

To achieve precisely defined API properties and safe and reproducible production, rigorous implem...

Manual metal tube sealing equipment

For small-batch productions where you utilize metal tubes as containers for your produc...

R&D bottle washer

When you pack your products in bottles, vials, syringes, and test tubes you need to wash them before fillin...

Up to four head automatic filling machine

When your consumer demand is increasing you will need new and more effective pac...

GMP homogenizing system

Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accur...

Small-scale laboratory dispersing machine

Developing and validating new processes requires reliable and highly versatile e...

Self-adhesive linear labeling machine for bottles

It is vital to have precise and long-lasting labels on bottles to avoid...

High pressure electric laboratory homogenizer

It’s vital that small units for experimentation can scale up with 100% accur...

High pressure pilot homogenizer

Biotech and pharmaceutical development programs often require a mixing method that achieves ...

High pressure industrial homogenizer

For any industrial pharmaceutical process that relies on high pressure homogenization ...

Pilot high pressure homogenizer

For maximum value, a high-pressure homogenizer that’s suitable for both laboratory and pilot...

High pressure air powered laboratory homogenizer

Offering lab-scale to small pharmaceutical production scale output for in...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a wa...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning an...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing components used in the productio...

In-line monoblock linear filler & capper

In many food, chemicals and cosmetic industry processes it is vital to have a...

Flowmeter filler

For larger production runs of food, non-food and cosmetics industries, where accuracy and volume of filling i...

Colloid mill

For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen.  ...

High-pressure homogenizer

When processes call for homogenized emulsions with extremely fine particle sizes the traditional t...

Compact monoblock filler

Filling and capping bottles and pots for food, chemical and cosmetics industries using separate mach...

Single head capper

For the stand-alone capping of bottles of up to 30 litre capacity for smaller-scale production you need a ...

Tube unloader and feeder

The pharmaceutical and cosmetic industries utilise high speed tube fillers on large-scale production...

Tube feeding unit for high volume and high speed tube filler

High performance tube-filling machines are used for large s...

Loading cassette for a tube filler

High performance tube-filling machines are used in the pharmaceutical and cosmetic indus...

Tube feeder for a small scale production tube filler

Low speed tube-filling machines are used for small scale production ...

High speed automatic tube filler

For high-volume lines filling pharmaceutical, cosmetic or food products into tube container...

High-capacity horizontal cartoner for pharma and cosmetics appliances

Cartoners take carton blanks which are formed and...

Automatic cartoner for applications in pharma and cosmetics

For high capacity production of cosmetics and pharmaceutical...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pharmaceutical products are packed ...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are packed in protective and decorati...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic products are sold in protective and de...

Medium speed tube filler and sealer

For scale-up filling of tube packaging for pharmaceuticals, cosmetics and food products...

Medium and high speed range automatic tube filler

When scaling up production of pharmaceutical, food or cosmetic products...

Low speed tube filler

Increasing numbers of products in the pharmaceutical, cosmetic and food industries are delivered in fle...

A two-component filling application tube filler

A wide variety of pharmaceutical, cosmetic and food products require tube-...

Servo controlled filler

For food and non-food liquid products that are high foam or have a high viscosity a specialist fillin...

Multi-head capper

For the stand-alone capping of bottles of up to 2.5litre capacity you need a robust and flexible machine wi...

High-speed unscrambler for large bottles

Large volume plastic bottling plants need high-speed unscramblers suitable for lar...

High-speed unscrambler for small bottles

Large-scale production of smaller volume bottled product needs a gentle, accurate ...

Low-speed unscrambler

Smaller plastic bottling lines need a lower cost, lower volume unscrambling machine that maintains gent...

Corundum disk mill

Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,mus...

Dispersing machine for emulsions and suspensions

Equipment operating under the rotor/stator principal is often employed wh...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Dispersing machine for very fine emulsions and suspensions

For continuous high performance mixing of solid and liquid ra...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Cone mill machine

When your raw materials include agglomorated suspensions of grainy or crystalline solids and your process n...

Inline batch mixer for solids and liquids

Several issues often arise when your process requires batch-wise mixing of powde...

Continuous homogenizing system

Certain mixing tasks present unique challenges and manufacturers need equipment that is speci...

High accuracy homogenizing system

When extremely high accuracy is required in your recipe or formulation traditional mixing...

Horizontal kneader

For high viscosity products, better results and reduced process times can be achieved with kneading type r...

Vertical kneader

Production of highly viscous products with high solid content often benefits from kneading processes rather t...

Continuous kneader

Effective mixing of highly viscous products with extremely high solids content can be difficult and the re...

Batch dispersing machine

Equipment operating under the rotor/stator principal is often employed when more traditional methods...

Batch dispersing machine for abrasive products

For mixing and dispersing tasks that cannot be completed by conventional st...

Batch dispersing machine for bottom entry into vessels

When your process requires high performance mixing or dispersion b...

Cost-effective homogenizing and emulsifying system

Manufacturers of cosmetic products need mixing equipment that is capab...

Dust-free continuous homogenizing system

Producers in a wide variety of industries benefit from equipment that can continuo...

Dilution system for two or more liquids in one pass

Onsite dilution of liquid process ingredients has historically been a...

Pilot dispersing machine for testing and scale-up

Innovators in process development need laboratory equipment that helps ...

In-line laboratory dispersing machine

Innovators in a wide variety of industries need laboratory equipment on which process...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

Jet flow agitator for high-viscosity media

Processes including homogenization, dispersing, suspension, emulsification and ...

Agitator for medium viscosity media

Mixing fluids of medium viscosity for many production processes requires an agitator wi...

Agitator for low viscosity media

Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale p...

Small batch filter press for oil seeds

Getting a high-quality oil filtration can be a challenging task,  with a filtration ...

Cold oil press for seeds

With a cold oil press, you can optimize the process of extracting oil from a wide variety of oil see...

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