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Topical semi-solid dosage forms are the mixture of oil and water which makes an emulsion in form of creams, lotions, ointments, and gels. These topical dosage forms come in tubes or bottles, depending on the type of medicine and are easy to apply and absorb into the skin.

What creams equipment do you need?

Pilot ultrasonic extractor

In the herbal medicine industry, an ultrasonic extractor is a valid alternative to conventional e...

Batch vacuum mixer for ointment

The production of creams or ointments can be either be a water in oil (w/o) or oil in water ...

Self-adhesive linear labeling machine for bottles

It is vital to have precise and long-lasting labels on bottles to avoid...

Cosmetic cream filler

From thin liquid baby oils and perfumes to thicker lotions and creams for hair and skincare, cosmetic p...

High pressure electric laboratory homogenizer

It’s vital that small units for experimentation can scale up with 100% accur...

High pressure pilot homogenizer

Biotech and pharmaceutical development programs often require a mixing method that achieves ...

High pressure industrial homogenizer

For any industrial pharmaceutical process that relies on high pressure homogenization ...

Pilot high pressure homogenizer

For maximum value, a high-pressure homogenizer that’s suitable for both laboratory and pilot...

High pressure air powered laboratory homogenizer

Offering lab-scale to small pharmaceutical production scale output for in...

Pharmaceutical formulation and mixing tanks

Preparation lines for formulating pharmaceuticals include fixed and mobile tan...

High shear lab mixer for creams

Lab-scale mixers are vital in the design or small-batch production of a range of pharmaceuti...

Filling Machine for Cosmetic Creams and Lotions

Liquid cosmetics have particular requirements when it comes to filling and...

Homogenizer for creams

Homogenization (or pharmaceutical micronization) is the process of reducing particle sizes, and is a v...

GMP washer

In order to guarantee zero cross-contamination between production batches, the proper cleaning of all product-conta...

GMP chamber washer

The thorough cleaning of small product contact parts has always been challenging, and traditional manual c...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a wa...

Portable IBC washer

The thorough cleaning of bulk containers and other storage and processing equipment is a vital step in th...

IBC bin washer and dryer

Many pharmaceutical processes use IBCs of multiple sizes throughout production. Careful washing and ...

CIP system for bulk tanks

Clean in Place (CIP) technology offers many advantages, but traditional systems are often inflexib...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning an...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing components used in the productio...

In-line monoblock linear filler & capper

In many food, chemicals and cosmetic industry processes it is vital to have a...

Flowmeter filler

For larger production runs of food, non-food and cosmetics industries, where accuracy and volume of filling i...

Colloid mill

For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen.  ...

High-pressure homogenizer

When processes call for homogenized emulsions with extremely fine particle sizes the traditional t...

Compact monoblock filler

Filling and capping bottles and pots for food, chemical and cosmetics industries using separate mach...

Sachet Machine

If you want to pack into eye-catching 4-side sealed sachets between 40×50 mm and 250×200 mm in size, ...

Single head capper

For the stand-alone capping of bottles of up to 30 litre capacity for smaller-scale production you need a ...

Tube unloader and feeder

The pharmaceutical and cosmetic industries utilise high speed tube fillers on large-scale production...

Tube feeding unit for high volume and high speed tube filler

High performance tube-filling machines are used for large s...

Loading cassette for a tube filler

High performance tube-filling machines are used in the pharmaceutical and cosmetic indus...

Tube feeder for a small scale production tube filler

Low speed tube-filling machines are used for small scale production ...

High speed automatic tube filler

For high-volume lines filling pharmaceutical, cosmetic or food products into tube container...

High capacity horizontal cartoner for pharmaceutical and cosmetic appliances

Cartoners take carton blanks which are fo...

Automatic cartoner for applications in pharmaceutical and cosmetics industry

For high capacity production of cosmetics...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pharmaceutical products are packed ...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are packed in protective and decorati...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic products are sold in protective and de...

Medium speed tube filler and sealer

For scale-up filling of tube packaging for pharmaceuticals, cosmetics and food products...

Medium and high speed range automatic tube filler

When scaling up production of pharmaceutical, food or cosmetic products...

Low speed tube filler

Increasing numbers of products in the pharmaceutical, cosmetic and food industries are delivered in fle...

A two-component filling application tube filler

A wide variety of pharmaceutical, cosmetic and food products require tube-...

Servo controlled filler

For food and non-food liquid products that are high foam or have a high viscosity a specialist fillin...

Multi-head capper

For the stand-alone capping of bottles of up to 2.5litre capacity you need a robust and flexible machine wi...

High-speed unscrambler for large bottles

Large volume plastic bottling plants need high-speed unscramblers suitable for lar...

High-speed unscrambler for small bottles

Large-scale production of smaller volume bottled product needs a gentle, accurate ...

Low-speed unscrambler

Smaller plastic bottling lines need a lower cost, lower volume unscrambling machine that maintains gent...

GMP homogenizing system

Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accur...

Corundum disk mill

Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,mus...

Dispersing machine for emulsions and suspensions

Equipment operating under the rotor/stator principal is often employed wh...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Dispersing machine for very fine emulsions and suspensions

For continuous high performance mixing of solid and liquid ra...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Cone mill

When your raw materials include agglomorated suspensions of grainy or crystalline solids and your process needs a st...

Inline batch mixer for solids and liquids

Several issues often arise when your process requires batch-wise mixing of powde...

Continuous homogenizing system

Certain mixing tasks present unique challenges and manufacturers need equipment that is speci...

High accuracy homogenizing system

When extremely high accuracy is required in your recipe or formulation traditional mixing...

Horizontal kneader

For high viscosity products, better results and reduced process times can be achieved with kneading type r...

Vertical kneader

Production of highly viscous products with high solid content often benefits from kneading processes rather t...

Continuous kneader

Effective mixing of highly viscous products with extremely high solids content can be difficult and the re...

Batch dispersing machine

Equipment operating under the rotor/stator principal is often employed when more traditional methods...

Batch dispersing machine for abrasive products

For mixing and dispersing tasks that cannot be completed by conventional st...

Batch dispersing machine for bottom entry into vessels

When your process requires high performance mixing or dispersion b...

Cost-effective homogenizing and emulsifying system

Manufacturers need production mixing equipment that is capable, flexib...

Dust-free continuous homogenizing system

Producers in a wide variety of industries benefit from equipment that can continuo...

Dilution system for two or more liquids in one pass

Onsite dilution of liquid process ingredients has historically been a...

Small-scale laboratory dispersing machine

Developing and validating new processes requires reliable and highly versatile e...

Pilot dispersing machine for testing and scale-up

Innovators in process development need laboratory equipment that helps ...

In-line laboratory dispersing machine

Innovators in a wide variety of industries need laboratory equipment on which process...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

Jet flow agitator for high-viscosity media

Processes including homogenization, dispersing, suspension, emulsification and ...

Agitator for medium viscosity media

Mixing fluids of medium viscosity for many production processes requires an agitator wi...

Agitator for low viscosity media

Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale p...

Small batch filter press for oil seeds

Getting a high-quality oil filtration can be a challenging task,  with a filtration ...

Cold oil press for seeds

With a cold oil press, you can optimize the process of extracting oil from a wide variety of oil see...

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Pharmaceutical creams and ointments are mostly used for the treatment of different skin problems, such as rashes, skin irritation, stings, fungal infections, etc. Unlike cosmetic skincare products, pharmaceutical creams are required to contain 99% of pure active ingredients, such as various Vitamins and Peptides as these are meant to penetrate deep into the skin to reach targeted cells and make a difference in the skin. Cosmetics creams and lotions only work on the epidermis, the outermost layer of the skin. Therefore, the active ingredients added to cosmetics products may be similar to ingredients found in pharmaceutical creams but are used in smaller concentrations.

Production processes for making creams and ointments

​Mixing is a critical stage in obtaining fine droplet size to form a stable emulsion and the right cream consistency. Ingredients, formulation and viscosity vary per product. However, a typical manufacturing process to create either a cream or ointment breaks down into four steps: Oil phase preparation, Water phase preparation, Forming the emulsion and Active ingredients dispersion.

Solid waxes, emollients and lubricants need to be dispersed into mineral or silicone oil. Heating might be required to melt some ingredients like waxes. Emulsifying, stabilizing and thickening agents are added and dispersed into a separate vessel with water. Hydration can be accelerated by additional heating. Prepared oil needs to be added to a water substance. The two phases need to be blended under strong agitation to form the emulsion. Active ingredients are also added in either phase and must be efficiently dispersed to achieve smooth consistency and texture of the cream.

High shear mixer vs conventional aerator

Mixing high viscosity and greasy pharmaceutical creams and ointments is a very challenging process. Using standard mixer like conventional agitator to incorporate powders into liquids and create a homogeneous and fine emulsion can cause several problems. One of them would be the formation of agglomerates which could lead to a longer mixing time due to difficulties in hydrating the thickeners.

High shear mixing is a preferred solution to use for creams and ointments. These are available for both batch or continuous processes and can eliminate intermediate stages of production that dramatically reduce the processing time. As shown in the video below, high shear mixer makes sure that the thickening agents are fully hydrated and other ingredients fully dispersed, which forms a stable emulsion in shorter period of time.

Formulating creams

Creams as emulsions can be relatively unstable, which requires to create an effective formulation through the careful selection of the correct excipients. Excipients allow to prevent the formulation instability and extend the product shelf life. Some of them include preservatives, emollients, emulsifiers, viscosity modifiers, solvents. Excipients can mix together to result the molecules organize on a microscopic scale and build structure in the formulation, called microstructure.

The creams with the right formulation are easy to apply and don’t leave much residue. Ideal formulation doesn’t make the cream greasy and creates the right texture, without large crystals that may result in skin irritation. Moreover, the right formulation should provide a proper dermal drug delivery into skin, which shows that the active ingredient being incorporated effectively.

Packing of creams and ointments

When filling topical formulations it is essential to get the amount of product in various consistencies per container just right and to be able to accommodate various container shapes and sizes. There are many factors that influence the decision for choosing a container to fill in topical dosage forms. Some of these factors are materials and visual appearance while others are specific to the usage of the product filled. The most common containers for filling creams are tubes and glass or plastic jars.

Tubes have narrow openings that protect the creams against contamination and preserves the product’s shelf life. Tubes are mostly made from low or high-density polyethylene and aluminum. They have various top shapes that can be applied. For example, triangular toppers allow to push out as much product as needed with precision. Push tops are also common for creams that need controlled amounts produced with each pump. Tubes can be of different diameters ranging from 16mm to 50mm and the capacity ranging from 5ml to 240ml.

Cream making equipment in action

Tube filling line

Equipment for mixing, dispersion and emulsification

Making cosmetic creams explained

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