Nasal spray filling solution

For precise nasal spray production, achieve seamless filling, stoppering, and capping to ensure product sterility and dosage accuracy, maintaining consistency across batches.

Fills, Stoppers, and Caps Nasal Spray Containers

The Hull i-Dositecno Nasal Spray Filling Machine, available as the BI and MI models, offers a robust solution for pharmaceutical and biotech manufacturers seeking precise and efficient fill-finish processes. This machine excels in filling, stoppering, and capping operations using a servo-driven, motion-controlled design, capable of handling up to 50 or 200 units per minute.

Ideal for applications ranging from nasal decongestant sprays to liquid vaccine vials, it fills containers as small as 100µL up to 500mL. The equipment integrates seamlessly into your existing production line, utilizing Siemens or Allen Bradley PLC-controlled servo motors for precise output rate and flow adjustments.

Constructed with high-quality materials like POMc for change parts, the machine offers adaptable filling solutions via a peristaltic pump or rotary piston. It ensures strict compliance with regulatory standards, including 21 CFR Part 11, cGMP, and GAMP5, and comes equipped for integration into RABS and isolation systems for ultimate product protection.

The design includes features such as a mechanical unscrambler and dedicated hopper for efficient container feeding, while non-destructive In-Process Weight Control (IPC) maintains batch consistency. Cleaning is simplified with options for CIP/SIP processes, and comprehensive customization is supported by ATS Scientific Products’ dedicated engineering team.

Benefits

  • Ensures product sterility and compliance with GMP and FDA standards, reducing regulatory risks.
  • Offers precise filling accuracy, minimizing product waste and enhancing yield consistency.
  • Adapts to various container sizes, reducing changeover times and increasing operational flexibility.
  • Integrates seamlessly into existing production lines, optimizing workflow efficiency.
  • Maintains batch consistency with non-destructive In-Process Weight Control (IPC), ensuring reliable output quality.

General


Applications
Liquid pharmaceuticals,Micro-dose liquid products,Pharmaceutical containers,Aseptic liquid formulations,Nasal sprays
End products
Antihistamine nasal sprays,Preservative-free nasal drops,Aseptic eye drop bottles,Liquid vaccine vials,Liquid vitamin supplements,Saline nasal rinses,Sterile saline solutions,Steroid nasal sprays,Nasal decongestant sprays
Steps before
Container Preparation,Component Sorting,Material Feeding
Steps after
Stoppering,Capping,Quality Control
Input ingredients
nasal spray solutions,bulk containers,plastic containers,liquid formulations,solid powder
Output ingredients
filled nasal spray containers,stoppered containers,capped containers,accurately dosed units
Market info

Technical Specifications


Filling speed
50–200 upm
Filling volume
100µL to 500 mL
Automation
PLC-controlled
Container type
Multiple vial formats
Dosing type
Peristaltic pump / ceramic / SS rotary piston
Cleanroom compatibility
Cleanroom ready
Changeover time
Quick changeover with POMc change parts

Operating Characteristics


Automation level
PLC-controlled servo motors
Batch vs. continuous operation
Batch
Servo-driven motion control
Yes
In-Process Weight Control (IPC)
100%,non-destructive
Cleanroom readiness
Cleanroom compliant
Flexibility in container size
Multiple vial formats
Product protection
RABS / isolation technology
Changeover time
Quick changeover with POMc parts
CIP/SIP
Available
Integrated steps
Filling,stoppering,capping

Material Compatibility


Cleanability
Cleanroom ready
Corrosive resistance (e.g. acids)
Yes,for certain materials like stainless steel
Biological compatibility
Pharmaceutical-grade components

Physical Characteristics


Feed method
Mechanical unscrambler,automatic container feed
Control panel type
Siemens or Allen Bradley PLC-controlled

Custom Options


Control panel type
Siemens/Allen Bradley PLC
Discharge method
Servo-driven motor
Filling method
Rotary Piston / Peristaltic Pump
Filling nozzle configuration
One or two filling nozzles
Container handling
Servo-driven star wheel transport
Feeding system
Mechanical unscrambler / Dedicated hopper
Pick and place capability
2-channel for tips and caps
Changeover parts material
Polyoxymethylene Copolymer (POMc)
Integration possibility
Open/Closed RABS,Isolation Technology