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Maker - Product Challenge

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Tablet Granulation Equipment

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

There are slight differences between human and animal pharmaceuticals, but that dissimilarity is enough to create new production challenges. Veterinary tablets formulation reflects the diversity of enzymes that different species use to break down substances. Although the methods involved are comparable to human drug manufacturing, equipment and processes need to adapt to a wider dosage variability in veterinary tablets.

Veterinary tablets

brochure_lb_bohle_granulation

Brochure_lb_bohle_granulation

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

Complete fluidization and even coating of particles

Pressure shock resistance of up to 12 bar, optimum for containment application

Capacity range of 1 to 500 kg

Efficient space utilization due to low installation height

Can be equipped with a moisture measurement system to determine moisture level during the drying process

A granulator is a high-speed knife mill designed to cut down large components of feedstock and reduce them to smaller particle sizes. Selecting the right scissor geometry and configuration allows granulators to process plastic bottles, organic fibers, films, wires, cables, and other difficult materials. Agglomeration granulators combine fine particles into larger granules by creating bonds between them. Bonds are formed by compressing fine particles or through the use of a binding agent.

Granulators

Pharmaceutical

Granulation

Connect directly with world leading manufacturers of Granulation equipment and find technology to build or improve your production line.

Granulation &#8211; Making.com

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Pharmaceutical industries employ several processes including drying, coating and granulation to create high-quality granules. Manufacturers can benefit

Fluidized bed system for the granulation and drying of pharmaceuticals &#8211; Making.com

We open production technology to everyone

Making.com

brochure_lb_bohle_brc

Brochure_lb_bohle_BRC

Wide production range, from less than 1kg/h up to 400 kg/h

Rotary sieve can be changed quickly according to process requirements

Uniform output through precise compaction force including ribbon thickness

Hygienic design and Washer nozzles allow WIP (Washing In Place)

Minimal product loss

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Compaction machines and technologies crush or compress materials and make them denser. Compaction can be used to simply save space or to shape materials into a desired form or format. Tablets, pellets, or briquets are formed by compactors but powder presses also help form cosmetic eyeshadow or face powder.

Compaction

When making tablets, pharmaceutical manufacturers need to use a mechanical process, like a rolling press for compaction, to produce granules from powders

Continuous roller compactor for dry granulation of pharmaceuticals &#8211; Making.com

A dishwasher tablet is an essential detergent. It consists of a pressed mixture of sodium and potassium salts, surfactant, fragrance, and other filler agents, mixed with the help of tablet making machines. The products’ use in America and Europe is high, unlike in the Asian continent, where the price limits its usage. Its global market size will reach $990 million in 2026 from $475.6million in 2019, according to Grand View Research forecasts.

Dishwasher tablets

The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.

Dry inhaler powder

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

Visual inspection window enables to access products during the process

Single frame and in-wall design allow to save up space

Reduces the risks of cross-contamination

Form, fill, and seal machines complete the packaging, filling, and sealing in one continuous process and eliminate the need for three separate machines. Most form, fill and seal systems use flexible films to form the primary package. Vertical machines are simpler and faster whereas horizontal systems are better suited to the packaging of solid products that do not flow well. Form, fill, and seal machines are widely used in the food industry for packaging snack foods, powdered products, liquids, and pastes and in the pharmaceutical industry for the production of IV bags, powder sachets, and stick packs.

Form fill sealing equipment

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Liquid

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Process

Batch

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

liquid

solid

Granulation is a common technique in production of pharmaceutical solid dosage forms. Due to high quality requirements of the formed granules in terms of

Granulation line for pharmaceutical solid dosage forms &#8211; Making.com

Turnkey granulation solution as reduced cost

100% compatible equipment

  Consistent control interface and features across equipment

Vacuum conveyor system reduces manual handling and improves throughput

Fluid bed dryers use a stream of hot air to reduce the moisture content of powders and granules. This principle is often used for the production of high-quality pharmaceutical powders as well as the production of animal feed, minerals, sand, and dairy products.

Fluid bed dryers

R&amp;D

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

A complete granulation line allows for the mixing and granulation of pharmaceutical compounds for the production of tablets. By linking fully compatible

Granulation line of mixer and fluid bed dryer &#8211; Making.com

sensum_patvis_apa_brochure_en-pdf

Sensum PATVIS APA

Production with immediate feedback by timely detection of variations

Continuous generation of process reports and statistical data

Ease of installation in a wide range of processes

Provision of real time data analysis with no need of calibrations

Continuous milling is a flow production method used to grind materials without interruption. It is often used in the production of foods, cosmetics, pharmaceuticals, chemicals, and minerals. The material to be processed flows in at one end and the milled output flows out at the other in a continuous process. By choosing the right combination of milling technology and processing power you can obtain the desired particle size distribution in an uninterrupted stream.

Continuous milling solutions

Continuous

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Milling machines are used to reduce the size of material by cutting, crushing, or grinding it. The choice of industrial milling equipment depends on the industry and the materials to work with. Besides, there is a significant difference between those aimed to remove layers from metal or other materials workpieces and those designed to reduce particle size for materials that come in bulk.

Milling

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Pelleting equipment transforms powdered, mashed, or grounded material into a denser cylindrical shape. Pellet processing compresses the fine material against a perforated die, where it will be shaped and cut. Although granulating and extrusion also produce pellet-like products, manufacturing pellets is a distinct process.

Pelleting

Products like granules, tablets and capsules require inspection at numerous steps in the production and packaging process. Since all pharmaceutical and

Particle analysation monitor &#8211; Making.com

brochure_ste_fluid-bed-dryer-pdf

Brochure_STE_Fluid-bed-dryer.pdf

Load valve to charge product by lance

Sight glass or window allowing you to observe the internal process

Low energy consumption compared to other types of dryers

Fluid bed drying is a pharmaceutical process carried out to reduce the humidity and achieve the required moisture content in the granules or powders. It

Fluid bed dryer for pharmaceutical solid dosage form &#8211; Making.com

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Brochure_STE_High-shear-mixer-granulator.pdf

No contact top cover

Counterflow pharma air to avoid cross contamination

Easy operation with recipe editing

A high-shear mixer produces flow and shear in a fluid to help disperse separate phases. Choosing a shear mixer requires multiple considerations including the degree of dispersion and homogeneity required, the targeted time cycle, heating or cooling requirements, and the desired batch volume or flow rate. High shear mixers are used in the pharmaceutical industry for the production of syrups, creams, and ointments, in the chemical industry for the dispersion of pigments or other powders in a liquid medium, and in the food industry for the preparation of sauces and dressings.

High-shear mixers

It is rather difficult to successfully produce a pharmaceutical solid dosage forms with the desired properties such as size, morphology, hardness and

Industrial high shear mixer granulator for drug formation &#8211; Making.com

Lab-scale machine, perfect for smaller batch sizes

Easy to operate with digital control panel

High-shear operation for superior agglomeration

For pilot and lab-scale pharmaceutical formulations, a high-shear granulation mixer is the perfect choice for cohesive materials. Traditional low shear

Entry-level high-shear mixer for drug formulation &#8211; Making.com

Around a third of your natural protein composition is collagen. But the human body still finds good use for more of it, whether to reinforce joints or aid digestion. Collagen powder processing breaks the chains of amino acids into smaller units, allowing them to be consumed at higher concentrations without changing your diet.

Collagen powder

Good product adaptation using different rollers and feed screws

Easy to clean

Automatic press forces

Chemical

Metal

Mineral

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

We carry dozens of metals around every day. The ubiquitous smartphone is built with no less than 20 metals, each with specific behaviors and purposes. Metals are a pervasive class of materials that have defined entire eras of human development. It is no exaggeration to say that metal processing equipment is the core of our metallic world. But, paradoxically, this manufacturing technology itself is mainly made of metal.

The nearly 5,000 known minerals on earth share some characteristics to be classified as minerals – they are inorganic, solid, naturally occurring elements and have a particular chemical formula and an ordered internal geometric structure. However, minerals are not all the same. One way to divide them is based on their physical characteristics such as hardness, luster, color, and shape. For example, the diamonds we use to make jewelry are very hard minerals while talc is a soft mineral; gold is a shiny mineral while others are less so.

Minerals

With the Pharmapaktor® Serie (Pharmapaktors series L, K and C 250) from Hosokawa Alpine, active substance mixtures are processed into granulate.

Pharmaceutical granulators are often used with active substance mixtures to be processed into granulates, a process also known as compaction. Dry

Pharmaceutical granulator &#8211; Making.com

Aluminium oxide or alumina is a naturally occurring compound of aluminium and oxygen made from bauxite, a dull and earthy rock with high aluminium content. Bauxite is the most common ore of aluminium and you can find it in tropical areas Most of the bauxite mined end up producing aluminium with specific aluminium oxide equipment. Statistics have shown that Australia and Guinea have the largest bauxite deposits in the world. Countries like China, Brazil, and India also have a large amount of the rock.

Aluminium oxide

Bentonite is a clay derived from the alteration of volcanic ash. Bentonite is solid, so after extracting it from the deposits, it has to be crushed and dried to reduce its moisture content up to 15%.

Bentonite

To make glue, you usually starting from gelatin, which is animal collagen. Glues help in the production of furniture, automobiles, clothing, paper, wood, art and craft, to name a few applications. The production of different glues depends on their industrial use. Different manufacturing processes and glue making equipment make it easier to create the many variations of this useful product.

Glue

Gypsum is a naturally occurring mineral that serves many purposes, with the United States producing the largest crude gypsum in the world. Cover walls, ceilings, plasters, fertilizers, cosmetics and some foods: gypsum’s vast applications granted it the recognition of "wonder mineral". Gypsum making equipment helps in making gypsum powder or board for industrial use.

Gypsum

Kaolin, also called china clay, is made from natural rock composed of aluminosilicate clay or kaolinite. Kaolin has wide applications in different industries. Moreover, their classification depends on their industrial use, which includes film formation, fiber extension, polymer extension and chemical composition. Choose a kaolin processing machine to help you make kaolin for beauty products, paper filler, coating, ceramics and even medicine.

Kaolin

A toner is a fine powder located in printer and copier cartridges. One peculiar property the product is their ability to act like liquids. Toner manufacturing equipment sees to it that the particle size is between 5 and 30 micrometers to flow through the cartridge.

Toner

Forged metal objects appear seamless, simple items. But as the use of metals changed over time and constructions became more intricate with additive manufacturing, a new way of processing materials surfaced. Metal powder manufacturing replaces the classic blacksmithing techniques, reducing scrap waste in the meantime. The final metal products, however, retain that shiny allure of the archetypal metal pieces.

Metal powder

Sulphur

Painting as an integral aspect of the human tradition dates to thousand years ago. Of the many properties of the product, the drying time is important to consumers. The thickness of the paint and environmental factors like humidity affect this parameter. Paint manufacturing equipment must include a humidity test chamber to assess the behavior of paint under different weather conditions.

Paint

When he was in Haiti in 1493, Christopher Columbus noticed that the natives were bouncing on rubber balls made from the milky sap of Hevea brasiliensis, also known as a rubber tree native to South America. The milky sap was nothing but latex, the source material for natural rubber. Latex processing technology includes equipment for coagulation techniques and rollers for natural latex and a sequence of mixers, pumps, and sieves for synthetic latex.

Latex

Colors present an enduring philosophical problem that generates lofty debates about subjectivism and consciousness. Meanwhile, ink manufacturing equipment turns colors into physical objects. Perhaps paradoxically, digitalization keeps fueling the use of printing ink. From custom clothing to secondary packaging to aircraft livery, inks are everywhere. Indeed, philosophical discussions are also primarily conducted in ink on paper.

As traced back to the first half of the 19th century, attempts at synthetic rubber production were simply to reproduce the original material due to the rubber shortage following World War II. Synthetic rubber production processes differentiate between producing the rubber, which can be done via solution polymerization and emulsion polymerization and creating the final product with the help of techniques such as molding and vulcanization.

Tablet Granulation Equipment

Which tablet granulation equipment equipment do you need?

Fluidized bed system for the granulation and drying of pharmaceuticals

Continuous roller compactor for dry granulation of pharmaceuticals

Granulation line for pharmaceutical solid dosage forms

Granulation line of mixer and fluid bed dryer

Particle analysation monitor

Fluid bed dryer for pharmaceutical solid dosage form

Industrial high shear mixer granulator for drug formation

Entry-level high-shear mixer for drug formulation

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