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Maker - Product Challenge

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Tablet Filling Equipment

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

There are slight differences between human and animal pharmaceuticals, but that dissimilarity is enough to create new production challenges. Veterinary tablets formulation reflects the diversity of enzymes that different species use to break down substances. Although the methods involved are comparable to human drug manufacturing, equipment and processes need to adapt to a wider dosage variability in veterinary tablets.

Veterinary tablets

brochure_multigel_automatic_counting_line-pdf

Brochure_Multigel_Automatic_counting_line.pdf

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

Economical way to upscale production of solid doses

Can count and fill a wide range of sizes and shapes of doses

High throughput for increased efficiency, up to 200,000 doses per hour

GMP design, with 316 stainless and FDA-approved materials

Touchscreen controls and monitoring for minimal operator input

Pharmaceutical

Filling lines

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

Connect directly with world leading manufacturers of filling lines equipment and find technology to build or improve your production line.

Filling - Making.com

Filling Lines Equipment - Making.com

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19th century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Process

Continuous

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

solid

For medium-scale production of solid doses such as tablets, capsules, and softgels that are provided in standard counts, an automated counting and filling

Automatic filling line for solid doses - Making.com

https://making-tst.imgix.net/2019/06/capsule-line.jpg

The marketplace for finding innovative production technology

Making.com

acg_world_1193_brochure-pdf

ACG_World_1193_brochure.pdf

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

Pelleted feed

Handles viscosities up to 40,000 cP

Reduces waste with 'no-capsule-no-fill' sensors

Supports oxygen-sensitive formulations

Versatile filling for various capsule ingredients

High output for medium to large batches

The two halves of a capsule shell are separately filled with your selected material before they are then pressed against one another and closed. Automatic capsule fillers orientate the shells in the precise position, fill them with your specified formula a join the ends. Capsules are then de-dusted and polished by micro brushes before they are ready for packaging.

Capsule fillers

Industrial

In the pharmaceutical world, encapsulation refers to various techniques to enclose and protect the drug ingredients by forming the capsule shell. Encapsulation equipment changes depending on whether the manufacturer needs to produce a soft or hard gel capsule. For instance, encapsulation systems and machines for softgels control the entire process from start to finish because their shells are filled at the same time they are produced. On the other hand, the filling of hard gel capsules comes by separating the body from the cap, and after the filling operations, the two parts are sealed together again, forming the shell.

Encapsulation

Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Purification

liquid

In the pharmaceutical industry, producing liquid-filled hard capsules with precision and minimal waste is crucial. Challenges include varying liquid

Liquid filling system for hard capsules - Making.com

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cremer_3228_brochure-pdf

Cremer_3228_brochure.pdf

Maintains 100% counting accuracy

High throughput of up to 200 bottles per minute

Easy to clean and maintain

Capable of handling various bottle shapes and solid dose types

Ensures product quality with Single Tablet Reject function

Bottle filling equipment entails transferring your products to a bottle which involves inspecting the material, and then conveyors feed it into the machine which then pours it into the vessels using volumetric technology and nozzles before capping them. Bottle filing varies not only in product type but in the size, shape, and material of the container too. Depending on your operation, filling systems may adopt in-line or rotary methods before transferring the bottles to the next stage of processing.

Bottle filling equipment

Packaging

Counting

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

In pharmaceutical manufacturing, filling bottles with precise quantities of solid dose products like pills, tablets, and capsules is vital for maintaining

In-motion bottle filling system for pharmaceuticals - Making.com

https://making-tst.imgix.net/2024/09/Cremer_3228_image.png

images-html

images.html

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Rapid changeover with patented trolley system

High production capacity up to 200,000 capsules per hour

Minimized product loss with no-cap-no-fill function

Precise dosing with capacitive weight inspection

User-friendly operation and easy cleaning

Fill level inspection ensures that each container is filled with exactly the desired volume of the product during a liquid filling operation. While transparent containers can utilize optical sensors for level detection, difficult to see through containers, such as cans or cartons lined with aluminum, must be scanned using X-rays. When choosing fill level inspection equipment, the size, shape, and opacity of the container must be considered. The production speed, the desired accuracy, and the amount of foaming on the liquid surface are also important parameters to consider. Fill level inspection systems are used to comply with quality control standards.

Fill level inspection systems

To claim that a tablet meets quality requirements, you must perform several inspections to ensure its efficacy and patient safety. In addition to the tests described in official compendia such as weight variation test or dissolution test, visual inspection or metal detection are equally important. Metal detection identifies ferrous, non-ferrous, or stainless steel contaminants in tablets while visual inspection can detect defects such as color deviations, bubbles, or cracks.

Tablet inspection system

A tablet press consists of two essential tools, namely dies and punches. It compresses powder or granules into a desired solid substance of uniform size and weight. After filling the dies with powder or granules, upper and lower punches are pressed together within the die hole to form tablets. Then the upper punches come back to their original position while the lower punches help the ejection of the tablet from the dies.

Tablet presses

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Sorting is the process of arranging items systematically, using a specified criterion, to categorize and group similar items and identify non-conforming items for removal. The choice of a sorting machine depends on the type of item to sort, the sorting criteria, the number of categories that the items need to be sorted into, sorting speed, and accuracy. Sorting machines can be used in the food processing industry for sorting and categorizing fruits, vegetables, empty bottles, crates, and other items; other examples include sorting of tablets and capsules by weight for quality control in the pharmaceutical industry. As well as sorting waste in the recycling industry. Manual sorting is a laborious task however, with the use of specialized equipment, manufacturers are able to automate their sorting at high speeds.

Sorting

Powder

In large-scale pharmaceutical production, ensuring efficient and accurate filling of capsules with various substances such as powders, pellets, and

Capsule filling system for powder, pellets, and tablets - Making.com

https://making-tst.imgix.net/2024/09/Harro_Hoefliger_4755_Image.png

Accurately fill capsules with multiple dosage forms

Integrated 100% gross weight control ensures precision

Quick set-up and changeovers with patented trolley system

Handles small product quantities and complex formulations

User-friendly with intuitive controls and easy cleaning

Batch

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

Industrial feeding systems allows you to control the flow of solid bulk materials throughout the manufacturing line. After loading your material onto the vibrating hopper, a screw at the base drives it out in uniform doses to the next stage of processing. New feeding technologies are designed to deal with challenges of powders clumping together in the hopper (bridging and ratholing) that interrupt the outflow. Common feeder systems include centrifugal feeders, vibratory feeders as well as elevator, linear and pneumatic feeders.

Feeding

Weighing

In pharmaceutical manufacturing, efficiently filling capsules with precise dosages is crucial for quality control and compliance with industry standards.

Commercial capsule filling for small scale production - Making.com

https://making-tst.imgix.net/2024/09/Harro_Hoefliger_4753_Image.png

ima_5491_brochure-pdf

IMA_5491_brochure.pdf

Hard Candy

Handles diverse product types and container shapes

Supports various closure styles

Ergonomic design for easy maintenance and format changeovers

High production speeds for medium- to high-demand lines

Modular design allows easy integration of additional systems

Food

To make candy, all you need to do is create a syrup by dissolving sugar and boiling it to your desired consistency. For medium to large scale candy production, candy making equipment fully automates the whole process and takes care of other production regulations and standards (such as hygiene and proper homogenization). Planning on getting one? There’s a wide range of choices to pick from.

Candy

A fresh salad with a walnut oil dressing or a peanut butter sandwich? A bag of roasted cashews or a pack of almond cookies? The common thread among these tasty treats is nut processing equipment. Not all nut ingredients are indeed nuts, botanically speaking. But the machinery that transforms shelled fruits, legumes, and drupes into fried snacks or a paste is similar. As for the food products, there is a nut recipe for every mood and occasion.

Nuts

In the confectionery industry, handling various product types and shapes while ensuring consistent dosing and filling in diverse formats is a complex

Vertical dosing and filling solution for confectionery packaging - Making.com

https://making-tst.imgix.net/2024/09/IMA_5491_Image.png

ima_5550_brochure-pdf

IMA_5550_brochure.pdf

Versatile dosing capabilities for various forms

High output capacities from 6,000 to 70,000 capsules per hour

Ergonomic design for easy operation and maintenance

Low changeover and cleaning times

Suitable for various capsule sizes ranging from 000 to 5

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

In pharmaceutical manufacturing, accurate and efficient capsule filling is crucial for maintaining dosage consistency and production speed. Traditional

Automatic capsule filling machines - Making.com

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Suitable to fill all capsule sizes

Can be supplied with tamping or dosator system

Change size operation takes less than 10 minutes

  Special dosing discs for minimal powder dosages (starting from 8 mg)

Equipped with both powder and liquids dosing stations

Liquid

R&amp;D

At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with chemicals or hazardous substances since they can be potentially dangerous to human health.

Packing

IN-CAP automatic bench top capsule filling machine by Dott.Bonapace is a bench top capsule fully automatic filling machine.

Automatic capsule filling machine for powders, pellets, tablets, mini-tablets, capsule in capsule or liquids. Test the automatic settings of

R&D automatic capsule filler - Making.com

https://making-tst.imgix.net/2015/04/incap.jpg

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.

Suppositories

A dishwasher tablet is an essential detergent. It consists of a pressed mixture of sodium and potassium salts, surfactant, fragrance, and other filler agents, mixed with the help of tablet making machines. The products’ use in America and Europe is high, unlike in the Asian continent, where the price limits its usage. Its global market size will reach $990 million in 2026 from $475.6million in 2019, according to Grand View Research forecasts.

Dishwasher tablets

The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

Patented ZRM technology for optimized yield and minimal dusting

Left -over of 20-50 grams depending on the model, output, and formulation characteristics

No Capsule-No Slug feature reduces further reduces formulation loss and dusting

Micro-dosing capability with +/- 2 mg accuracy

Optional Rapid Transfer Port

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

The Securefill 12T from ACG-Pam is a fully automatic contained capsule filler for highly active substances.

For pharmaceutical formulations that are highly active specialized capsule filling equipment is often required for operator safety and protection of

Tablet Filling Equipment

Which tablet filling technology do you need?

Automatic filling line for solid doses

Liquid filling system for hard capsules

In-motion bottle filling system for pharmaceuticals

Capsule filling system for powder, pellets, and tablets

Commercial capsule filling for small scale production

Vertical dosing and filling solution for confectionery packaging

Automatic capsule filling machines

R&D automatic capsule filler

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