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Maker - Product Challenge

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Tablet sorting

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

There are slight differences between human and animal pharmaceuticals, but that dissimilarity is enough to create new production challenges. Veterinary tablets formulation reflects the diversity of enzymes that different species use to break down substances. Although the methods involved are comparable to human drug manufacturing, equipment and processes need to adapt to a wider dosage variability in veterinary tablets.

Veterinary tablets

ci-precision-weight-checking-brochure-pdf

CI-Precision-weight-checking-brochure.pdf

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Easily and automatically sort by weight or number within a compact benchtop footprint

Save time with sorting rate of up to 75 units per minute

GMP design with quick and easy cleaning, all contact components stainless steel or PEEK

Highly accurate CI Precision balance

Extreme accuracy up to +/- 0.5mg for even more precision

Option of a hopper for larger batches

Pharmaceutical

Sorting Machines

Sorting is the process of arranging items systematically, using a specified criterion, to categorize and group similar items and identify non-conforming items for removal. The choice of a sorting machine depends on the type of item to sort, the sorting criteria, the number of categories that the items need to be sorted into, sorting speed, and accuracy. Sorting machines can be used in the food processing industry for sorting and categorizing fruits, vegetables, empty bottles, crates, and other items; other examples include sorting of tablets and capsules by weight for quality control in the pharmaceutical industry. As well as sorting waste in the recycling industry. Manual sorting is a laborious task however, with the use of specialized equipment, manufacturers are able to automate their sorting at high speeds.

Sorting

Connect directly with world leading manufacturers of sorting machines and equipment and find technology to build or improve your production line.

Sorting &ndash; Making.com

Sorting Machines and Equipment - Making.com

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

R&amp;D

Batch

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Weighing

solid

The CI Precision SADE SP-B40 is a benchtop checkweigher for tablets and capsules that's easy to use and improves the accuracy and speed of your process.

For laboratory pharmaceutical R&amp;D work or use in clinical trials, a high-accuracy small-scale benchtop weight sorter is the perfect solution. However,

Benchtop weight sorter for tablets &amp; capsules &ndash; Making.com

We open production technology to everyone

Making.com

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

Reclaims weight-rejected product, reduces wastage

Sorts a variety of doses without downtime for parts change

Suitable for continuous operation at up to 210,000 units per 24 hours

GMP design, all contact components stainless steel or PEEK

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

For medium scale production, you can improve line efficiency and reduce setup costs by opting for a fully flexible weight sorter that can handle a wide

Waste minimization weight sorter for tablets & capsules &ndash; Making.com

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

Sort a variety of doses without downtime for parts change

Suitable for continuous operation at up to 105,000 units per 24 hours

Minimal downtime thanks to quick and easy maintenance

The SADE SP sorters from CI Precision for accurate weight sorting of tablets or capsules can handle a wide range of product shapes and sizes.

Saving costs and improved production efficiencies are possible by opting for a pharmaceutical weight sorter that is fully flexible and able to handle a

Versatile weight sorter for tablets &amp; capsules &ndash; Making.com

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Made of high quality stainless steel material

  Suitable and adjustable for wide variety of product sizes

New technology counting device programmable logic combined to the fiber optics

Small in size and compact

To claim that a tablet meets quality requirements, you must perform several inspections to ensure its efficacy and patient safety. In addition to the tests described in official compendia such as weight variation test or dissolution test, visual inspection or metal detection are equally important. Metal detection identifies ferrous, non-ferrous, or stainless steel contaminants in tablets while visual inspection can detect defects such as color deviations, bubbles, or cracks.

Tablet inspection system

Packaging

Continuous

Counting

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

The KZ-1 electronic counter by Dott Bonapace guarantees the utmost versatility in counting.

This machine has been designed to offer an ever-precise and reliable count of capsules, tablets and pearls of every size. Semi-automatic electronic

R&D electronic counter for capsules and tablets &ndash; Making.com

R&D electronic counter for capsules and tablets - Making.com

Originally only manufactured in discoid shape, tablet today also come in triangular, rectangular, round, oval, oblong, or cylindrical varieties. Colors can vary to distinguish different medicines, and tablets are often stamped with symbols, letters, and numbers, enabling them to be identified.

According to their route of administration and the method of manufacture, it is possible to classify tablets into <a href="https://making.com/chewable-tablets" target="_blank" rel="noopener">chewable tablets</a>, <a href="https://making.com/effervescent-tablets" target="_blank" rel="noopener">effervescent tablets</a> and <a href="https://making.com/multi-layer-tablets" target="_blank" rel="noopener">multi-layer tablets</a>, to name a few. Still, the compressed tablet remains the most popular dosage form nowadays.

<h2>Production processes involved in making pharmaceutical tablets</h2>
In the pharmaceutical industry, the methods used for tablet making can be classified as <a href="https://making.com/technologies/granulating" target="_blank" rel="noopener">granulation</a> (wet granulation and dry granulation) and direct compression.

Granulation is a complex multi-stage process in which small powder particles are combined together to form agglomerates called granules.

The main difference between wet granulation and dry granulation is that wet granulation involves a granulating fluid like water, isopropanol, ethanol, or mixtures thereof. In contrast, dry granulation is the formation of granules without using any liquid solution.

&nbsp;

Wet granulation vs. dry granulation

Dry granulation can be accomplished with two methods, slugging and roller compaction, and it is used above all for those tablet ingredients that are sensitive to moisture or are unable to withstand elevated temperatures.

In wet granulation, powder particles are bound together using liquid solutions to achieve particle enlargement. The granulating fluid should be volatile to be easily removed by drying and should be non-toxic.

Direct compression refers to a process in which powdered <a href="https://making.com/active-pharmaceutical-ingredients-api" target="_blank" rel="noopener">APIs</a> are mixed with excipients and lubricants without involving granulation steps. It has grown in popularity because it provides the shortest, cheapest, and most effective way to produce tablets while minimizing processing time, steps, and equipment required. This tablet production method is suitable for moisture and heat-sensitive API ingredients. Direct compression requires a tablet press in which the upper and lower punches are pressed together within the die hole and compress the tablet until it is formed.

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Tablet making equipment for direct compression

The tablet equipment used for compression is the single punch tablet press and the rotary tablet press. The difference is that the single punch tablet press has two punches (upper and lower), but it uses only the upper one for compression. The rotary press has multiple punches and uses both the upper and the lower ones to compress the granules.

<h2>Uncoated tablets vs. coated tablets. When is a tablet coating machine needed?</h2>
Have you ever wondered why some tablets are coated and others are not?

Let’s start by understanding the difference, although the name already says it all. <a href="https://making.com/uncoated-tablets" target="_blank" rel="noopener">Uncoated tablets</a> are simply made by compressing the granules with no coating added afterward. They don't taste good and are harder to swallow, especially for children. This can be an excellent reason to use a coating; for instance, tablets are coated to mask an unpleasant taste.

An example of coated tablets is <a href="https://making.com/enteric-coated-tablets" target="_blank" rel="noopener">enteric coated tablets</a>. The enteric coating is necessary when the tablet’s active ingredient is acid sensitive. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity. This involves spraying the film-forming material onto the tablet surface as the tablets rotate in the pan.

<p style="margin: 0cm 0cm 12.0pt 0cm;"><span lang="en-NL" style="font-family: 'Helvetica',sans-serif; color: #282319;">Solid dosage forms such as tablets are commonly packed in <a href="https://making.com/technologies/blister-packing-equipment" target="_blank" rel="noopener">blister packs</a>. This type of packaging assures the integrity of each dose since each cavity is separate, so if one of their seals is breached, this doesn’t compromise the quality of the whole product</span></p>
<p style="margin: 0cm 0cm 12.0pt 0cm;"><span lang="en-NL" style="font-family: 'Helvetica',sans-serif; color: #282319;">The main aim of pharmaceutical packaging, like all others, is usually to protect products from any physical and biological damage and from external conditions that can alter the property of the product inside. </span></p>

Keep your tablet safe by choosing suitable packaging

<h2>The importance of serialization in the pharmaceutical industry</h2>
When it comes to informing the buyer, medical packaging must provide correct information about product name, ingredients, use, and dose, to mention a few. This way, consumers are more aware of product origin or manufacture. To be able to access all this information, product traceability needs to be provided.

The most commonly used standard to facilitate traceability on drug units is serialization. A barcode needs to be printed on a different level of drug packaging (primary, secondary, and tertiary). With the help of this printed symbol, it is easier to track and trace the origin of a drug and reduce the chance of counterfeit products.

Tablet Making Equipment in Action

Tablet press - automated line

Tablet visual inspection

Tablet Making Equipment

Connect directly with world-leading equipment manufacturers to find processing and packing technology to set up or improve your tablet production processes.

Tablets &ndash; Making.com

Tablet Making Equipment - Making.com

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Tablet coating requires spraying, mixing, and drying procedures that must be carried out simultaneously under strict conditions to maintain the coating's stability. For a high-quality result, liquid coatings must be applied uniformly to every tablet to protect them from light and moisture.
<h3>Spray, mix, and dry tablets quickly and evenly</h3>
The Tablet Coaters BTC from Bohle is a system that combines mixing, spraying, and drying, to produce uniformly coated tablets. The system consists of a flat tablet bed with a long pan that sprays the tablets while being mixed carefully and continuously by helical baffles. The systematic forced guidance in the pan keeps the load in constant motion, preventing twinning and loss of solids and coating. Thanks to the elongated pan, the flat tablet bed allows minimum static pressure, which helps prevent the tablets’ breakage.

Emptying the system can be done quickly by reversing the rotational direction of the pan. Air is supplied and exhausted through the perforated pan to quickly dry the spray-coated tablets. The system is equipped with a multi-panel display for operation controls and can be integrated with CIP system.

Pharmaceutical tablet coating machine

Who knew that dragee and tablet making had something in common? The sweet connection to the pharmaceutical world lies in the art of coating, which has its

The sweet world of pharmaceutical tablets - The trifecta for achieving coating uniformity &ndash; Making.com

The sweet world of pharmaceutical tablets &#8211; The trifecta for achieving coating uniformity

Deborah

Powder containment is the cornerstone of chemical and pharmaceutical manufacturing. Floating particles do not only represent efficiency loss but serious hazards too. Lack of tightness during the powder discharge process leads to cross-contamination and operational health risks.


<h3>Dock transfer systems squarely in place</h3>
The ASBV active/passive valve interface by Andocksysteme locks into position, minimizing exposure of material during powder discharge. The system has two split valves – one active, one passive – that can be easily and reliably centred on each other at a tolerance of ± 14 mm.

Once the units are docked, the valve discs open simultaneously, preventing exposure of the products during transfers. The dust-tight environment achieves contamination values lower than 1µg/m3.

The ASBV solution is fitted with EPDM seals and are optional with a wide range of materials, such as PTFE, offering top-range chemical resistance. All seals are made from FDA-approved materials and can handle a wide range of temperatures as well as explosion-proof executions.

Washing the ASBV interface is simple as the system can be connected to a WIP loop to flush out residual powders. These containment solutions serve applications with an exceptional performance and are easy to be integrated. Moreover, high quality parts and reduced complexity drives simple maintenance.

High containment split butterfly valve

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

The rise of high-potency ingredients (HPAPI) is taking medication into unchartered territory. Since the turn of the century, the pharmaceutical industry

Closing the containment loop in HPAPI manufacturing &ndash; Making.com

Closing the containment loop in HPAPI manufacturing

Nathanael

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

What's new in pharmaceutical packaging? During Pharmapack, we met Chantal Younes, Key Account Manager at Aptar CSP Technology, who introduced us to the

#Changemaker: Ready to protect your pharmaceutical products from moisture? &ndash; Making.com

#Changemaker: Ready to protect your pharmaceutical products from moisture?

Thousands of different capsules are produced every day, so it is inevitable that some of them will come out defect in shape or size, with a colour

How reliable imaging plays an important role in capsule visual inspection &ndash; Making.com

How reliable imaging plays an important role in capsule visual inspection

Irina Lescika

Chewable or conventional aspirin is used to treat fever and pain. But there is any relevant difference between the two, apart from the way they are administered?

Taking aspirin helps young and old treat cold symptoms, fever, and pain. Due to psychological or physical problems, over half of the population has

Chewable or regular aspirin: what is the difference? &ndash; Making.com

Chewable or regular aspirin: what is the difference?

We are happy to share our knowledge on making pharmaceuticals and nutraceuticals. Send us a message and we will help you solve your production challenge.

IndustryExpertPharma

Food

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Formulation challenges for making chewable vitamin tablets for kids. Which production technology is required?

Thanks to their fun shapes, flavours, colouring agents and for being easy to eat, chewable tablets are a kid-friendly choice when it comes to taking

Making chewable multivitamin tablets for kids &ndash; Making.com

Making chewable multivitamin tablets for kids

We have all come across desiccants at some point in our lives. They come in little white packets or cans in packaged products with the strict instruction,

Keeping pharmaceuticals moisture free &ndash; Making.com

Keeping pharmaceuticals moisture free

Did I take my medicine this morning or not? Let's be honest. How often have we asked ourselves this question and failed to find an answer simply because…

#Changemaker: Keep track of your medicine every day with FabriSol sticker &ndash; Making.com

#Changemaker: Keep track of your medicine every day with FabriSol sticker

Do you know how long it takes a tree to grow? To answer this question precisely, you have to consider various factors such as climate or the tree species,

#Changemaker: Turning grass into pharmaceutical packaging &ndash; Making.com

#Changemaker: Turning grass into pharmaceutical packaging

Find production technology for Tablet sorting, and connect directly with leading machine manufacturers worldwide.

Tablet sorting

Which tablet sorting equipment do you need?

Benchtop weight sorter for tablets & capsules

Waste minimization weight sorter for tablets & capsules

Versatile weight sorter for tablets & capsules

R&D electronic counter for capsules and tablets

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Which tablet sorting equipment do you need?

Benchtop weight sorter for tablets &amp; capsules

Waste minimization weight sorter for tablets &#038; capsules

Versatile weight sorter for tablets &amp; capsules