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Maker - Product Challenge

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Changemakers

Equipment For Pressing Tablets

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

There are slight differences between human and animal pharmaceuticals, but that dissimilarity is enough to create new production challenges. Veterinary tablets formulation reflects the diversity of enzymes that different species use to break down substances. Although the methods involved are comparable to human drug manufacturing, equipment and processes need to adapt to a wider dosage variability in veterinary tablets.

Veterinary tablets

Vitamin C is an essential nutrient, but the human species lost the ability to produce it biologically during the course of evolution. Instead, we source the substance either from whole foods or vitamin C manufacturing. The chemical characteristics of the natural nutrient and processed compound are the same, but supplements offer higher concentrations, especially to persons with nutrient deficiencies.

Vitamin C

Lab-scale design is economical for smaller runs

Capable of producing a range of tablet shapes and sizes

Fully automatic weight control includes automatic fault rejection

Easy-to-use touch screen operator controls

Fully 21CFR part 11 compatible for simple regulatory compliance

A tablet press consists of two essential tools, namely dies and punches. It compresses powder or granules into a desired solid substance of uniform size and weight. After filling the dies with powder or granules, upper and lower punches are pressed together within the die hole to form tablets. Then the upper punches come back to their original position while the lower punches help the ejection of the tablet from the dies.

Tablet presses

Pharmaceutical

Pressing

Connect directly with world leading manufacturers of Pressing equipment and find technology to build or improve your production line.

Pressing &#8211; Making.com

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Process

R&amp;D

Batch

Compaction machines and technologies crush or compress materials and make them denser. Compaction can be used to simply save space or to shape materials into a desired form or format. Tablets, pellets, or briquets are formed by compactors but powder presses also help form cosmetic eyeshadow or face powder.

Compaction

The process of forming allows you to shape your products homogeneously. Forming machines are fed the manufactured material in bulk and cut it down to specification, so the process takes place between formulation of the mass and the packaging of the final item.

A special class of this equipment – Form, Fill, and Seal Machines (FFS) – creates bags and pouches from flat material such as plastic sheets, fills them with your designated product, and seals them.

Forming

solid

Automated pressing of tablets saves time and improves quality. In R&amp;D or laboratory environments a dedicated minimal form factor tablet press provides

Lab scale single layer tablet press &#8211; Making.com

We open production technology to everyone

Making.com

The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

High speed, high efficiency volume tablet press

Disk interchange system allows quick changeover

Can produce a wide variety of dosage forms

Optional tablet weight control system available

Efficient operation with a small footprint

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

For pharmaceutical tablet producers looking to reduce waste, costs and  increase production volume, a high efficiency rotary tablet press is the ideal

Rotary tablet press &#8211; Making.com

Flexible tablet presses for medium volume production with features designed for reduced maintenance

High speed and high pressure for superior results

Comprehensive HMI with simple controls and full 21CFR part 11 reporting

Round or oblong tablet production with turret interchange

Up to 30% productivity increase over previous generation machines

High performance tablet presses for the modern production environment need to be fast, accurate and flexible. Rapid changeover, simple operation and high

Single layer tablet press &#8211; Making.com

High capacity, fully flexible tablet presses with features designed for reduced maintenance

Double-layer capable with first layer sampling

30% productivity increase over previous generation machine

High performance tablet presses that are capable of producing both single and double-layer tablets offer the maximum flexibility to a multi-product

Single and double layer tablet press &#8211; Making.com

acg-pam-protab-brochure-pdf

ACG-Pam-Protab-brochure.pdf

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.

Suppositories

A dishwasher tablet is an essential detergent. It consists of a pressed mixture of sodium and potassium salts, surfactant, fragrance, and other filler agents, mixed with the help of tablet making machines. The products’ use in America and Europe is high, unlike in the Asian continent, where the price limits its usage. Its global market size will reach $990 million in 2026 from $475.6million in 2019, according to Grand View Research forecasts.

Dishwasher tablets

Easy access to all important areas

Minimal product loss

Instant detection of faulty punches during operation

Lightweight assemblies and peripherals designed for easy removal

Mechanical changeover in 30 minutes

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Packaging

Continuous

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

The Protab 300 from ACG Pam is a simplified rotary tablet press designed for small and medium batch pharmaceutical producers.

Creating batches of consistent high quality pharmaceutical grade tablets from your powdered ingredients requires equipment that complies with strict

Single rotary tablet press &#8211; Making.com

acg-pam-legacy-6100-brochure-pdf

ACG-Pam-Legacy-6100-brochure.pdf

Compression force adjustment for 1st and 2nd stages

Virtually tool-less cleaning and changeover procedures

Use with D, B, BB, and BBS tooling types

Stand alone operating panel

Integrated security hierarchy and password protection

The Legacy 6100 tablet press from ACG Pam is a tablet press of proven design and well known quality.

Successful pharmaceutical manufacturers know that high quality, reliable equipment is essential in order to be competitive in highly regulated and highly

Economic tablet press &#8211; Making.com

brochure_multigel_tabletpress-pdf

Brochure_Multigel_TabletPress.pdf

Lab-scale tablet press with robust, high-quality construction for longevity

No special installation, single-phase electricity only required

Adjustable tablet diameter and variety of punch shapes for flexibility

Simple control with in-built counter for accurate batch monitoring

Product contact pathway all stainless steel for easy cleaning

For lab work or small-scale production, a purpose-designed tablet press that meets your exact requirements offers distinct benefits in terms of economic

Benchtop tablet press &#8211; Making.com

Optional glove box for pressing tablets in controlled environments

Multiple access points in glove box simplify servicing

Ergonomic design enhances operator comfort and productivity

High speed containment presses make pharmaceutical tablets in closed environments with glove box access. Negative pressure inside the containment prevents

High Speed Containment Tablet Press &#8211; Making.com

brochure_kikusui_high-speed-tablet-press-pdf

Brochure_Kikusui_high-speed-tablet-press.pdf

Turret exchanges within 20 minutes reduce downtime

5 Kw electric motor delivers high production volumes

Head guard, dust seals and bellows control lost powder

Enclosed feeder and vacuum suction minimise powder loss

High speed pharmaceutical tablet presses convert powder to tablets. The operations should be quick and simple, and deliver high volumes with low

High Speed Tablet Press &#8211; Making.com

Production machine quality from laboratory-scale equipment

High quality tablet samples from small amounts of granules

Capable of scaling up to 28,800 tablets per hour

Pharmaceutical research and development projects may require small samples of high quality tablets for testing. Laboratory tablet presses must have full

Laboratory Tablet Press &#8211; Making.com

brochure_kikusui_high-speed-double-sided-tablet-press-pdf

Brochure_Kikusui_high-speed-double-sided-tablet-press.pdf

Fast turret changes for reducing changeover time

Easy switching to hybrid head for bi-layer production

10-ton pre and main rollers enable precise tablet compression

To achieve as much as double the output of single-sided tablet press, the upper and lower surfaces of the turrets where the tablets are pressed have to be

High Speed Double-Sided Tablet Press &#8211; Making.com

brochure_bonals_be40

Brochure_Bonals_BE40

Powder aspiration system

Quick change over, less than10 minutes

Easy adjustment of compression speed

Minimal powder waste

Small and medium batch capacity  

Chemical tablet formulas allow granules to break away under the conditions you would have designed them for. Powder presses distribute particles from the stock material evenly onto molds and subject the it to pressure to produce a dense block. Powder tablets often include a precise mixture of products and presses combine the correct dosage to form multi-layered slabs ready for packaging.

Powder presses

Chemical

Cosmetic

According to a legend, Cleopatra soaked her sails in her perfume so that Mark Antony could smell her ships before they arrived. This is to say that, from soaps and shampoos to perfumes, conditioners and pomades, cosmetics have always been highly valued and used for their properties of aesthetic enhancement. Cosmetics are a broad class of topical agents applied for various purposes such as cleansing, protecting, beautifying, or otherwise altering your appearance. As a result, a wide array of processing equipment is used in the cosmetics industry.

Cosmetics

Detergents are cleaning agents that help remove dirt and grease from porous and non-porous surfaces. Industrial production of detergents began after World War I. Still, it was after the 1950s and 1960s that the detergent industry grew exponentially due in part to the development of new detergent manufacturing equipment.

Detergents

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Hundreds of different refill tablets, of various shapes or sizes, are on the market today. To get a range of soap, shampoo or lotion tablets, the powdered

Eccentric press for refill tablets &#8211; Making.com

Originally only manufactured in discoid shape, tablet today also come in triangular, rectangular, round, oval, oblong, or cylindrical varieties. Colors can vary to distinguish different medicines, and tablets are often stamped with symbols, letters, and numbers, enabling them to be identified.

According to their route of administration and the method of manufacture, it is possible to classify tablets into <a href="https://making.com/chewable-tablets" target="_blank" rel="noopener">chewable tablets</a>, <a href="https://making.com/effervescent-tablets" target="_blank" rel="noopener">effervescent tablets</a> and <a href="https://making.com/multi-layer-tablets" target="_blank" rel="noopener">multi-layer tablets</a>, to name a few. Still, the compressed tablet remains the most popular dosage form nowadays.

<h2>Production processes involved in making pharmaceutical tablets</h2>
In the pharmaceutical industry, the methods used for tablet making can be classified as <a href="https://making.com/technologies/granulation" target="_blank" rel="noopener">granulation</a> (wet granulation and dry granulation) and direct compression.

Granulation is a complex multi-stage process in which small powder particles are combined together to form agglomerates called granules.

The main difference between wet granulation and dry granulation is that wet granulation involves a granulating fluid like water, isopropanol, ethanol, or mixtures thereof. In contrast, dry granulation is the formation of granules without using any liquid solution.

&nbsp;

Wet granulation vs. dry granulation

Dry granulation can be accomplished with two methods, slugging and roller compaction, and it is used above all for those tablet ingredients that are sensitive to moisture or are unable to withstand elevated temperatures.

In wet granulation, powder particles are bound together using liquid solutions to achieve particle enlargement. The granulating fluid should be volatile to be easily removed by drying and should be non-toxic.

Direct compression refers to a process in which powdered <a href="https://making.com/active-pharmaceutical-ingredients-api" target="_blank" rel="noopener">APIs</a> are mixed with excipients and lubricants without involving granulation steps. It has grown in popularity because it provides the shortest, cheapest, and most effective way to produce tablets while minimizing processing time, steps, and equipment required. This tablet production method is suitable for moisture and heat-sensitive API ingredients. Direct compression requires a tablet press in which the upper and lower punches are pressed together within the die hole and compress the tablet until it is formed.

&nbsp;

Tablet making equipment for direct compression

The tablet equipment used for compression is the single punch tablet press and the rotary tablet press. The difference is that the single punch tablet press has two punches (upper and lower), but it uses only the upper one for compression. The rotary press has multiple punches and uses both the upper and the lower ones to compress the granules.

<h2>Uncoated tablets vs. coated tablets. When is a tablet coating machine needed?</h2>
Have you ever wondered why some tablets are coated and others are not?

Let’s start by understanding the difference, although the name already says it all. <a href="https://making.com/uncoated-tablets" target="_blank" rel="noopener">Uncoated tablets</a> are simply made by compressing the granules with no coating added afterward. They don't taste good and are harder to swallow, especially for children. This can be an excellent reason to use a coating; for instance, tablets are coated to mask an unpleasant taste.

An example of coated tablets is <a href="https://making.com/enteric-coated-tablets" target="_blank" rel="noopener">enteric coated tablets</a>. The enteric coating is necessary when the tablet’s active ingredient is acid sensitive. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity. This involves spraying the film-forming material onto the tablet surface as the tablets rotate in the pan.

<p style="margin: 0cm 0cm 12.0pt 0cm;"><span lang="en-NL" style="font-family: 'Helvetica',sans-serif; color: #282319;">Solid dosage forms such as tablets are commonly packed in <a href="https://making.com/technologies/blister-packing-equipment" target="_blank" rel="noopener">blister packs</a>. This type of packaging assures the integrity of each dose since each cavity is separate, so if one of their seals is breached, this doesn’t compromise the quality of the whole product</span></p>
<p style="margin: 0cm 0cm 12.0pt 0cm;"><span lang="en-NL" style="font-family: 'Helvetica',sans-serif; color: #282319;">The main aim of pharmaceutical packaging, like all others, is usually to protect products from any physical and biological damage and from external conditions that can alter the property of the product inside. </span></p>

Keep your tablet safe by choosing suitable packaging

<h2>The importance of serialization in the pharmaceutical industry</h2>
When it comes to informing the buyer, medical packaging must provide correct information about product name, ingredients, use, and dose, to mention a few. This way, consumers are more aware of product origin or manufacture. To be able to access all this information, product traceability needs to be provided.

The most commonly used standard to facilitate traceability on drug units is serialization. A barcode needs to be printed on a different level of drug packaging (primary, secondary, and tertiary). With the help of this printed symbol, it is easier to track and trace the origin of a drug and reduce the chance of counterfeit products.

Tablet Making Equipment in Action

Tablet press - automated line

Tablet visual inspection

Tablet Making Equipment

Connect directly with world-leading equipment manufacturers to find processing and packing technology to set up or improve your tablet production processes.

Tablets &#8211; Making.com

Tablet Making Equipment - Making.com

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Tablet coating requires spraying, mixing, and drying procedures that must be carried out simultaneously under strict conditions to maintain the coating's stability. For a high-quality result, liquid coatings must be applied uniformly to every tablet to protect them from light and moisture.
<h3>Spray, mix, and dry tablets quickly and evenly</h3>
The Tablet Coaters BTC from Bohle is a system that combines mixing, spraying, and drying, to produce uniformly coated tablets. The system consists of a flat tablet bed with a long pan that sprays the tablets while being mixed carefully and continuously by helical baffles. The systematic forced guidance in the pan keeps the load in constant motion, preventing twinning and loss of solids and coating. Thanks to the elongated pan, the flat tablet bed allows minimum static pressure, which helps prevent the tablets’ breakage.

Emptying the system can be done quickly by reversing the rotational direction of the pan. Air is supplied and exhausted through the perforated pan to quickly dry the spray-coated tablets. The system is equipped with a multi-panel display for operation controls and can be integrated with CIP system.

Pharmaceutical tablet coating machine

Who knew that dragee and tablet making had something in common? The sweet connection to the pharmaceutical world lies in the art of coating, which has its

Equipment For Pressing Tablets

Which equipment for pressing tablets equipment do you need?

Lab scale single layer tablet press

Rotary tablet press

Single layer tablet press

Single and double layer tablet press

Single rotary tablet press

Economic tablet press

Benchtop tablet press

High Speed Containment Tablet Press

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