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Maker - Product Challenge

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Changemakers

Tablet Drying Equipment

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

There are slight differences between human and animal pharmaceuticals, but that dissimilarity is enough to create new production challenges. Veterinary tablets formulation reflects the diversity of enzymes that different species use to break down substances. Although the methods involved are comparable to human drug manufacturing, equipment and processes need to adapt to a wider dosage variability in veterinary tablets.

Veterinary tablets

Works well in tropical climates with high humidity where other technologies fail

Excellent corrosion resistance and long life due to aluzinc construction

  Easy integration into your existing facility due to multiple energy input options including electricity, steam and gas

Easily remove contaminants from the system with the washable rotor

No contamination from desiccant carry over

Chemical

Food

Pharmaceutical

Industrial Drying Equipment

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Find Industrial drying equipment for your manufacturing process and connect with a global network of leading production technology suppliers.

Drying - Making.com

Industrial Drying Equipment - Making.com

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

Our food chain starts in the soil, growing crops and livestock. But between the fields and the stores, there is a line of industrial food processing equipment. Processes may be as minimalistic as cleaning fruit and as complex as homogenizing milk alternatives made from pressed legumes. In each case, processing technology is an important link in the food production chain.

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Packaging

Process

R&amp;D

Continuous

Industrial dehumidification involves the process of removing moisture as well as controlling humidity. For example, warehouses that store grains need a controlled climate to avoid mildew and other moisture-related issues that can ruin or spoil the product. Refrigerant and desiccant dehumidifiers are used to reduce or maintain the level of humidity. Refrigerant dehumidifiers pass the air over a cold coil, cooling the air to the point where its water vapor begins to condense. Instead, desiccant dehumidifiers pass the air through a rotor containing a moisture-absorbing material. Commercial dehumidifiers are somewhat similar to their industrial counterpart in terms of function. The only big difference is the scale at which the equipment is being used.

Dehumidifying

The CONSORB CZ series from Seibu Giken can work with hot water for regeneration or with water in combination with an electric heater.

Humid ambient conditions such as those in tropical climates make dehumidification more challenging as there is a large difference in moisture content

Sorption dehumidifier for deep drying - Making.com

https://making-tst.imgix.net/2016/09/Consorb-CZ-1.jpg

The marketplace for finding innovative production technology

Making.com

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Brochure_lb_bohle_granulation

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

Complete fluidization and even coating of particles

Pressure shock resistance of up to 12 bar, optimum for containment application

Capacity range of 1 to 500 kg

Efficient space utilization due to low installation height

Can be equipped with a moisture measurement system to determine moisture level during the drying process

A granulator is a high-speed knife mill designed to cut down large components of feedstock and reduce them to smaller particle sizes. Selecting the right scissor geometry and configuration allows granulators to process plastic bottles, organic fibers, films, wires, cables, and other difficult materials. Agglomeration granulators combine fine particles into larger granules by creating bonds between them. Bonds are formed by compressing fine particles or through the use of a binding agent.

Granulators

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Granulation

Pharmaceutical industries employ several processes including drying, coating and granulation to create high-quality granules. Manufacturers can benefit

Fluidized bed system for the granulation and drying of pharmaceuticals - Making.com

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Flexibility with top, bottom, or tangential spray technologies

Compact design fits rooms with low ceilings

Rapid Change principle allows quick bowl changes

Convenient access to filter elements

GMP-compliant with CIP and WIP cleaning concepts

Fluid bed dryers use a stream of hot air to reduce the moisture content of powders and granules. This principle is often used for the production of high-quality pharmaceutical powders as well as the production of animal feed, minerals, sand, and dairy products.

Fluid bed dryers

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Pilot

To coat your consumer products with color or taste-enhancing substances, specialized technologies are available that ensure all the contents are individually and evenly covered. The process starts with loading your goods onto rotating drums, exposing the products to spray nozzles that treat them with your prescribed coating formula.

Coating

solid

When you're transitioning from laboratory to large-scale production, optimizing processes like granulating, drying, and coating is crucial. Space

Fluid bed processor for granulating, drying, and coating in pilot scale - Making.com

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Excellent corrosion resistance and long life due to stainless steel chassis

Portable dehumidifier for small tough jobs

Better control with a self-regulating heater

The CONSORB DC series dehumidifiers from Seibu Giken are ideal for facilities with surplus heat or when dehumidifying very damp air.

Small, humid areas can be difficult to dehumidify in humid ambient conditions such as those in tropical climates. A large difference in moisture content

Sorption dehumidifier for large temperature differences - Making.com

https://making-tst.imgix.net/2016/09/Consorb-DC-10.jpg

Works in cold climates at dew points below 0°C

Save space with a small footprint and compact humidifier that delivers great performance

Energy efficient: All energy is accumulated in the dry air

Dessicant Dehumidifiers

Dehumidify at sub-zero dew points with an air-chilled condensation sorption dehumidifier with the AQUASORB from Seibu Giken.

It is not always possible to duct out the wet air from a dehumidifier servicing an enclosed facility. In such cases, the water is condensed out from the

Sorption dehumidifier with air-chilled condenser - Making.com

https://making-tst.imgix.net/2016/06/Aquasorb.jpg

Around a third of your natural protein composition is collagen. But the human body still finds good use for more of it, whether to reinforce joints or aid digestion. Collagen powder processing breaks the chains of amino acids into smaller units, allowing them to be consumed at higher concentrations without changing your diet.

Collagen powder

The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.

Dry inhaler powder

In 1682, Denis Papin found a method to remove collagen from animal bones, discovering gelatin. But it was the inventor Peter Cooper who developed gelatin powder processing. In 1845 he secured his invention with US patent 4084 for a dessert of gelatin powder called “portable gelatin”.

Gelatin powder

It took the scientific community almost 70 years to agree on the name ‘protein’ and discard the popular alternative, proteid. But protein powder processing still needed another five decades to be commercialized in the 1950s. Once extraction and purification could be industrialized, protein powder soon became a basic staple supplement.

Protein powder

Available in a variety of batch sizes to suit your exact requirements

Fluid bed drying and mixing/agglomeration in one unit for reduced cost

Fully 21CFR part 11 compliant HMI

Fully touch-screen operation for ease of use

Low every consumption

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Batch

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

liquid

Designed for pharmaceutical R&amp;D, a lab-scale fluid bed dryer and mixer/granulator combination provides a value-for-money solution that allows for

Fluid bed dryer and mixer for lab scale - Making.com

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Powder detergent is one of the most widespread washing solutions used in the laundry of fabrics. Since they contain no water, powder detergents are lighter than liquid detergent or pods, which results in cheaper transport and, thus, a more affordable choice for the end consumer. Although manufacturers can formulate their powder detergents differently, the detergent powder production process relies on a combination of builders, surfactants, and enzymes.

Powder detergent

Small footprint and ease of use - perfect for lab work

Fully height adjustable top and bottom spray arms gives more flexibility for less cost

Simple touchscreen controls with 21CFR part 11 compliant software for record keeping

Sampling system for monitoring results during the cycle

Industrial filtration equipment separates solid matter from liquid by using a filter medium. The filter allows only the fluid to pass through but retains the solid matter. The choice of filtration equipment depends on the particle size, the consistency of the mixture, and the nature of your product.

Filtration

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

Fluidised bed drying (FBD) is a common process in the pharmaceutical industry for drying compounds to achieve the required moisture content, as well as

Fluid bed dryer for lab scale - Making.com

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The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

Robust construction, built to 12 bar pressure resistance throughout

Designed for single operator ease of use

Variety of capacities available up to 1000l to suit all production needs

Advanced filter maintenance reduces downtime and increases fluid bed performance

Quick and simple cleaning with built-in CIP system

The Sejong D Series is a production scale fluid bed dryer for use in pharma scenarios where powder fluid processes are required.

Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for drying compounds to achieve the required moisture content, as well as

Fluid bed dryer for production scale - Making.com

https://making-tst.imgix.net/2017/09/Untitled-6.jpg

brochure_ste_fluid-bed-dryer-pdf

Brochure_STE_Fluid-bed-dryer.pdf

A dishwasher tablet is an essential detergent. It consists of a pressed mixture of sodium and potassium salts, surfactant, fragrance, and other filler agents, mixed with the help of tablet making machines. The products’ use in America and Europe is high, unlike in the Asian continent, where the price limits its usage. Its global market size will reach $990 million in 2026 from $475.6million in 2019, according to Grand View Research forecasts.

Dishwasher tablets

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

Load valve to charge product by lance

Sight glass or window allowing you to observe the internal process

Low energy consumption compared to other types of dryers

Granules

Fluid bed drying is a pharmaceutical process carried out to reduce the humidity and achieve the required moisture content in the granules or powders. It

Fluid bed dryer for pharmaceutical solid dosage form - Making.com

https://making-tst.imgix.net/2020/09/Fluid-bed-dryer_STE.jpg

acg_world_1191_brochure-pdf

ACG_World_1191_brochure.pdf

Smooth and efficient capsule loading

Flexible operation with manual and automatic gelatine replenishment

Better in-process control with automatic viscosity control

Prevents wastage of gelatine

Effective airflow management for improved seal drying

The two halves of a capsule shell are separately filled with your selected material before they are then pressed against one another and closed. Automatic capsule fillers orientate the shells in the precise position, fill them with your specified formula a join the ends. Capsules are then de-dusted and polished by micro brushes before they are ready for packaging.

Capsule fillers

Pellets

Industrial

Manual

A loading system feeds your continuous or batch processing machine with the specified material or item in line with the flow of production. Loaders transfer the articles from one stage of preparation to the next with uniformity and accuracy.

Loading

Sealing

In pharmaceutical manufacturing, ensuring accurate and secure sealing of two-piece hard capsules, especially when filled with liquids of varying

Capsule band sealer for liquid-filled hard capsules - Making.com

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Tablet Drying Equipment

Which tablet drying technology do you need?

Sorption dehumidifier for deep drying

Fluidized bed system for the granulation and drying of pharmaceuticals

Fluid bed processor for granulating, drying, and coating in pilot scale

Sorption dehumidifier for large temperature differences

Sorption dehumidifier with air-chilled condenser

Fluid bed dryer and mixer for lab scale

Fluid bed dryer for lab scale

Fluid bed dryer for production scale

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