Chewable Tablets Equipment
Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.
Which chewable tablets equipment do you need?
Premium vacuum conveyor
Sorption dehumidifier with air-chilled condenser
Small portable dehumidifier
Sorption dehumidifier for large temperature differences
Sorption dehumidifier for deep drying
Dehumidifier for difficult wet airflows
Sorption dehumidifier for overpressured rooms
Heat recycling sorption dehumidifier
Industrial desiccant dehumidifier
Large scale desiccant dehumidifier
Small feeder with flexible wall hopper
Entry-level high-shear mixer for drug formulation
Granulation line of mixer and fluid bed dryer
Lab scale single layer tablet press
Rotary tablet press
Single and double layer tablet press
Single layer tablet press
Automatic tablet coater for lab scale
Side-load case packer
High Speed Visual Inspection System for Tablets
Contained Visual Inspection System
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Apply chewable tablets to antacid drugs
Antacids release cations that neutralize excess stomach acids and are made with a range of magnesium ingredients such as magnesium carbonate, magnesium trisilicate, and magnesium hydroxide.
Formulating antacid remedies into chewable tablets speeds up the dissolution rate. Sweeteners such as sucrose is a necessary expedient, adding sweetness and acting as a plasticizer to make the tables chewable.
Keep the hardness value to within 12 kilogram-force
The US Food and Drugs Administration recommends a low hardness threshold in the formulation of the final product. A kilogram-force value above 12 is admitted only with explicit authorization.
The chewing difficulty index is measured by force required to crush the tablet. The hardness value of chewable tablets is determined by loading the product until the breaking point. Measure the diametrical tensile strength for round tablets and flexural tensile strength for elongated ones.
Add alternative diluents to offset dryness effect of mannitol
Odorless and white, mannitol is a suitable diluent in chewable tablet blends with most ingredients. While it adds mouthfeel, mannitol also causes dryness in the mouth.
Diluent concentrations can be balanced with polyols like sorbitol that let off a cooling sensation besides a sweet taste. Mannitol registers 50% lower than sucrose on the sweetness index.