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Enteric coated tablets labeling Equipment

Labels provide customers with important information about both your product and your brand. Different labeling technology attaches the printed film to the packaging using a range of methods such as shrink wrapping, side sealing, and adhesives. For added traceability and protection, you may also use serialization coding equipment and anti-tampering labeling systems.

Labeling

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

<span style="font-weight: 400;">In the pharmaceutical industry, product serialization is the cornerstone of all legislative requirements for traceability. An automated inline coding and labeling system provides the easiest and most reliable way of addressing serialization needs without adversely impacting on line performance.</span>
<h2>Folding-box serialization units for high flexibility/high speed</h2>
<span style="font-weight: 400;">The Amacoder range from Hicof are industry-leading serialization solutions for the pharmaceutical industry, available in two specifications:</span>

<span style="font-weight: 400;">Amacoder FLEX - offers the maximum flexibility for packaging sizes. The maximum box depth is 300 mm and the maximum throughput is 75 boxes per minute (depending on box size). This is ideal for batch production and lines with frequent size changeover.</span>

<span style="font-weight: 400;">Amacoder SPEED - offers the highest speed at up to 150 boxes per minute for a maximum box depth capped at 200mm. This is perfect for dedicated smaller box lines where maximum throughput is desirable.</span>

<span style="font-weight: 400;">The Hicof Amacoder machines are supplied as standard with one inkjet printing unit and one cartridge and one camera on the operator side. Additional printing heads are available as an option. Two labelers enable the application of tamper-evident seals on both sides of the folding box. All box flap configurations are supported, making the Amacoder suitable for use with any existing line.</span>

<span style="font-weight: 400;">The Amacoder line has been designed to reduce moving parts and complexity as far as possible, offering an attractive price point as well as reducing the footprint to a minimum. The slower movement of boxes through the Amacoder means a very low rejection rate, offering further cost savings.</span>

<span style="font-weight: 400;">The code-reading camera is fully ISO/IEC 15415 compliant, and the complete coding and labeling line offers a comprehensive corporate, easy to operate, GxP compliant database to an integrated solution. The Amacoder IT system allows the processing of all serialization data, supports related business processes and offers optional interfaces to business and governmental partners.</span>

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Serialization coding and labeling equipment

Labels are a key component in pharmaceutical packaging lines as they include a lot of data. Multiple packaging lines require many label print formats to be used with different products. Packaging lines using manual labor use separate stations for printing, inspection and serialization of label reels. But multiple stations increase the product cycle time, reduce productivity and may even jeopardize product quality with human handling. A single automatic workstation integrates all activities of printing, control and serialization of a variety of label reels for multiple products such as ampoules and vials.


<h2>Printing, control and serialization of label reels across multiple packaging lines</h2>
Trackroll from SEA VISION is a workstation that prints, controls and serializes labels in reels. It is suitable to all production environments and can be easily transported on the production line. It can handle labels applicable to products such as ampoules, vials, cartons and more. The label reels are automatically printed and inspected with variable data and both serialized and non-serialized codes in real time. It is also capable of executing PQV control on pre-printed artworks. Automatic unwinding and rewinding of label reels is performed. Cameras and light unit facilitate inspection of variable data and codes printed on the reels. Powerful software integration with machine PLC ensures removal of any rejected code and transfers only the correct code to the end of process. Printing of offline label reels makes the workstation flexible to be used in several packaging lines.

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Serialized labels inspection and printing station

Including serialization and aggregation inspection systems to packaging lines helps manufacturers to make the distribution chain more efficient while ensuring consumer safety. Having different systems that handle serialization, aggregation and visual inspection can require different training and be time-consuming. A single system that can manage all three fuctionalities in one could be a solution to reduce effort, time, and cost.
<h2>Complete track and trace solution for serialization, aggregation and quality inspection</h2>
The Hector system from Hicof is a system with a complete track and trace system for serialization, aggregation and quality inspection. It can manage the process of serial numbering with different printing systems such as Thermo Inkjet, Continuous Inkjet or Laser printing. The Hector system has a controller that can be connected to cameras for the print inspection process. Its integrated register allows tracking processes through machines based on encoder signals. Hector system features a wide range of optical systems that helps in managing the aggregation of serialized products over multiple packaging levels. It can create individual identifiers of the aggregated container by connecting to label printing systems. Hector manages the visual quality inspection process as Pharmacode reading, filling control of Blister cavities, and quality inspection of tablets and molded products.

Serialization and aggregation inspection system

Traceability is critical to quality assurance in the pharmaceutical sector. But serializing individually packaged items may create bottlenecks in a production cycle. Besides the printing and labeling steps, serialization systems must ensure seamless interoperability with other process stages.
<h2>Serialization solution for pharma product packaging</h2>
Item Serialization Units from Dec Group are custom-built solutions for individually packaged products. The system offers complete solutions including vision inspection, robotics, software, and printing components.

The product loading capacity ranges from 150 to 400 p/min and is either manually operated or automatic. Moreover, the onboard labeler features temper evidence functionality. The units integrate into standard production equipment and software platforms designed for the pharmaceutical industry.

Individual item serialization equipment

Tablet coating requires spraying, mixing, and drying procedures that must be carried out simultaneously under strict conditions to maintain the coating's stability. For a high-quality result, liquid coatings must be applied uniformly to every tablet to protect them from light and moisture.
<h3>Spray, mix, and dry tablets quickly and evenly</h3>
The Tablet Coaters BTC from Bohle is a system that combines mixing, spraying, and drying, to produce uniformly coated tablets. The system consists of a flat tablet bed with a long pan that sprays the tablets while being mixed carefully and continuously by helical baffles. The systematic forced guidance in the pan keeps the load in constant motion, preventing twinning and loss of solids and coating. Thanks to the elongated pan, the flat tablet bed allows minimum static pressure, which helps prevent the tablets’ breakage.

Emptying the system can be done quickly by reversing the rotational direction of the pan. Air is supplied and exhausted through the perforated pan to quickly dry the spray-coated tablets. The system is equipped with a multi-panel display for operation controls and can be integrated with CIP system.

Pharmaceutical tablet coating machine

L.B. Bohle is a technology leader in machines, systems and processes for the pharmaceutical, chemical, food and nutraceutical industries. Our focus is on equipment for tablet manufacturing.

Who knew that dragee and tablet making had something in common?

The sweet connection to the pharmaceutical world lies in the art of coating, which has its roots in the confectionery industry. Both dragee and tablet coating involves the application of a layer of material – sugar for dragee and a polymer film for tablets - around a core, be it a nut or a drug substance.

But as you may know, in the pharmaceutical industry, rules and regulations are kings. According to the pharmacopeias, coated tablets must pass the test on uniformity of dosage units. Obtaining a uniform coating across all tablets in a batch may seem simple, but it is actually a complex process involving spraying, mixing, and drying.


<h2>Can you guess what might cause tablet coatings to be uneven?</h2>
How about improper mixing, inconsistent drying, or poor atomization? All those factors can cause uneven coating thickness…and that’s where the coater design comes in.

For instance, a pan with a small bed surface may not provide enough space for the tablets to move freely, causing uneven coating distribution. Or if the tablet bed is not flat, this can lead to tablets accumulating in the center or on the sides of the pan.

If the baffles are not properly designed, they can cause dead spots that the coating solution may not be able to reach. In addition, the number of nozzles and nozzle-to-nozzle distance can lead to areas of undercoating or overcoating.
<h2>Good things come in threes.</h2>
We talked with <a href="https://lbbohle.com/" target="_blank" rel="noopener">L.B. Bohle</a>'s technology expert, Tobias Borgers, on the ins and outs of their coating machine, and what makes it stand out in the industry.

“<em>Bohle technology contains three unique design principles which assure a good coating uniformity,</em>” explains Tobias.

First, the pan geometry provides a large tablet bed surface which allows the incorporation of a high number of spray guns, resulting in time savings of up to 40% during the coating process.

Second, helical baffles offer continuous and homogenous axial mixing within the tablet bed, preventing the formation of dead zones and minimizing tablet damage or twinning by avoiding acceleration peaks.

Third, the air principle allows for drying to occur within the tablet bed while keeping the rest of the coater and the spray guns cool.

“<em>In this way, spray losses are reduced to a minimum which leads to coating efficiencies of &gt;95%,”  </em>Tobias concludes.

Remember, coating isn’t just for candies. However, while an uneven coating on candy may only result in an unpleasant look and taste, a poorly coated pharmaceutical tablet can severely affect the patient's health.

The sweet world of pharmaceutical tablets - The trifecta for achieving coating uniformity

Pharmaceutical

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Making.com is a new online platform that helps makers find production technology quicker by grouping it around the products they make.

What's new in pharmaceutical packaging?



During <a href="https://www.pharmapackeurope.com/en/home.html" target="_blank" rel="noopener">Pharmapack</a>, we met Chantal Younes, Key Account Manager at <a href="https://www.csptechnologies.com/" target="_blank" rel="noopener">Aptar CSP Technology</a>, who introduced us to the world of active packaging.

The pharmaceutical industry is subject to strict regulations, so that's why manufacturers are very meticulous when formulating their products but especially about their packaging, which must keep their products safe. Due to the formulation or active ingredient, pharmaceutical products can present significant stability issues if they come in contact with moisture or oxygen.

This is where Aptar CSP Technology comes in. Aptar CSP Technology has developed several active packaging solutions to protect pharmaceutical products and ensure extended shelf life.

The company has developed a new class of highly engineered polymer compounds that protect drug products, probiotics, and drug delivery systems from impurities, oxygen, and moisture. The polymer can be extruded into a film, injection molded, or blow molded.

#Changemaker: Ready to protect your pharmaceutical products from moisture?

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

Did I take my medicine this morning or not?

Let's be honest. How often have we asked ourselves this question and failed to find an answer simply because… our memory sometimes doesn’t serve us right!

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Coming to the rescue of patients who need to keep track of their chronic medication and adhere to their daily treatment plan is FebriSol, a scratch-card calendar developed by Studio Fundi.

At <a href="https://www.pharmapackeurope.com/en/home.html" target="_blank" rel="noopener">Pharmapack</a>, we had the pleasure of meeting Ricky Stoch, the founder of <a href="https://studiofundi.com/" target="_blank" rel="noopener">Studio Fundi</a>, who showed us how simple it is to use FebriSol.

All the patient has to do is scratch off the day’s metallic coating that will reveal the check mark after taking the pill.

Current solutions for daily tracking are inconvenient and expensive.  FebriSol is a low-cost alternative that can help you keep track of your medicine every day.

#Changemaker: Keep track of your medicine every day with FabriSol sticker

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Enteric coated tablets labeling Equipment

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Serialization coding and labeling equipment

Serialized labels inspection and printing station

Serialization and aggregation inspection system

Individual item serialization equipment

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