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Compaction machines and technologies crush or compress materials and make them denser. Compaction can be used to simply save space or to shape materials into a desired form or format. Tablets, pellets, or briquets are formed by compactors but powder presses also help form cosmetic eyeshadow or face powder.

Compaction

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric coated tablets

Pharmaceutical granulators are often used with active substance mixtures to be processed into granulates, a process also known as compaction.


<h2>Dry granulation of pharmaceutical powders</h2>
With the Pharmapaktor® Serie (Pharmapaktors series L, K, and C 250) from Hosokawa Alpine, active substance mixtures are processed into granulate.

For this, the powder is first pressed into flakes/pellets. These are often crushed with a Flake Crusher into granulate.

Compaction (dry granulation) is understood to be the compression of powder between two synchronized, counter-rotating rollers. The powder is fed to the counter-rotating rollers in a regulated manner. Here, adhesive forces between the product particles are created under high pressure between the rollers.

For capsule or sachet filling the granulate must be de-dusted in a screening machine. The sieved fines can then be directly fed to the Pharmapaktor again

Pharmaceutical granulator

<span style="font-weight: 400;">Automated pressing of tablets saves time and improves quality. In R&amp;D or laboratory environments a dedicated minimal form factor tablet press provides maximum flexibility for the production of smaller batch sizes.</span>
<h2>Plug-and-play tablet press designed for lab and R&amp;D environments</h2>
<span style="font-weight: 400;">The Sejong Pharmatech P130S has been designed from the ground up as a lab-scale tablet press, and offers features that make it extremely flexible in pharmaceutical R&amp;D.</span>

<span style="font-weight: 400;">Available in 3 models offering 9,600, 19,200 and 24,300 units per hour, the P130S is capable of producing both round or oblong tablets up to 25mm across and up to 8.5mm in depth, allowing for a wide variety of sizes.</span>

<span style="font-weight: 400;">The unit has a mechanical bar and round type feeder and offers full automatic weight control (AWC) for the rejection of any faulty tablets, removing the need for manual intervention for quality control.</span>

<span style="font-weight: 400;">Featuring a full touch screen interface, the P130S makes it easy for operators to control all aspects of the machine’s function via a graphical HMI. The control system features full 21CFR part 11 reporting compatibility, offering simple regulatory compliance.</span>

Lab scale single layer tablet press

<span style="font-weight: 400;">For pharmaceutical tablet producers looking to reduce waste, costs and  increase production volume, a high efficiency rotary tablet press is the ideal choice. The latest technology allows for a high level of accuracy and automated quality control, meaning continuous production with little user input required.</span>
<h2>Flexible, reliable high speed rotary tablet press for volume production environments</h2>
<span style="font-weight: 400;">The Sejong Pharmatech P210S rotary tablet press is a high performance machine available in a range of output capacities up to 158,000 units per hour. This flexible machine can produce round or oblong tablets up to 25mm in diameter/length and up to 8.5mm thick.</span>

<span style="font-weight: 400;">The P210S offers a press pressure of up to 6,000 kgf, providing optimal compression results and minimising formation faults, yet the machine only has a small footprint of 800mm x 1300mm.</span>

<span style="font-weight: 400;">Advanced features include a turret-type disk interchange system for quick and easy changes to dosage form, and a single impeller feeder that simplifies cleaning and maintenance yet improves powder flow, increasing the fill efficiency and therefore improving throughput.</span>

<span style="font-weight: 400;">P210S also features a fully automatic discharge chute with three-position operation for good, reject and sampling. A newly enhanced compressions roll and dust collection system minimises powder leakage, and the optional integrated weight control system allows independent control of weight and hardness. The user-interface is a fully graphical touch screen type for ease of use, and the system offers full 21CFR part 11 compliance for regulatory recording.</span>

Rotary tablet press

<span style="font-weight: 400;">High performance tablet presses that are capable of producing both single and double-layer tablets offer the maximum flexibility to a multi-product production environment. Rapid changeover, simple operation and high volumes with minimum rejection rate are all key features required by modern pharmaceutical production.</span>
<h2>High volume, double-layer capable tablet press that increases productivity by 30%</h2>
<span style="font-weight: 400;">The Sejong Pharmatech P320D and P580D series of double-layer capable tablet presses have been designed to offer immediate productivity improvements to tablet production lines. Designed to provide up to 10,000kgf of pressure and outputs of over 720,000 units per hour of single tablets and over 160,000 units per hour of double-layer tablet, these units offer some of the highest levels of performance.</span>

<span style="font-weight: 400;">The P320D and P580D series features an efficient single impeller feed system, reducing the number of parts required, simplifying and speeding up cleaning and maintenance. A new design of powder feed pipe improves powder flow, allowing for greater efficiency and higher output compared to other press designs.</span>

<span style="font-weight: 400;">The user interface is based on a clear 15” touch screen display, with clear and simple layout and controls. Advanced features include a completely graphical error display system in case of malfunction or performance issue, directing operator to the fault for rapid resolution. The operating system is fully 21CFR part 11 compatible, meaning record keeping for regulatory compliance and optimum performance is simple.</span>

<span style="font-weight: 400;">The P320D and P580D features a fully automatic discharge chute with sample gate. Rejected tablets are also automatically sorted when the machine sensors detect a defective tablet or as a result of the automatic weight control system. For double-layer tablet production, 1st layer sampling is available to ensure quality across both layers.</span>

<span style="font-weight: 400;">All punches and rails are protected by advanced load cells that constantly monitor the machine performance and prevent these vital parts from damage, prolonging machine life and reducing maintenance. Upper and lower punches benefit from an automated lubrication system, removing the need for operator input.</span>

Single and double layer tablet press

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Enteric coated tablets compaction

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Pharmaceutical granulator

Lab scale single layer tablet press

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Single and double layer tablet press

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