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Enteric coated tablets compaction Equipment

Compaction machines and technologies crush or compress materials and make them denser. Compaction can be used to simply save space or to shape materials into a desired form or format. Tablets, pellets, or briquets are formed by compactors but powder presses also help form cosmetic eyeshadow or face powder.

Compaction

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Pharmaceutical granulators are often used with active substance mixtures to be processed into granulates, a process also known as compaction.


<h2>Dry granulation of pharmaceutical powders</h2>
With the Pharmapaktor® Serie (Pharmapaktors series L, K, and C 250) from Hosokawa Alpine, active substance mixtures are processed into granulate.

For this, the powder is first pressed into flakes/pellets. These are often crushed with a Flake Crusher into granulate.

Compaction (dry granulation) is understood to be the compression of powder between two synchronized, counter-rotating rollers. The powder is fed to the counter-rotating rollers in a regulated manner. Here, adhesive forces between the product particles are created under high pressure between the rollers.

For capsule or sachet filling the granulate must be de-dusted in a screening machine. The sieved fines can then be directly fed to the Pharmapaktor again

Pharmaceutical granulator

<span style="font-weight: 400;">Automated pressing of tablets saves time and improves quality. In R&amp;D or laboratory environments a dedicated minimal form factor tablet press provides maximum flexibility for the production of smaller batch sizes.</span>
<h2>Plug-and-play tablet press designed for lab and R&amp;D environments</h2>
<span style="font-weight: 400;">The Sejong Pharmatech P130S has been designed from the ground up as a lab-scale tablet press, and offers features that make it extremely flexible in pharmaceutical R&amp;D.</span>

<span style="font-weight: 400;">Available in 3 models offering 9,600, 19,200 and 24,300 units per hour, the P130S is capable of producing both round or oblong tablets up to 25mm across and up to 8.5mm in depth, allowing for a wide variety of sizes.</span>

<span style="font-weight: 400;">The unit has a mechanical bar and round type feeder and offers full automatic weight control (AWC) for the rejection of any faulty tablets, removing the need for manual intervention for quality control.</span>

<span style="font-weight: 400;">Featuring a full touch screen interface, the P130S makes it easy for operators to control all aspects of the machine’s function via a graphical HMI. The control system features full 21CFR part 11 reporting compatibility, offering simple regulatory compliance.</span>

Lab scale single layer tablet press

<span style="font-weight: 400;">For pharmaceutical tablet producers looking to reduce waste, costs and  increase production volume, a high efficiency rotary tablet press is the ideal choice. The latest technology allows for a high level of accuracy and automated quality control, meaning continuous production with little user input required.</span>
<h2>Flexible, reliable high speed rotary tablet press for volume production environments</h2>
<span style="font-weight: 400;">The Sejong Pharmatech P210S rotary tablet press is a high performance machine available in a range of output capacities up to 158,000 units per hour. This flexible machine can produce round or oblong tablets up to 25mm in diameter/length and up to 8.5mm thick.</span>

<span style="font-weight: 400;">The P210S offers a press pressure of up to 6,000 kgf, providing optimal compression results and minimising formation faults, yet the machine only has a small footprint of 800mm x 1300mm.</span>

<span style="font-weight: 400;">Advanced features include a turret-type disk interchange system for quick and easy changes to dosage form, and a single impeller feeder that simplifies cleaning and maintenance yet improves powder flow, increasing the fill efficiency and therefore improving throughput.</span>

<span style="font-weight: 400;">P210S also features a fully automatic discharge chute with three-position operation for good, reject and sampling. A newly enhanced compressions roll and dust collection system minimises powder leakage, and the optional integrated weight control system allows independent control of weight and hardness. The user-interface is a fully graphical touch screen type for ease of use, and the system offers full 21CFR part 11 compliance for regulatory recording.</span>

Rotary tablet press

<span style="font-weight: 400;">High performance tablet presses that are capable of producing both single and double-layer tablets offer the maximum flexibility to a multi-product production environment. Rapid changeover, simple operation and high volumes with minimum rejection rate are all key features required by modern pharmaceutical production.</span>
<h2>High volume, double-layer capable tablet press that increases productivity by 30%</h2>
<span style="font-weight: 400;">The Sejong Pharmatech P320D and P580D series of double-layer capable tablet presses have been designed to offer immediate productivity improvements to tablet production lines. Designed to provide up to 10,000kgf of pressure and outputs of over 720,000 units per hour of single tablets and over 160,000 units per hour of double-layer tablet, these units offer some of the highest levels of performance.</span>

<span style="font-weight: 400;">The P320D and P580D series features an efficient single impeller feed system, reducing the number of parts required, simplifying and speeding up cleaning and maintenance. A new design of powder feed pipe improves powder flow, allowing for greater efficiency and higher output compared to other press designs.</span>

<span style="font-weight: 400;">The user interface is based on a clear 15” touch screen display, with clear and simple layout and controls. Advanced features include a completely graphical error display system in case of malfunction or performance issue, directing operator to the fault for rapid resolution. The operating system is fully 21CFR part 11 compatible, meaning record keeping for regulatory compliance and optimum performance is simple.</span>

<span style="font-weight: 400;">The P320D and P580D features a fully automatic discharge chute with sample gate. Rejected tablets are also automatically sorted when the machine sensors detect a defective tablet or as a result of the automatic weight control system. For double-layer tablet production, 1st layer sampling is available to ensure quality across both layers.</span>

<span style="font-weight: 400;">All punches and rails are protected by advanced load cells that constantly monitor the machine performance and prevent these vital parts from damage, prolonging machine life and reducing maintenance. Upper and lower punches benefit from an automated lubrication system, removing the need for operator input.</span>

Single and double layer tablet press

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Making.com is a new online platform that helps makers find production technology quicker by grouping it around the products they make.

Did I take my medicine this morning or not?

Let's be honest. How often have we asked ourselves this question and failed to find an answer simply because… our memory sometimes doesn’t serve us right!

&nbsp;

Coming to the rescue of patients who need to keep track of their chronic medication and adhere to their daily treatment plan is FebriSol, a scratch-card calendar developed by Studio Fundi.

At <a href="https://www.pharmapackeurope.com/en/home.html" target="_blank" rel="noopener">Pharmapack</a>, we had the pleasure of meeting Ricky Stoch, the founder of <a href="https://studiofundi.com/" target="_blank" rel="noopener">Studio Fundi</a>, who showed us how simple it is to use FebriSol.

All the patient has to do is scratch off the day’s metallic coating that will reveal the check mark after taking the pill.

Current solutions for daily tracking are inconvenient and expensive.  FebriSol is a low-cost alternative that can help you keep track of your medicine every day.

#Changemaker: Keep track of your medicine every day with FabriSol sticker

Pharmaceutical

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

What's new in pharmaceutical packaging?



During <a href="https://www.pharmapackeurope.com/en/home.html" target="_blank" rel="noopener">Pharmapack</a>, we met Chantal Younes, Key Account Manager at <a href="https://www.csptechnologies.com/" target="_blank" rel="noopener">Aptar CSP Technology</a>, who introduced us to the world of active packaging.

The pharmaceutical industry is subject to strict regulations, so that's why manufacturers are very meticulous when formulating their products but especially about their packaging, which must keep their products safe. Due to the formulation or active ingredient, pharmaceutical products can present significant stability issues if they come in contact with moisture or oxygen.

This is where Aptar CSP Technology comes in. Aptar CSP Technology has developed several active packaging solutions to protect pharmaceutical products and ensure extended shelf life.

The company has developed a new class of highly engineered polymer compounds that protect drug products, probiotics, and drug delivery systems from impurities, oxygen, and moisture. The polymer can be extruded into a film, injection molded, or blow molded.

#Changemaker: Ready to protect your pharmaceutical products from moisture?

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

Tablet coating requires spraying, mixing, and drying procedures that must be carried out simultaneously under strict conditions to maintain the coating's stability. For a high-quality result, liquid coatings must be applied uniformly to every tablet to protect them from light and moisture.
<h3>Spray, mix, and dry tablets quickly and evenly</h3>
The Tablet Coaters BTC from Bohle is a system that combines mixing, spraying, and drying, to produce uniformly coated tablets. The system consists of a flat tablet bed with a long pan that sprays the tablets while being mixed carefully and continuously by helical baffles. The systematic forced guidance in the pan keeps the load in constant motion, preventing twinning and loss of solids and coating. Thanks to the elongated pan, the flat tablet bed allows minimum static pressure, which helps prevent the tablets’ breakage.

Emptying the system can be done quickly by reversing the rotational direction of the pan. Air is supplied and exhausted through the perforated pan to quickly dry the spray-coated tablets. The system is equipped with a multi-panel display for operation controls and can be integrated with CIP system.

Pharmaceutical tablet coating machine

L.B. Bohle is a technology leader in machines, systems and processes for the pharmaceutical, chemical, food and nutraceutical industries. Our focus is on equipment for tablet manufacturing.

Who knew that dragee and tablet making had something in common?

The sweet connection to the pharmaceutical world lies in the art of coating, which has its roots in the confectionery industry. Both dragee and tablet coating involves the application of a layer of material – sugar for dragee and a polymer film for tablets - around a core, be it a nut or a drug substance.

But as you may know, in the pharmaceutical industry, rules and regulations are kings. According to the pharmacopeias, coated tablets must pass the test on uniformity of dosage units. Obtaining a uniform coating across all tablets in a batch may seem simple, but it is actually a complex process involving spraying, mixing, and drying.


<h2>Can you guess what might cause tablet coatings to be uneven?</h2>
How about improper mixing, inconsistent drying, or poor atomization? All those factors can cause uneven coating thickness…and that’s where the coater design comes in.

For instance, a pan with a small bed surface may not provide enough space for the tablets to move freely, causing uneven coating distribution. Or if the tablet bed is not flat, this can lead to tablets accumulating in the center or on the sides of the pan.

If the baffles are not properly designed, they can cause dead spots that the coating solution may not be able to reach. In addition, the number of nozzles and nozzle-to-nozzle distance can lead to areas of undercoating or overcoating.
<h2>Good things come in threes.</h2>
We talked with <a href="https://lbbohle.com/" target="_blank" rel="noopener">L.B. Bohle</a>'s technology expert, Tobias Borgers, on the ins and outs of their coating machine, and what makes it stand out in the industry.

“<em>Bohle technology contains three unique design principles which assure a good coating uniformity,</em>” explains Tobias.

First, the pan geometry provides a large tablet bed surface which allows the incorporation of a high number of spray guns, resulting in time savings of up to 40% during the coating process.

Second, helical baffles offer continuous and homogenous axial mixing within the tablet bed, preventing the formation of dead zones and minimizing tablet damage or twinning by avoiding acceleration peaks.

Third, the air principle allows for drying to occur within the tablet bed while keeping the rest of the coater and the spray guns cool.

“<em>In this way, spray losses are reduced to a minimum which leads to coating efficiencies of &gt;95%,”  </em>Tobias concludes.

Remember, coating isn’t just for candies. However, while an uneven coating on candy may only result in an unpleasant look and taste, a poorly coated pharmaceutical tablet can severely affect the patient's health.

The sweet world of pharmaceutical tablets - The trifecta for achieving coating uniformity

Find production technology for Enteric coated tablets compaction, and connect directly with leading machine manufacturers worldwide

Enteric coated tablets compaction Equipment

Which enteric coated tablets compaction equipment do you need?

Pharmaceutical granulator

Lab scale single layer tablet press

Rotary tablet press

Single and double layer tablet press

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