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Maker - Product Challenge

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Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

If you've ever heard the acronym WFI spoken, know that we're not talking about wireless technology to connect your computer. WFI stands for water for injection, a sterile water used as a solvent to dilute other solutions for injections to the body. Traditionally, WFI was only produced through the distillation process using water for injection equipment until other methods such as reverse osmosis, electrodeionization, and ultrafiltration were developed.

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Water for injection

Glycerine is a water-soluble liquid mix of alcohol and sugar. It is a by-product of the oil and fats industry that offers added value to various industries. There are three ways to process it: transesterification, saponification, and fat splitting (hydrolysis). In 2020 these 3 forms of glycerine production reached around 4 million metric tons, with a global market of $1.68 billion.

Glycerine

<em>“How clean does my equipment needs to be?” </em>That's what manufacturers often wonder about in order to meet the high sterilization standards the pharmaceutical industry demands. Lending manufacturers helping hand have been single-use bags, also known as disposable, first introduced in the late 1990s. They immediately gained popularity because they reduce the risk of cross-contamination, minimalize cleaning and sterilization demands, and require a low capital cost.

Single-use bags

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BEE-International-positioning.pdf

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BEE-International-proof-of-concept.pdf

Making ice cream is all about mixing and homogenizing. First you need to blend, pasteurize and standardize your mixture. Then store it in tanks and freeze and aerate the mix until it reached the right consistency. Now you can add fruits, cookies and other solids if you like. In the final step the mix goes through an air blast hardening machine and it's ready to store and ship.

Ice cream

To produce condensed milk, you need to remove a large portion of the water content from the milk. Usually, you add sugar to it to create a sweet flavor. First, milk is standardized and pasteurized. Then, it goes through an evaporation process to remove the excess water content while sugar is added. After that, the mixture undergoes homogenization. The condensed milk is cooled and crystallized before being ready for packaging.

Condensed milk

Salad dressing has found its way onto dinner plates for millennia as a quick way to liven up leafy dishes. Experimentation with oil, vinegar, wine, salt, and other ingredients developed into the broad selection of dressings we enjoy today. Through a process of emulsifying the basic formula, adding additional elements, and then bottling and labeling the final mixture, consumers have easy access to reliable tastes on demand.

Salad dressing

You can make emulsions by combining two immiscible liquids (oil and water, for example) in a suspension through the use of force. The use of emulsifiers is necessary to keep this mixture stable and permanent.

Emulsions

All plastics are polymers, but not all polymers are plastics. Polymer production is a multi-step process that transforms raw materials into products that we use in our day-to-day life with the help of polymer process equipment such as extruders, calenders and injection molding machines.

Polymers

Cosmetic serums are a very light formulation with a high density of active ingredients dispersed in oil, water, or gel. This makes serums well suited to the delivery of vitamins, antioxidants, and anti-aging ingredients, but provide less moisturization and protection. Serum production is mainly divided into stages related to optimal mixing and preventing degradation of the active ingredients.

Serums

Basically, to make milk powder, you need to remove the water content from the liquid milk and turn it into powder. How to do it? After pasteurizing and homogenizing the milk, milk’s water content is removed through filtration, evaporation, and drying. You have then to cool and sieve it before filling the containers. Here's how you get milk powder.

Milk powder

Although the first association with almond milk might be the modern plant-based lifestyle trend, it is dated even back to the Middle Ages when it was used as an alternative to cow milk during Catholic fasting. Once harvested, almonds undergo a series of treatments in almond milk manufacturing equipment, such as bleaching, peeling, and grinding, to get the delicious final product for breakfast and desserts.

Almond milk

Creamier, sweeter and versatile are the key adjectives when talking about cashew milk, especially compared to other plant-based milk. Additionally, it is rich in vitamins B and D, as well as essential minerals. Being a blend of cashew kernels and water, the cashew nut milk processing equipment includes a peeling and washing machine, a colloid mill, and a blending tank.

Cashew milk

Although invented in the 1990s by Rickard Öste, oat milk has only recently grown to be one of the most popular milk alternatives in coffee shops, and it owes it to its smooth mouthfeel and creamy texture. Extracted the plant materials from oats with water, this non-dairy milk is high in fibers, low in saturated fats, and eco-friendly. Oat milk processing equipment helps prepare raw materials, starting with harvest over kilning and making them into flakes or flour, and mixing the prepared materials with water and enzymes.

Oat milk

First mentioned on a stone slab of the Eastern Han dynasty in ancient China, soy milk has survived centuries and spread from Asia to Global consumption due to the rising popularity of plant-based alternatives. To produce soymilk, raw materials must be harvested, prepared, and blended with water and desired ingredients, such as flavors and vitamins, in soymilk processing equipment.

Soy milk

Guaranteed scale-up from R&D to manufacturing

  Numerous pre- and post-processing options and accessories

Modular construction for reduced ongoing costs

Full user control over pressure

  Capable of continuous operations for use in small-scale production

Continuous milling is a flow production method used to grind materials without interruption. It is often used in the production of foods, cosmetics, pharmaceuticals, chemicals, and minerals. The material to be processed flows in at one end and the milled output flows out at the other in a continuous process. By choosing the right combination of milling technology and processing power you can obtain the desired particle size distribution in an uninterrupted stream.

Continuous milling solutions

High-pressure homogenizers are used in bio-pharmacy applications to obtain intracellular components like enzymes and proteins from bacteria, fungi, and animal cells through cell rupture. They are also used in other biotech processes such as the production of nanoparticles for tissue engineering and in the development of new drugs, vaccines, antibiotics, and chemicals. The choice of a high-pressure homogenizer depends on the mixture to be processed, desired particle size distribution, and the type of force to be applied to the particles.

High pressure homogenizers

Chemical

Cosmetic

Food

Pharmaceutical

Homogenization Equipment

Homogenization is the process of reducing particle size in mixtures to improve the consistency, uniformity, and stability of the product. The choice of a homogenizer depends on the nature of the product, desired particle size, the physical state of the ingredients, and pressure requirements during the process. Homogenization is widely used in the biotech industry for cell lysis and in the pharmaceutical industry for the emulsification of creams and ointments; it also finds applications in the cosmetics and food industries for improving the consistency and uniformity of various products.

Homogenization

Connect directly with world leading manufacturers of Homogenization equipment and find technology to build or improve your production line.

Homogenization &ndash; Making.com

Find Homogenization Equipment &ndash; Making.com

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

According to a legend, Cleopatra soaked her sails in her perfume so that Mark Antony could smell her ships before they arrived. This is to say that, from soaps and shampoos to perfumes, conditioners and pomades, cosmetics have always been highly valued and used for their properties of aesthetic enhancement. Cosmetics are a broad class of topical agents applied for various purposes such as cleansing, protecting, beautifying, or otherwise altering your appearance. As a result, a wide array of processing equipment is used in the cosmetics industry.

Cosmetics

The topical route is a convenient route for the self-administration of drugs. But turning a pharmaceutical formulation into an easy-to-use cream involves specialized cream manufacturing equipment. Topical dosage forms are essentially an emulsion of oil and water.  But the ratios can be changed to process it into lotions, ointments, and gels.

Cream

Milk can be consumed as a stand-alone product (whole, low-fat or skim) or can be the starting point for food industry products such as cheese, butter, yogurt, condensed milk, and ice cream. In order to process milk and other dairy products, you need specialized dairy production equipment which then encapsulates different processes such as pasteurization, homogenization, and fermentation.

Dairy

Our food chain starts in the soil, growing crops and livestock. But between the fields and the stores, there is a line of industrial food processing equipment. Processes may be as minimalistic as cleaning fruit and as complex as homogenizing milk alternatives made from pressed legumes. In each case, processing technology is an important link in the food production chain.

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

With the right processing machines, almonds, cashews, pine nuts, hemp, coconut, oat and soy can be processed into healthy plant-based milk. To produce it, grind the raw materials, screen, soak and mix them till you obtain a milky white liquid.

Plant-based milk

Sauces bring personality to a dish. From a spicy, dense Zhoug to a tangy, runny Suero, sauces add an extra dimension of flavor, texture, and mouthfeel. But developing recipes into industrial products with long shelf lives and consistent tastes is a complex process. Specialized sauce making equipment prepares and combines the ingredients into delicious, high-quality foods. The result is a sauce ready to elevate meals.

Sauce

Process

R&amp;D

Continuous

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

Milling machines are used to reduce the size of material by cutting, crushing, or grinding it. The choice of industrial milling equipment depends on the industry and the materials to work with. Besides, there is a significant difference between those aimed to remove layers from metal or other materials workpieces and those designed to reduce particle size for materials that come in bulk.

Milling

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

liquid

solid

Biotech and pharmaceutical development programs often require a mixing method that achieves both particle size reduction and complete cell lysis. When

High pressure pilot homogenizer &ndash; Making.com

We open production technology to everyone

Making.com

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Ketchup processing begins with tons of tomato paste that is mixed and heated together with sugar, vinegar, and spices in a cooking kettle. After cooking, any remaining fibers and particles are filtered out. Once it reaches the right viscosity, your tomato ketchup production process is finished and ready for packaging and transport.

Ketchup

Scaled to meet capacity, process and regulatory requirements

Designed for efficient, continuous 24/7 operation

Suitable for micro and nano emulsions and dispersions

Modular design for reduced maintenance costs

Colour touchscreen operation with real-time schematics and performance data

Metal

Mineral

We carry dozens of metals around every day. The ubiquitous smartphone is built with no less than 20 metals, each with specific behaviors and purposes. Metals are a pervasive class of materials that have defined entire eras of human development. It is no exaggeration to say that metal processing equipment is the core of our metallic world. But, paradoxically, this manufacturing technology itself is mainly made of metal.

The nearly 5,000 known minerals on earth share some characteristics to be classified as minerals – they are inorganic, solid, naturally occurring elements and have a particular chemical formula and an ordered internal geometric structure. However, minerals are not all the same. One way to divide them is based on their physical characteristics such as hardness, luster, color, and shape. For example, the diamonds we use to make jewelry are very hard minerals while talc is a soft mineral; gold is a shiny mineral while others are less so.

Minerals

For any industrial pharmaceutical process that relies on high pressure homogenization it’s vital that the equipment used is robust enough to cope with the

High pressure industrial homogenizer &ndash; Making.com

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BEE-International-Nano-DeBee-leaflet.pdf

Toast spread, oatmeal topping or salad dressing - nut butter can be used in various ways. Although in a culinary sense classified as such, peanuts, almonds, cashews and pecans, the popular choices for nut butter are, botanically speaking, not nuts. They are processed in a series of nut butter processing equipment to get the creamy, rich product ready for consumption.

Nut butter

Designed for the lab, with minimum sample size only 5ml

Fully customisable for process duration, pressure, flow and force

  Simple to clean and maintain

100% scale-up guarantee

Sampling is the process of aseptically drawing a sample from the process for analysis, without disturbing the bioprocess itself. The bioprocess needs to be carefully controlled by measuring important process variables and parameters. These parameters include pH, temperature, dissolved oxygen, foam/level, and agitation. The controllers use PID or auto-tuning adaptive control to measure and regulate the process parameters. The choice of a suitable controller depends on the identification of critical process variables.

Biotech sampling and control

Research and development work often requires the production of small and ultra-small batches. Laboratory mills allow limited production of experimental batches without the need for interrupting work on production machines. Typical applications of laboratory mills include new product development, process improvement, and quality control work. The choice of a suitable laboratory mill depends on your milling technique requirement, the batch size range, and the nature of the product that needs to be processed.

Laboratory mills

It’s vital that small units for experimentation can scale up with 100% accuracy. Ease of use, reliability and simple maintenance means increased work

High pressure electric laboratory homogenizer &ndash; Making.com

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BEE-International-Mini-DeBee-leaflet.pdf

Easy to clean and maintain, minimal downtime

100% scalability guarantee

Cost-effective electric power

Adjustable pressure to 45,000 PSI

Highest process intensity in the industry

For maximum value, a high-pressure homogenizer that’s suitable for both laboratory and pilot/small scale pharmaceutical production is the ideal choice.

Pilot high pressure homogenizer &ndash; Making.com

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BEE-International-Micro-DeBee-leaflet.pdf

Flexible enough to use in the lab through to small-scale production

Simple to clean and maintain, no disassembly

Can it be said that we live in the Plastic age? Basically, yes. From pillows over toothbrushes, and packaging to utensils, plastic is a widely used material in our day-to-day lives. But what is it? Plastics are synthetic or semi-synthetic materials built of polymers that are easily shaped into various structures with the help of plastic processing equipment such as extruders and molders.

Plastics

Offering lab-scale to small pharmaceutical production scale output for in one unit means maximum cost-benefit when acquiring a homogenizer. Capable of

High pressure air powered laboratory homogenizer &ndash; Making.com

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Ipros_ProcessVessels.pdf

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Ipros_Company-brochure.pdf

ipros_biopharma-pdf

Ipros_Biopharma.pdf

Did you know that in the 30s, cosmetic creams that contained radioactive material were booming on the market because they promised to reduce wrinkles? Thank God that's no longer the case. To make a cosmetic cream today, you need to create a stable mixture of oil and water and add an emulsifier to join these otherwise immiscible substances.

Cosmetic creams

The most significant decision when making ointments is likely to be the choice between automatic or semi-automatic processes for it. This impacts on individual phases of the ointment cream manufacturing process - the water phase and oil phase.

Ointment

The easiest and most commonly used method of making gels is mixing gelling agents with water to form a weakly cohesive internal structure. The gel production process is pretty linear and straightforward, from mixing hydrocolloids and water to labeling and sealing containers.

Gels

Every minute, your skin loses between 30,000 and 40,000 dead skin cells. This means losing millions of cells every day, which makes your skin look less glowing. Being a moisturizing agent, body lotion has the power to hydrate your skin and  give the glow back to it. Production involves water and oil phases, which you then mix with an emulsifier and blend until homogeneous. Preservatives are essential for any solution containing water for the prevention of microbial growth.

Body lotion

Overcomes unwanted air and foaming of suspensions

Fully bespoke build, with a wide range of capacities

Mobile solution for vessel capacity under 500 litres

Fully stainless GMP construction

ATEX compliant

A vacuum mixer mixes ingredients in an environment devoid of air to avoid incorporation of bubbles into the mix which can lead to foaming, formation of air pockets in the final product, fouling in heat exchangers, and cavitation. Mixing speed, level of vacuum, batch volume, nature and particle size of ingredients, heating or cooling requirements are all important considerations when selecting a vacuum mixer. Vacuum mixers are widely used in the pharmaceutical, chemical, and food industries for mixing ingredients sensitive to air.

Industrial vacuum mixers

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Logistics

Batch

The production of high quality pharmaceuticals often requires mixing of suspensions and similar solutions. A key challenge to overcome is the unwanted

Vacuum mixer for suspensions &ndash; Making.com

Colors present an enduring philosophical problem that generates lofty debates about subjectivism and consciousness. Meanwhile, ink manufacturing equipment turns colors into physical objects. Perhaps paradoxically, digitalization keeps fueling the use of printing ink. From custom clothing to secondary packaging to aircraft livery, inks are everywhere. Indeed, philosophical discussions are also primarily conducted in ink on paper.

Mayonnaise is created by blending oil with eggs, and then flavoring with vinegar, mustard, herbs, and spices. The eggs are a natural emulsifier that creates a uniform mixture. Ingredients are pumped into mayonnaise manufacturing equipment. First, a dynamic mixer maintains the desired level of emulsification of the mixture, which then moves on to packaging and bottling once reaching a satisfactory consistency.

Mayonnaise 

Cheese is the most demanding food in the entire dairy family to emulate using non-animal and dairy free ingredients. The complex physical and taste profiles of animal-derived milk products make plant-based cheese manufacturing challenging to pull off. But the growing appetite for lactose-free and non dairy products is serving alternative platters of cheese.

Plant-based cheese

Shampoo is a unique form of cleaning agent composed primarily of water and some form of surfactant. This surfactant provides the ability to bind oily substances for removal without leaving a residue, as traditional soaps might. The production process involves the batch mixing of its laboratory-defined formula, quality control, and filling stages.

Shampoo

In 2009, billionaire Stanley Ho made the winning bid for a giant white truffle weighing 3.3 pounds during an auction. Price: $330,000. Looking at the price, there's no need to explain why truffles are called the diamonds of the kitchen. After harvesting, they are selected to be sold fresh or processed to make truffle products such as truffle cream. Truffle processing involves cleaning, cutting, grinding, cooking, packaging, and sterilizing.

Truffle cream

After shaving, anti-aging, with organic ingredients, for the feet... Lotions are many. They compose the skincare world, which has been growing in recent years. More consumers look for the benefits of products that promise to enhance well-being and self-care. Whether you want to help prevent wrinkles, provide vitamins or just hydrate your consumers’ skin, get your formula and select lotion making equipment to get started.

Homogenization technology for biopharmaceuticals

Which homogenization technology for biopharmaceuticals equipment do you need?

High pressure pilot homogenizer

High pressure industrial homogenizer

High pressure electric laboratory homogenizer

Pilot high pressure homogenizer

High pressure air powered laboratory homogenizer

Vacuum mixer for suspensions

Economic dispersing machine for emulsions and suspensions

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