Variable density pellets extruder and spheronizer
When developing pharmaceutical formulations, having the ability to produce pellets with varied densities is crucial. It allows you to optimize dissolution profiles, modify pellet porosity, and increase drug loading, enhancing the overall effectiveness of your formulations.
Produce pellets with variable densities
The Caleva Variable Density Kit from Caleva Process Solutions enables the development of pellets with different densities, increasing the chances of achieving a successful formulation. This kit includes the Caleva Variable Density Extruder and the bench-top Multi Bowl Spheronizer with a 250 mm diameter bowl. The Variable Density Extruder features a design that allows for a range of screen thicknesses, from 1 mm to 12 mm, enabling the production of extrudates of varying densities. By adjusting the extruder screen hole depth, the density of the extrudate can be controlled, improving extrudate quality and leading to consistent, high-quality spheres during spheronization. The smooth surfaces and uniform size distribution of the pellets result in higher usable yields. Designed for both laboratory and full-scale production support, this equipment facilitates rapid and trouble-free scale-up to production environments.
Benefits
- Ability to modify pellet density during formulation development
- Improved extrudate quality and smoother surface
- Consistent sphere roundness and size distribution
- Enhanced drug loading in unit doses for clinical trials
- Facilitates easy scale-up to production