Automatic vial capping system
Ensure precise capping and sealing for sterile vial production with a compact, high-speed solution that integrates seamlessly into aseptic lines, enhancing efficiency and maintaining product integrity.

Caps, Stoppers, and Seals Vials Efficiently
The AS-2 HYGEIA from Siempharma is an automatic capping and sealing solution tailored for high-precision packaging of pharmaceuticals, nutraceuticals, and cosmetics. This compact monobloc machine excels in stoppering and alu-sealing vials, accommodating volumes up to 500ml while adhering to aseptic conditions. The AS-2 supports full or partial rubber stoppering, complemented by flawless alu-sealing for both traditional and flip-off caps. Configured with an intermittent motion system, it capably manages high-speed operations and integrates seamlessly with your existing production line via included infeed and outfeed conveyor systems. The unit is CFR21 part 11 / EU ANNEX 11 compliant, and manufactured to meet GMP standards, ensuring regulatory adherence across industries. Its modular construction, featuring a robust AISI 304 stainless steel frame and FDA-approved contact parts, ensures easy cleaning and maintenance. With an intuitive touch screen HMI interface, operators can quickly learn and configure the machine, optimizing performance and efficiency. Designed with Industry 4.0 compatibility, the AS-2 HYGEIA can be installed under various environmental control systems, including LAF, open RABS, and closed RABS, to suit your operational needs.
Benefits
- Ensures product integrity and compliance with aseptic capping and sealing.
- Increases operational efficiency through high-speed intermittent motion.
- Simplifies training and operation with an intuitive touch screen interface.
- Facilitates quick changeovers and reduced downtime with easy-size parts and maintenance.
- Enhances production flexibility with compatibility across various environmental systems.
- Applications
- Nutraceuticals,Cosmetics,Pharmaceuticals
- End products
- Serum and lotion vials,Liquid foundation vials,Lyophilized vials,Vitamin supplements in vials,Herbal extract vials,Sterile injectable vials
- Steps before
- Cleaning,Sterilization,Vial Preparation
- Steps after
- Inspection,Leak Testing,Labeling,Packaging
- Input ingredients
- empty vials,rubber stoppers,alu-caps
- Output ingredients
- closed vials,capped vials,vials with rubber stoppers,vials with alu-seals
- Market info
- Automation
- Automatic intermittent motion
- Capacity
- Small to large volume vials (up to 500ml)
- Changeover time
- Easy change size parts
- Cleaning method
- Easy cleaning and maintenance operations
- User interface
- Touch Screen HMI
- Compliance
- CFR21 part 11 / EU ANNEX 11 ready
- Compliance
- INDUSTRY 4.0 standard
- Construction material
- AISI 304 stainless steel
- Vial compatibility
- Vials without rubber stopper or alu-cap
- Stopper type
- Full or partial rubber stoppering
- Sealing type
- Alu-sealing with traditional or flip-off all-caps
- Automation level
- Automatic intermittent motion
- Batch vs. continuous operation
- Batch
- CIP/SIP
- Easy cleaning
- Cleaning method
- Manual
- Changeover time
- Easy change size parts
- Energy efficiency
- INDUSTRY 4.0 standard compliant
- Compact footprint
- Ultra-compact layout
- Construction Material
- AISI 304 stainless steel
- Modular System
- Intermittent motion monobloc
- Safety Features
- Tempered glass doors with safety interlock switches
- Contact Material
- FDA or other approved materials
- Customization Options
- Possibility to install under LAF,open RABS,closed RABS or Isolator
- Control Interface
- Touch Screen HMI
- Control panel type
- User-friendly and intuitive Touch Screen HMI
- Integration possibilities
- Possibility to install the machine under LAF,open RABS,closed RABS or Isolator
- Compliance,Certifications
- CFR21 part 11 / EU ANNEX 11 ready
- Compliance,Certifications
- Machine compliant with the INDUSTRY 4.0 standard
- Compliance,Certifications
- Manufactured according to CE rules
- Material option
- All parts in contact with the product are in FDA or other approved materials