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During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

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A vial for every application

Vials really do have millions of uses based on the material and application. Glass vials have been used for hundreds of years to store liquid pharmaceutical products. But glass is not always the same. For instance, The United States Pharmacopeia (USP) classifies glass into borosilicate glass as Type I and soda-lime-silica glass as Type II and III, with the difference being that  Type II has a special treatment to increase hydrolytic resistance.

Borosilicate glass contains at least 5% of boric oxide and is used for injectables with acid, neutral and alkaline pH. Amber-colored vials, created by adding iron to the glass, protect the substance from UV light and are suitable for light-sensitive samples.

 

Plastic vials, made of polypropylene or polyethylene, are widely used in cosmetics and law enforcement agencies. Compared to glass vials, they have lower chances of leaching and are much easier to handle. Plastic vials have excellent resistance to bases, alcohol, and acids. Special vials are also made for specific applications like cryogenic or liquid scintillation. Cryogenic vials are made of special polypropylene material to withstand extremely low temperatures. Scintillation vials are mostly glass vials used in liquid scintillation counting; this process is used to measure the substance’s radioactive activity.

Single-dose vials or multi-dose vials?

In medical applications, single-dose and multiple-dose vials are available. Single-dose vials are intended for one-time use and do not contain anti-microbial preservatives. The contents must be used within an hour after opening and any remaining contents must be discarded. These vials must be appropriately disposed of afterward. Multi-dose vials contain more than one dose of medication and contain anti-microbial preservatives to prevent the growth of bacteria after opening. It must be used for a single patient as much as possible to avoid cross-contamination and must not be used after the beyond-use date indicated on the label.

Coat your vials to improve chemical resistance

Glass delamination occurs in the inner surface of the container when exposed to chemicals due to chemical reactions and leaching of elements from the glass. As a result, glass flakes appear mixed with the chemical solution. If you think about it, this is a serious quality issue. Leaching of elements from the glass, such as sodium affects the pH level of the solution over time and may even lose the product’s efficacy.

As a solution, glass vials are treated by the vapor phase deposition silanization (or siliconization) method. This process involves applying a silicon solution to the surface as a protective layer to minimize the interaction between the vial and the substance. This method provides a uniform glass coating that improves the chemical resistance and gives a low adsorption characteristic preventing chemicals from sticking to the surface.

Aseptic vial filling equipment to ensure the safety of pharmaceutical products

Aseptic filling is fundamental in pharmaceutical industries to guarantee the quality and safety of its products from contaminants that may cause a reaction to the product leading to health risks when used. Exposure to contaminants also deteriorates the product quickly. The filling process starts with a vial washer before it goes to depyrogenation tunnels to remove pyrogens such as endotoxins and exotoxins. After sterilizing, vials are filled and stoppered by vial filling equipment. Then, they go to the capping and crimping machine for sealing.

Vial labeling and serialization equipment for product traceability

Serialization is a process used for product traceability operations. Information such as production-expiration date, lot number, and serial numbers are stored in a data center. By assigning a unique code to a drug packaging, counterfeiting of drug products can be prevented. Serialization is usually integrated with the labeling process of the vials. A high-resolution printer writes the labels with all the information required and then a code-reading camera is used during the verification process for readability.

Which vials technology do you need?

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Laminar flow shielded cell for radiopharmaceutical research

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Shielded cell for radiopharmaceutical synthesis

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Fully automatic linear labeling system for bottles

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Rotary washing system for pharmaceutical containers

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Semi-automatic washer for pharmaceutical containers

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High-speed washing system for ampoules and vials

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Automatic external washing system for ampoules and vials

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Ampoule filling and closing system

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Aseptic small / medium batch filling and closing system

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Compact filler and closer for vial processing

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Superheated water sterilization autoclave for pharmaceutical applications

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Continuous motion horizontal cartoner for blister packs

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X-ray scanner for sealed container inspection

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X-ray inspection system for wet environments

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Serialisation system for medicine bottles

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Bottle and vial inspection and coding system

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X-ray inspection module for pre-filled syringe needles

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Lab headspace analyzer for small volume parenterals

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Headspace gas analyzer for large volume parenterals

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Headspace analyzer for small volume parenterals

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Headspace analyzing system for small volume parenterals

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Headspace analyzation for small volume parenterals

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Automated container closure integrity tester

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Automated Cci tester for primary packaging containers

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Non-destructive headspace analyzer for pharmaceutical packages

Ensure non-destructive and accurate headspace analysis fo...

Automated headspace analyzer for small volume parenterals

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Automated headspace analysis for small volume parenterals

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Visual inspection for small volume parenterals

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Automated visual inspection for small volume parenterals

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Combined Avi and Cci tester for vials

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Combined visual and container closure integrity testing for vials

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Combined visual and container closure integrity tester for vials

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Automated container closure integrity tester for pharmaceutical packaging

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Automated Cci tester for pharmaceutical containers

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Blow/fill/seal packaging for laboratory and clinical trials

Streamline your small-scale pharmaceutical production with p...

Insertion technology for sterile blow/fill/seal systems

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Omnidirectional inspection system for bottles and vials

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Vial capping machine for pharmaceutical production

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Vial powder dispensing system

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Nested fillers for vials, pre-filled syringes, and cartridges

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Vertical ultrasonic washing for pharmaceutical containers

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Vial filling and stoppering system for aseptic production

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Automatic inspection system for ampoules and vials

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X-ray inspection for pharmaceutical vials

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Automatic inspection and leak test for pharma containers

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Automatic leak detection system for pharmaceutical containers

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Oral liquid bottle filling & capping system

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Sterilizing and drying tunnel for pharmaceutical vials

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Vertical ultrasonic washing system for oral liquid bottles

Ensure optimal cleaning and sterilization with a compact vert...

High-purity nitrogen generator for pharmaceutical and food industries

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Industrial freeze dryer for pharmaceutical applications

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Sterilization and drying tunnel for glass bottles

Ensure aseptic integrity and regulatory compliance in injectable produc...

Gravity rotary filling for large infusion bottles

Ensure precise filling and secure stoppering of large infusion bottles ...

High capacity automatic blister packaging system

Streamline your production line with a high-speed blister packaging syste...

Secondary packaging cartoner for ampoules and vials

Optimize your aseptic production with efficient high-capacity carton ...

Auto loading & unloading system for freeze dryers

Efficiently manage vial handling in freeze-drying processes with automa...

Mobile transfer loading system for freeze dryers

Streamline your lyophilization process with a high-capacity mobile loadin...

Saturated steam sterilizer for pharmaceutical production

Ensure sterility for a diverse range of pharmaceutical products ...

Steam & air mixture sterilizer for parenteral solutions

Achieve robust and effective sterilization for delicate pharmaceu...

Leak detection and gas filling for electric switchgears

Achieve precise leak detection and efficient gas filling for elec...

Freeze dryer & filling line aseptic isolator for cytotoxic products

Handle cytotoxic and high-potent drugs with precisi...

Sterile lyophilisation and filling line

Ensure aseptic conditions while freeze-drying biopharmaceuticals and high-potent dr...

pharmaceutical lyophilised filling line

For high-precision production of moisture-sensitive drugs, this aseptic system ensu...

Vial filling line and freeze dryer system

For seamless drug production, integrate reliable vial filling with precision fre...

Dry heat sterilization and depyrogenation oven for glassware

Achieve precise sterilization and depyrogenation of glasswa...

Gmp freeze dryer for small batch production

Optimize small-scale biopharmaceutical production with precise freeze-drying t...

Sublimation front monitoring system for freeze drying

Ensure precise control over your freeze-drying process with real-ti...

Aseptic ophthalmic filling isolator

Ensure sterility and precision in ophthalmic solutions with a controlled aseptic enviro...

Sterile lyophilized filling line

Ensure sterility and precision in filling pharmaceuticals with advanced isolator lines desi...

Sterile lyophilised filling solution

Achieve precise filling and control of moisture-sensitive pharmaceuticals while ensuri...

Sterility test isolators for continuous batch testing

Ensure aseptic integrity during high-throughput sterility testing w...

Freeze dryer for small batch scale-up in biotech and pharma

Optimize freeze-drying processes for small batches or high-v...

Bulk vial liquid filling system

Ensure reliable and efficient processing of critical biopharmaceutical and pharmaceutical li...

Robotic pick and place platform for food packaging

Enhance your packaging efficiency and product quality with a scalable ...

Medical device assembly and labeling solutions

Streamline assembly and labeling processes for medical devices with technol...

Assembly solutions for medical devices

Optimize your medical device production with specialized assembly solutions that ens...

Automated visual inspection for pharmaceutical products

Ensure the integrity and safety of your parenteral products with ...

Case packer for diverse food products

Optimize your packaging line with this versatile case packer, capable of handling a w...

Vaporized hydrogen peroxide decontamination chamber

Ensure aseptic material safety with a decontamination chamber designe...

Biodecontamination system for small pharmaceutical enclosures

Achieve reliable sterilization in compact settings with th...

Pharmaceutical grade washer for biotechnology and pharmaceutical manufacturing

Efficiently clean and prepare your labo...

Pharmaceutical grade washer for large components

Ensure compliance and maximize productivity with a high-performance solut...

Pure steam generator for pharmaceutical applications

Ensure your sterilization process consistently achieves high purity ...

Bottle induction seal integrity inspection

Ensure uncompromised product quality by accurately inspecting and verifying the...

Pilot freeze dryer for laboratory and small-scale production

Achieve precise temperature and vacuum control for consiste...

Pilot-production freeze dryer for diagnostic kits and Api

Optimize your lyophilization process with this versatile freez...

Robotic filler for aseptic pharmaceutical production

Streamline your aseptic filling process with high-speed robotic prec...

Lyophilization process optimization sensors

Achieve precise real-time monitoring of water vapor during freeze-drying, stre...

Rotary filler for pharmaceutical vials

Optimize precision and efficiency in fill-finish operations with a rotary system des...

Optimized lyophilization with Smart freeze dryer technology

Streamline lyophilization cycle development with cutting-edg...

Benchtop freeze dryer for laboratory research

Streamline your lab’s freeze-drying processes with precision temperatu...

Rtu debagging system for pharmaceutical sterile environments

Designed to streamline your fill-finish process, this syste...

Ready-to-use denesting equipment for pharmaceutical fill-finish

Ensure sterility and precision in your fill-finish workf...

Robotic syringe filling system for sterile pharmaceutical production

For high-precision liquid dosing in sterile enviro...

Pharmaceutical liquid and powder filling solution

Achieve precise filling and capping of diverse formulations with a vers...

Vial washer for pharmaceutical processing

Ensure efficient vial washing with minimal water usage, reducing particulates an...

Production lyophilizer for pharmaceuticals

Ensure precise freeze-drying for high-value pharmaceuticals with cutting-edge t...

R&d and process development freeze dryer

Speed up your biologic development with precise lyophilization control, ensuring r...

Small scale pharmaceutical filler and stoppering system

Optimize your R&D operations with a versatile filling and st...

Vial tray loader for pharmaceutical processing

Streamline your vial handling process with a high-speed, flexible tray load...

Depyrogenation tunnel for pharmaceutical vials

Achieve reliable sterility with fully automated depyrogenation tunnels, ens...

External vial washer for pharmaceutical industry

Ensure complete decontamination of vial exteriors with precision washing ...

Vial capping system for aseptic processing

Ensure precise vial sealing under aseptic conditions while maintaining high thr...

Micro-line vial filling solution for biopharmaceuticals

Ensure batch consistency and sterility in fill-finish operations ...

Freeze dryer loading and unloading systems for pharmaceutical processes

Optimize aseptic pharmaceutical processes with ...

Benchtop dissolution tester for multiple test runs

Streamline your laboratory’s workflow with a fully automated ben...

Ampoule filling and sealing line

Streamline your ampoule production with an integrated solution that expertly handles everyt...

Triple combi filling and stoppering system for vials and ampoules

Optimize your liquid formulation process with a versa...

Combi r&d ampoule and vial filling equipment

Optimize your R&D operations with a versatile machine designed for preci...

Vial washing system for internal and external cleaning

Streamline vial preparation with comprehensive washing, sterilizin...

Injection stretch-blow molding system for Pet containers

For manufacturers aiming to produce versatile, high-quality PET ...

Rotary stoppering and capping for vials

Achieve precise and efficient stoppering, capping, and crimping for high-speed vial...

Rotary vial filling and stoppering system

For high-speed production of sterile injectable vials, this continuous motion ro...

Nested syringe filling and stoppering system

Optimize your syringe production with precise filling and stoppering, ensurin...

External washing and drying system for sealed vials

Ensure contamination-free packaging of liquid vials with this precise...

Continuous motion rotary vial filling and stoppering solution

Optimize your vial production with a high-speed, continuou...

Automatic vial capping system

Ensure precise capping and sealing for sterile vial production with a compact, high-speed solu...

Automatic labelling system for pharmaceutical vials

Ensure precise and efficient packaging for cylindrical containers wit...

Automatic labelling system for pharmaceutical vials and bottles

Optimize your bottle labelling process with precision al...

Automatic linear filling stoppering system for large volume vials

Ensure precise vial filling and secure sealing with a...

Automatic capping solution for pharmaceutical vials

Cap your liquid formulations with precision and efficiency using this...

Vertical case packer for bottles and vials

Efficiently pack hard-to-handle items like bottles and vials with precision aut...

Single-mold continuous bottle Bfs solution

Optimize aseptic production with this advanced solution, offering superior ster...

Blow-fill-seal system for small volume injection production

Ensure precise aseptic liquid packaging with integrated blow...

Plastic bottle Bfs leak detection solution for small volume injections

Ensure sealed integrity with precision leak dete...

Vial washing drying filling sealing line for pharmaceutical production

Streamline your vial production with this integr...

Laboratory series steam sterilizers

Ensure the sterility of your labware and culture media with reliable steam-based steril...

Non Pvc soft bag form fill seal system

Efficiently form, fill, and seal non-PVC infusion bags while ensuring precision and ...

Automatic loading and unloading system for freeze-drying

Eliminate contamination risks and improve operational efficiency...

Cartoner for pharmaceutical products

Effortlessly streamline your packaging line with compact cartoning capabilities, ensur...

Rotary transfer system for pharmaceutical product filling

Ensure precise and hygienic filling of diverse pharmaceutical ...

Sterile filling platform for pharmaceuticals

Achieve precise, high-speed aseptic filling and packaging with advanced compl...

Aseptic handling and fill-finish platform for Rtu syringes, vials, and cartridges

Ensure aseptic precision and high t...

Semi-automatic filling solution for syringes and vials in isolators

Achieve precise aseptic fill-finish operations for ...

Filling and assembling solution for Ivd and Poc products

Optimize precision and efficiency in cleanroom environments with...

Hygienic Cartoning Machine For Pharma and Health Products

When packing single or multiple vials, ampoules or devices int...

Laboratory liquid viewer for colored glass bottles

In the pharmaceutical industry, an inspection to detect any particulat...

Laboratory liquid viewer for varying light conditions

In the pharmaceutical industry, you must inspect liquids in vials o...

Benchtop peristaltic dispenser

When you fill vials and ampoules, high standards of hygiene are required to avoid the risk of...

Benchtop piston filling equipment for vials in trays

Vials are difficult to fill individually through manual methods due ...

Laboratory liquid viewer for transparent glass bottles

Impurities like hair, fibers, or glass, sourced from the environme...

R&D bottle cap press

When you are a small-scale producer of liquids contained in bottles with press-on lids and caps you need...

Semi-automatic vial crimper

In a small production line, crimping vials manually can cause fatigue to your operator due to mu...

R&D bottle washer

When you pack your products in bottles, vials, syringes, and test tubes you need to wash them before fillin...

Pharmaceutical data management software

A typical pharmaceutical production handles numerous work flow activities like mana...

Pharmaceutical rotary labeling machine for vials

Small, cylindrical-shaped glass bottles or vials are mainly used for vacc...

Labeling machine for BFS containers

The pharmaceutical sector is unquestionably one of the major industries that rely on th...

Entry-level filler for large-volume parenterals

Large volume parenterals are unit-dose containers that are larger than 100...

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method of choice for the delivery of in...

Continuous pack cartoner

High volume automatic cartoning is vital for large scale production of cosmetic or pharmaceutical pr...

Online fraction collector for offline bioprocess analysis

Many bioprocesses require offline analysis of samples to monit...

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables marke...

Table top sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables ...

Cleaning and sterilization systems

An increasingly vital part of high quality pharmaceutical production is a dedicated Clea...

Rotary vial washing machine

When washing vial, ampoules, or cartridges for pharmaceutical production there is often a trade-...

Industrial vial capping machine

The high capacity production of pharmaceuticals delivered in vials and cartridges requires a...

External vial washing machine

Exterior washing solutions for vials often suffer from high water consumption and low throughp...

Aseptic vial cap sealing machine

Aseptic production methods are at the heart of the latest development in pharmaceuticals in...

Vial sterilization tunnel

Sterilization of vials, ampoules and syringes before filling is a vital step in the production of ...

Vial filling machine

The volume filling of vials, cartridges and syringes is a vital part of the production of a wide range o...

Aseptic automatic vial filling machine

Current and future developments in pharmaceuticals increasingly rely on aseptic prod...

Aseptic automatic vial washing machine

The production of the latest high value pharmaceuticals often requires aseptic handl...

Automatic vial tray loader

In modern pharmaceutical production, end-line processes are often still manual or slow. This can ...

Nested syringe filling machine

Increasingly, pre-sterilized Ready To Use (RTU) nested vials, cartridges and syringes are the...

Sterile compounding system

Hospitals and compounding centres have traditionally used manual aseptic compounding processes. A...

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

High-capacity horizontal cartoner for pharma and cosmetics appliances

Cartoners take carton blanks which are formed and...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pharmaceutical products are packed ...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are packed in protective and decorati...

Flexible automatic inspection machine for ampoules, vials, cartridges

If you are looking to improve the efficiency of y...

Flexible automatic inspection machine for syringes

Manufacture of pre-filled syringes requires the highest quality inspec...

Small automatic inspector for ampoules, vials, or cartridges

Inspect small batch production of ampoules, vials, or cartr...

Semi-automatic inspection machine for ampoules, vials or cartridges

If you need to increase the efficiency of your manu...

Visual and HVLD inspection for ampoules, vials and cartridges

Do you need to improve the efficiency and capability of yo...

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries ...

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space...

Microbiological safety cabinet class II

This handy device offers the most advanced features in product-operator protection ...

Biosafety cabinet class II for cytotoxic medicines

For the manipulation of hazardous substances utilized during the prepa...

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Biological safety cabinet class III

Specially designed for the handling of microbiological agents, when working with indige...

High-speed aseptic injectable vial filling machine

Fill up to 24,000 vials per hour with pharmaceutical powders or liquid...

Labeling machines for pharmaceutical bottles

Labels for ampoules, vials and bottles are typically applied at the end of th...

Pharmaceutical bottles inspection machine

For the visual inspection of small to medium batch-sizes of vials, ampoules or b...

Aseptic liquid filler for vials

Compact modular aseptic filler of vials with parenteral medicines and freeze-dried products.

Compact laboratory freeze dryer

Particularly suitable for research centers requiring greater freeze drying capacity. Some of...

GMP freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in ac...

Custom engineered freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are design...

Pilot freeze dryer for scale up

Designed for biological, pharmaceutical and food products formulation and “scale up...

Superheated water shower autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Dry heat depyrogenation oven

Specially designed for the drying and sterilization of glass containers, vials or ampoules, and...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

Small bottle checkweigher

Any small-diameter bottle, containing prescription medication or cosmetic applications, can be pro...

Versatile checkweigher

This Versatile checkweigher is equipped with a highly versatile strain gauge load cell. It is also sui...

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