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Vials making equipment

During crime scene investigations in any movie, you’ve probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Which vials technology do you need?

Hygienic Cartoning Machine For Pharma and Health Products

Hygienic Cartoning Machine For Pharma and Health Products

When packing single or multiple vials, ampoules or devices into…

Benchtop piston filling equipment for vials in trays

Benchtop piston filling equipment for vials in trays

Vials are difficult to fill individually through manual methods due t…

Pharmaceutical rotary labeling machine for vials

Pharmaceutical rotary labeling machine for vials

Small, cylindrical-shaped glass bottles or vials are mainly used for vacci…

Visual and HVLD inspection for ampoules, vials and cartridges

Visual and HVLD inspection for ampoules, vials and cartridges

Do you need to improve the efficiency and capability of you…

Semi-automatic inspection machine for ampoules, vials or cartridges

Semi-automatic inspection machine for ampoules, vials or cartridges

If you need to increase the efficiency of your manua…

Small automatic inspector for ampoules, vials, or cartridges

Small automatic inspector for ampoules, vials, or cartridges

Inspect small batch production of ampoules, vials, or cartri…

Flexible automatic inspection machine for ampoules, vials, cartridges

Flexible automatic inspection machine for ampoules, vials, cartridges

If you are looking to improve the efficiency of yo…

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Aseptic liquid filler for vials

Aseptic liquid filler for vials

Compact modular aseptic filler of vials with parenteral medicines and freeze-dried products.

R&D bottle washer

R&D bottle washer

When you pack your products in bottles, vials, syringes, and test tubes you need to wash them before filling…

Benchtop peristaltic dispenser

Benchtop peristaltic dispenser

When you fill vials and ampoules, high standards of hygiene are required to avoid the risk of …

Semi-automatic vial crimper

Semi-automatic vial crimper

In a small production line, crimping vials manually can cause fatigue to your operator due to mul…

Laboratory liquid viewer for transparent glass bottles

Laboratory liquid viewer for transparent glass bottles

Impurities like hair, fibers, or glass, sourced from the environmen…

Laboratory liquid viewer for varying light conditions

Laboratory liquid viewer for varying light conditions

In the pharmaceutical industry, you must inspect liquids in vials or…

Laboratory liquid viewer for colored glass bottles

Laboratory liquid viewer for colored glass bottles

In the pharmaceutical industry, an inspection to detect any particulate…

Automatic vial tray loader

Automatic vial tray loader

In modern pharmaceutical production, end-line processes are often still manual or slow. This can c…

Entry-level filler for large-volume parenterals

Entry-level filler for large-volume parenterals

Large volume parenterals are unit-dose containers that are larger than 100m…

Labeling machine for BFS containers

Labeling machine for BFS containers

The pharmaceutical sector is unquestionably one of the major industries that rely on the…

Nested syringe filling machine

Nested syringe filling machine

Increasingly, pre-sterilized Ready To Use (RTU) nested vials, cartridges and syringes are the …

Aseptic automatic vial washing machine

Aseptic automatic vial washing machine

The production of the latest high value pharmaceuticals often requires aseptic handli…

Aseptic automatic vial filling machine

Aseptic automatic vial filling machine

Current and future developments in pharmaceuticals increasingly rely on aseptic produ…

External vial washing machine

External vial washing machine

Exterior washing solutions for vials often suffer from high water consumption and low throughpu…

Industrial vial capping machine

Industrial vial capping machine

The high capacity production of pharmaceuticals delivered in vials and cartridges requires a …

Vial filling machine

Vial filling machine

The volume filling of vials, cartridges and syringes is a vital part of the production of a wide range of…

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Vial sterilization tunnel

Vial sterilization tunnel

Sterilization of vials, ampoules and syringes before filling is a vital step in the production of r…

Rotary vial washing machine

Rotary vial washing machine

When washing vial, ampoules, or cartridges for pharmaceutical production there is often a trade-o…

Packaging machine for syringes in trays

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method of choice for the delivery of inj…

Online fraction collector for offline bioprocess analysis

Online fraction collector for offline bioprocess analysis

Many bioprocesses require offline analysis of samples to monito…

Horizontal cartoner for pharma and cosmetics

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons for…

Table top sterile filling line for injectables

Table top sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables m…

Start-up sterile filling line for injectables

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables market…

Sterile filling line for injectables

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries r…

High-speed aseptic injectable vial filling machine

High-speed aseptic injectable vial filling machine

Fill up to 24,000 vials per hour with pharmaceutical powders or liquids…

Labeling machines for pharmaceutical bottles

Labeling machines for pharmaceutical bottles

Labels for ampoules, vials and bottles are typically applied at the end of the…

Pharmaceutical bottles inspection machine

Pharmaceutical bottles inspection machine

For the visual inspection of small to medium batch-sizes of vials, ampoules or bo…

GMP laboratory freeze dryer

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

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A vial for every application


Vials really do have millions of uses based on the material and application. Glass vials have been used for hundreds of years to store liquid pharmaceutical products. But glass is not always the same. For instance, The United States Pharmacopeia (USP) classifies glass into borosilicate glass as Type I and soda-lime-silica glass as Type II and III, with the difference being that  Type II has a special treatment to increase hydrolytic resistance.


Borosilicate glass contains at least 5% of boric oxide and is used for injectables with acid, neutral and alkaline pH. Amber-colored vials, created by adding iron to the glass, protect the substance from UV light and are suitable for light-sensitive samples.


 


Plastic vials, made of polypropylene or polyethylene, are widely used in cosmetics and law enforcement agencies. Compared to glass vials, they have lower chances of leaching and are much easier to handle. Plastic vials have excellent resistance to bases, alcohol, and acids. Special vials are also made for specific applications like cryogenic or liquid scintillation. Cryogenic vials are made of special polypropylene material to withstand extremely low temperatures. Scintillation vials are mostly glass vials used in liquid scintillation counting; this process is used to measure the substance’s radioactive activity.

Single-dose vials or multi-dose vials?

In medical applications, single-dose and multiple-dose vials are available. Single-dose vials are intended for one-time use and do not contain anti-microbial preservatives. The contents must be used within an hour after opening and any remaining contents must be discarded. These vials must be appropriately disposed of afterward. Multi-dose vials contain more than one dose of medication and contain anti-microbial preservatives to prevent the growth of bacteria after opening. It must be used for a single patient as much as possible to avoid cross-contamination and must not be used after the beyond-use date indicated on the label.

Coat your vials to improve chemical resistance


Glass delamination occurs in the inner surface of the container when exposed to chemicals due to chemical reactions and leaching of elements from the glass. As a result, glass flakes appear mixed with the chemical solution. If you think about it, this is a serious quality issue. Leaching of elements from the glass, such as sodium affects the pH level of the solution over time and may even lose the product’s efficacy.


As a solution, glass vials are treated by the vapor phase deposition silanization (or siliconization) method. This process involves applying a silicon solution to the surface as a protective layer to minimize the interaction between the vial and the substance. This method provides a uniform glass coating that improves the chemical resistance and gives a low adsorption characteristic preventing chemicals from sticking to the surface.


Aseptic vial filling equipment to ensure the safety of pharmaceutical products

Aseptic filling is fundamental in pharmaceutical industries to guarantee the quality and safety of its products from contaminants that may cause a reaction to the product leading to health risks when used. Exposure to contaminants also deteriorates the product quickly. The filling process starts with a vial washer before it goes to depyrogenation tunnels to remove pyrogens such as endotoxins and exotoxins. After sterilizing, vials are filled and stoppered by vial filling equipment. Then, they go to the capping and crimping machine for sealing.

Vial labeling and serialization equipment for product traceability


Serialization is a process used for product traceability operations. Information such as production-expiration date, lot number, and serial numbers are stored in a data center. By assigning a unique code to a drug packaging, counterfeiting of drug products can be prevented. Serialization is usually integrated with the labeling process of the vials. A high-resolution printer writes the labels with all the information required and then a code-reading camera is used during the verification process for readability.


Processing steps involved in vials making

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