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Industrial sterilization processes are employed in different industries to completely eliminate all living microorganisms from the final product. For instance, in food processing, sterilization equipment is used to produce a stable product with a long shelf-life by eradicating harmful bio-contaminants. Instead, in the medical field, sterilization technologies aim to prevent the transmission of microbes to patients by sterilizing all the tools and medical devices that come in contact with the patient. Most sterilization equipment, such as autoclaves, employs high-temperature pressurized steam to destroy bacteria and disinfect surfaces from spores. Other methods include radiation sterilization or using chemicals such as hydrogen peroxide for disinfection.

Sterilization

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

Specially designed for sterilizing large batches of parenteral solutions.


<h2>Excellent temperature uniformity can be rapidly obtained in the chamber by the high volume water flow</h2>
Steridelta W autoclaves from Telstar Life-Sciences are superheated water sterilization autoclaves specially designed for sterilizing large batches of parenteral solutions. The units have a high technical performance and GMP design in accordance with the applicable European standards: PED, CE marking, etc. They have a compact, modular structure allowing for quick installation and commissioning.

In terms of effectiveness, the Superheated water shower autoclave, has been designed and constructed to enable the process to be rapidly validated and it has a reliable control system that provides a homogeneous and repeatable temperature distribution in the chamber.

Superheated water shower autoclave

Specially designed for the drying and sterilization of glass containers, vials or ampoules, and high-temperature resistant metal products using ultra filtered hot air.


<h2>Sterilize high-temperature resistant products using ultra filtered hot air</h2>
The Pyromega ovens from Telstar Life-Sciences are designed for the sterilization and/or depyrogenation of pharmaceutical and biotechnology products, such as glass containers, vials or ampoules and high temperature resistant metal products using ultra filtered hot air in Class 10,000 (ISO 7) or Class 100 (ISO 5). The units are supplied in a compact format with all components readily accessible and can be installed to span two rooms; one for loading and the other clean or sterile unloading room.

The design of the Dry heat depyrogenation oven offers excellent performance for processing materials utilized in the sterile or aseptic area and/or finished product terminal sterilization.

Dry heat depyrogenation oven

<span style="font-weight: 400;">Sterilization of vials, ampoules and syringes before filling is a vital step in the production of regulated pharmaceuticals. Traditional sterilization units offer throughput levels that are below those demanded by modern production facilities. A dedicated, modern depyrogenation solution offers faultless sterilisation combined with enhanced throughput to meet efficiency demands.</span>
<h2>High throughput depyrogenation Tunnel with cooling chamber</h2>
<span style="font-weight: 400;">ST tunnels from Steriline have been designed to sterilize and to depyrogenate glass containers using a continuous process. Their careful design ensures that they maintain an ISO5 environment throughout all parts of the machine, including cooling chamber.</span>

<span style="font-weight: 400;">The Steriline ST series of sterilisation tunnels covers the entire range of needs, from very compact tunnels to the largest options for very high speed production, with throughputs up to 37,000 pcs/h. All ST tunnels feature thermal cycles that ensure pyrogens are reduced by a minimum of 3 or 6 log.</span>

<span style="font-weight: 400;">The ST tunnels have been designed to operate as efficiently as possible while maintaining a compact form factor, allowing them to be used in almost any facility, including upgrading existing lines.</span>

Vial sterilization tunnel

<span style="font-weight: 400;">Hospitals and compounding centres have traditionally used manual aseptic compounding processes. As well as being labour intensive, these also allow for the introduction of human error, both into dosing and mislabelling, and potential for breaching sterility. A 21st century automatic aseptic compounding system using robotic and RFID technology overcomes these problems at a stroke, increasing productivity, reducing lead times, and guaranteeing dosing accuracy and traceability.</span>
<h2>Complete robotic aseptic compounding system</h2>
<span style="font-weight: 400;">Steriline’s ACS Aseptic Compounding System is a computer-controlled system for compounding intravenous doses into IV or other containers within an ISO 5 environment. It has been designed for use in hospitals and compounding centres, and operates in accordance with all appropriate regulations, including labeling in accordance with industry “best practice” standards.</span>

<span style="font-weight: 400;">The ACS can handle both hazardous and non-hazardous medication, and can be used for both patient specific and batch production. Based around tried and tested Isolator technology, ACS includes vaporized hydrogen peroxide (VHP) sterilization as standard. This means it can be installed in an ISO 8 background environment, as per GMP Annex 11.</span>

<span style="font-weight: 400;">The ACS uses cutting edge automation and robotics technology to remove the need for human intervention to:</span>
<ul>
 	<li><span style="font-weight: 400;">Sterilize all items with (VHP) prior to compounding;</span></li>
 	<li>Calculate all conversions between weight and volume;</li>
 	<li>Reconstitute powder drugs with the appropriate fluid;</li>
 	<li>Dilute liquids to required concentrations;</li>
 	<li>Remove excess liquid from IV bags and bottles;</li>
 	<li>Compound doses into empty containers (including syringes, IV bags, and elastomeric infusors);</li>
 	<li>Manage in-process waste.</li>
</ul>
<span style="font-weight: 400;">Safety is paramount, and the Steriline ACS features a raft of features to ensure environmental, operator and patient safety, including ISO5 isolator technology; access restriction systems; zero cross-contamination risk operation; complete identification of all items via combination of vision, RFID and barcode systems; guaranteed traceability.</span>

Sterile compounding system

<span style="font-weight: 400;">An increasingly vital part of high quality pharmaceutical production is a dedicated Clean in Place/Wash in Place/Sterilize in Place system (CIP / WIP / SIP). The best way to implement a CIP/SIP solution is to design it into your process. Automating your cleaning cycles has the effect of converting a batch pharmaceutical process into a continuous operation of production and cleaning cycles, increasing efficiency and output, and reducing cost.</span>
<h2>Bespoke CIP/SIP systems for pharmaceutical processes</h2>
<span style="font-weight: 400;">Ipros can supply a full range of CIP/SIP systems for the pharmaceutical industry, ranging from mobile independent units through to complex systems with diverse CIP satellites fed with conditioned cleaning solutions. Everything is tailored to your exact requirements.</span>

<span style="font-weight: 400;">The CIP systems designed by Ipros can be incorporated into any equipment used in the pharmaceutical industry, including both solid and liquid dosage formulation systems. By incorporating spray systems, tank cleaners, nozzles and seals to your line the cleaning process will be fully automated, eliminating manual cleaning, reducing the cleaning cycle time, and reducing the use of water and cleaning solutions.</span>

<span style="font-weight: 400;">At the heart of every system is an advanced Wash Liquid Preparation Unit (WLPU). This controls and monitors all preheating, mixing and pumping of detergents and pure water. It can automatically adjust flow rate, detergent concentration, temperature and wash time, and allows full process validation.</span>

<span style="font-weight: 400;">All Ipros CIP/SIP system skids are designed, engineered, fabricated and tested inhouse, ensuring your exact requirements are met throughout the entire phase, from initial design through to commissioning in your plant.</span>

Cleaning and sterilization systems

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Vials sterilizing

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Superheated water shower autoclave

Dry heat depyrogenation oven

Vial sterilization tunnel

Sterile compounding system

Cleaning and sterilization systems

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