Continuous motion rotary vial filling and stoppering solution

Optimize your vial production with a high-speed, continuous motion solution designed for precise filling and secure stoppering, ensuring seamless integration into aseptic environments while minimizing downtime and maintenance.

Fills, Stopps, and Caps Aseptic Liquid Vials

The RFS-100/200 HYGEIA by Siempharma is a continuous motion rotary vial filling-stoppering machine, designed for high-speed aseptic processing of liquid formulations. It excels in pharmaceuticals by efficiently handling small to large volume vials, including complex applications like vaccine and biopharmaceutical vial production. Its multi-turret filling system allows precise filling and stoppering, accommodating up to 200 pieces per minute. With optional integration of an alu-capping station, it seamlessly fits into existing production lines. The machine is encased in a robust AISI 304 stainless steel structure, ensuring durability and corrosion resistance. Compliance with GMP standards, CFR21 part 11, and EU ANNEX 11 highlights its commitment to stringent regulatory environments. User-friendly HMI and easy-change size parts enhance operational flexibility, while the automatic vial rejection system maintains quality without halting production. Engineering support and customizable configurations are available to meet specific manufacturing needs.

Benefits

  • Enhances productivity with continuous motion operation handling up to 200 vials per minute.
  • Maintains product quality by seamlessly integrating aseptic filling, ensuring sterility.
  • Reduces maintenance costs with durable design and minimal wear on mechanical parts.
  • Increases operational flexibility with easy size changes and user-friendly interface.
  • Ensures regulatory compliance with GMP standards and CFR21 part 11 readiness.

General


Applications
Biopharmaceuticals,Liquid formulations,Pharmaceuticals
End products
Insulin vials,Antibiotic vials,Hormone replacement therapy vials,Radiopharmaceutical vials,Eye drop vials,Biological therapeutic proteins,Monoclonal antibody solutions,Rehydration solutions,Vaccine vials,Chemotherapy drug vials
Steps before
Vial production,Aseptic preparation,Liquid formulation
Steps after
Rubber stoppering,Aluminum capping,Quality control,Rejection of faulty vials,Packing
Input ingredients
vials,liquid products,lyo products,rubber stoppers,alu-seals
Output ingredients
capped vials,sealed vials,stoppered vials
Market info

Technical Specifications


Speed
Up to 200 pieces per minute
Vial Size
Up to 500 ml
Automation
Continuous Motion
Filling Method
Rotary filling
Stoppering
Full or Partial Rubber Stoppering
Capsize
Alu-seals
Capping Turrets
2 Turrets with 8 Heads Each
Machine Compliance
CE Rules
User Interface
Touch Screen HMI
Standards Compliance
GMPs,INDUSTRY 4.0
Support for Filling
Liquid and Lyo Products
Size Change Parts
Easy Change
Infeed System
Infeed conveyor belt with inverter for speed adjustment

Operating Characteristics


Working Mechanism
Continuous Motion,Rotary
Integrated Steps
Vial Filling,Stoppering,Alu-Capping
CIP/SIP
CIP 121°C / SIP 135°C
Automation Level
PLC / Touch Screen HMI
Batch vs. Continuous Operation
Inline Continuous
Cleaning Method
Facilitated Cleaning
Changeover Time
Easy Change Size Parts

Material Compatibility


Abrasion resistance
Low level wear
Cleanability
Easy to clean
Corrosive resistance (e.g. acids)
AISI 304 stainless steel
Biological compatibility
Aseptic production compatible

Physical Characteristics


Machine footprint
Compact
Structure material
AISI 304 stainless steel
Safety guards
Stainless steel frame with safety interlock switches
Clear separation for sections
Vial transport and drive mechanisms
Control panel type
Touch Screen HMI
Discharge method
Outfeed conveyor belt

Custom Options


Control panel type
Touch Screen HMI
Integration possibilities
Alu-capping station integration (monobloc solution)