Continuous motion rotary vial filling and stoppering solution
Optimize your vial production with a high-speed, continuous motion solution designed for precise filling and secure stoppering, ensuring seamless integration into aseptic environments while minimizing downtime and maintenance.

Fills, Stopps, and Caps Aseptic Liquid Vials
The RFS-100/200 HYGEIA by Siempharma is a continuous motion rotary vial filling-stoppering machine, designed for high-speed aseptic processing of liquid formulations. It excels in pharmaceuticals by efficiently handling small to large volume vials, including complex applications like vaccine and biopharmaceutical vial production. Its multi-turret filling system allows precise filling and stoppering, accommodating up to 200 pieces per minute. With optional integration of an alu-capping station, it seamlessly fits into existing production lines. The machine is encased in a robust AISI 304 stainless steel structure, ensuring durability and corrosion resistance. Compliance with GMP standards, CFR21 part 11, and EU ANNEX 11 highlights its commitment to stringent regulatory environments. User-friendly HMI and easy-change size parts enhance operational flexibility, while the automatic vial rejection system maintains quality without halting production. Engineering support and customizable configurations are available to meet specific manufacturing needs.
Benefits
- Enhances productivity with continuous motion operation handling up to 200 vials per minute.
- Maintains product quality by seamlessly integrating aseptic filling, ensuring sterility.
- Reduces maintenance costs with durable design and minimal wear on mechanical parts.
- Increases operational flexibility with easy size changes and user-friendly interface.
- Ensures regulatory compliance with GMP standards and CFR21 part 11 readiness.
- Applications
- Biopharmaceuticals,Liquid formulations,Pharmaceuticals
- End products
- Insulin vials,Antibiotic vials,Hormone replacement therapy vials,Radiopharmaceutical vials,Eye drop vials,Biological therapeutic proteins,Monoclonal antibody solutions,Rehydration solutions,Vaccine vials,Chemotherapy drug vials
- Steps before
- Vial production,Aseptic preparation,Liquid formulation
- Steps after
- Rubber stoppering,Aluminum capping,Quality control,Rejection of faulty vials,Packing
- Input ingredients
- vials,liquid products,lyo products,rubber stoppers,alu-seals
- Output ingredients
- capped vials,sealed vials,stoppered vials
- Market info
- Speed
- Up to 200 pieces per minute
- Vial Size
- Up to 500 ml
- Automation
- Continuous Motion
- Filling Method
- Rotary filling
- Stoppering
- Full or Partial Rubber Stoppering
- Capsize
- Alu-seals
- Capping Turrets
- 2 Turrets with 8 Heads Each
- Machine Compliance
- CE Rules
- User Interface
- Touch Screen HMI
- Standards Compliance
- GMPs,INDUSTRY 4.0
- Support for Filling
- Liquid and Lyo Products
- Size Change Parts
- Easy Change
- Infeed System
- Infeed conveyor belt with inverter for speed adjustment
- Working Mechanism
- Continuous Motion,Rotary
- Integrated Steps
- Vial Filling,Stoppering,Alu-Capping
- CIP/SIP
- CIP 121°C / SIP 135°C
- Automation Level
- PLC / Touch Screen HMI
- Batch vs. Continuous Operation
- Inline Continuous
- Cleaning Method
- Facilitated Cleaning
- Changeover Time
- Easy Change Size Parts
- Abrasion resistance
- Low level wear
- Cleanability
- Easy to clean
- Corrosive resistance (e.g. acids)
- AISI 304 stainless steel
- Biological compatibility
- Aseptic production compatible
- Machine footprint
- Compact
- Structure material
- AISI 304 stainless steel
- Safety guards
- Stainless steel frame with safety interlock switches
- Clear separation for sections
- Vial transport and drive mechanisms
- Control panel type
- Touch Screen HMI
- Discharge method
- Outfeed conveyor belt
- Control panel type
- Touch Screen HMI
- Integration possibilities
- Alu-capping station integration (monobloc solution)