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sensor-technology

Sensor-technology

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Batch

Sufficient oxygen is critical to the success of processes like cell culture and fermentation, in order to support cell growth. Measuring oxygen online provides concurrent control and can signal alarms and automatically trigger remedial action. Polarographic sensors using special electrodes need polarization at least for several hours.


<h2>Optical Technology for Determining Oxygen Concentration Levels</h2>
Getinge Applikon’s Lumisens Sensors avoid these project delays because they use optical technology that is ready right away. This method takes accurate measurements even at low oxygen concentration levels, where polarographic sensors may be less accurate.

Lumisens optical sensors for the Getinge Applikon bioreactor range are suitable for 250mm to 3,000mm total volumes. Bespoke technology separates the glass sensor from the electronics, promoting long sensor life despite repeated sterilizations. Strong magnets accurately position the components together,

These optical sensors measure the phase shift between excitation and emission, which directly relates to partial oxygen pressure. This assures precision, reliability, low cross-sensitivity, and fast response to red light excitation.

Optical Dissolved Oxygen Sensors

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

The fermentation process stimulates enzymatic activity in organic substrates to transform their chemical composition. Fermentation is aided by storying the biomaterials in anaerobic environments, allowing the microorganisms to decompose their nutrient structures. The process is integral to some of the most popular products throughout time such as wine, beer, cheese, and kimchi. But besides the food sector, fermentation is also an important stage in the industrial manufacturing of chemicals, pharmaceuticals, and biofuels.

Fermentation

liquid

Continuous

This is the X-ray inspection system you need for detecting contaminants that are difficult to detect. Using high sensitivity sensors, the system features supplementary inspection functions such as “Package Check”.


<h2>Ultra high definition X-ray for low-contrast contaminant detection</h2>
The KD74-h series from Anritsu has maximum detection sensitivity, i.e. it can detect a metal ball of 0.2-mm dia at production line speed. The sensors make it possible to detect low-contrast contaminants such as bone and plastics. The additional “Package Check” function made it possible to detect the contents trapped in the packaging seal wrap.

The four high definition models of this series are: KD7405CWT and KD7405DWH (for minute metals). Others are KD7416DWH and KD7417DWH for wide-conveyor type available. The X-ray output is maximum 350 Watts.

High sensitivity X-ray inspection system

solid

Biopharmaceutical manufacturers are increasingly making use of Single-use pressure sensors to enhance efficiency, make equipment more versatile for use in a variety of processes, and decrease risk of cross contamination. Today even sensing technology enjoys the convenience and maintenance savings of disposable technology.
<h2>Accurate pressure sensing in a preprogrammed, easy set up, disposable package</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the bio pharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciPres system is single use pressure sensor that is easy to use, pre-calibrated, and ready for plug-and-play integration into your bio pharmaceutical production process.  The sensors are barcoded for traceability, medical grade, and NIST traceable.  They are accurate to +/- .02 bar at maximum allowable pressure of 4.1 bar.

Five sizes are available accommodating flow rates from 1 L/min to 60 L/min.  These sensors are compatible with may commonly used types of sanitation including, NaOH, NaCl, formaldehyde, autoclaving, and gamma irradiation.  Scilog has extensive experience developing single use sensors and these can be found used in a wide variety of bio-pharmaceutical process equipment.  They can also be integrated with the Sci-Pres monitor for stand-alone monitoring of up to three pressure sensor inputs.

Single-use pressure sensor

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Biopharmaceutical manufacturers are increasingly making use of single-use conductivity sensors to enhance efficiency, make equipment more versatile for use in a variety of processes, and decrease risk of cross contamination. Today even sensing technology enjoys the convenience and maintenance savings of disposable technology.
<h2>Accurate electrolyte conductivity and temperature sensing in a preprogrammed, easy set up, disposable package</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciCon system is single use temperature and conductivity sensor that is easy to use, pre-calibrated, and ready for plug-and-play integration into your biopharmaceutical production process.  The sensors are barcoded for traceability, medical grade, and NIST traceable.  For conductivity they are accurate to +/- 2.5 mS of full range with range of 1 uS/cm to 200 mS/cm.  For temperature effective range is 4 -50 C with an accuracy of +/- 0.5 C.  Five sizes are available accommodating flow rates from 1 L/min to 60 L/min.  These sensors are compatible with may commonly used types of sanitization including, NaOH, NaCl, formaldehyde, autoclaving, and gamma irradiation.  Scilog has extensive experience developing single use sensors and these can be found used in a wide variety of biopharmaceutical process equipment.  They can also be integrated with the SciCon monitor for stand-alone monitoring and automated documentation using the SciDoc software package.

Single-use conductivity sensor

Biopharmaceutical manufacturers are increasingly making use of single-use temperature sensors to enhance efficiency, make equipment more versatile for use in a variety of processes, and decrease risk of cross contamination. Today even sensing technology enjoys the convenience and maintenance savings of disposable technology.
<h2>Accurate temperature sensing in a preprogrammed, easy set up, disposable package</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciTemp system is single use temperature sensor that is easy to use, pre-calibrated, and ready for plug-and-play integration into your biopharmaceutical production process.  The sensors are barcoded for traceability, medical grade, and NIST traceable.  Their effective temperature measurement range is -40 to 150 C with an accuracy of +/- 0.5 C in the 4 to 70 C range.  Five sizes are available accommodating flow rates from 1 L/min to 60 L/min.  These sensors are compatible with may commonly used types of sanitization including, NaOH, NaCl, formaldehyde, autoclaving, and gamma irradiation.  Scilog has extensive experience developing single use sensors and these can be found used in a wide variety of biopharmaceutical process equipment.  They can also be integrated with the SciTemp monitor for stand-alone monitoring of up to two temperature sensor inputs.

Single-use temperature sensor

<span style="font-weight: 400;">For many bioprocesses, precise measurement of media flow rates is vital to process monitoring, additive delivery, filtration, sample delivery, and more. The use of a highly accurate automated flow rate measurement system that is also capable of controlling pumps can bring significant advantages to delivery quality and accuracy across processes.</span>
<h2>Accurate flow rate measurement and automatic pump control unit</h2>
<span style="font-weight: 400;">The Flow Reader from Flownamics is a highly accurate fluid flow rate sensor and pump controller.</span>

<span style="font-weight: 400;">Flow Reader features a patented dual sensor technology for outstanding accuracy down to as low as 0.01ml/minute.</span>

<span style="font-weight: 400;">The sensor operates by using sterile air bubbles injected into the fluid path. By tracking the leading edge of the bubble through a known volume past two discrete sensors, a high accuracy reading is obtained.</span>

<span style="font-weight: 400;">The read tube is gamma radiated and disposable and can be welded directly into your fluid path if required. </span>

<span style="font-weight: 400;">Flow Reader is then able to provide feedback to any pumping system capable of receiving 0-10V control inputs, including the Flownamics FP-101, eliminating the need for recalibrations.</span>

Fluid sensor technology for flow rate measurement

The vast majority of all biotechnological processes are aerobic, where a microorganism or cell responds to the liquid phase oxygen concentration in regulating its overall metabolism. Knowing the exact oxygen content in the working atmosphere is critical for your process.


<h2>DO2 Sensor optimized for bioprocesses</h2>
The Dissolved Oxygen sensor is a measuring device that informs about the dissolved oxygen in biotechnology processes, which is a basis for process optimization and control.

The AppliSens Low-Drift DO2 sensor from Getinge Applikon is specifically designed for long-term, stable, and accurate measurements in bioprocesses, such as fermentation and cell culture applications. Designed to withstand repeated sterilizations without failure.

The DO2 sensor has a titanium membrane module to minimize the measurement drift, and the available autoclave polarization module allows you to reduce start-up time for your cultures.

Dissolved Oxygen sensor

pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. New technologies are emerging that warrant accurate measurement and improve durability even in high-temperature steam-sterilization processes.


<h2>Acidity sensor optimized for bioprocesses</h2>
The pH sensor from Getinge Applikon is constructed using FDA approved materials, like the non-toxic solid gel electrolyte. Furthermore this sensor has an internal pressure, which reduces cross contamination. The pH sensor is designed to withstand repeated sterilization cycles without failure.

pH Sensor

<span style="font-weight: 400;">High performance tube-filling machines are used in the pharmaceutical and cosmetic industries. Their performance is greatly enhanced by the use of automated feed-in systems, delivery the empty tubes accurately and quickly to maximise the efficiency of the filler. Loading systems are available in a variety of formats, including the flexible cassette type.</span>


<h2>Feed cylindrical tubes via a cassette</h2>
<span style="font-weight: 400;">Ensuring a constant supply of appropriately orientated empty tubes, the IWK TZM Cassette Tube Feeding Magazine is suitable to supply machines operating at up to 120 tubes per minute.</span>

<span style="font-weight: 400;">The TZM allows for uninterrupted operation because it holds tubes in a reservoir between the tube filler and tube feeding magazine. Tubes in the reservoir are processed first, meaning restocking the filler will not impact on the operation. A photo-electric backup sensor monitors</span>

<span style="font-weight: 400;">the tubes in the reservoir ensuring it does not run empty.</span>

<span style="font-weight: 400;">The TZM aligns tubes into singles by using pneumatic baffle plate movements in the magazine and the reservoir area. Individual tubes are picked up at the far end of the tube filler chute and loaded in the tube filling machine.</span>

<span style="font-weight: 400;">Suitable for use with laminar flow, the TZM gently handles tubes, minimising damage to fragile materials. The TZM is able to handle all commercially available tube materials, and operates with tubes of diameter 13.5 mm to 40 mm, and length 60 mm to 230 mm.</span>

<span style="font-weight: 400;">Size changeovers are very quick to minimise downtime and don’t require the use of any tools.</span>

Loading cassette for a tube filler

Conveyor systems are used for moving materials from one location to another. Considerations for choosing a suitable industrial conveying system include the nature of the product, its physical state, the desired conveying rate, and sensitivity of the product to heat and mechanical shock. Conveying equipment is used in the food, pharmaceutical, chemical, biomass, and mineral industries to move materials around a warehouse as well as to transport bulk powders, granules, and grains for processing and filling. These types of systems are usually automated and there is a wide variety of solutions to choose when it comes to the type of conveyor. Types include screw, gravity, chain, roller and belt conveyors.

Conveying

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

A loading system feeds your continuous or batch processing machine with the specified material or item in line with the flow of production. Loaders transfer the articles from one stage of preparation to the next with uniformity and accuracy.

Loading

Sensors

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