Rising demand for sophisticated forms of drug delivery

Pre-filled syringes are gaining popularity over traditional syringes and vials and are considered one of the fastest-growing markets in drug delivery and pharmaceutical packaging industries. Pre-filled syringes address most of the issues from the traditional vial and syringe drug delivery such as less risk of contamination during administration as there is no need to draw out substances from a separate container and elimination of on-site vial cleaning and depyrogenation. Additionally, the exact fill volume of pre-filled syringes ensures that the correct dosage is administered to the patient, thereby minimizing potential dosage errors.

For healthcare providers, prefilled syringes provide the exact dosage for injection, preventing potential dosage error and offering quick and convenient drug administration. For pharmaceutical companies, pre-filled syringes eliminate drug overfill with its correct dosage. This means less waste of drugs and better efficiency in manufacturing since vials are usually overfilled to ensure that the transfer of drugs from vial to syringe is adequate.

Less contamination, safer application, from a material called Cyclo Olefin Polymer

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Pre-filled syringe filling machine for bubble-free liquid contents

Pharmaceutical companies that manufacture complex biologics require less headspace by using the bubble-free filling method. This is done by a stoppering technique called vacuum placement. A vacuum is pulled in each syringe that causes a differential pressure. The pressure draws the plunger into the syringe, leaving minimal headspace between the product and the plunger.

Advantages of a bubble-free pre-filled syringe filling machine are dosing accuracy with the removal of air bubbles, assurance of sterility because of fewer chances of plunger movement during shipping, and biologic stability due to less oxygen content that can affect oxygen-sensitive drugs. In addition to the filling machine, a labeling machine can also be used to apply labels to pre-filled syringes. This ensures that the syringes are properly labeled, which is important for tracking and tracing purposes.