Tell us about your production challenge

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue. These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

What injectables equipment do you need?

Semi-automatic forming and sealing blister machine

As a producer of light bulbs, the packaging is a critical factor in pr...

Automatic medical forming and sealing blister machine for packing capsules and tablets

Product safety is very importa...

Clinical trial lab sealer for a laminar airflow bench

When running small production for clinical trials, stability studie...

Automatic forming and sealing blister machine for packing syringes

Controlling contamination is on every manufacturer&#...

Pharmaceutical rotary labeling machine for vials

Small, cylindrical-shaped glass bottles or vials are mainly used for vacc...

Labeling machine for BFS containers

The pharmaceutical sector is unquestionably one of the major industries that rely on th...

Low speed Filler for large-volume parenterals

Large-volume parenteral bottles are usually manufactured with a resin that c...

Entry-level filler for large-volume parenterals

Large volume parenterals are unit-dose containers that are larger than 100...

Ethylene oxide sterilizer

When medical devices like syringes, catheters, dialysis cartridges, plastic dressings and sutures ...

API powders storage bottle

Users who prefer rigid storage over single-use pharma charge bags, require lightweight solutions ...

Pharmaceutical pure steam generator

Dry, saturated steam can be used to sterilise pharmaceutical manufacturing equipment, a...

Water distillation system

Water used in pharmaceutical processes must meet high standards of regulatory bodies. These includ...

Vapor compression distiller

Water for injections must be of highest achievable quality to eliminate the possibility of conta...

Reverse Osmosis water filtration system

Reverse osmosis uses a partially permeable membrane to remove undesirable molecules...

Ampoule filling machine

Filling ampoules or vials with parenteral fluids are an essential matter for which you need to consid...

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method of choice for the delivery of in...

Continuous pack cartoner

High volume automatic cartoning is vital for large scale production of cosmetic or pharmaceutical pr...

Horizontal cartoner for pharmaceutical applications

Automatic cartoning for cosmetic or pharmaceutical products is a requ...

Laboratory scale active freeze dryer

The laboratory-scale active freeze-drying is used for dehydrating high-value products ...

Active freeze dryer

Freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying ...

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables marke...

Table top sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables ...

Vacuum mixer for suspensions

The production of high quality pharmaceuticals often requires mixing of suspensions and similar...

Purified water storage tank

Many pharmaceutical and cosmetic production lines require holding vessels for the storage of liq...

Cleaning and sterilization systems

An increasingly vital part of high quality pharmaceutical production is a dedicated Clea...

GMP washer

In order to guarantee zero cross-contamination between production batches, the proper cleaning of all product-conta...

GMP chamber washer

The thorough cleaning of small product contact parts has always been challenging, and traditional manual c...

Rotary vial washing machine

When washing vial, ampoules, or cartridges for pharmaceutical production there is often a trade-...

Industrial vial capping machine

The high capacity production of pharmaceuticals delivered in vials and cartridges requires a...

External vial washing machine

Exterior washing solutions for vials often suffer from high water consumption and low throughp...

Aseptic vial cap sealing machine

Aseptic production methods are at the heart of the latest development in pharmaceuticals in...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a wa...

Vial sterilization tunnel

Sterilization of vials, ampoules and syringes before filling is a vital step in the production of ...

Vial filling machine

The volume filling of vials, cartridges and syringes is a vital part of the production of a wide range o...

Aseptic automatic vial filling machine

Current and future developments in pharmaceuticals increasingly rely on aseptic prod...

Aseptic automatic vial washing machine

The production of the latest high value pharmaceuticals often requires aseptic handl...

Automatic vial tray loader

In modern pharmaceutical production, end-line processes are often still manual or slow. This can ...

Nested syringe filling machine

Increasingly, pre-sterilized Ready To Use (RTU) nested vials, cartridges and syringes are the...

Closed restricted access barrier system

Pharmaceutical production techniques often require isolation of compounds and chemi...

Portable IBC washer

The thorough cleaning of bulk containers and other storage and processing equipment is a vital step in th...

IBC bin washer and dryer

Many pharmaceutical processes use IBCs of multiple sizes throughout production. Careful washing and ...

CIP system for bulk tanks

Clean in Place (CIP) technology offers many advantages, but traditional systems are often inflexib...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning an...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing components used in the productio...

Feeder with flexible wall hopper

The varying properties of dry powder products mean that specialized feeders are required fo...

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powd...

Colloid mill

For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen.  ...

High-pressure homogenizer

When processes call for homogenized emulsions with extremely fine particle sizes the traditional t...

Microencapsulation system for your drug delivery system

Whether you want to improve the stability of nutrients, protect a...

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

Magnetic agitator

Reliable mixing and agitation are essential to any quality production process that involves a fluid. This n...

High capacity horizontal cartoner for pharmaceutical and cosmetic appliances

Cartoners take carton blanks which are fo...

Automatic cartoner for applications in pharmaceutical and cosmetics industry

For high capacity production of cosmetics...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pharmaceutical products are packed ...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are packed in protective and decorati...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic products are sold in protective and de...

Transfer system for high-containment environments

A high-performance transfer port system that combines ultimate safety, ...

Purified water systems

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need...

Half-suit tester

Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...

Glove tester

Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...

Flexible automatic inspection machine for ampoules, vials or cartridges

If you are looking to improve the efficiency of...

Flexible automatic inspection machine for syringes

Manufacture of pre-filled syringes requires the highest quality inspec...

Small automatic inspector for ampoules, vials, or cartridges

Inspect small batch production of ampoules, vials, or cartr...

Semi-automatic inspection machine for ampoules, vials or cartridges

If you need to increase the efficiency of your manu...

Visual and HVLD inspection for ampoules, vials and cartridges

Do you need to improve the efficiency and capability of yo...

GMP homogenizing system

Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accur...

Multipurpose and R&D freeze dryer

A multipurpose unit in the research and development field. Some of the most common ap...

High containment split butterfly valve

Transferring active pharmaceutical ingredients from one vessel to another can lead t...

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries ...

Negative pressure isolator

Used for products biologically hazardous, that also require minimized cross contamination.

Corundum disk mill

Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,mus...

Downflow booth

Provides the highest levels of operator protection from potentially harmful airborne contaminants generated dur...

Vertical laminar flow cabinet

HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area ...

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work a...

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space...

Microbiological safety cabinet class II

This handy device offers the most advanced features in product-operator protection ...

Biosafety cabinet class II for cytotoxic medicines

For the manipulation of hazardous substances utilized during the prepa...

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Biological safety cabinet class III

Specially designed for the handling of microbiological agents, when working with indige...

Dispersing machine for emulsions and suspensions

Equipment operating under the rotor/stator principal is often employed wh...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Dispersing machine for very fine emulsions and suspensions

For continuous high performance mixing of solid and liquid ra...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Cone mill

When your raw materials include agglomorated suspensions of grainy or crystalline solids and your process needs a st...

Inline batch mixer for solids and liquids

Several issues often arise when your process requires batch-wise mixing of powde...

Continuous homogenizing system

Certain mixing tasks present unique challenges and manufacturers need equipment that is speci...

High accuracy homogenizing system

When extremely high accuracy is required in your recipe or formulation traditional mixing...

Horizontal kneader

For high viscosity products, better results and reduced process times can be achieved with kneading type r...

Vertical kneader

Production of highly viscous products with high solid content often benefits from kneading processes rather t...

Continuous kneader

Effective mixing of highly viscous products with extremely high solids content can be difficult and the re...

Batch dispersing machine

Equipment operating under the rotor/stator principal is often employed when more traditional methods...

Batch dispersing machine for abrasive products

For mixing and dispersing tasks that cannot be completed by conventional st...

Batch dispersing machine for bottom entry into vessels

When your process requires high performance mixing or dispersion b...

Cost-effective homogenizing and emulsifying system

Manufacturers need production mixing equipment that is capable, flexib...

Dust-free continuous homogenizing system

Producers in a wide variety of industries benefit from equipment that can continuo...

Dilution system for two or more liquids in one pass

Onsite dilution of liquid process ingredients has historically been a...

Small-scale laboratory dispersing machine

Developing and validating new processes requires reliable and highly versatile e...

Pilot dispersing machine for testing and scale-up

Innovators in process development need laboratory equipment that helps ...

In-line laboratory dispersing machine

Innovators in a wide variety of industries need laboratory equipment on which process...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

Jet flow agitator for high-viscosity media

Processes including homogenization, dispersing, suspension, emulsification and ...

Agitator for medium viscosity media

Mixing fluids of medium viscosity for many production processes requires an agitator wi...

Agitator for low viscosity media

Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale p...

Microdosing machine for sterile powders

Fill sterile pharmaceutical powders into vials under aseptic conditions with a spee...

High-speed aseptic injectable vial filling machine

Fill up to 24,000 vials per hour with pharmaceutical powders or liquid...

Vial, ampoule or bottle inspection machine

For the visual inspection of small to medium batch-sizes of vials, ampoules or ...

High-speed blister machine

If you are looking for a compact machine that produces blisters with an output of up to 700 blist...

Horizontal intermittent motion cartoner

User-friendly cartooning solution with an intermittent motion for a wide range of p...

Horizontal continuous motion cartoner

An automatic cartoning machine designed for both high-speed operations and medium pac...

Compact blister machine

A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...

Depyrogenation tunnels for ampoules, vials and bottles

Sterilize and depyrogenize ampoules, vials, bottles and similar gl...

Automatic washing machine for ampoules

Automatic washing machine designed for cleaning ampoules and achieving a maximum out...

Aseptic liquid filler for vials

Compact modular aseptic filler of vials with parenteral medicines and freeze-dried products.

Monobloc small volume liquid filler

These intermittent motion monobloc machines are designed for filling various liquids in...

High-speed small volume liquid filler

Fill liquid pharmaceutical, nutraceutical and cosmetic products in ampoules and bottl...

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Compact laboratory freeze dryer

Particularly suitable for research centers requiring greater freeze drying capacity. Some of...

GMP freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in ac...

Custom engineered freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are design...

Pilot freeze dryer for scale up

Designed for biological, pharmaceutical and food products formulation and “scale up...

Ethylene oxide sterilization chamber

Designed for the terminal sterilization of temperature sensitive medical-health produc...

Superheated water shower autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Steam and air mixture sterilization autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Saturated steam GMP laboratory autoclave

For processing a wide range of products: solid, porous and liquids in a laboratory...

Dry heat depyrogenation oven

Specially designed for the drying and sterilization of glass containers, vials or ampoules, and...

Aseptic barrier systems

Designed for sterile product and Potent API’s either with low or high OEL requirements.

Restricted-access barrier systems

Create a physical barrier between the operator and the product. More flexible than an iso...

Pure steam generator

Pure steam is mainly used in the pharmaceutical industry and in biotechnology for sterilization, water f...

Electrical pure steam generator

Pure steam is defined as the steam which when condensed becomes WFI quality water in accorda...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

Vertical peeler centrifuge

A vertical peeler centrifuge is used to separate solids, usually to separate fine particles from ...

Vertical scraper centrifuges

Vertical Bottom discharge Centrifuges work discontinuously, discharging the solids to the botto...

Small bottle checkweigher

Any small-diameter bottle, containing prescription medication or cosmetic applications, can be pro...

Versatile checkweigher

This Versatile checkweigher is equipped with a highly versatile strain gauge load cell. It is also sui...

Laboratory spiral jet mill

Ideal for the ultra-fine size reduction on a laboratory scale of dry materials up to Mohs’ ...

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Manufacturing parenteral formulations

Fragile molecules such as protein formulations would be destroyed using the alimentary canal and are therefore administered by injection. When making injectable formulations the drugs are stored in liquid or, if unstable at higher temperatures, lyophilized form. To ensure a stable active medium during storage and make the preparation isotonic with blood, liquid formulations combine active ingredients with a minimum amount of excipients such as solvents, solubilizers, suspending, and buffering agents, and antimicrobial preservatives.

Water for injections(WFI) is used as the vehicle for aqueous injections. For non-aqueous injections, fixed oils of vegetable origin are used as vehicles. Water for Injection is used in the preparation of medicines as a vehicle and sterilized water for injection is used when solving or diluting substances or preparations before use. WFI is obtained by distillation or reverse osmosis and meets all chemical requirements for PW (Purified Water) with an additional bacterial endotoxin parameter.

Lyophilized drugs allow storage at higher temperatures after freeze-drying is used to remove water from a liquid drug and create a solid powder or cake. In protein formulations, stabilizers are added to replace the water and preserve the molecule structure. Before administration, a lyophilized drug is reconstituted by combining a liquid diluent with the freeze-dried powder and mixing before injected into the body.

Vaccine development and production technology

Applikon Biotechnology is specialized in human vaccine production systems, as well as in systems for the production of therapeutic agents using both cell culture and microbial cultures.

Their advanced bioreactor systems can be used from the initial screening stage up to full-scale production using the same platform to minimize scale-up risks and guarantee a short time to market in product development.

Visual and high voltage leak detection (HVLD) inspection

Inspection of sealed glass vessels for contaminants, correct fill volume, sealing, and for example tip-cap effects or black spot particles. How convenient to cover all quality inspection requirements at once?

CMP Pharma’s NIKE-LT’s recirculation feature allows re-inspection following rejection by only one or two cameras (user selectable) which brings false rejection rates down reducing unnecessary wastage.

Sterile filling and packing of injectables

Sterile dosage forms must be free from any microorganisms, dust, fibers, and foreign particles, and should be isotonic. Although standards and legislation may differ worldwide there are several regulations to ensure the product or safe and effective new and generic drugs on the market such as USP/JP/EP standards and Current Good Manufacturing Processes (GMP) compliance.

Small-volume parenteral solutions (SVPs) are injections provided in containers 100 ml or less and can be designed for single and for multiple uses.  A large volume parenteral (LVP) is a single-use unit dose container of greater than 100ml designed to carry fluids, calories, and electrolytes.

For light-sensitive substances, colored glass containers such as vials or ampoules are used. If possible containers are made transparent for easier visual inspection. Containers are made, as far as possible, from material that is sufficiently transparent to permit visual inspection. Closures are equipped with a firm seal to prevent the entry of microorganisms and other contaminants while permitting the withdrawal of a part of the whole of the contents without removal of the closure. Closures for multidose containers are sufficiently elastic to allow the puncture to reseal when the needle is withdrawn.

Equipment for making injectables in action

Applikon next generation in microbioreactors

Vial filling line

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