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Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

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Dual-chamber cartridges as innovative packaging for freeze-dried products

In the lyophilization process, water is removed from a product after freezing and placing it under a vacuum to change ice directly to vapor without passing through the liquid phase. Vials are the most used packaging for freeze-drying products due to their simple assembly. The fact that they have a large volume facilitates heat transfer and rapid sublimation during drying.

However, more innovative packaging such as dual-chamber syringes or cartridges made their entrance as packaging forms of freeze-dried substances. Dual-chamber syringes are good for single-dose applications and filling volumes of 0.1 to 5mL.

Dual-chamber cartridges instead are meant for single and multiple doses with a filling volume of 0.1 to 1mL. The main difference with the dual-chamber syringes is their closure system in which the cartridge has an injection membrane for needles and is mostly used in applications like pen systems which require careful calibration. They are also available with special closures that can be sealed in the lyophilizer, creating a nitrogen atmosphere over the product. Advantages of dual-chamber drug delivery systems include accurate dosing, minimal reconstitution errors, and fewer steps for preparation and injection.

Pharmaceutical cartridges – the perfect match for pre-filled syringes

Pre-filled syringe cartridges have many advantages over traditional syringes. These advantages revolve around convenience, sterility and accuracy. If a patient requires a quick injection or there is an emergency, having a pre-filled syringe cartridge ready is more convenient than filling a standard syringe. This way, health workers can also be sure to provide accurate dosage to patients instead of overfilling or underfilling the barrel, which can negatively affect the treatment. An important advantage is that drugs into cartridges can remain sterile for about two or three years instead the medications in standard syringes will have a shelf life of about 12 hours.

Insulin pens make self-injection easier

Insulin pens are gaining popularity for diabetic patients that need insulin injections.  Most patients prefer using insulin pens over vials and syringes because are more convenient to use through self-injection as they already contain the exact dosage needed. They are safer with less needle exposure from the environment and also less painful when injecting them to the body due to smaller needle size.

Insulin pens can be reusable and disposable. Reusable pens only need the needle and cartridge disposed of after every use. The disposable pens have a pre-filled cartridge and as the name says, the whole pen is disposed of after use. Another advantage of using insulin pens is overall cost savings from lesser medication waste due to the exact dosage filled per insulin pen.

Pharmaceutical cartridge filling equipment for safety and compliance

Pharmaceutical cartridges must undergo aseptic filling through a pharmaceutical cartridge filling equipment. The process involves handling medications that may be sensitive to other elements and ensuring that the substance is free from contaminants that may cause health risks once patients use it.

The process starts with washing the cartridges before sending them to a depyrogenation tunnel so you can remove pyrogens. Then you can fill the cartridges with the substance and seal them with a plunger or stopper. After sealing, they are sent to a labeling and coding machine for all the labels and serial coding. Then, they are loaded on a tray and ready for packaging. These should be done under a sterile environment as per pharmacopeia standards.

Processing steps involved in pharmaceutical-cartridges making

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