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Maker - Product Challenge

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Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries requires flexible automation to accommodate format changes and optimize production. Also, vial sizes can range from 0.1 ml to 500 ml and syringes from 0.1 ml to 20 ml.
<h2>Fill, stop and crimp syringes and vials of all sizes</h2>
XI-I is specially designed by i-Dositecno for pharma filling, able to fill sterile liquid and powder in doses from 1 to 500 mls into vials and syringes.

4,000 units per hour can be produced for formats up to 80 mm diameter in a simple configuration, while 7,000 units per hour can be attained for smaller units up to 26 mm diameter in a double configuration.

Filling is by means of peristaltic pump, stainless steel rotary pump, ceramic rotary pump or CIP/SIP rotary pump. Stoppers are introduced by pick and place and capsule introduction and crimping are also completely servo driven.

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Sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables market, sterile conditions and accurate metering are still required for filling, stopping and crimping a wide range of container sizes.
<h2>Fill vials and syringes in basic, yet flexible, configuration</h2>
The i-Dositecno MI-I is specially designed for sterile pharma filling, able to fill sterile liquid and powder in doses from 1 to 500 mls into vials and syringes.

3,000 units per hour can be produced for formats up to 80 mm diameter in simple configuration, while 6,000 units per hour can be attained for smaller units up to 26 mm diameter in a double configuration.

Filling is achieved by means of peristaltic, stainless steel rotary, ceramic rotary or CIP/SIP rotary pump. Stoppers are introduced by servo-driven pick and place, however, capsule introduction and crimping heads are controlled by pneumatics.

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Start-up sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables market, sterile conditions and high-quality metering still need to be maintained.
<h2>Space-saving fill, stop and crimp line for vials</h2>
The table top BI-I from i-Dositecno can fill sterile liquid and powders in doses from 1 to 500 mls into vials, as well as specialized micro-dosing.

It can produce up to 2.000 units per hour for injectable vials from 2R to 500H as well as install rubber stoppers ranging from 12 mm to 32 mm and alu-caps 12 mm to 32 mm in size.

Filling is achieved by means of a peristaltic pump or a servo auger filler for micro-dosing which can meter as little as 0.150g. Stoppers are introduced by pneumatic pick and place and alu-caps loaded by chute, with crimping performed by pneumatics.

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Table top sterile filling line for injectables

<span style="font-weight: 400;">The volume filling of vials, cartridges and syringes is a vital part of the production of a wide range of pharmaceuticals. Traditionally, high-accuracy filling machines operated slowly, decreasing line efficiency and creating a bottleneck for production. The latest generation of vial filling machines offer extreme accuracy coupled with high capacity and a wide range of options.</span>
<h2>High capacity filler for vials, cartridges and syringes</h2>
<span style="font-weight: 400;">Steriline’s VFM Vial Filling Machines have been engineered to offer exceptional accuracy and speed when filling non-toxic and toxic viscous or water-like liquids. Engineers have built the VFM into a reduced footprint for maximum flexibility.</span>

<span style="font-weight: 400;">A completely linear transport system offers the maximum throughput, with the ability to handle up to 24,000 pcs/h. This design also facilitates easy, all-round access which makes maintenance and changeover tasks quick and simple, reducing downtime.</span>

<span style="font-weight: 400;">To meet your exact requirements, VFM can be fitted with peristaltic and/or volumetric pumps actuated by servomotors. This allows not only for precise filling, but also the quick and simple adjustment of individual pumps via the intuitive HMI.</span>

<span style="font-weight: 400;">With a built in 100% IPC or statistical check weighing system with feedback, dosing is automatically changed if required to ensure accuracy even at the greatest throughput speeds.</span>

<span style="font-weight: 400;">VFM is able to fill vials from 2R-100H vial and cartridges from 1-3 ml. It is fully compliant with all relevant cGMP, GAMP and 21CFR Part11 requirements.</span>

Vial filling machine

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

A pre-filled syringe or PFS is a single-dose disposable syringe that is supplied loaded with the substance to be injected. By using a pre-filled syringe filling machine, you can have excellent dosage accuracy due to the exact filling of medications. During administration, safety from potential contaminants is also ensured as they are directly injected after opening. To further minimize the risk of contamination, pre-filled syringes are often filled and sealed in a sterile environment using stainless steel equipment.

Pre-filled Syringes

Pharmaceutical packaging is a mix &amp; match of liquids/pastes/creams/solids &amp; vials/cartridges/syringes/tubes. And this is not even the entire range of options available today.

We asked how many machines pharma manufacturers need to fill the different formulas into the right container format.

Moritz Eggenberger answered that for us: just one system.

<a href="https://zellwag.com/" target="_blank" rel="noopener">Zellwag Pharmtech</a> developed a filling solution that handles multiple types of solutions and containers.

Besides filling, the innovative technology can be customized to meet varying handling requirements and capping techniques.

Nested containers with screw capping? Puck transport and stoppering? Buffer table combined with pilferproof capping? Check, check, and check.

Pharma packaging options are endless, but the filling &amp; capping system is one.

#Changemaker: One filling solution for all pharma containers

Find production technology for Pharmaceutical cartridges dosing, and connect directly with leading machine manufacturers worldwide

Pharmaceutical cartridges dosing

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Sterile filling line for injectables

Start-up sterile filling line for injectables

Table top sterile filling line for injectables

Vial filling machine

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