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Powder Handling Equipment

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

Baking powder is perhaps the best-known secret of baking. The leavening agent forms bubbles in dough and batter to give muffins, cakes, and no-yeast pizza their tempting lift. First developed in the 19th century, baking powder production turned baking into the home activity we know today.

Baking powder

Chili powder

Curry powder

The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.

Dry inhaler powder

If you want to make your eyes more attractive and add depth and dimension to them, applying color to your lids is what it takes. Eyeshadow serves this purpose and is available in powder, liquid, pencil and mousse form. In an eyeshadow production line, compact eyeshadows are produced by grinding and mixing powders before compaction, whereas molded eyeshadows are made from waxes and oils mixed with pigments and then poured into molds. Instead, by mixing oils, gelling agents, elastomers, and pigments you can make a mousse eyeshadow.

Eyeshadow

Looking beautiful is hard work. Queen Elizabeth I knows this well. Just think she used so many cosmetics and makeup containing toxic materials, especially lead-based face powder, that she even died from them. Today fortunately, you no longer need lead to make face powder. Simply mix pigments, fillers, dry and wet binders, and compress the mixture using a powder compacting press. Then the face powder is ready to be applied using a powder puff.

Face powder

Flour processing technology has changed drastically since the days of the millstone pulled by a mule. But demand for more refined flour means that the production process is now slower than with more rudimentary techniques. When mixed with water, protein in wheat flour form an elastic gluten structure, giving bakery products their irresistible fluffiness.

Flour

Food powder is the result of drying and pulverizing food. It has been around since the astronauts when out to space. Fruits have a short shelf life and are difficult to preserve due to their high water content.  Fruit powder processing allows you to keep the nutrients of the fruits for a longer time, even off-season.

Fruit powder

In 1682, Denis Papin found a method to remove collagen from animal bones, discovering gelatin. But it was the inventor Peter Cooper who developed gelatin powder processing. In 1845 he secured his invention with US patent 4084 for a dessert of gelatin powder called “portable gelatin”.

Gelatin powder

<span style="font-weight: 400;">Any coffee-drinker can agree that a cup of coffee in the morning can brighten up their day. As the most convenient way of making coffee, many people choose to make coffee at home. Whether you want to make Moka coffee or filtered coffee, you need ground coffee that is grind appropriately for the coffee brewing method of your choice. These ground coffee are manufactured by roasting and grinding processes. </span>

Ground coffee

Gypsum is a naturally occurring mineral that serves many purposes, with the United States producing the largest crude gypsum in the world. Cover walls, ceilings, plasters, fertilizers, cosmetics and some foods: gypsum’s vast applications granted it the recognition of "wonder mineral". Gypsum making equipment helps in making gypsum powder or board for industrial use.

Gypsum

Do you know that the famous classical music composer and pianist Ludwig van Beethoven insisted on drinking a cup of coffee made from exactly 60 pieces of coffee beans? Currently, around 50% of the world’s green coffee beans undergo processing through instant coffee manufacturing equipment to produce instant coffee. The process requires roasting, grinding, brewing, and heating to obtain the extract; the coffee extract will either go through a spray drying process or a freeze-drying process.

Instant coffee

Instant soup is quite popular due to its ease of use and quick preparation. Products like cup noodles and vegetable soup mixes are some of the examples commonly used by consumers. The instant soup processing equipment is used to dehydrate or dry components of the soup mixture to prolong shelf life and preserve the taste of the vegetables and other components.

Instant soup

Forged metal objects appear seamless, simple items. But as the use of metals changed over time and constructions became more intricate with additive manufacturing, a new way of processing materials surfaced. Metal powder manufacturing replaces the classic blacksmithing techniques, reducing scrap waste in the meantime. The final metal products, however, retain that shiny allure of the archetypal metal pieces.

Metal powder

Basically, to make milk powder, you need to remove the water content from the liquid milk and turn it into powder. How to do it? After pasteurizing and homogenizing the milk, milk’s water content is removed through filtration, evaporation, and drying. You have then to cool and sieve it before filling the containers. Here's how you get milk powder.

Milk powder

Powder detergent is one of the most widespread washing solutions used in the laundry of fabrics. Since they contain no water, powder detergents are lighter than liquid detergent or pods, which results in cheaper transport and, thus, a more affordable choice for the end consumer. Although manufacturers can formulate their powder detergents differently, the detergent powder production process relies on a combination of builders, surfactants, and enzymes.

Powder detergent

It took the scientific community almost 70 years to agree on the name ‘protein’ and discard the popular alternative, proteid. But protein powder processing still needed another five decades to be commercialized in the 1950s. Once extraction and purification could be industrialized, protein powder soon became a basic staple supplement.

Protein powder

ilc-dover-bioprocessing-powder-handling-solutions-guide-pdf

ILC-Dover-bioprocessing-powder-handling-solutions-guide.pdf

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ILC-Dover-single-use-approaches-to-powder-transfer-white-paper.pdf

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Cross-contamination-in-drug-manufacturing.pdf

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

Reduced fill time due to the fully open top

Available volumes of up to 1000L reduce the number of bags required

Large diameter charge necks up to 200mm allow rapid emptying

Required cleaning is given by fold-over neck design which protects the stand during filling

Contained transfer systems are designed to safely transfer the product or waste items in or out of contained or sterile areas. Valves are used to regulate the flow in contained transfer systems. The choice of a suitable containment system depends on the form of source and target containers, the physical state of the product and the volume of the product to be transferred. These systems find applications in transferring pharmaceutical powders from drums to the process equipment, filling bulk chemicals in transportation bags or safely discharging them into mixing tanks.

Contained transfer systems

A flexible containment solution prevents product loss and ensures that personnel is not exposed to harmful substances by locking in the product as it is transferred from one container to another. The choice of a containment system depends on the physical state of the product, the type of container from which the product is being transferred, and the type of container to which it is being moved. Flexible containment solutions are widely used in the pharmaceutical, food, and chemical industries to comply with health and safety regulations.

Flexible containment solutions

A flexible intermediate bulk container is an industrial container designed for the transportation and storage of dry, flowable products in bulk packages. Selection of big bag filling equipment requires consideration of the type of particles to be packaged, type of bag to be used, filling weight/volume per bag, and production volume. Big bag filling equipment is used in the food industry for packaging seeds, spices, salt, and starch. In the pharmaceutical industry it is used for packaging of active ingredients; in the chemical industry for the filling of bulk chemicals, fertilizers, pigments, and plastic granules.

Flexible intermediate bulk containers

Single-use technologies are increasingly being used in the biotech industry due to lower costs, lower risk of cross-contamination, flexibility, and convenience. A single-use bioreactor uses disposable bags instead of a culture vessel to carry out the bioprocess. Using disposable bags, instead of reusable bioreactors, can help reduce the setup time and the time between production cycles. It also reduces sterilization demands for vessel reuse, leading to significant cost savings. In addition to single-use bags, single-use sensors are also employed for efficient and low-cost bioprocessing. Single-use applications are especially suitable for the production of biopharmaceutical products.

Single use systems

Pharmaceutical

Handling

Connect directly with world leading manufacturers of Handling equipment and find technology to build or improve your production line.

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Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Logistics

Packaging

Process

R&amp;D

Batch

Bagging is the process of packaging measured portions of a product into bags that protect it from spoilage, enable easy and safe transportation, and secure the product against tampering and pilferage. The choice of bagging equipment depends on the desired mass or volume per bag, the flow characteristics of the product, and bag construction and design. Bags vary in size from small sachets to bulk flexible containers. Bagging systems are often the last processing step that is generally integrated into a production line.

Bagging

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

solid

ILC Dover is an industry leader in contained material handling solutions for high tech manufacturers and end users including NASA.

Filling of transportation bags and discharging them into mix tanks or reactor vessels is often a source of contamination and there potential exposure of

Flexible contained handling of powder transfer bags &#8211; Making.com

We open production technology to everyone

Making.com

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Brochure_Ezi-Dock_Flexible-Charge-bags.pdf

Flat packing in bulk saves on transport and storage

Each charge bag is labelled with batch and bag number

Wide range of connecting clamps facilitates interfaces

High-density polyethylene blanking stoppers available

Product can be supplied gamma sterilised as needed

Containers for handling pharmaceutical and biopharmaceutical powders may be disposable, to avoid cross-contamination with other products. However, they

Single-use powder handling bag &#8211; Making.com

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Pre-packaged liners reduce operator error

Continuous liner design increases containment reducing risk of contamination and employee exposure

Interfaces directly with a wide array of existing process equipment

Can also be used with bag in / bag out processes with rigid isolators and flexible enclosures

<span style="font-weight: 400">At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with </span><span style="font-weight: 400">chemicals or hazardous substances since they can be potentially dangerous to human health. </span>

Packing

A disposable drum liner for continuous production of powders.

Powdered products are handled every day in the pharmaceutical and bioprocess industries and an efficient means of filling drums while maintaining

Flexible contained powder discharge into drums &#8211; Making.com

ilc-dover-doverpac-charging-brochure-pdf

ILC-Dover-Doverpac-charging-brochure.pdf

Capacities from 20 to 2000 L are available

Integrated sampling sleeves for quick material sampling without sacrificing containment

100% pressure testing and inspection of every system

Nanogram level containment performance achieved during testing of typical dry powder transfer operations

Manufactured from ILC developed rugged ArmorFlex film

A fast and clean powder transfer solution for maximum containment during both charging and offloading operations.

Flexible contained powder charging solution &#8211; Making.com

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Brochure_DEC_PTS

Around a third of your natural protein composition is collagen. But the human body still finds good use for more of it, whether to reinforce joints or aid digestion. Collagen powder processing breaks the chains of amino acids into smaller units, allowing them to be consumed at higher concentrations without changing your diet.

Collagen powder

The fishmeal powder market forecast shows that its global market value will reach USD 10.3 billion by 2025. Expanding since 2019, at an annual growth rate of 6.5%. Fishmeal powder production has strong business potential with the increase of applications in animal feed, pet food, and fortified foods.

Fishmeal powder

Cocoa minus its fats makes cocoa powder. Deriving this culinary element follows a careful process of roasting and winnowing cocoa beans before the nibs are ground, generating a liquor. The butter that results from melting fats is removed to leave the ingredient that defines recipes from brownies to a Frostbite cocktail.

Cocoa powder

Everything tastes like porridge, the saying goes. That may be an exaggeration, but in theory, reaction flavors could make everything taste the same. Thankfully, flavorists and chemists in the flavor industry are more inventive than that, and colorful process flavors treat our taste buds to a broad palette of sensations, flavors and aromas.

Reaction flavors

Safe transfer of different powders (sticky, fine, non-free-flowing, humid, etc.)

Hygienic PTS design allows full CIP/SIP operation

Safe transport of toxic products or explosive dust powder 

Handles powder effectively (no product retention, particle damage, segregation)

Easy to clean (No need for dismantling)

ATEX compliant

Industrial feeding systems allows you to control the flow of solid bulk materials throughout the manufacturing line. After loading your material onto the vibrating hopper, a screw at the base drives it out in uniform doses to the next stage of processing. New feeding technologies are designed to deal with challenges of powders clumping together in the hopper (bridging and ratholing) that interrupt the outflow. Common feeder systems include centrifugal feeders, vibratory feeders as well as elevator, linear and pneumatic feeders.

Feeding

A loading system feeds your continuous or batch processing machine with the specified material or item in line with the flow of production. Loaders transfer the articles from one stage of preparation to the next with uniformity and accuracy.

Loading

Loading powder from a container source to vessels, tanks, or mixers that are under pressure may be hazardous as it tends to explode due to electrostatic

Powder transfer system &#8211; Making.com

<h3>Crush primary materials to free valuable grains from impurities</h3>
The first step to pulverizing a solid is through a crusher. The raw material is downsized to flakes, chips, or granules by crushing technology. Some bulk types, such as plastics or resins, are broken down into filaments.

Crushing breaks the grains away from gangue materials, particularly in the case of ore. Undesired compounds such as common silicate and carbonates are removed using separation technology like magnetic separators for metals and froth flotation for hydrophobics.

One of the main attributes of powders is flowability. Dry materials with a similar particle structure flow more easily than powders of different shapes. However, size is also an important variable in industrial powder handling.

Flowability decreases with the particle size as powders display greater <a href="https://www.shear-test.com/doc/arching_and_ratholing_in_silos.php">cohesion and internal friction</a> the smaller they become. To prevent ratholes or bridging and facilitate flow, advanced manufacturing equipment applies anti-clogging systems. These powder processing systems and techniques are designed to move fine to ultra-fine bulk in specialized powder applications from <a href="https://making.com/products/pharmaceutical-powders">pharmaceuticals</a> to <a href="https://making.com/products/food">food</a> to <a href="https://making.com/face-powder">cosmetics</a>.

Use anti-clogging powder process equipment to ensure flowability

<h3>Avoid unwanted agglomeration by coating powders in anti-adherent components</h3>
Manufacturing technology often subjects powders to thermal stresses that could degrade their processability. High pressure friction and heat lead to surface diffusion, bonding particles together.

To prevent such undesired agglomeration, coat the powder particles in an anti-adherent substance like magnesium stearate. The water-insoluble compound is sprayed onto the material in a mixing drum to create a film around the particles.

Mineral and metal powders present unique challenges in terms of processing, particularly when they are comminuted to finer materials. Particles become harder as their surface area increases, making them more challenging to densify.

Ductile metals like aluminum and copper <a href="https://www.sciencedirect.com/book/9781856174220/handbook-of-non-ferrous-metal-powders" target="_blank" rel="noopener">retain plastic deformation properties</a> down to particle sizes of 50-100 nanometers. But beyond that, powders need to be subjected to high temperatures to be effectively compacted.

Heat mineral and metal fine powders to overcome resistance to compaction 

Particles of nanometric scale bond together to form nanopowders. As the ratio between surface area and volume increases, the characteristics of the atoms become more pronounced.

For instance, nanocrystalline materials such as titanium alloys nickel exhibit enhanced hardness and plasticity.  Advancements in powder processing technology allow engineering at the nanoparticle level, opening opportunities for new lightweight materials with solid structural stability.

Reduce powders to their nanostructures to maximize their properties

<h3>Develop nanopowders either by bonding particles or downsizing granules</h3>
There are two ways to approach the <a href="https://sustainable-nano.com/2014/06/10/two-ways-to-make-nanoparticles/" target="_blank" rel="noopener">production of nanopowders</a>: large-to-small or small-to-large. When working with large materials like metals or minerals, the powders are generated by attrition. The techniques here are primarily mechanical, using dry milling equipment like jet mills or roll mills.

If you work with molecules such as sodium, the process goes from small to large by bonding molecules together to form the particle. This involves electromagnetic techniques like electrospinning and electrodepositing.

Powder Manufacturing Equipment

Powder processing technology

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Incorporating solids into liquids is a critical process in producing paints, coatings, and battery components. But this step raises serious emissions concerns. Pumping the materials from one mixing vessel to the next promotes the release of dust particles and solvents into the air.


<h2>Fully enclosed batch mixing system for paints and coatings</h2>
The CMX 2000 inline mixer from IKA incorporates powders into liquids in an enclosed and complete system. Featuring a dosing feeder for solids and recirculation technology, the solution limits the mixing process to one machine and reduces the potential for emissions.

The multi-level pump is designed to keep high-viscosity materials flowing without leaving deposits in the mixing container. The chemicals are recirculated to ensure consistent blending and prevent the formation of agglomerates in the final mix.

Solid may be fed with a bulk bag unloader, a hopper, sack-emptying boxes, or directly from the bag with a suction lance. The CMX 2000 is available for batch sizes between 2 and 5.000 liters.

Inline solid-liquid mixer for chemicals and paints

Painting as an integral aspect of the human tradition dates to thousand years ago. Of the many properties of the product, the drying time is important to consumers. The thickness of the paint and environmental factors like humidity affect this parameter. Paint manufacturing equipment must include a humidity test chamber to assess the behavior of paint under different weather conditions.

Paint

Chemical

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

Pigments are colorants that are not soluble in the host material and scatter light and are therefore opaque. Pigments can be organic or man-made and derive from animals, plants, rocks or minerals and metal oxides, like for example titanium oxide.

Pigment

Red, yellow, green, purple, blue… Paints and lacquers, a mix of pigments and possibilities, can bring colors to life and turn plain walls and surfaces

Powder and liquid, a delicate equilibrium in paint production &#8211; Making.com

Powder and liquid, a delicate equilibrium in paint production

Deborah

Organic volatile compounds from fruits, vegetables and herbs are essential to manufacturing flavors, extracts, and pure powders. But elevating temperatures during the evaporation process risks altering their chemical structure and lowering the quality of the final product.


<h2>Gentle freeze-drying for fruit powders, herbal extracts, and flavors</h2>
The DryBand system by Bucher Merk is a dynamic belt dryer designed to dry delicate food ingredients. The material moves through an intermediate vacuum chamber between the top and bottom belt section. The drying unit has a vacuum range of 0.5 to 50 mbar and a feeding rate of up to 4,000 kg/h.

The continuous system can be configured for variable or constant drying with heating plates underneath the belt. A crushing device at the discharge end breaks the dried products into powders after drying. Meanwhile, the vapors are collected in an integrated condenser.

Vacuum belt dryer for fruit, vegetable and herbal extracts

Food

Our food chain starts in the soil, growing crops and livestock. But between the fields and the stores, there is a line of industrial food processing equipment. Processes may be as minimalistic as cleaning fruit and as complex as homogenizing milk alternatives made from pressed legumes. In each case, processing technology is an important link in the food production chain.

Herbs have always been shrouded in mystery. The delicate plans produce overpowering bouquets and potent remedies. Herbal extraction technology gets to the core of this mystery and makes bioactive compounds available for a range of applications. Rich in antioxidants, anti-inflammatories, and aromas, herbal extracts are vital ingredients for medicines, foods, cosmetics, and wellness products.

Powder Handling Equipment

Which powder handling equipment equipment do you need?

Flexible contained handling of powder transfer bags

Single-use powder handling bag

Flexible contained powder discharge into drums

Flexible contained powder charging solution

Powder transfer system

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