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Cannabinoids are natural compounds obtained from the Cannabis sativa plant. The most utilized among these compounds are delta-9-tetrahydrocannabinol (THC, a psychotropic substance) and Cannabidiol (CBD, a non-psychotropic substance, mainly deployed for nutraceutical purposes) which can be obtained directly from the plant or by extraction. These components can be used both for medical and non-medical uses.

What cannabinoids equipment do you need?

Automatic centrifuge for cannabis

Centrifugation is the most effective step and efficient way of producing cannabis extract...

Fully certified CBD crude oil extraction machine

Traditional extraction processes involving hot solvent (ethanol) or Co2 m...

Conditioned seed drying machine

It’s essential to dry moist seeds before you process and store them. Seeds with too high or ...

Seed disinfection machine

It’s essential to disinfect seeds to eliminate bacterial infections and to protect them from these...

Seed extraction machine

The supply of high quality seeds is essential as it significantly contributes to the success of every...

Seed threshing machine

After threshing seeds from plant material, various cleaning steps still have to be done to ultimately ...

Magnetic seed separator

It is challenging to separate seeds with cracks or holes from undamaged seeds. The way to do that is ...

Air screen seed cleaning machine

The quality of seeds and grains starts to deteriorate once they have been harvested. Thus, ...

Seed storage cabinet

The proper storage of seeds is essential in conserving their vitality, and to maintain germination power...

Seed priming equipment

Seed priming is a controlled hydration technique in which seeds are soaked in water or low osmotic pot...

Seed coating machine with integrated dryer

Seed coating refers to the covering of seeds with external fluids, biologicals,...

Benchtop cannabis filter press

Therapeutic uses for cannabis oil are becoming more widely available. For pharmaceutical uses...

GMP washer

In order to guarantee zero cross-contamination between production batches, the proper cleaning of all product-conta...

GMP chamber washer

The thorough cleaning of small product contact parts has always been challenging, and traditional manual c...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a wa...

Portable IBC washer

The thorough cleaning of bulk containers and other storage and processing equipment is a vital step in th...

IBC bin washer and dryer

Many pharmaceutical processes use IBCs of multiple sizes throughout production. Careful washing and ...

CIP system for bulk tanks

Clean in Place (CIP) technology offers many advantages, but traditional systems are often inflexib...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning an...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing components used in the productio...

High capacity horizontal cartoner for pharmaceutical and cosmetic appliances

Cartoners take carton blanks which are fo...

Automatic cartoner for applications in pharmaceutical and cosmetics industry

For high capacity production of cosmetics...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pharmaceutical products are packed ...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are packed in protective and decorati...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic products are sold in protective and de...

Transfer system for high-containment environments

A high-performance transfer port system that combines ultimate safety, ...

Purified water systems

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need...

Half-suit tester

Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...

Glove tester

Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...

Cabinet dryer for cannabis

If you need careful drying for products like pharmaceutical-grade cannabis buds then traditional ...

Negative pressure isolator

Used for products biologically hazardous, that also require minimized cross contamination.

Downflow booth

Provides the highest levels of operator protection from potentially harmful airborne contaminants generated dur...

Vertical laminar flow cabinet

HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area ...

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work a...

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space...

Microbiological safety cabinet class II

This handy device offers the most advanced features in product-operator protection ...

Biosafety cabinet class II for cytotoxic medicines

For the manipulation of hazardous substances utilized during the prepa...

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Biological safety cabinet class III

Specially designed for the handling of microbiological agents, when working with indige...

Wiped film evaporator

With wiped film distillation, a substantial decrease of boiling temperature is obtained by reducing the...

Pilot multi-stage distiller

If generating an scalable data and bring in results with small sample quantities of high-boiling...

Pilot wiped film distiller

Generate scalable data and results during the pilot tests with wiped film distillation,  distill ...

Pilot short path distiller

Generate scalable data and results during the pilot tests with short path distillation, distill o...

Laboratory multi-stage distiller

A laboratory multi-stage distillers that combines the wiped film and short path distillatio...

Laboratory wiped film distiller

Reach reliable conclusions testing the distillation of high-boiling or highly viscous materi...

Laboratory short path distiller

Get to reliable conclusions for the separation of high-boiling and heat-sensitive products u...

Horizontal thin film evaporators

Horizontal thin film evaporators can increase the residence time of the product and achieve...

Thin film dryers

Dry dissolved or slurried crystallizing or amorphous products to a pourable powder.

Short path evaporators

With short path distillation, a substantial decrease of boiling temperature is obtained by reducing th...

Aseptic barrier systems

Designed for sterile product and Potent API’s either with low or high OEL requirements.

Restricted-access barrier systems

Create a physical barrier between the operator and the product. More flexible than an iso...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Both THC and CBD help with medical conditions such as pain, nausea anxiety, inflammations, and many more. When it comes to cannabinoid products, the pharmaceutical industry can focus on different market segments such as prescription, consumer health, nutraceutical, and so on. Applications are to be found in the form of, but not limited to, creams, tablets, capsules, and powder.

Production processes for making cannabis and cannabinoids

After growing, harvesting, cutting, and drying of the raw material is the first step in order to get a good quality cannabis biomass after which the extraction process starts. There are several extraction methods, three of them being light hydrocarbon extraction, ethanol extraction, and CO2 extraction. This will deliver crude cannabis oil. The next step is distillation, which separates THC from terpenes, lipids, impurities, and solvents. Then. the cannabinoid isolate is mixed to break apart the chemical bonds of the cannabinoids and reduce the size of their particles. A good method for this is homogenization, where all particles undergo the same mixing forces, this leads to less variation in the end results. This step will produce a quality distillate that will meet pharmaceutical-grade standards and that can be used in a wide variety of products.

Depending on the desired end product, the post-processing is started to – for example – reduce the THC level or start a process in which the extracted and distilled oil can then be made into creams, pills, or edibles. Finally, (sterile) filling, capping and labeling are the last steps of the production process and need to be in line with pharmaceutical regulation to ensure quality.

The production, distribution, and consumption of cannabinoids are regulated individually in each country and international laws and regulations vary greatly. This makes for a fragmented legal landscape when it comes to cannabis-derived pharmaceutical products. In the majority of the EU, there is a THC limit in CBD products of around 0.2 percent.

Faster CBD distillation

Cold ethanol (-40 C) can be used as a solvent to extract cannabidiol. For this method, ethanol is fed into an extractor, together with the cannabis biomass and extraction takes place for a few hours, after which the mass is recirculated to reach a high extraction level. In contrast to other methods of extraction like CO2 extraction, a pressurized system is not needed for cold ethanol extraction.

With cold ethanol extraction technology, all lipids are left behind during the extraction process, which allows cannabinoid processing facilities to reduce the extraction process down from several days to just a few hours.

Several steps of the production process with more traditional ways of extraction, like winterization, solvent recovery, and decarbing, usually take up to 3 to 5 days. Cold ethanol extraction skips these steps and takes less than a day to go from extraction to distillation. Check out the below video on Devex CBD extraction technology for more information.

CBD supplements in gummies

Gummies are a good alternative for taking CBD. A current trend to reduce the production time in making gummies is starchless depositing. With this,  the long drying period that is common with starch depositing, where filled trays need to rest for well over 24 hours in a drying room while the starch removes the water from the product, are a thing of the past.

Starchless depositing has been a standard procedure for hard candy for many years and with the help of silicon molds, gelatine gummies can be deposited without starch as well. The silicone molds are moistened using a release agent and jelly is deposited into the molds. Demolding can start after a mere 20 minutes as the jelly has a dry matter content from the beginning.

This leads to a limited risk of cross-contamination. In order to better respond to GMP standards, starch-free depositing for gummies is gaining more and more traction in the pharmaceutical cannabis market.

Formulation and filling of cannabis oil

To get to the end-product be it capsules, extract syringes, vape cartridges or any other form, the cannabis extract (oil, distillate or isolate) is mixed in the formulation process step with for example olive oil or terpenes. Here, calculations are done to determine how much extract is needed to reach the target medicinal potency of cannabinoids per dose.

The subsequent packaging and labeling production steps include bottling, filling, capping. Labelling and cartoning. When it comes to medicinal (or recreational) products that will be ingested, an (aseptic) filling machine that meets industry hygiene requirements is crucial. Pharmaceutical standards call for 316L grade stainless steel, PTFE and Viton. The machine needs to meet GMP requirements for sterile manufacturing in the pharma industry and be able to pre-sterilize vials, syringes, or ampoules, ensure safe sealing. Ultrasonic technology for one can help get rid of all kinds of microbe, E.coli, or other bacteria on a vial ampoule or oral liquid bottle in the process.

Cannabis Making Equipment in Action

High pressure homogenizer

Distillation equipment

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