Let's make eye drops
Find innovative production technology for making eyedrops and connect directly with world-leading specialists.
Eyedrops processing is quite literally a sight for sore eyes. There is no shortage of eye care products, from eyewashes to anesthetics to antibiotics. But formulating eyedrops is a complex affair with multiple safety checkpoints. Technological advances bring a pair of fresh eyes to manufacturing, ensuring higher-quality products for specialized applications.
Which eyedrops technology do you need?
Hygienic Cartoning Machine For Pharma and Health Products
When packing single or multiple vials, ampoules or devices into…
Agitator bead mill for API
To achieve precisely defined API properties and safe and reproducible production, rigorous impleme…
Laboratory liquid viewer for transparent glass bottles
Impurities like hair, fibers, or glass, sourced from the environmen…
Laboratory liquid viewer for varying light conditions
In the pharmaceutical industry, you must inspect liquids in vials or…
Laboratory liquid viewer for colored glass bottles
In the pharmaceutical industry, an inspection to detect any particulate…
High speed bottle filler with inspection
Medicines in tablet, capsule, or soft gel forms undergo various processes before re…
Low speed Filler for large-volume parenterals
Large-volume parenteral bottles are usually manufactured with a resin that ca…
Pharmaceutical bottle filling machine
Filling machines for pharmaceutical bottles must achieve high production speeds while …
Pharmaceutical formulation and mixing tanks
Preparation lines for formulating pharmaceuticals include fixed and mobile tank…
Sampling probe for bioreactor samples
In biopharmaceutical and chemical industries, sampling is vital to develop, maintain, …
Start-up sterile filling line for ophthalmics
Commencing ophthalmic production requires sterile conditions and accurate met…
Sterile filling line for ophthalmics
Demanding very high standards, the ophthalmic market requires quality solutions for fil…
Ampoule filling machine
Filling ampoules or vials with parenteral fluids are an essential matter for which you need to conside…
Small bottle checkweigher
Any small-diameter bottle, containing prescription medication or cosmetic applications, can be prop…
Versatile checkweigher
This Versatile checkweigher is equipped with a highly versatile strain gauge load cell. It is also suit…
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Contact usFormulate eyedrops with a thickening agent to increase contact time
Vehicles for eyedrops are prepared from aqueous media, making them thin solutions. A runny product is less effective because it reduces contact time with the cornea. Formulate the solution with a viscolizer such as hyaluronic acid or polyvinyl alcohol to address this challenge.
These adjuvants increase the product’s viscosity so that it has a longer period in the eye and produces higher bioavailability.
Incubate the eyedrops solution in a microbial medium to test its sterility
Eyedrop solutions must pass the sterility test before they can be deposited into containers for shipping. The procedure involves inoculating the sample with a microbiological environment like a soy-bean casein digest medium.
The samples are deemed sterile if no growth is observed after 5 days of direct incubation. In the case of indirect incubation using a membrane filtration method, the testing period must run for 14 days.
Eyedrops processing using alternative preservatives
Multi-use eye drop products contain preservatives to prevent microbial growth. The most common agent used in manufacturing is benzalkonium chloride (BAK). But this substance raises health issues, especially in cases of dry eye disease.
A special polymer named PQ-1 (Polyquaternium-1) is used as an alternative preservative for both dry eye preparations and glaucoma medications. An anti-bacterial, PQ-1 keeps the product free from pathogens. But because of its larger molecular size, it does not penetrate human cells and drastically lowers the toxic risks compared to BAK.
Print the vital information directly on the packaging
The eyes are delicate organs, and packaging for ophthalmic drugs must adhere to stricter safety parameters than other dosage forms.
Bottle openings have to be sealed to protect the solution and ensure the validity of the use-by date. Besides the expiry information, the packaging must include the date of manufacture and storage recommendations.
