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Hyaluronic acid making equipment

Hyaluronic acid is a natural lubricant found in all mammals. An effective humectant, its molecules can hold a thousand times their weight in water. However, hyaluronic acid extraction is a complex biotechnological process that requires a specialized manufacturing technique.

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Defat rooster combs at low temperatures before hyaluronic acid extraction


The rooster comb contains an appreciable amount of hyaluronic acid (HA), making it a primary source for production. Isolated and cleansed, the combs are reduced in size using a grinder before extraction.


The material is suspended in acetone at about 8°C for several hours to break down unwanted chemicals. The procedure is repeated until the combs are dried, resulting in a white, fibrous substance. This is then purified with saline citrate and centrifuged at a high rpm to separate the sediment from the gel-like extract.


Vacuum-dry processed HA to retrieve sodium hyaluronate

The hyaluronic acid extraction process can be refined to produce a highly-concentrated sodium hyaluronate. The derivative is the salts of HA and is used primarily in medical formulations and cosmetic creams.

Manufacturers treat extracted hyaluronic acid with a water-based solvent and pass the substance through a vacuum dryer. The process obtains sodium hyaluronate in the form of a powder that can be then mixed with other materials and chemicals.

Manufacture vegan hyaluronic acid in batch to address stability concerns

Non-animal hyaluronic acid is produced by fermenting a safe strain of bacteria from plants like wheat. Although continuous production prolongs the lifetime of bacterial cultures, the high dilution rate in a chemostat presents a challenge to molecular stability. For this reason, manufacturers typically rely on batch processes.

Plant-based oral dosage types such as HPMC mean that HA supplements can be completely vegan. However, non-animal products are more frequently designed for skincare products.

Target osteoarthritis and other issues with hyaluronic acid supplements


The human body generates hyaluronic acid, but the levels decrease with age. In fact, HA products are primarily designed to treat problems related to osteoarthritis.


However, hyaluronic acid supplements are also thought to prevent various issues, from chronic fatigue syndrome to fibromyalgia. HA is a versatile material distributed in solid, liquid, or semi-solid formats. But nutraceutical preparations are often found as capsules, tablets, or softgels.


Processing steps involved in hyaluronic-acid making

Which hyaluronic acid technology do you need?

GMP homogenizing system

GMP homogenizing system

Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accura…

Cost-effective homogenizing and emulsifying system

Cost-effective homogenizing and emulsifying system

Manufacturers of cosmetic products need mixing equipment that is capabl…

Inline batch mixer for solids and liquids

Inline batch mixer for solids and liquids

Several issues often arise when your process requires batch-wise mixing of powder…

Semi-automatic vial crimper

Semi-automatic vial crimper

In a small production line, crimping vials manually can cause fatigue to your operator due to mul…

Benchtop piston filling equipment for vials in trays

Benchtop piston filling equipment for vials in trays

Vials are difficult to fill individually through manual methods due t…

Cosmetic cream filler

Cosmetic cream filler

From thin liquid baby oils and perfumes to thicker lotions and creams for hair and skincare, cosmetic pr…

Filling machine for creams

Filling machine for creams

Liquid cosmetics have particular requirements when it comes to filling and capping containers. Mor…

In-line monoblock linear filler & capper

In-line monoblock linear filler & capper

In many food, chemicals and cosmetic industry processes it is vital to have a …

Flowmeter filler

Flowmeter filler

For larger production runs of food, non-food and cosmetics industries, where accuracy and volume of filling is…

Microencapsulation system for your drug delivery system

Microencapsulation system for your drug delivery system

Whether you want to improve the stability of nutrients, protect an…

Agitator for low viscosity media

Agitator for low viscosity media

Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale pr…

Agitator for medium viscosity media

Agitator for medium viscosity media

Mixing fluids of medium viscosity for many production processes requires an agitator wit…

Jet flow agitator for high-viscosity media

Jet flow agitator for high-viscosity media

Processes including homogenization, dispersing, suspension, emulsification and d…

Laboratory dispersing machine for low-viscous masses

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting al…

In-line laboratory dispersing machine

In-line laboratory dispersing machine

Innovators in a wide variety of industries need laboratory equipment on which processe…

Pilot dispersing machine for testing and scale-up

Pilot dispersing machine for testing and scale-up

Innovators in process development need laboratory equipment that helps t…

Dilution system for two or more liquids in one pass

Dilution system for two or more liquids in one pass

Onsite dilution of liquid process ingredients has historically been as…

Dust-free continuous homogenizing system

Dust-free continuous homogenizing system

Producers in a wide variety of industries benefit from equipment that can continuou…

Batch dispersing machine for bottom entry into vessels

Batch dispersing machine for bottom entry into vessels

When your process requires high performance mixing or dispersion bu…

Batch dispersing machine for abrasive products

Batch dispersing machine for abrasive products

For mixing and dispersing tasks that cannot be completed by conventional sti…

Batch dispersing machine

Batch dispersing machine

Equipment operating under the rotor/stator principal is often employed when more traditional methods …

Continuous kneader

Continuous kneader

Effective mixing of highly viscous products with extremely high solids content can be difficult and the res…

Vertical kneader

Vertical kneader

Production of highly viscous products with high solid content often benefits from kneading processes rather th…

Horizontal kneader

Horizontal kneader

For high viscosity products, better results and reduced process times can be achieved with kneading type ra…

High accuracy homogenizing system

High accuracy homogenizing system

When extremely high accuracy is required in your recipe or formulation traditional mixing …

Continuous homogenizing system

Continuous homogenizing system

Certain mixing tasks present unique challenges and manufacturers need equipment that is specif…

Checkweigher for stand-up pouches

Checkweigher for stand-up pouches

When working with several lines of stand-up pouches, you can benefit from controlling the …

Checkweigher for sachets and sticks

Checkweigher for sachets and sticks

The checkweighers for multiple lanes have a 1.5 times faster response speed and 2 times …

Laboratory scale active freeze dryer

Laboratory scale active freeze dryer

The laboratory-scale active freeze-drying is used for dehydrating high-value products t…

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