Let's make hyaluronic acid
Hyaluronic acid is a natural lubricant found in all mammals. An effective humectant, its molecules can hold a thousand times their weight in water. However, hyaluronic acid extraction is a complex biotechnological process that requires a specialized manufacturing technique.
Which hyaluronic acid equipment do you need?
Cost-effective homogenizing and emulsifying system
Inline batch mixer for solids and liquids
In-line continuous blender
Conical screw mixer
Conical screw vacuum dryer
High-shear impact mixer
Laboratory scale active freeze dryer
Laboratory conical screw vacuum dryer
Laboratory high shear impact mixer
Miniature scale high-shear mixer
Vertical paddle dryer
Checkweigher for sachets and sticks
Checkweigher for stand-up pouches
Continuous homogenizing system
High accuracy homogenizing system
Horizontal kneader
Vertical kneader
Continuous kneader
Batch dispersing machine
Batch dispersing machine for abrasive products
Batch dispersing machine for bottom entry into vessels
GMP homogenizing system
Dust-free continuous homogenizing system
Dilution system for two or more liquids in one pass
Pilot dispersing machine for testing and scale-up
In-line laboratory dispersing machine
Laboratory dispersing machine for low-viscous masses
Jet flow agitator for high-viscosity media
Agitator for medium viscosity media
Agitator for low viscosity media
Microencapsulation system for your drug delivery system
Flowmeter filler
In-line monoblock linear filler & capper
Filling machine for creams
Cosmetic cream filler
Self-cleaning candle filtration system
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Select your hyaluronic acid process
Tell us about your production challenge
Defat rooster combs at low temperatures before hyaluronic acid extraction
The rooster comb contains an appreciable amount of hyaluronic acid (HA), making it a primary source for production. Isolated and cleansed, the combs are reduced in size using a grinder before extraction.
The material is suspended in acetone at about 8°C for several hours to break down unwanted chemicals. The procedure is repeated until the combs are dried, resulting in a white, fibrous substance. This is then purified with saline citrate and centrifuged at a high rpm to separate the sediment from the gel-like extract.
Vacuum-dry processed HA to retrieve sodium hyaluronate
The hyaluronic acid extraction process can be refined to produce a highly-concentrated sodium hyaluronate. The derivative is the salts of HA and is used primarily in medical formulations and cosmetic creams.
Manufacturers treat extracted hyaluronic acid with a water-based solvent and pass the substance through a vacuum dryer. The process obtains sodium hyaluronate in the form of a powder that can be then mixed with other materials and chemicals.
Manufacture vegan hyaluronic acid in batch to address stability concerns
Non-animal hyaluronic acid is produced by fermenting a safe strain of bacteria from plants like wheat. Although continuous production prolongs the lifetime of bacterial cultures, the high dilution rate in a chemostat presents a challenge to molecular stability. For this reason, manufacturers typically rely on batch processes.
Plant-based oral dosage types such as HPMC mean that HA supplements can be completely vegan. However, non-animal products are more frequently designed for skincare products.
Target osteoarthritis and other issues with hyaluronic acid supplements
The human body generates hyaluronic acid, but the levels decrease with age. In fact, HA products are primarily designed to treat problems related to osteoarthritis.
However, hyaluronic acid supplements are also thought to prevent various issues, from chronic fatigue syndrome to fibromyalgia. HA is a versatile material distributed in solid, liquid, or semi-solid formats. But nutraceutical preparations are often found as capsules, tablets, or softgels.