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Hyaluronic acid is a natural lubricant found in all mammals. An effective humectant, its molecules can hold a thousand times their weight in water. However, hyaluronic acid extraction is a complex biotechnological process that requires a specialized manufacturing technique.

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Defat rooster combs at low temperatures before hyaluronic acid extraction

The rooster comb contains an appreciable amount of hyaluronic acid (HA), making it a primary source for production. Isolated and cleansed, the combs are reduced in size using a grinder before extraction.

The material is suspended in acetone at about 8°C for several hours to break down unwanted chemicals. The procedure is repeated until the combs are dried, resulting in a white, fibrous substance. This is then purified with saline citrate and centrifuged at a high rpm to separate the sediment from the gel-like extract.

Vacuum-dry processed HA to retrieve sodium hyaluronate

The hyaluronic acid extraction process can be refined to produce a highly-concentrated sodium hyaluronate. The derivative is the salts of HA and is used primarily in medical formulations and cosmetic creams.

Manufacturers treat extracted hyaluronic acid with a water-based solvent and pass the substance through a vacuum dryer. The process obtains sodium hyaluronate in the form of a powder that can be then mixed with other materials and chemicals.

Manufacture vegan hyaluronic acid in batch to address stability concerns

Non-animal hyaluronic acid is produced by fermenting a safe strain of bacteria from plants like wheat. Although continuous production prolongs the lifetime of bacterial cultures, the high dilution rate in a chemostat presents a challenge to molecular stability. For this reason, manufacturers typically rely on batch processes.

Plant-based oral dosage types such as HPMC mean that HA supplements can be completely vegan. However, non-animal products are more frequently designed for skincare products.

Target osteoarthritis and other issues with hyaluronic acid supplements

The human body generates hyaluronic acid, but the levels decrease with age. In fact, HA products are primarily designed to treat problems related to osteoarthritis.

However, hyaluronic acid supplements are also thought to prevent various issues, from chronic fatigue syndrome to fibromyalgia. HA is a versatile material distributed in solid, liquid, or semi-solid formats. But nutraceutical preparations are often found as capsules, tablets, or softgels.

Processing steps involved in hyaluronic-acid making

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