Let's make dry powder inhalers
The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.
Which dry inhaler powder equipment do you need?
Modular assembly line for healthcare products
Bellows for pharmaceutical powders
High containment segment ball valve
High containment sampler
Removable GMP compliant connections for tubing
Premium vacuum conveyor
In-line continuous blender
Conical screw vacuum dryer
High-shear impact mixer
Laboratory high shear impact mixer
Miniature scale high-shear mixer
Restricted-access barrier systems
Transfer system for high-containment environments
Glove tester
Half-suit tester
Vertical laminar flow cabinet
Biological safety cabinet class III
Negative pressure isolator
Dosing machine for nonfree-flowing powders
Metal detection system for aluminum packages
Checkweigher for sachets and sticks
Checkweigher for stand-up pouches
Flexible contained handling of powder transfer bags
Flexible contained powder charging solution
Flexible contained charging for split butterfly valves
Crimping system
Flexible enclosures
Flexible contained drum transfer system
Flexible contained powder discharge into FIBC’s
Flexible contained powder discharge into drums
Filter dryer
Spherical dryer
Centrifugal disc filter
Magnetic agitator
Small feeder with flexible wall hopper
Horizontal vacuum dryer with eccentric agitator
Rotary vacuum dryer
Vacuum tray dryer with clean-in-place system
Horizontal paddle vacuum dryer
Laboratory-scale vacuum tray drying oven
Fluid bed dryer and mixer for lab scale
Fluid bed dryer for lab scale
Fluid bed dryer for production scale
Portable IBC washer
IBC bin washer and dryer
CIP system for bulk tanks
GMP washer
Vacuum sack lifter
Pharmaceutical container lifter
Bin blender
Mobile drum lifter
Container lifter
Powder transfer vessel
GMP Jib crane
R&D V-type powder blender
Single-use powder handling bag
Metal detector for pharmaceutical powders
API powders storage bottle
Single-use containment valve
High containment closing system
Gravimetric powder microdosing 0.400 - 2 g
Gravimetric powder microdosing 2 - 100 g
Fast gravimetric powder microdosing 50 - 200 g
Hygienic mobile scale
Hygienic floor scale with lifting device
Hygienic floor scale
High containment big bag discharge docking system
Accurate multiple dosing system for powders
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Select your dry inhaler powder process
Tell us about your production challenge
Mill inhaler powder materials to achieve good particle size distribution
The recommended particle diameters for optimal aerosols preparation range from 1 to 5 µm. Smaller particles clump together while larger diameters lose their cohesive properties.
Reduce the diameters of coarse particles before mixing the ingredients for dry inhaler powder formulation. Jet milling applies high-impact forces combined with compressed gas to produce micro sizes.
Engineered blends improve the processing of dry inhaler powder formulations
Add carrier particles to the API mix to improve the processing properties of bulk powders. However, the particles of drugs and carriers must be chemically compatible. Their reciprocal adhesive forces need to be powerful enough to hold the mixture together during filling and storage. At the same time, they need to be quickly detachable during aerosol administration.
Coarse lactose monohydrate improves powder flowability during manufacturing and provides good carrier-particle separation. Lactose blends are formulated with drug contents of 5% (w/w) or less.
HPMC capsules are more stable for mono-dose inhaler systems
Mono-dose inhalers deliver a single serving of powder formulation by loading a capsule into the device before each use. Depending on the system, the capsule is activated by sheer force opening, needle-piercing, or cutting the capsule. But moisture content is a critical consideration for each technique.
Very dry conditions apply pressure on traditional gelatin-based capsules, causing them to crack before use. Hypromellose capsules (HPMC), on the other hand, is less hygroscopic and behaves well in both wet and arid environments.