Let's make dry powder inhalers
Find innovative production technology for making dry inhaler powder and connect directly with world-leading specialists.
The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.
Which dry inhaler powder equipment do you need?
Modular assembly line for healthcare products
Assembly setups need to be constantly rethought and reconfigured to adapt qui…
Bellows for pharmaceutical powders
Thermal and mechanical changes can lead to stresses in industrial piping systems. These s…
High containment segment ball valve
Valves fitted in blenders and dryers can have dead spaces that prevent complete processi…
High containment sampler
Drawing a sample for evaluation from a running process is not a simple task, especially when dealing …
Removable GMP compliant connections for tubing
Tubing frameworks can have rough welding joints, corners and sharp angles th…
Premium vacuum conveyor
When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g.…
In-line continuous blender
When you consider shifting pharmaceutical mixing processes from batch to continuous, accurate in-l…
Conical screw vacuum dryer
The conical screw vacuum dryer is particularly suitable for the final drying of powders, granules,…
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Select your dry-inhaler-powder process
Tell us about your production challenge
Mill inhaler powder materials to achieve good particle size distribution
The recommended particle diameters for optimal aerosols preparation range from 1 to 5 µm. Smaller particles clump together while larger diameters lose their cohesive properties.
Reduce the diameters of coarse particles before mixing the ingredients for dry inhaler powder formulation. Jet milling applies high-impact forces combined with compressed gas to produce micro sizes.
Engineered blends improve the processing of dry inhaler powder formulations
Add carrier particles to the API mix to improve the processing properties of bulk powders. However, the particles of drugs and carriers must be chemically compatible. Their reciprocal adhesive forces need to be powerful enough to hold the mixture together during filling and storage. At the same time, they need to be quickly detachable during aerosol administration.
Coarse lactose monohydrate improves powder flowability during manufacturing and provides good carrier-particle separation. Lactose blends are formulated with drug contents of 5% (w/w) or less.
HPMC capsules are more stable for mono-dose inhaler systems
Mono-dose inhalers deliver a single serving of powder formulation by loading a capsule into the device before each use. Depending on the system, the capsule is activated by sheer force opening, needle-piercing, or cutting the capsule. But moisture content is a critical consideration for each technique.
Very dry conditions apply pressure on traditional gelatin-based capsules, causing them to crack before use. Hypromellose capsules (HPMC), on the other hand, is less hygroscopic and behaves well in both wet and arid environments.
