Let's make dry powder inhalers
The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.
Which dry inhaler powder equipment do you need?
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Modular assembly line for healthcare products
Assembly setups need to be constantly rethought and reconfigured to adapt qu...
Bellows for pharmaceutical powders
Thermal and mechanical changes can lead to stresses in industrial piping systems. These ...
High containment segment ball valve
Valves fitted in blenders and dryers can have dead spaces that prevent complete process...
High containment sampler
Drawing a sample for evaluation from a running process is not a simple task, especially when dealing...
Removable GMP compliant connections for tubing
Tubing frameworks can have rough welding joints, corners and sharp angles t...
Premium vacuum conveyor
When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g...
In-line continuous blender
When you consider shifting pharmaceutical mixing processes from batch to continuous, accurate in-...
Conical screw vacuum dryer
The conical screw vacuum dryer is particularly suitable for the final drying of powders, granules...
High-shear impact mixer
When you need to mix cohesive powders with liquids or melt binders and require a homogenous end-produ...
Laboratory high shear impact mixer
A Laboratory high shear impact mixer can be used to simulate different processes; from s...
Miniature scale high-shear mixer
When you have a very limited amount of powder available, you can still test your processes ...
Restricted-access barrier systems
Create a physical barrier between the operator and the product. More flexible than an iso...
Transfer system for high-containment environments
A high-performance transfer port system that combines ultimate safety, ...
Glove tester
Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...
Half-suit tester
Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...
Vertical laminar flow cabinet
HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area ...
Biological safety cabinet class III
Specially designed for the handling of microbiological agents, when working with indige...
Negative pressure isolator
Used for products biologically hazardous, that also require minimized cross contamination.
Dosing machine for nonfree-flowing powders
Fill poorly flowing powders, dry syrups and similar substances into various gla...
Metal detection system for aluminum packages
The magneto reflection system is ideal for detection of metals in aluminium f...
Checkweigher for sachets and sticks
The checkweighers for multiple lanes have a 1.5 times faster response speed and 2 times...
Checkweigher for stand-up pouches
When working with several lines of stand-up pouches, you can benefit from controlling the...
Flexible contained handling of powder transfer bags
Filling of transportation bags and discharging them into mix tanks or...
Flexible contained powder charging solution
Filling of transportation bags and discharging them into mix tanks or reactor ...
Flexible contained charging for split butterfly valves
Poly bottles with split butterfly valves are often used to transfe...
Crimping system
Flexible disposable containment systems in the form of specially designed plastic bags are an excellent choice...
Flexible enclosures
Maintaining the purity of products as well as avoiding worker exposure to potentially harmful substances ...
Flexible contained drum transfer system
Transferring powders from drums to process equipment such as reactors or mills can ...
Flexible contained powder discharge into FIBC’s
Flexible intermediate bulk containers known as FIBC’s are commonly used ...
Flexible contained powder discharge into drums
Powdered products are handled every day in the pharmaceutical and bioproces...
Filter dryer
The pharmaceutical and bioprocess industries need filtration processes of particularly high quality to ensure the...
Spherical dryer
Drying vessels that are simple, reliable, and easy to maintain increases product quality and process efficienc...
Centrifugal disc filter
The pharmaceutical and bioprocess industries need filtration processes of particularly high quality t...
Magnetic agitator
Reliable mixing and agitation are essential to any quality production process that involves a fluid. This n...
Small feeder with flexible wall hopper
In many laboratory applications and production processes, smaller quantities of powd...
Horizontal vacuum dryer with eccentric agitator
Conventional dryers are inefficient and can lead to significant mechanical...
Rotary vacuum dryer
Powdered products tend to agglomerate during vacuum drying. This adds an additional step to the productio...
Vacuum tray dryer with clean-in-place system
Cabinet tray dryers can be difficult to clean, making their use difficult for...
Horizontal paddle vacuum dryer
Agitated vacuum dryers can be difficult to clean which makes them unsuitable for multi-produc...
Laboratory-scale vacuum tray drying oven
Vacuum drying is used to remove moisture from sensitive materials. Drying small ba...
Fluid bed dryer and mixer for lab scale
Designed for pharmaceutical R&D, a lab-scale fl...
Fluid bed dryer for lab scale
Fluidised bed drying (FBD) is a common process in the pharmace...
Fluid bed dryer for production scale
Fluidized bed drying (FBD) is a common process in the ...
Portable IBC washer
The thorough cleaning of bulk containers and other storage and processing...
IBC bin washer and dryer
Many pharmaceutical processes use IBCs of multiple sizes throughout ...
CIP system for bulk tanks
Clean in Place (CIP) technology offers many advantages, but tradit...
GMP washer
In order to guarantee zero cross-contamination between production batches, the prop...
Vacuum sack lifter
In the production of pharmaceuticals and other high-hygiene environments, manual handling of inputs or int...
Pharmaceutical container lifter
Moving larger or heavier containers from height is out of the scope for standard handling eq...
Bin blender
Many pharmaceutical processes require the blending of powders or other granular ingredients, the mixing of settled...
Mobile drum lifter
The production of pharmaceuticals and other hygienic products often requires the handling of large and bul...
Container lifter
Container handling in the pharmaceutical industry brings its own set of unique challenges. Traditional barrel...
Powder transfer vessel
Intermediate bulk storage of pharmaceutical product requires specialist containers. For increased effi...
GMP Jib crane
Vacuum manual handling systems are the ideal way of quickly and safely moving small to medium sized loads in all...
R&D V-type powder blender
Many pharmaceutical processes rely on the complete blending and homogenizing of different powdered...
Single-use powder handling bag
Containers for handling pharmaceutical and biopharmaceutical powders may be disposable, to av...
Metal detector for pharmaceutical powders
Powdered and granulated pharmaceuticals require careful screening against metal ...
API powders storage bottle
Users who prefer rigid storage over single-use pharma charge bags, require lightweight solutions ...
Single-use containment valve
Safe transfer of liquids and hazardous powders into systems can be a challenge in pharma, bioph...
High containment closing system
Pharma and biopharma laboratories need fast effective solutions for tightly sealing bags for...
Gravimetric powder microdosing 0.400 - 2 g
If you need to process high value food, pharmaceuticals or chemicals, there is ...
Gravimetric powder microdosing 2 - 100 g
Powders and granules are commonly dosed for the manufacturing of pharmaceuticals, ...
Fast gravimetric powder microdosing 50 - 200 g
Micro-dosing powders of high-value food or chemical products can be challen...
Hygienic mobile scale
Having a reliable and accurate weighing and measuring solution is absolutely essential, especially in t...
Hygienic floor scale with lifting device
The food and pharmaceutical industries require maintaining high levels of sanitati...
Hygienic floor scale
The food and pharmaceutical industries require maintaining high levels of sanitations as well as logisti...
High containment big bag discharge docking system
The discharge of materials demands strict containment, particularly in ...
Accurate multiple dosing system for powders
Dosing multiple powders in a batch process is time inefficient, especially whe...
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Select your dry inhaler powder process
Tell us about your production challenge
When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
Contact usMill inhaler powder materials to achieve good particle size distribution
The recommended particle diameters for optimal aerosols preparation range from 1 to 5 µm. Smaller particles clump together while larger diameters lose their cohesive properties.
Reduce the diameters of coarse particles before mixing the ingredients for dry inhaler powder formulation. Jet milling applies high-impact forces combined with compressed gas to produce micro sizes.
Engineered blends improve the processing of dry inhaler powder formulations
Add carrier particles to the API mix to improve the processing properties of bulk powders. However, the particles of drugs and carriers must be chemically compatible. Their reciprocal adhesive forces need to be powerful enough to hold the mixture together during filling and storage. At the same time, they need to be quickly detachable during aerosol administration.
Coarse lactose monohydrate improves powder flowability during manufacturing and provides good carrier-particle separation. Lactose blends are formulated with drug contents of 5% (w/w) or less.
HPMC capsules are more stable for mono-dose inhaler systems
Mono-dose inhalers deliver a single serving of powder formulation by loading a capsule into the device before each use. Depending on the system, the capsule is activated by sheer force opening, needle-piercing, or cutting the capsule. But moisture content is a critical consideration for each technique.
Very dry conditions apply pressure on traditional gelatin-based capsules, causing them to crack before use. Hypromellose capsules (HPMC), on the other hand, is less hygroscopic and behaves well in both wet and arid environments.
Processing steps involved in dry-inhaler-powder making
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