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The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.

What dry inhaler powder equipment do you need?

Accurate multiple dosing system for powders

Dosing multiple powders in a batch process is time inefficient, especially whe...

Hygienic floor scale

The food and pharmaceutical industries require maintaining high levels of sanitations as well as logisti...

Hygienic mobile scale

Having a reliable and accurate weighing and measuring solution is absolutely essential, especially in t...

Fast gravimetric powder microdosing 50 - 200 g

Micro-dosing powders of high-value food or chemical products can be challen...

Gravimetric powder microdosing 2 - 100 g

Powders and granules are commonly dosed for the manufacturing of pharmaceuticals, ...

Gravimetric powder microdosing 0.400 - 2 g

If you need to process high value food, pharmaceuticals or chemicals, there is ...

Single-use powder handling bag

Containers for handling pharmaceutical and biopharmaceutical powders may be disposable, to av...

API powders storage bottle

Users who prefer rigid storage over single-use pharma charge bags, require lightweight solutions ...

Single-use containment valve

Safe transfer of liquids and hazardous powders into systems can be a challenge in pharma, bioph...

High containment closing system

Pharma and biopharma laboratories need fast effective solutions for tightly sealing bags for...

High containment sampler

Drawing a sample for evaluation from a running process is not a simple task, especially when dealing...

R&D V-type powder blender

Many pharmaceutical processes rely on the complete blending and homogenizing of different powd...

Miniature scale high-shear mixer

When you have a very limited amount of powder available, you can still test your processes ...

Laboratory high shear impact mixer

A Laboratory high shear impact mixer can be used to simulate different processes; from s...

High-shear impact mixer

When you need to mix cohesive powders with liquids or melt binders and require a homogenous end-produ...

In-line continuous blender

When you consider shifting pharmaceutical mixing processes from batch to continuous, accurate in-...

Conical screw vacuum dryer

The conical screw vacuum dryer is particularly suitable for the final drying of powders, granules...

Conical screw mixer

When you want to mix segregative, free-flowing powders and pastes that require perfect mixing quality and...

Pharmaceutical container lifter

Moving larger or heavier containers from height is out of the scope for standard handling eq...

Vacuum sack lifter

In the production of pharmaceuticals and other high-hygiene environments, manual handling of inputs or int...

Bin blender

Many pharmaceutical processes require the blending of powders or other granular ingredients, the mixing of settled...

Container lifter

Container handling in the pharmaceutical industry brings its own set of unique challenges. Traditional barrel...

Mobile drum lifter

The production of pharmaceuticals and other hygienic products often requires the handling of large and bul...

Powder transfer vessel

Intermediate bulk storage of pharmaceutical product requires specialist containers. For increased effi...

GMP Jib crane

Vacuum manual handling systems are the ideal way of quickly and safely moving small to medium sized loads in all...

Feeder with flexible wall hopper

The varying properties of dry powder products mean that specialized feeders are required fo...

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powd...

Checkweigher for sachets and sticks

The checkweighers for multiple lanes have a 1.5 times faster response speed and 2 times...

Centrifugal disc filter

The pharmaceutical and bioprocess industries need filtration processes of particularly high quality t...

Spherical dryer

Drying vessels that are simple, reliable, and easy to maintain increases product quality and process efficienc...

Filter dryer

The pharmaceutical and bioprocess industries need filtration processes of particularly high quality to ensure the...

Premium vacuum conveyor

When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g...

Bellows for pharmaceutical powders

Thermal and mechanical changes can lead to stresses in industrial piping systems. These ...

High containment split butterfly valve

Transferring active pharmaceutical ingredients from one vessel to another can lead t...

High containment segment ball valve

Valves fitted in blenders and dryers can have dead spaces that prevent complete process...

Removable GMP compliant connections for tubing

Tubing frameworks can have rough welding joints, corners and sharp angles t...

Hygienic floor scale with lifting device

The food and pharmaceutical industries require maintaining high levels of sanitati...

Dosing machine for nonfree-flowing powders

Fill poorly flowing powders, dry syrups and similar substances into various gla...

Checkweigher for stand-up pouches

When working with several lines of stand-up pouches, you can benefit from controlling the...

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Mill inhaler powder materials to achieve good particle size distribution

The recommended particle diameters for optimal aerosols preparation range from 1 to 5 µm. Smaller particles clump together while larger diameters lose their cohesive properties.

Reduce the diameters of coarse particles before mixing the ingredients for dry inhaler powder formulation. Jet milling applies high-impact forces combined with compressed gas to produce micro sizes.

Engineered blends improve the processing of dry inhaler powder formulations

Add carrier particles to the API mix to improve the processing properties of bulk powders. However, the particles of drugs and carriers must be chemically compatible. Their reciprocal adhesive forces need to be powerful enough to hold the mixture together during filling and storage. At the same time, they need to be quickly detachable during aerosol administration.

Coarse lactose monohydrate improves powder flowability during manufacturing and provides good carrier-particle separation. Lactose blends are formulated with drug contents of 5% (w/w) or less.

HPMC capsules are more stable for mono-dose inhaler systems

Mono-dose inhalers deliver a single serving of powder formulation by loading a capsule into the device before each use. Depending on the system, the capsule is activated by sheer force opening, needle-piercing, or cutting the capsule. But moisture content is a critical consideration for each technique.

Very dry conditions apply pressure on traditional gelatin-based capsules, causing them to crack before use. Hypromellose capsules (HPMC), on the other hand, is less hygroscopic and behaves well in both wet and arid environments.

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