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Maker - Product Challenge

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Changemakers

Liquid Dosing Equipment

Although the first association with almond milk might be the modern plant-based lifestyle trend, it is dated even back to the Middle Ages when it was used as an alternative to cow milk during Catholic fasting. Once harvested, almonds undergo a series of treatments in almond milk manufacturing equipment, such as bleaching, peeling, and grinding, to get the delicious final product for breakfast and desserts.

Almond milk

Creamier, sweeter and versatile are the key adjectives when talking about cashew milk, especially compared to other plant-based milk. Additionally, it is rich in vitamins B and D, as well as essential minerals. Being a blend of cashew kernels and water, the cashew nut milk processing equipment includes a peeling and washing machine, a colloid mill, and a blending tank.

Cashew milk

To produce condensed milk, you need to remove a large portion of the water content from the milk. Usually, you add sugar to it to create a sweet flavor. First, milk is standardized and pasteurized. Then, it goes through an evaporation process to remove the excess water content while sugar is added. After that, the mixture undergoes homogenization. The condensed milk is cooled and crystallized before being ready for packaging.

Condensed milk

Your earliest memory of medicine is probably a jar of cough syrup with a plastic dosing spoon attached. Although widely produced as remedies for children, medicated syrups are also available for adults. Making cough syrup starts by dissolving active ingredients into a purified water and sugar solution. But it is the distinct flavorings and colorants that persist in people’s minds long after the illness is cured.

Cough syrup

The body produces earwax to protect the ear canal from microbial growth. But no one wants too much protection of this kind. Thankfully, simple solutions are available over the counter to medicate excess cerumen. Besides wax removal, eardrops and OTIC manufacturing provides an effective delivery technique to treat infections or administer anesthetic.

Eardrops

The easiest and most commonly used method of making gels is mixing gelling agents with water to form a weakly cohesive internal structure. The gel production process is pretty linear and straightforward, from mixing hydrocolloids and water to labeling and sealing containers.

Gels

Although invented in the early 20th century by Otto Rohm, detergents gained popularity in the 1950s due to the development of modern technology and washing machines which started replacing scrub boards. The liquid detergent manufacturing process involves three key stages: soap premix manufacture, ingredient mixing and enzyme addition.

Liquid detergents

After shaving, anti-aging, with organic ingredients, for the feet... Lotions are many. They compose the skincare world, which has been growing in recent years. More consumers look for the benefits of products that promise to enhance well-being and self-care. Whether you want to help prevent wrinkles, provide vitamins or just hydrate your consumers’ skin, get your formula and select lotion making equipment to get started.

Lotion

Mayonnaise is created by blending oil with eggs, and then flavoring with vinegar, mustard, herbs, and spices. The eggs are a natural emulsifier that creates a uniform mixture. Ingredients are pumped into mayonnaise manufacturing equipment. First, a dynamic mixer maintains the desired level of emulsification of the mixture, which then moves on to packaging and bottling once reaching a satisfactory consistency.

Mayonnaise 

Although invented in the 1990s by Rickard Öste, oat milk has only recently grown to be one of the most popular milk alternatives in coffee shops, and it owes it to its smooth mouthfeel and creamy texture. Extracted the plant materials from oats with water, this non-dairy milk is high in fibers, low in saturated fats, and eco-friendly. Oat milk processing equipment helps prepare raw materials, starting with harvest over kilning and making them into flakes or flour, and mixing the prepared materials with water and enzymes.

Oat milk

The most significant decision when making ointments is likely to be the choice between automatic or semi-automatic processes for it. This impacts on individual phases of the ointment cream manufacturing process - the water phase and oil phase.

Ointment

First mentioned on a stone slab of the Eastern Han dynasty in ancient China, soy milk has survived centuries and spread from Asia to Global consumption due to the rising popularity of plant-based alternatives. To produce soymilk, raw materials must be harvested, prepared, and blended with water and desired ingredients, such as flavors and vitamins, in soymilk processing equipment.

Soy milk

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

If you've ever heard the acronym WFI spoken, know that we're not talking about wireless technology to connect your computer. WFI stands for water for injection, a sterile water used as a solvent to dilute other solutions for injections to the body. Traditionally, WFI was only produced through the distillation process using water for injection equipment until other methods such as reverse osmosis, electrodeionization, and ultrafiltration were developed.

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Water for injection

steriline_filling-machines_vfm-pdf

STERILINE_Filling-Machines_VFM.pdf

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

Continuous, high accuracy filling of vial, cartridges and syringes

Nitrogen purge of vessels before, during and after filling maintaining quality

Small form factor and linear layout reduces downtime for maintenance or changeover

Can operate at up to 24,000 pcs/h

Volumetric dosing systems

Chemical

Pharmaceutical

Dosing equipment

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

Connect directly with world leading manufacturers of Dosing equipment and find technology to build or improve your production line.

Dosing - Making.com

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Liquid

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Packaging

Process

Continuous

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

liquid

The volume filling of vials, cartridges and syringes is a vital part of the production of a wide range of pharmaceuticals. Traditionally, high-accuracy

Vial filling machine - Making.com

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The marketplace for finding innovative production technology

Making.com

printable-sheet-specifications-bi-i-pdf

printable-sheet-specifications-BI-I.pdf

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

A pre-filled syringe or PFS is a single-dose disposable syringe that is supplied loaded with the substance to be injected. By using a pre-filled syringe filling machine, you can have excellent dosage accuracy due to the exact filling of medications. During administration, safety from potential contaminants is also ensured as they are directly injected after opening. To further minimize the risk of contamination, pre-filled syringes are often filled and sealed in a sterile environment using stainless steel equipment.

Pre-filled Syringes

After being used to contain the blood of martyrs after death or to store the anointing oil of French monarchs, today ampoules are the first choice in packaging injectables. You create ampoules by melting the glass tube into the desired shape and seal them at the neck by melting the top of the glass tube. The only way for you to extract the contents from an ampoule is by breaking the glass at its breaking point, making it perfect for single dose applications only.

Ampoules

Holds up to 2 heads

Can perform micro-dosing

Integrated weighing and quality control

Easy sterilization using H2O2

Built to cGMP and FDA standards

Aseptic filling equipment is crucial for sensitive products, as they need to be filled into their primary packaging in an environment free from contamination caused by harmful bacteria, viruses, or other microorganisms. Choosing an aseptic filling solution requires consideration of the physical form of the product, the type of primary packaging, the volume to be dosed per package, and the production speed. Aseptic fillers are widely used for cleaning, filling, and sealing pre-sterilized vials, cartridges, ampoules, and syringes in the pharmaceutical industry. Aseptic filling is also used in the food industry to process for example, dairy products that need harmful bacteria's minimized, or ensure shelf-stable products that do not require refrigeration. In these industries, aseptic equipment is integrated into the production line for maximum isolation and sterilization. And, can either be configured as an automated or manual process, depending on standards that the products require.

Aseptic filling equipment

Sterile Filling Solutions

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Batch

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Almost all manufacturers will require industrial storage systems and solutions at some point during their production process. The raw materials that go into your products need dedicated storage solutions to protect them from spoilage and contamination before they enter the manufacturing cycle. Storage usually refers to particular storage space. For example, having enough warehouse storage. Or clearing out a production facility for more floor space.  However, in this case, we are referring to the equipment and solutions that make storage manageable and easier. Such equipment includes solutions such as storage racks, pallet racks and shelving systems. These are just some of many storage options available to manufacturers. Advanced technology facilitates the management of heavy duty and high density tank and silo systems by automating the delivery system and linking it with the rest of the production line.

Storage

solid

Where a compact solution is required for filling vials for the injectables market, sterile conditions and high-quality metering still need to be

Table top sterile filling line for injectables - Making.com

https://making-tst.imgix.net/2016/11/BI-I-001.jpg

brochure_multigel_suppositoriesmachine-pdf

Brochure_Multigel_SuppositoriesMachine.pdf

Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.

Suppositories

Full temperature control of the molten compounds ensuring consistency and quality

Reel-based system for rapid loading and unloading

Wide dosage range available to meet your exact requirements

Full GMP design with FDA-approved materials

Easily combines with S-MND 6000 to complete a suppository production line

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Small-to-medium scale production of suppositories using pre-formed shells can be slow where manual filling is used. An automated filling solution that can

Suppository filling machine - Making.com

https://making-tst.imgix.net/2019/06/suppositories-machine.jpg

easy-solutions-from-ingredients-to

EASY Solutions from Ingredients to

Electrolyte drinks

Pineapples, oranges, passion fruit, you name it. A fruit juice process begins with selecting and cleaning the raw material of your choice and goes through steps like extraction and a filtration machine until it reaches market shelves in bottles. Juice processing equipment varies according to the amount of water in the fruit.

Fruit juice

Originally developed as medicinal remedies, soft drinks quickly burst into a whole new category of non-alcoholic beverages. To make a soft drink, simply dissolve one part syrup into five parts water. For extra punch, add carbon dioxide to turn the mixture into a fizzy drink.

Soft drinks

Chocolate milk is a beverage containing milk flavored with chocolate powder or chocolate syrup. Cocoa powder, sweetener, sugar, and carrageenan are mixed with the milk and then pasteurized. As cocoa powder has a higher density than milk, carrageenan is used as a thickening agent to prevent cocoa powder from settling to the bottom.

Chocolate milk

Mineral water is mother nature’s cocktail of dissolved solids. The concentration of essential chemicals in the water makes it an excellent source of nutrients and electrolytes. Although your bottled product retains most of the properties present at its natural condition, the water still needs some help before it can be safely consumed.

Mineral water

Kombucha is a fermented drink made out of sweetened black or green tea. This slightly fizzy, sweet, and sour beverage has recently gained popularity for its health benefits. The main step in the kombucha making process is fermentation. Add the symbiotic culture of bacteria and yeast known as SCOBY at the base of the sweetened black or green tea to set off this reaction. The rest is up to your creativity. Enhance your kombucha with artificial or natural additives depending on the flavor you want to achieve.

Kombucha

Accurate dosing and mixing

Tailored production capacity based on customer request

From 5,000 to 60,000 liters per hour

Compact in size

MOVEliquid

Food

A beverage is any kind of liquid or drink, usually other than water, made for human consumption. Beverages are further classified into two categories: alcoholic beverages and non-alcoholic beverages. Alcoholic beverages refer to liquids that contain 1% to 75% of liquor and are produced by fermentation such as wine, beer, or distillation such as vodka, rum, tequila. Non-alcoholic beverages are drinks that don’t have any liquor such as tea, coffee, fruit juices, soft drinks, and carbonated beverages. They can be produced premix or postmix, depending on the setup of your production line.

Beverages

Our food chain starts in the soil, growing crops and livestock. But between the fields and the stores, there is a line of industrial food processing equipment. Processes may be as minimalistic as cleaning fruit and as complex as homogenizing milk alternatives made from pressed legumes. In each case, processing technology is an important link in the food production chain.

Protein

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

Juice production lines require multiple ingredients to be typically mixed with water. The incorporation of ingredients like juice powder, aroma and

Mixing tanks for beverages - Making.com

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a_due_1041_brochure-pdf

A_Due_1041_brochure.pdf

Ensures precise mineral content

Handles a variety of ingredients

Continuous, automated operation

Integrated safety filtration and disinfection

Scalable flow rate from 10,000 to 100,000 liters per hour

Micro dosing systems

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Blending

Industrial disinfection equipment use antimicrobial agents to destroy microorganisms found on machines, floors, walls, and other surfaces. In industry, disinfection of machinery and the production area is important to prevent product contamination which may lead to spoilage and health hazards for workers and the consumer. The choice of industrial cleaning equipment depends on the level of disinfection needed, the sanitizing agent, the size of the area or objects to be treated, and the suitable method of treatment such as sterilization, pasteurization, exposure to ultraviolet light, or chemical fogging.

Disinfection

Industrial filtration equipment separates solid matter from liquid by using a filter medium. The filter allows only the fluid to pass through but retains the solid matter. The choice of filtration equipment depends on the particle size, the consistency of the mixture, and the nature of your product.

Filtration

In water treatment industries, achieving precise mineral balance is critical. Challenges arise when ensuring consistent mineral content and maintaining

Water remineralization system for mineral and flavored water production - Making.com

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blendtech_2111_brochure-pdf

BLENDTECH_2111_brochure.pdf

Effective removal of impurities

Supports capacities up to 35 m³/h

Available in continuous or discontinuous configurations

Different levels of automation available

Ensures high-quality end products

Fruit

Syrup

Clarifying

<span style="font-weight: 400">The heating process is a step of raising the temperature of food, pharma, cosmetics, and many other types of products. You may employ different heating solutions for this process, depending on the type of product you intend to manufacture. Selecting the appropriate heater machine for your product is quite important since various products require different ranges of temperatures and different ways of heat transfer using exchangers. Industrial heating equipment varies in two ways - the type of material it can process and the reaction you want to achieve.</span>

Heating

When producing fruit juices, nectars, and soft drinks, achieving a clear syrup is crucial for maintaining product quality and appearance. Addressing

Syrup clarification for fruit juices and soft drinks - Making.com

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cam_packaging_2702_brochure-pdf

CAM_Packaging_2702_brochure.pdf

Neige de lait in French or neve di latte in Italian, as referred to in very old texts and both meaning milk snow, has been used in recipes since the 15th century. Withstanding the test of time, whipped cream is still one of the most beloved dessert toppings. What starts with milk ends as a silky delicacy with the help of whipped cream equipment and specified manufacturing processes.

Whipped cream

Accurate synchronization of irregular-shaped bottles

Dribble and drop recovery system

Quick-release clamps for easy dismounting

CIP system for easy cleaning

High-density product handling capability

Bottle filling equipment entails transferring your products to a bottle which involves inspecting the material, and then conveyors feed it into the machine which then pours it into the vessels using volumetric technology and nozzles before capping them. Bottle filing varies not only in product type but in the size, shape, and material of the container too. Depending on your operation, filling systems may adopt in-line or rotary methods before transferring the bottles to the next stage of processing.

Bottle filling equipment

A bottle sorter automatically sorts empty bottles at high speeds by size, color or shape before filling. A bottle unscrambler receives empty bottles in bulk and positions them on a moving conveyor for further processing. Both pieces of equipment are generally integrated into a complete and automated production line. Considerations for selecting a bottle sorter or unscrambler include the size, shape, and material of the bottles, production speed, and sorting criteria. Bottle sorters and unscramblers are used in the food industry for packaging fruit juices, oils, and other liquid products; in the pharmaceutical industry, they are used for the filling of vials, ampoules, and bottles.

Bottle sorters and unscramblers

A belt conveyor system uses pulleys or drums to keep an endless loop of conveying belts in continuous motion for material handling. Considerations for choosing a suitable conveyor belt system include the physical form of the product, processing requirements, and the desired speed and volume of transportation. Belt conveying systems find numerous applications in the food, pharmaceutical, and chemical industries such as filling and packaging operations. In the biomass industry, these systems are used for moving biomass feedstock to the boiler. In the mineral industry, conveying belts process and transport granular and crushed minerals. Conveyor belts are heavy-duty machinery that is used to move materials from one place to another. They are commonly used in factories, warehouses, and other industrial settings to move items such as boxes, containers, and other materials along a production line.

Liquid Dosing Equipment

Which liquid dosing technology do you need?

Vial filling machine

Table top sterile filling line for injectables

Suppository filling machine

Mixing tanks for beverages

Water remineralization system for mineral and flavored water production

Syrup clarification for fruit juices and soft drinks

Linear intermittent motion filling system for high-density liquids

Electronic filling system for non-carbonated beverages

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