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Maker - Product Challenge

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Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

Chromatographic monolithic columns for working with large proteins, viruses, VLPs and pDNA require the high structural strength and contamination protection usually provided by expensive medical grade stainless steel.
<h2>Separate complex biomolecules using strong, versatile multi-use columns</h2>
CIMmultus™ disposable monolithic columns from BIA Separations have the structural integrity and leachable profile of medical grade stainless steel, but the process economics of a single or multi-use device.

With the introduction of composite materials into an epoxy-based housing and the application of USP Class VI Parylene C coating to the entire column surface, CIMmultus™ columns offer safety and high performance.

CIMmultus™ columns can be used at any step in the separation process and, with their 2 µm flow-through channels allowing convective mass transfer, make a perfect choice for the purification of viruses, VLPs, plasmids, antibodies, PEGylated proteins and other large biomolecules.

Disposable monolithic columns

Samples taken at various process steps need to be analysed quickly and accurate results delivered, without affecting the state or condition of the original sample.
<h2>Understand a bioprocess through real-time monitoring</h2>
CIMac™ Analytical Columns from BIA Separations are short bed, high performance monolithic columns offering all the advantages of CIM® monolithic technology. They are primarily intended for fast, efficient, and reproducible separations of biomolecules like large proteins, plasmid DNA, and viral particles.

Small volume and short column length allow operation at high volumetric flow rates (from 1 to 30 column volumes/min), enabling product quantity and purity information to be available in just a few minutes.

The CIMac™ Analytical Columns are pre-packed in dedicated stainless steel housings and allow user-friendly connections to HPLC equipment, hence they can be effectively used for both the in-process and final control of various samples from different purification processes.

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Short bed monolithic columns for analytics

When developing a pDNA purification process for eventual transfer into production, efficient examination and selection of protocols is critical.
<h2>Develop plasmid purification procedures quickly</h2>
BIA Separations' CIMmultus™ HiP2 Plasmid Process Pack™ is intended to help scientists easily develop their pDNA purification process and transfer it to production.

Allowing developers to select only the relevant parts of the recommended protocol that best fits their needs, the pack saves time and money on all scales.

The CIMmultus™ HiP2 Plasmid Process Pack™ contains one weak anion-exchange (DEAE) and one hydrophobic (C4 HLD) column and a protocol describing the purification procedure of specific plasmids.

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Plasmid process pack for your pDNA purification process

To purify a specific large biomolecule, for example IgM or a virus or virus-like particle, the first step is to screen the working conditions. Different mobile phases and column chemistries are then tested, according to the biochemical properties of that particular large molecule.
<h2>Efficiently identify, isolate and recover large biomolecules</h2>
The CIMmultus™ Purification Screening Kit from BIA Separations is intended to help scientists quickly discover the optimal stationary phase chemistry for their particular application.

The kit includes two different 1mL CIMmultus™ ion-exchange columns (QA and SO3) and one hydrophobic interaction chemistry column (OH).

By using one of the selected chemistries and applying proper working conditions, the user will be able to discover the combination that will result in appropriate purity and excellent recovery of their required large biomolecule.

Purification screening kit for large biomolecules

Find production technology for Insulin separation, and connect directly with leading machine manufacturers worldwide

Insulin separation

Which insulin separation equipment do you need?

Disposable monolithic columns

Short bed monolithic columns for analytics

Plasmid process pack for your pDNA purification process

Purification screening kit for large biomolecules

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