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Pharmaceutical Powder Drying Equipment

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.

Dry inhaler powder

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

brochure_ike_catalog-pdf

Brochure_IKE_catalog.pdf

Black pepper

Black Soldier fly larvae (BSF or BSFL), also known by its scientific name, Hermentia Illucens, offer great nutritional values, making them an excellent alternative protein source for animal feed and pet food. Black soldier fly technologies have evolved sufficiently to turn the insect into a viable food ingredient. But there is no official authorization for human consumption yet and you are unlikely to find them at a restaurant anytime soon.

Black soldier fly protein

Crickets are better known for their nighttime serenades than for their nutritional notes, but their serious protein content as well as vitamin B12 content and iron, moves them into the category of superfoods. With a light brown color and a nutty taste, cricket protein powder is a versatile dietary ingredient that makes it difficult to go off-tune with your recipes.

Cricket protein

Fruit dehydration is the earliest form of food preservation, with the earliest written record of dried fruits dating back to ancient Mesopotamian tablets, which contain the world’s earliest known recipes. Today, some of the most popular dried fruit snacks are raisins, dates, mango, pineapple, prunes, figs and apricots. Dried fruit processing equipment helps preserve the nutrients and sweetness of the fruit and prolongs its shelf life.

Dried fruit

Drying meat was the prevalent method of conserving meat cuts when food could not be chilled. But dried meat products developed into delicacies and remained a culinary mainstay long after the functional need for preservation was answered with refrigeration. The ancient techniques have been replaced by dried meat processing equipment, but the time-honored recipes remain unchanged.

Dried meat

In classical Greek, oregano means “mountain adornment,” Indeed, the desiccated herb embellishes many age-old recipes. Traditionally, the fragrant leaves were collected and left to air dry in a shaded area. But that method leaves the plants exposed to open field risks such as pest attacks. Today, dried oregano processing equipment creates a hygienic environment that allows the plant to release moisture faster while retaining more natural compounds.

Dried oregano

Around 1860, American businessman James Spratt made dog biscuits by mixing vegetables, flour, beetroot, and meat. His novel idea came after he noticed dogs eating leftover biscuits from ships in England. Following the commercial success in Britain, he started production in America, and it didn’t take long before others developed their own baked pet food formulas. But the need for more palatability led to experiments beyond the oven. In 1956, extruded dry pet food production made its splash on the market.

Dry pet food

Only one percent of the entire plant species on the planet produces essential oils, but that amount has found its way into various products, from perfumes to foods. Flower extraction systems are similarly diverse, and picking the right ones depends on the organic material and the final product.

Flower extract

Mealworms are a classic angling bait, but their high protein content makes them more than just a snack for fish. The fresh larvae of the insect have long been consumed in Southeast Asia and, in 2021, the European Commission approved dried yellow mealworm as an edible product.

Mealworm protein

The ubiquitous plastic shopping bag was first designed as a reusable carrier. Its inventor, Sten Gustaf Thulin, will have been appalled to see his creation turn into a single-use object. But this disposable tendency is common to all plastic materials, from screw taps to milk carton lining. With plastic recycling equipment, however, plastic waste can be reprocessed and given a second lease of life.

Recycled plastic

The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

Chinese legend has it that tea was created by accident over 2700 years BC. A servant boiled drinking water for his emperor when leaves from the Camellia sinensis tree fell into it – and the emperor decided to taste the drink. While to make tea nowadays on a medium to large-scale you need tea processing equipment like dryers instead of just a tree and wind blowing it, mythology adds a special flavor to the tea industry story.

From cassava to sweet potatoes, various types of vegetables are processed to make one mixed bag of vegetable chips. Mainly consisting root vegetables like taro and parsnip, vegetable chips are often introduced as a healthy alternative to potato chips. To make these chips, you first need to slice the vegetables and cook them depending on your product; you can simply bake them or fry them, deep fry them, or dry them. After this process, flavorings are added to the chips.

Vegetable chips

Much lower cost than traditional electric drying solution

Fully automatic drying via touchscreen control - set and forget

Optional remote monitoring function via the internet

Gentle dehydrating with no flavour transfer - dry multiple products at once

Only requires standard 220v mains power, no other connections required

Drying cabinets consist of an enclosed chamber where products to be dried are placed on stainless steel trays. These drying systems reduce the relativity humidity allowing the moisture to evaporate quickly. Cabinet dryers are widely used for reducing the moisture content of sensitive products.

Drying Cabinets

Feed

Food

Industrial Drying Equipment

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Find Industrial drying equipment for your manufacturing process and connect with a global network of leading production technology suppliers.

Drying - Making.com

Industrial Drying Equipment - Making.com

Feed ingredients

Our food chain starts in the soil, growing crops and livestock. But between the fields and the stores, there is a line of industrial food processing equipment. Processes may be as minimalistic as cleaning fruit and as complex as homogenizing milk alternatives made from pressed legumes. In each case, processing technology is an important link in the food production chain.

If Popeye needed spinach for his power, you need healthy snacks to boost your energy! From dried fruit chips to nuts and protein bars, healthy snacks have become more popular since the 2000s, and the global healthy snack market will reach USD 98 billion by 2025. In the wide range of healthy snacks, raw fruits and vegetables appear as the main ingredient, and these snacks focus on the high protein content and reduced fat or carbohydrate percentages. Also, “less processed” and “less amount of added chemicals” are the primary trend in making healthy snacks as the clean eating movement began after the 2000s.

Healthy snacks

With the increase in the world population and rising concerns for environmental sustainability, the market for suitable new protein sources is expanding rapidly. Traditional agricultural methods alone can’t deliver sufficient protein to meet the projected food demand over the next decades. Insects provide an alternative source of nutrients. But insect protein does not mean direct insect consumption. Extracting protein and amino acids from farmed insects is more sustainable and efficient. Specialized insect protein processing technology is driving the transformation toward new protein sources.

Insect protein

Meat

Pet food is a specialty food mostly based on formulated ingredients for various nutritional and dietary requirements. Pet food formulas are becoming more diverse and complex, considering the special health conditions and needs of young and aging pets that live in cities. The production of pet food is similar to processing food in general when it comes to fresh feedstock and flesh products.

Pet food

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Ancient civilizations discovered that plant extracts were useful for the treatment of pathologies. The origin of plant extraction cannot be specifically verified, but we can infer that the earliest attempts at plant extraction were more intuitive than scientific. Today, the extraction of compounds is a precise process with plant extraction systems complimenting traditional knowledge.

Plant extracts

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Protein

A snack is a small portion of food ready to eat and simple and fast to prepare. People usually consume snacks during the day between traditional meals such as breakfast, lunch, or dinner. Snack foods include simple products such as nuts, dried fruits, peanuts as well as packaged and processed foods. Puffed corn products made by extrusion or flavored potato chips are examples of processed foods.

Snacks

Spice manufacturing is one of the world's oldest trading products. The word spice refers to any dried part of a plant other than the leaves and is used for seasoning and food coloring. Spices are made from dried barks, roots, berries, and twigs, while green leafy parts of plants are considered herbs. Well-known examples include cinnamon, chilies, star anise, ginger, garlic salt, turmeric, cumin, or pepper, as well as pre-mixed blends such as Masala, Five-Spice Powder, or Old Bay.

Spices

Process

Batch

solid

The production of high-quality biltong and similar dried meat products can pose problems with maintaining product quality, as well as the high energy cost

Industrial drying cabinet - Making.com

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The marketplace for finding innovative production technology

Making.com

brochure_lb_bohle_granulation

Brochure_lb_bohle_granulation

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Complete fluidization and even coating of particles

Pressure shock resistance of up to 12 bar, optimum for containment application

Capacity range of 1 to 500 kg

Efficient space utilization due to low installation height

Can be equipped with a moisture measurement system to determine moisture level during the drying process

A granulator is a high-speed knife mill designed to cut down large components of feedstock and reduce them to smaller particle sizes. Selecting the right scissor geometry and configuration allows granulators to process plastic bottles, organic fibers, films, wires, cables, and other difficult materials. Agglomeration granulators combine fine particles into larger granules by creating bonds between them. Bonds are formed by compressing fine particles or through the use of a binding agent.

Granulators

Pharmaceutical

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Granulation

Pharmaceutical industries employ several processes including drying, coating and granulation to create high-quality granules. Manufacturers can benefit

Fluidized bed system for the granulation and drying of pharmaceuticals - Making.com

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ima_5492_brochure-pdf

IMA_5492_brochure.pdf

Ensures efficient drying and granulation

Easily accessible for maintenance

Safe for use with solvents (ATEX compliant)

High containment for reliable operation

Accurate spraying control for consistent results

Granules

Continuous

To coat your consumer products with color or taste-enhancing substances, specialized technologies are available that ensure all the contents are individually and evenly covered. The process starts with loading your goods onto rotating drums, exposing the products to spray nozzles that treat them with your prescribed coating formula.

Coating

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

In pharmaceutical manufacturing, achieving optimal drying, granulation, and pellet coating can be challenging due to the need for precise control and high

Fluid bed processor for pharmaceutical granulation and drying - Making.com

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pfaudler-mavag-filtration_drying-pdf

Pfaudler-Mavag-Filtration_Drying.pdf

A toner is a fine powder located in printer and copier cartridges. One peculiar property the product is their ability to act like liquids. Toner manufacturing equipment sees to it that the particle size is between 5 and 30 micrometers to flow through the cartridge.

Toner

Many customer options available including heated agitator and quick closure system

Several options for mounting in your facility

Capacities available from 100 L to 4000 L

High up-time allowed by simple maintenance and cleaning and a robust, simple design

Vacuum dryers are typically used to dry fabrics that are sensitive to heat. They find application in the production of active pharmaceutical ingredients, fine chemicals, and food products. Contact us to find out which vacuum dryer is most suitable for your specific application.

Vacuum dryers

R&amp;D

liquid

Drying vessels that are simple, reliable, and easy to maintain increases product quality and process efficiency.

Drying vessels that are simple, reliable, and easy to maintain increases product quality and process efficiency in this highly sensitive industry.

Spherical dryer - Making.com

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brochure_-hmbv_drying-pdf

Brochure_-HMBV_Drying.pdf

It took the scientific community almost 70 years to agree on the name ‘protein’ and discard the popular alternative, proteid. But protein powder processing still needed another five decades to be commercialized in the 1950s. Once extraction and purification could be industrialized, protein powder soon became a basic staple supplement.

Protein powder

Around a third of your natural protein composition is collagen. But the human body still finds good use for more of it, whether to reinforce joints or aid digestion. Collagen powder processing breaks the chains of amino acids into smaller units, allowing them to be consumed at higher concentrations without changing your diet.

Collagen powder

Hyaluronic acid is a natural lubricant found in all mammals. An effective humectant, its molecules can hold a thousand times their weight in water. However, hyaluronic acid extraction is a complex biotechnological process that requires a specialized manufacturing technique.

Hyaluronic acid

All plastics are polymers, but not all polymers are plastics. Polymer production is a multi-step process that transforms raw materials into products that we use in our day-to-day life with the help of polymer process equipment such as extruders, calenders and injection molding machines.

Polymers

When he was in Haiti in 1493, Christopher Columbus noticed that the natives were bouncing on rubber balls made from the milky sap of Hevea brasiliensis, also known as a rubber tree native to South America. The milky sap was nothing but latex, the source material for natural rubber. Latex processing technology includes equipment for coagulation techniques and rollers for natural latex and a sequence of mixers, pumps, and sieves for synthetic latex.

Latex

Antibiotics

Smooth transition to the production plant

Best features of the reconstituted product (shape, color, volume)

Preservation sensitive compounds and high temperature properties: vitamins, proteins, enzymes, etc

Very low final moisture of the lyophilized product: high stability

Compatible with aseptic conditions: production of sterile products

It goes by many names. Freeze drying, lyophilization, or cryodesiccation is a form of dehydration that involves freezing the product to remove its water content and then removing the ice by sublimation – this means going from the solid to the gaseous state without going through the liquid phase. Freeze dryers are widely used in the pharmaceutical industry to increase the shelf life of products such as vaccines and other injectables. Due to their ability to best preserve the flavors, freeze dryers are used for food preservation in the food industry by dehydrating high-value products such as seasonal fruits or coffee. Industrial freeze drying systems are usually comprised of multiple components including vacuum pumps, stainless steel condensers, some form of heating and lastly, a chamber for drying where the materials are placed and processed.

Freeze dryers

Biomass

Ceramic

Chemical

Metal

Mineral

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Ceramics are defined as inorganic and non-metallic materials. Tthey are typically brittle, hard, and elastic as well as resistant to heat and corrosion; in fact, after shaping them into the desired shape, they are heated in an oven called kiln at very high temperatures (1,000 °C to 1,600 °C). Kaolinite and aluminum oxide are the best-known examples of ceramics.

Ceramics

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

We carry dozens of metals around every day. The ubiquitous smartphone is built with no less than 20 metals, each with specific behaviors and purposes. Metals are a pervasive class of materials that have defined entire eras of human development. It is no exaggeration to say that metal processing equipment is the core of our metallic world. But, paradoxically, this manufacturing technology itself is mainly made of metal.

The nearly 5,000 known minerals on earth share some characteristics to be classified as minerals – they are inorganic, solid, naturally occurring elements and have a particular chemical formula and an ordered internal geometric structure. However, minerals are not all the same. One way to divide them is based on their physical characteristics such as hardness, luster, color, and shape. For example, the diamonds we use to make jewelry are very hard minerals while talc is a soft mineral; gold is a shiny mineral while others are less so.

Minerals

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Pigments are colorants that are not soluble in the host material and scatter light and are therefore opaque. Pigments can be organic or man-made and derive from animals, plants, rocks or minerals and metal oxides, like for example titanium oxide.

Pigment

Can it be said that we live in the Plastic age? Basically, yes. From pillows over toothbrushes, and packaging to utensils, plastic is a widely used material in our day-to-day lives. But what is it? Plastics are synthetic or semi-synthetic materials built of polymers that are easily shaped into various structures with the help of plastic processing equipment such as extruders and molders.

Plastics

The 1 liter laboratory scale freezer dryer from Hosokawa Micron is quicker and less labor intensive than traditional tray-type freeze dryers.

The laboratory-scale active freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying processes. The

Laboratory scale active freeze dryer - Making.com

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The classification of sunflower seeds changes according to the pattern of its shell or hull. If the shell is solid black, it is an oilseed sunflower. With these, you produce sunflower oil. If the shell is striped, it is a non-oil sunflower seed or confectionery sunflower seed. These usually become snack food products. Whether to make them as snacks or oil, processing sunflower seeds include steps like drying, screening and cleaning, grading, roasting and de-hulling, flavoring, grinding, pressing, refining, and packing.

Pharmaceutical Powder Drying Equipment

Which pharmaceutical powder drying technology do you need?

Industrial drying cabinet

Fluidized bed system for the granulation and drying of pharmaceuticals

Fluid bed processor for pharmaceutical granulation and drying

Spherical dryer

Laboratory scale active freeze dryer

Industrial dehydration machine

Continuous wet granulator and dryer for R&D

Fluid bed granulator for pharmaceutical applications

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