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Insulin bioprocessing Equipment

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

Manufacturers in the bioprocessing industries are increasingly turning to single-use solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high-quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value-added tasks.


<h2>A disposable 3D bag for production bioprocess containment manufactured in strict cleanroom conditions</h2>
JM BioConnect is known for certified top of industry quality and customer service, including very short lead times. The company's disposable 3D bags use a film specifically developed by JM BioConnect to meet the needs of bio processors from laboratory to production plant scale.  The film, known as JMS Flex Film, is manufactured to the highest quality standards and has the highest clarity of any film used for bag manufacture.  It is manufactured under laminar flow conditions in the class 7 cleanroom.  The 3D bags are available in sizes from 50L to 3.500 L and include a completely inert polyethylene fluid contact layer.  They are resistant to damage caused by gamma sterilization, have very low oxygen permeability (.1cc/sqrM.bar.day), and are unsurpassed in clarity and flexibility.

3D disposable bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for their production infrastructure needs.  Experienced producers know that the flexibility, cleanliness, and convenience of high quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value added tasks.


<h2>A disposable liner for reusable rigid vessels that avoids contamination while eliminating required cleaning</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times. The company's disposable tank liners are constructed from a 350 micron thick LDPE film with a completely inert fluid contact layer similar to that in JM BioConnect's other disposable bag products using JMS Flex Film.  The  film used in the tank liners is thicker and manufactured to a 3D shape to better fit the restraining vessel, but it has similarly low extractable and leachable compounds and is excellently suited for media and buffer preparation in support of subsequent bioprocesses.  Typical use is to install the tank liner into a cylindrical vessel and fill with liquid.  A powder is then added and mixed to create a buffer or media for subsequent bioprocess.  After mixing, the contained fluid can be pumped or drained out and the tank liner disposed of.  The process can begin again with the installation of a new tank liner and no required cleaning of the vessel.  Liners are also available with a bottom end drain port and supporting hoses and fittings to meet the customer's needs.

Disposable tank liners

Manufacturers in the bioprocessing industries are increasingly turning to disposable solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high-quality, single-use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value-added tasks.


<h2>A complete manifold system composed of  single-use components of the highest quality</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company's disposable tubing and containment solutions can be combined into complete manifold systems accommodating an entire upstream or downstream bioprocess.  The modular and interchangeable design of the disposable units including tubing, connectors, and bags, allow several bags to be connected to one another and to other supporting equipment such as pumps and filters according to the customer's needs.   These systems can be scaled from lab and pilot to full production plant needs.  All components used in the single-use manifold systems are fully compliant with cGMP regulations as well as 21CFR part 11.  They meet USP class 6 standards and are completely free from any animal-derived material.

Disposable manifold bags for bioprocesses

Bio-processors require reliable, high quality, easy to maintain, filtration equipment to ensure efficient processing and high-quality outputs. Selecting the right supporting equipment like filters and tubing eliminates potential variables that can make your upstream or downstream bioprocess unpredictable, and hinder production with high maintenance demand.


<h2>Modular filter sets with tubing and connections ready for integration into your bioprocess manifold system</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company offers filter sets that provide conveniently bundled filter housings, high-quality tube, and connectors in one package that is easy to install in your manifold system.  A wide variety of sizes and filter media options are available. The set is configured with the correct hose size and fitting style at the time of order so it is immediately ready for integration into your manifold system upon arrival. These Normal flow filtration sets for bioprocesses will prove to be a valuable acquisition.

Normal flow filtration sets for bioprocesses

Bioprocessors must use ingredients of known high quality and consistency.  Inconsistent or poor quality raw materials are often the cause of inefficient or failed processes.  Separation of mixtures of liquids with different densities or settling of liquids with suspended solids during storage or transport is often the cause of varying raw material quality and associated process issues.


<h2>A disposable vessel for liquids with an integrated, magnetically actuated, mixing pump for homogenizing contained liquids</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company's Jetmixer single use mixing system consists of a reusable mixing machine with a motor and magnetic power coupling and a single use bags with integrated mixing pumps.  When the bags are placed in the mixing machine, the pumps are acted on  by the magnetic power coupling and rotation is induced inside the bag without the need to open it.  The pumps draw fluid in vertically from the center of the bag and expel it horizontally along the bottom.  This sets up a current that continually sweeps the entire volume of the bag and mixes all the contained fluid.

Disposable mixer bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value added tasks.


<h2>A disposable pillow bag for bioprocess containment manufactured in strict clean room conditions</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company's pillow bags use a film specifically developed by JM BioConnect to meet the needs of bioprocessors from laboratory to production plant scale.  The film, known as JMS Flex Film is manufactured to the highest quality standards and has the highest clarity of any film used for bag manufacture.  It is manufactured under laminar flow conditions in a class 7 clean room.  The pillow bags are available in sizes from 50mL to 50L and include a completely inert polyethylene fluid contact layer.  They are resistant to damage caused by gamma sterilization, have very low oxygen permeability (.1cc/sqrM.bar.day), and are unsurpassed in clarity and flexibility.

Disposable pillow bags for bioprocesses

Sensitive bioprocess applications requires equipment that will not interfere with the chemical and biological processes being carried out.  At the same time, production bioprocesses, in particular those that involve peristaltic pumping, require robust tubing not prone to wear or mechanical failures.  Traditional transfer tubing for these more rigorous ans sensitive bioprocesses often proves inadequate.


<h2>A robust biocompatible tube designed for longevity in production peristaltic pumping applications</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company offers tubing solutions specifically designed for use in peristaltic pumps in bioprocess production environments. The tubes are of the PharMed BPT brand and are completely bio-compatible and less permeable to gasses and vapors than traditional silicone tubes.  This makes the PharMed BPT tubes ideal for protecting sensitive biological processes like cell culture, fermentation, separation, synthesis, and purification.  At the same time, they have been formulated for enhanced flex and wear characteristics allowing trouble free used in peristaltic pumping applications.  The combination of these qualities increases the efficiency of the bio-production process by reducing down time from tubing failure without making any sacrifices in bio compatibility.

Biocompatible tubing for peristaltic pumps

Manufactueres in the bioprocessing industries are increasingly turning to single use solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value added tasks.


<h2>High quality pre-assembled tubing splitters for convenient addition to your fluid transfer or manifold system</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The Company provides a line of pre-assembed high quality fluid transfer tubes for bioprocesses that is ready for integration into your system.  The Y-sets split one tubing line into to and are frequently used for connecting several single use bags together with supporting equipment making a manifold for an upstream or downstream bioprocess.  A wide variety of sizes and fitting styles is available.  Use of the pre-assembled Y-sets improves efficiency by avoiding the need to stock, track, and manually assemble a high number of smaller fittings and raw tube that make up the Y-set.  Maintenance time in your system will also be improved as damaged or worn sets can be replaced as a whole using the ready-made tube connections.

Y sets tubing for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value added tasks.


<h2>Disposable tubing manufactured under strict clean room and quality standards</h2>
JM BioConnect is known for top of industry certified quality and customer service including very short lead times. The company has developed a unique thermoplastic tubing known as Solmed TubeFelx 4502.  This tubing is made from TPE--the cleanest biologically compatible material and is manufactured in a completely controlled clean room environment.  It contains no animal derived ingredients or oils.  This tubing is weldable by all commercial tubing welders and sealers and can be sterilized by autoclave, gamma radiation, UV, and ETO processes.  It is suitable for use with peristaltic pumps and rated for pressure up to 3 bar.  The tubing is designed to be used to in conjunction with various other JM Bioconnect products to create process manifolds for both upstream and downstream bioprocesses.

Disposable tubing for manifolds in bioprocesses

Tangential Flow Filtration is an essential to the biopharmaceutical processing industry. An efficient, controlled, and documented, TFF process helps producers in the product development, process development, and production phases and experienced biopharmaceutical producers know that investment in automation and maintenance reduction of this equipment is always a good decision.
<h2>Fully automated Tangential Flow Filtration with all single use wetted components</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs. The company’s SciPure 200 system is a fully automated, single use TFF system with electronic HMI and specialized software. All wetted components of the system including sensors are single-use consumable items. The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance. The system responds to sensor feedback to maintain user-defined transmembrane pressure and flow rates simultaneously.

Automated single use tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutical processing industry.  An efficient, controlled, and documented, TFF process helps producers in the product development, process development, and production phases and experienced biopharmaceutical producers know that investment in automation and maintenance reduction of this equipment is always a good decision.


<h2>Semi-Automated Tangential Flow Filtration with all single use wetted components</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs. The company’s SciPure 150 system is a semi-automated, single-use TFF system with electronic HMI and specialized software.  All wetted components of the Semi-automated tangential flow filtration system including sensors are single-use consumable items.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The Semi-automated tangential flow filtration system responds to sensor feedback to maintain user-defined trans membrane pressure or process flow rates.

Semi-automated tangential flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing industry to prepare liquids and solutions for further processing.  A wide variety of commercially available filters are used and efficient and consistent processing often requires careful control of the filtration process parameters.  Experienced biopharmaceutical producers know that investment in automation and maintenance reduction of this equipment is always a good decision.
<h2>Semi-Automated Normal Flow Filtration with all single use wetted components</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciPure 140 system is a semi automated, single use NFF system with electronic HMI, PID pump control, and specialized software.  All wetted components of the system including sensors are single-use consumable items.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The system responds to sensor feedback to maintain user-defined constant rate or constant pressure filtration process parameters.

Semi-automated normal flow filtration system

Single use bags for biopharmaceutical process containment and liquid storage are being used with increasing frequency in the industry due to their convenience, efficiency, and inherent cleanliness.  Integration of single use bags into biopharmaceutical processes is a great way to reduce required maintenance, and improve the versatility of equipment without increasing risk of cross contamination.
<h2>A mobile, vertical bag holder with integrated scale compatible with bags from any manufacturer</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs. The company’s WeighStation system is a wheeled bag stand that works with single use bags from any manufacturer.  The system includes integrated load cells and local display which allow it to be used as a stand-alone scale or to be integrated into other Scilog processing platforms for metered dispensing and purification.  The system has a minimized footprint and superior mobility when compared to a traditional floor scale.  The mobility and use of single use bags allow this piece of equipment to support several processes in your facility rather than being dedicated to just one.

Bag holder and weighing platform for bioprocesses

Tangential Flow Filtration is an essential to the biopharmaceutical processing industry.  An efficient, controlled, and documented, lab scale TFF process helps producers in the product development and process development phases and experienced biopharmaceutical producers know that investment in automation and maintenance reduction of this laboratory equipment simplifies development work and speeds implementation of new products and processes.
<h2>Semi-Automated Tangential Flow Filtration for the laboratory</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s PureTec system is a semi automated, TFF system with electronic HMI and specialized software.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The system responds to sensor feedback to maintain user-defined transmembrane pressure or process flow rates.  Disposable pressure sensors are included on the permeate, retentate, and feed lines.  An integrated electronic scale for permeate monitoring, magnetic stirrer, and programmable peristaltic pump are also included allowing completely unattended TFF processing to user specified parameters.  With the addition of the SciDoc documentation package 15 filtration parameters can be calculated, displayed, and documented providing the information and control you need for maximized yield.

Lab scale tangential flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing industry to prepare liquids and solutions for further processing.  A wide variety of commercially available filters are used and efficient and consistent processing often requires careful control of the filtration process parameters and behavior of the filter medium used.  Experienced biopharmaceutical producers know that laboratory testing and documentation of NFF processes prior to implementation at a production scale is an important step in developing an efficient process.
<h2>Semi-Automated Normal Flow Filtration for the laboratory</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s FilterTec system is a semi automated, NFF system with electronic HMI and specialized software.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The system responds to sensor feedback to maintain user-defined filter back pressure or filtrate flow rates.  A disposable pressure sensors and integrated electronic scale are included as well as a programmable peristaltic pump allowing completely unattended NFF processing to user specified parameters.  With the addition of the SciDoc documentation package 15 filtration parameters can be calculated, displayed, and documented providing the information and control you need for developing an optimized NFF process.

Lab scale normal flow filtration system

Biopharmaceutical manufacturers require precisely known liquid quantities for testing and process development but time spent measuring and dispensing liquids in the laboratory is expensive and adds no value to the final product.  Use of an automated system for accurately dispensing liquids saves time and labor allowing laboratory personnel to focus on value added tasks.
<h2>High precision, high accuracy automated liquid dispensing with the touch of a button</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s LabTec system is an automated liquid dispensing system allowing up to 10 user defined dispensing volumes to be established and accurately repeated at the touch of a button.  Accuracy is improved while laboratory technician’s time is saved by avoiding the need to repeatedly measure liquid amounts.  Accuracy of better than 1% is typically achieved.  The system can dispense by volume, or when connected to an electronic balance, by weight and weight ratio.  Dispensing by weight provides enhanced accuracy while dispensing by weight ratio saves even more labor by automatically dispensing the correct amount of fluid based on the weight of substance already in the vessel.  In this way, accurate dilutions can be made without the technician having to carefully measure either substance.  A roughly measured sample of one substance is added to the vessel and the correct amount of diluent is automatically dispensed based on the user defined required weight ratio.  When used with the SciDoc Documentation system the LabTec also compiles, displays and documents up to 10 process parameters providing real-time information about the dispensing progress and status.

Automated dispensing system for bioprocesses

Biopharmaceutical manufacturers are increasingly making use of Single-use pressure sensors to enhance efficiency, make equipment more versatile for use in a variety of processes, and decrease risk of cross contamination. Today even sensing technology enjoys the convenience and maintenance savings of disposable technology.
<h2>Accurate pressure sensing in a preprogrammed, easy set up, disposable package</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the bio pharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciPres system is single use pressure sensor that is easy to use, pre-calibrated, and ready for plug-and-play integration into your bio pharmaceutical production process.  The sensors are barcoded for traceability, medical grade, and NIST traceable.  They are accurate to +/- .02 bar at maximum allowable pressure of 4.1 bar.

Five sizes are available accommodating flow rates from 1 L/min to 60 L/min.  These sensors are compatible with may commonly used types of sanitation including, NaOH, NaCl, formaldehyde, autoclaving, and gamma irradiation.  Scilog has extensive experience developing single use sensors and these can be found used in a wide variety of bio-pharmaceutical process equipment.  They can also be integrated with the Sci-Pres monitor for stand-alone monitoring of up to three pressure sensor inputs.

Single-use pressure sensor

Biopharmaceutical manufacturers are increasingly making use of single-use conductivity sensors to enhance efficiency, make equipment more versatile for use in a variety of processes, and decrease risk of cross contamination. Today even sensing technology enjoys the convenience and maintenance savings of disposable technology.
<h2>Accurate electrolyte conductivity and temperature sensing in a preprogrammed, easy set up, disposable package</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciCon system is single use temperature and conductivity sensor that is easy to use, pre-calibrated, and ready for plug-and-play integration into your biopharmaceutical production process.  The sensors are barcoded for traceability, medical grade, and NIST traceable.  For conductivity they are accurate to +/- 2.5 mS of full range with range of 1 uS/cm to 200 mS/cm.  For temperature effective range is 4 -50 C with an accuracy of +/- 0.5 C.  Five sizes are available accommodating flow rates from 1 L/min to 60 L/min.  These sensors are compatible with may commonly used types of sanitization including, NaOH, NaCl, formaldehyde, autoclaving, and gamma irradiation.  Scilog has extensive experience developing single use sensors and these can be found used in a wide variety of biopharmaceutical process equipment.  They can also be integrated with the SciCon monitor for stand-alone monitoring and automated documentation using the SciDoc software package.

Single-use conductivity sensor

Biopharmaceutical manufacturers are increasingly making use of single-use temperature sensors to enhance efficiency, make equipment more versatile for use in a variety of processes, and decrease risk of cross contamination. Today even sensing technology enjoys the convenience and maintenance savings of disposable technology.
<h2>Accurate temperature sensing in a preprogrammed, easy set up, disposable package</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciTemp system is single use temperature sensor that is easy to use, pre-calibrated, and ready for plug-and-play integration into your biopharmaceutical production process.  The sensors are barcoded for traceability, medical grade, and NIST traceable.  Their effective temperature measurement range is -40 to 150 C with an accuracy of +/- 0.5 C in the 4 to 70 C range.  Five sizes are available accommodating flow rates from 1 L/min to 60 L/min.  These sensors are compatible with may commonly used types of sanitization including, NaOH, NaCl, formaldehyde, autoclaving, and gamma irradiation.  Scilog has extensive experience developing single use sensors and these can be found used in a wide variety of biopharmaceutical process equipment.  They can also be integrated with the SciTemp monitor for stand-alone monitoring of up to two temperature sensor inputs.

Single-use temperature sensor

Efficient harvest from the bioreactor is essential to any successful cell culture process but is often labor intensive as laboratory personnel closely monitor and adjust filtration process parameters.  Experienced bioprocessors know that investment in automation of the harvest process yields higher quality, enhanced safety, and better efficiency, giving them an edge over competitors.
<h2>Walk-away automation of your cell culture harvest process</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s HarvestClear filtration system is a combination of Scilog’s fluid handling technology and pressure sensing with a single use filtration manifold optimized to clarify high cell density bioreactor outputs.  Three sizes are available to accommodate bioreactor outputs from 1L to 20L.  The fluid handling system is based on an automated laboratory scale NFF system with electronic HMI and specialized software.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The system responds to sensor feedback to maintain user-defined filter back pressure or filtrate flow rates.  A disposable pressure sensors and optional integrated electronic scale are included as well as a programmable peristaltic pump allowing completely unattended NFF processing of bioreactor outputs to user specified parameters.  Filter manifolds are provided in a gamma-irradiated sterile and pre-flushed state ready for use.  Once the user defined parameters are entered, the system can run unattended freeing personnel to focus on other tasks.

Automated cell culture clarification system

Chromatographic monolithic columns for working with large proteins, viruses, VLPs and pDNA require the high structural strength and contamination protection usually provided by expensive medical grade stainless steel.
<h2>Separate complex biomolecules using strong, versatile multi-use columns</h2>
CIMmultus™ disposable monolithic columns from BIA Separations have the structural integrity and leachable profile of medical grade stainless steel, but the process economics of a single or multi-use device.

With the introduction of composite materials into an epoxy-based housing and the application of USP Class VI Parylene C coating to the entire column surface, CIMmultus™ columns offer safety and high performance.

CIMmultus™ columns can be used at any step in the separation process and, with their 2 µm flow-through channels allowing convective mass transfer, make a perfect choice for the purification of viruses, VLPs, plasmids, antibodies, PEGylated proteins and other large biomolecules.

Disposable monolithic columns

Samples taken at various process steps need to be analysed quickly and accurate results delivered, without affecting the state or condition of the original sample.
<h2>Understand a bioprocess through real-time monitoring</h2>
CIMac™ Analytical Columns from BIA Separations are short bed, high performance monolithic columns offering all the advantages of CIM® monolithic technology. They are primarily intended for fast, efficient, and reproducible separations of biomolecules like large proteins, plasmid DNA, and viral particles.

Small volume and short column length allow operation at high volumetric flow rates (from 1 to 30 column volumes/min), enabling product quantity and purity information to be available in just a few minutes.

The CIMac™ Analytical Columns are pre-packed in dedicated stainless steel housings and allow user-friendly connections to HPLC equipment, hence they can be effectively used for both the in-process and final control of various samples from different purification processes.

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Short bed monolithic columns for analytics

When developing a pDNA purification process for eventual transfer into production, efficient examination and selection of protocols is critical.
<h2>Develop plasmid purification procedures quickly</h2>
BIA Separations' CIMmultus™ HiP2 Plasmid Process Pack™ is intended to help scientists easily develop their pDNA purification process and transfer it to production.

Allowing developers to select only the relevant parts of the recommended protocol that best fits their needs, the pack saves time and money on all scales.

The CIMmultus™ HiP2 Plasmid Process Pack™ contains one weak anion-exchange (DEAE) and one hydrophobic (C4 HLD) column and a protocol describing the purification procedure of specific plasmids.

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Plasmid process pack for your pDNA purification process

To purify a specific large biomolecule, for example IgM or a virus or virus-like particle, the first step is to screen the working conditions. Different mobile phases and column chemistries are then tested, according to the biochemical properties of that particular large molecule.
<h2>Efficiently identify, isolate and recover large biomolecules</h2>
The CIMmultus™ Purification Screening Kit from BIA Separations is intended to help scientists quickly discover the optimal stationary phase chemistry for their particular application.

The kit includes two different 1mL CIMmultus™ ion-exchange columns (QA and SO3) and one hydrophobic interaction chemistry column (OH).

By using one of the selected chemistries and applying proper working conditions, the user will be able to discover the combination that will result in appropriate purity and excellent recovery of their required large biomolecule.

Purification screening kit for large biomolecules

Dry fogging provides safe, effective microbiological cleaning of critical areas in biotech, pharmaceutical and other industries where the highest levels of sterility are required. Let's find out if this compact disinfection system can serve you.


<h2>Thoroughly decontaminate exposed surfaces</h2>
The DosyMist by SolidFog uses H2O2 atomisation under controlled release to provide airborne decontamination and hinder the spread of bacterial growth on surfaces, filters, materials and equipment. A small, easy to manoeuvre unit made of medical grade stainless steel, the DosyMist digitally tracks its operation using Siemens PLC control for consistency of results. Designed to operate effectively on areas from 2 to 100 m³, this system has applications in the agri-food and pharmaceutical industries, health facilities, public and industrial premises and
research laboratories.

Compact H2O2 disinfection system

In the food industry, as an example, during lab-testing and studies, chromatography columns are used to detect and quantify spoilage indicators such as pyruvic acid in milk. In such cases, it is essential to make use of chromatography columns that possess great industrial compatibility. Having a tolerance for errors like accidental air, flow, and pressure variations proves to be critical during such practices as this will increase the margin for error that could fail a study, allowing for a wider spectrum of tests to be successfully carried out.
<h2>Mini radial chromatography columns for virus validation</h2>
The mini radial chromatography columns by Proxcys are robust, resulting in exceptional industrial compatibility due to their large tolerance for errors, like the entry of air, flow, and pressure variations. They are used to closely mimic full-scale radial processes with smaller bed volumes ranging between 3 and 30 centimeters.

The design of the Mini Column comes with an integrated valved packing port that results in an improved column overall performance and easy handling. The clear acrylic cylinder provides the conditions to study the behavior of the resin and bed build up during the column packing.

The use of the selected material in combination with the straight forward design eliminates the need for learning any time-consuming processes giving you the freedom to focus on further operations and testing.

Lab-scale radial chromatography columns for virus validation

In chromatography, you must always take into account the apparatus that is being utilized for particular processes to maximize success and limit the waste of resources. This makes disposable chromatography columns the ideal choice as they are made specifically for platform technologies and project campaign processing. Furthermore, small-scale development work or rapid scaled-down manufacturing are often performed by Single Use Prepacked Radial (SUPR) columns which are used to closely mimic full-scale radial processes that allow for a cost-effective quality outcome.
<h2>Single-use and Pre-packed columns for small development</h2>
The Single-Use-Pre-packed Radial columns (SURP columns) of Proxcys come in custom sizes ranging between lab volumes of 60ml and process size of 375L column volume with a flowrate of 0,005L - 200L per minute. The full cGMP compliant pilot or process column allows for fast processing in a plug-and play-mode. This means that there is no need for physical device configuration or user intervention in resolving resource conflicts when installed.

Pre-packed and qualified columns are available for use for extended periods in campaigns or dedicated projects. Once they serve their purpose, their unique disposable cartridge design helps towards minimizing waste and saving costs.

The SURP disposable column technology is available across various bed heights between 2 and 20cm and column volumes of up to 200L. The selected columns can be safely packed and qualified through the Proxcys packing report alongside the resin of choice.

Pre-packed and pre-validated chromatography columns

Radial flow chromatography processes require special attention and the right use of high-quality appliances in order to deliver upon specific laboratory requirements. This is where the bubble trap becomes an integral part of the process as it efficiently removes any unwanted gas or air bubbles in process fluids without providing areas where harmful bacteria could accumulate.
<h2>Bubble and gases bubble trap extractor</h2>
Bubble traps are an essential part of the pharmaceutical, food, and chemical industries that are responsible for the extraction of bubbles and gases from chromatographic processes and operations. Bubble traps are most often used in combination with Proxcys Radial Flow Chromatography columns or are simply installed inline onto piping, skids, or for stand-alone use via an expended foot.

The bubble traps are designed in accordance with customer requirement specifications and can range between volumes of 0.5L to 60L. Moreover, the bubble traps have various outlets and inlets that allow for the implementation of add-ons like an expanded feed for stand-alone use in laboratory environments. In general, the standard material of manufacturing is 316L stainless steel with a borosilicate glass cylinder. Additionally, onto the glass cylinder, a straight or at 90-degree elbow Tri-Clamp inlet and outlet to connect to piping are available for a wide range of process flows.

Still, it is completely optional to upgrade materials to a higher grade of steel. All of the materials that have been used come with the proper certifications for usage in pharmaceutical production.

Automated bubble traps for chromatography

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