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Maker - Product Challenge

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Industrial sampling equipment are systems that allow manufacturers to test (in other words to take a sample of) the products they are manufacturing. This process is generally implemented as a means of quality control but it can also be used as a mean to ensure that production processes adhere to certain regulatory standards. Quality control in your manufacturing process starts with precision sampling techniques. Automated systems deliver consistent samples at a pre-set rate for accurate testing and probing. Sampling technology uses a calibration system involving a series of sensors to extract the material at high levels of reliability.

Sampling

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

<span style="font-weight: 400;">An accurate and sterile sampling of cultures is vital throughout the biopharmaceutical development process. For constant, accurate monitoring, a reliable automated system is needed that transfers bioprocess samples directly from bioreactors to a range of analytical devices without intervention while maintaining the highest levels of sterility. For small-scale development, the availability of a more cost-effective entry-level system brings large economic advantages.</span>
<h2>Affordable automated bioreactor sampling</h2>
<span style="font-weight: 400;">The Seg-Flow 1200 Automated Bioreactor Sampling System from Flownamics is an economical alternative to the larger Seg-Flow 4800. It is available in two models, the Seg-Flow 1200 and the Seg-Flow 1200 Plus.</span>

<span style="font-weight: 400;">Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.</span>

<span style="font-weight: 400;">By incorporating a disposable, single-use flow path, the Seg-Flow 1200 is easy to use and requires little maintenance and no specialist operator training.</span>

<span style="font-weight: 400;">Samples can be collected from up to 2 reactors and delivered to 2 analyzers or collectors. Built-in expansion capability means this can be extended to 4 reactors with the Sample Module.</span>

<span style="font-weight: 400;">Integrated control functions such as an automated feed from an at-line glucose measurement can be quickly and easily implemented.</span>

<span style="font-weight: 400;">The Seg-Flow 1200 can be used with small laboratory vessels right up to large full-scale production vessels with 12, 19, and 25 mm models.</span>

<span style="font-weight: 400;">The unique Flownamics FISP filter probe used in the Seg-Flow 1200 ensures a sterile, cell-free sample can be taken from any vessel.</span>

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Entry-level automated online sampling system

<span style="font-weight: 400;">An accurate, automated sampling of cultures is a key requirement in the development of biopharmaceuticals. For automated sampling across a larger number of bioreactors, a robust and reliable automated system is needed to accurately transfer bioprocess samples directly to a range of analytical devices while maintaining the highest levels of sterility. For medium-scale operations, a cost-effective and efficient system is required to improve process performance.</span>
<h2>Automated multiple bioreactor sampling</h2>
<span style="font-weight: 400;">The Flownamics Seg-Flow 4800 is a fully automated online sampling solution for up to 8 bioreactor vessels. Using unique FISP cell-free sampling probes, the Seg-Flow can deliver accurate samples to up to 4 analyzers.</span>

<span style="font-weight: 400;">Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.</span>

<span style="font-weight: 400;">Rapid and accurate sampling is available for user-defined sample sizes from as little as 250 to 15 ml.</span>

<span style="font-weight: 400;">The internal Flow-Web web server logs data and information for each vessel or stream independently and allows viewing and control from any PC or mobile device.</span>

<span style="font-weight: 400;">The Seg-Flow features a single-use fluid path from the vessel to the analyzer to reduce operating and maintenance costs. The sample line is automatically cleaned or sterilized after each sample. The user-friendly operating system means minimal training is required, and setup is straightforward.</span>

<span style="font-weight: 400;">The Sefg-Flow’s highly flexible operating software can be tailored to your specific applications. It allows data to be saved in spreadsheet format or automatically exported to other software. System status and reporting can be quickly checked from any device with a browser and internet access.</span>

Automatic sampling system for bioprocess monitoring

<span style="font-weight: 400;">Accurate sampling is vital for improving a wide variety of industrial, chemical, and biofuel processes. A sampling solution that provides  24/7 automated, real-time analyte monitoring, fraction collection, feed control, and data processing will allow increased process performance and development to maximize performance.</span>
<h2>Automated sampling for up to eight vessels</h2>
<span style="font-weight: 400;">The Flownamics Seg-Flow 8000i is a fully automated online sampling system that offers multiple process monitoring and control solutions designed for biofuel, chemical or industrial processes.</span>

<span style="font-weight: 400;">The Seg-Flow’s patented segmented online sampling technology means rapid and accurate sampling for up to 8 vessels and sample delivery to up to 4 analyzers and/or fraction collectors. It uses a chemically inert fluid path with automated cleaning or sterilizing after each sample. </span><span style="font-weight: 400;">A number of feed control options are available for maximum flexibility, and the Seg-Flow 8000i can control up to 2 pumps per vessel.</span>

<span style="font-weight: 400;">The 8000i is scaled independent and can be used with laboratory, pilot, or production vessels. It utilizes the unique FISP in-situ sampling probe, which provides an aseptic barrier between the vessel and the Seg-Flow system. </span><span style="font-weight: 400;">The Seg-Flow features a built-in touchscreen HMI, providing control over many samples and feed options. The easy-to-use system requires minimal training and allows parameters to be programmed within minutes.</span>

<span style="font-weight: 400;">The internal Flow-Web web server logs data and information for each vessel or stream independently and allows viewing and control from any PC or mobile device.</span>

<span style="font-weight: 400;">Sefg-Flow’s highly flexible operating software can be tailored to your specific applications. It allows data to be saved in spreadsheet format or automatically exported to other software. System status and reporting can be quickly checked from any device with a browser and internet access.</span>

Online sampling system for larger scale bioprocesses

<span style="font-weight: 400;">Many bioprocesses require offline analysis of samples to monitor development and optimize performance. By using an automated fraction collector, the collection process can be accelerated and delivered with increased accuracy. Compatibility with automated reactor samplers is vital.</span>
<h2>Collect fractions from reactor vessels automatically</h2>
<span style="font-weight: 400;">The Flownamics FlowFraction is used in conjunction with the Flownamics Seg-Flow sampling systems. It allows the online collection of fractions from up to eight reactor vessels for further offline analysis of a range of bioprocesses.</span>

<span style="font-weight: 400;">The FlowFraction system is customizable to accommodate various tube types and sizes and can sample volumes from 250 µl to 50 ml. An added benefit is that vials can be equipped with a septum as a piercing option is available. For storage, racks in a range of standard sizes can be shipped with the FlowFraction, but custom rack sizes can also be produced to meet exact requirements.</span>

<span style="font-weight: 400;">A range of advanced options can be specified to meet your requirements perfectly, including temperature control modules featuring Peltier or water-based cooling systems. Using the options Seg-Flow Sample module, sample dilutions, and reagent additions can be performed before vial deposits.</span>

<span style="font-weight: 400;">Thanks to the included Flownamics WebFlow software, the interface allows easy control and data capture with minimal operator training. Maintenance time is reduced thanks to all internal fluid paths being self-cleaned after each sample.</span>

Online fraction collector for offline bioprocess analysis

<span style="font-weight: 400;">In biopharmaceutical and chemical industries, sampling is vital to develop, maintain, and improve processes. This needs to be done in aseptic conditions. The risk of contaminating either the test sample or the reactor can be eliminated by using a dedicated sampling probe designed to operate with the range of sample ports in use across all scales of production.</span>
<h2>Risk-free sampling for use with bioreactor top ports</h2>
<span style="font-weight: 400;">The Flownamics FISP F-Series is a dedicated sampling probe capable of withdrawing sterile, cell-free samples from fermenters and bioreactors with 12mm or 19mm top ports from lab scale up to production.</span>

<span style="font-weight: 400;">FISP is a sterilizable 316 stainless steel carrier that is surrounded by a tubular, microporous membrane.</span>

<span style="font-weight: 400;">FISP has been designed to withstand the temperatures, pressures, and chemicals found in fermentation environments and is perfect for aerobic or anaerobic bacteria, yeast, fungi, algae, insect, and mammalian cell cultures. Its design provides risk-free sampling thanks to a sterile barrier provided by its 0.2-micron filter. It offers the flexibility of being able to be used for submerged feeding or adding sterile media.</span>

<span style="font-weight: 400;">Compatible with Clean in Place (CIP), Sterilize in Place (SIP), and autoclaving, the FISP is easy to maintain and intuitive to use, with no specialist training required.</span>

<span style="font-weight: 400;">The FISP has been developed to work seamlessly with the Flownamics Seg-Flow range of automated samplers for use in fully automated test scenarios.</span>

Sampling probe for bioreactor samples

<span style="font-weight: 400;">Accurate, sterile sample collection is vital across a range of biopharmaceutical, chemical, and industrial processes. To eliminate the risk of contaminating either the culture or the sample, specially designed probes developed to withstand fermentation environments can deliver accurate, cell-free samples for monitoring and development.</span>
<h2>Risk-free sampling for use with bioreactor side ports</h2>
<span style="font-weight: 400;">The Flownamics FISP D-Series is a dedicated sampling probe capable of withdrawing sterile, cell-free samples from fermenters and bioreactors with 25mm side ports from lab scale up to production.</span>

<span style="font-weight: 400;">At the heart of FISP is a fully sterilizable carrier that’s encompassed by a specially designed micro-porous membrane. This has been designed to cope with the most extreme fermentation environments, and it’s ideal for use with anaerobic and aerobic bacterial cultures, yeasts and fungi, and mammal and insect cells.</span>

<span style="font-weight: 400;">With a 0.2 micron filter, FISP’s sterile barrier means zero-risk samples can be taken. Its robust design also means it can easily be used to add media or feeding of cultures. </span><span style="font-weight: 400;">FISP is simple to use and requires no additional operator training. It’s also simple to sterilize and can be used as an autoclave and</span><span style="font-weight: 400;"> manual sampling process. FISP is fully compatible with the Seg-Flow range - Flownamics’ automated sampling products.</span>

Sampling probe suitable for fermenter samples

<span style="font-weight: 400;">The ability to expand your automatic sampling solution provides increased flexibility and improved return on investment for your system. The addition of a precise sample distributor with enhanced features allows samples to be sent to an extended range of analyzers or other equipment.</span>
<h2>Enhanced sample distribution accessory for Seg-Flow automated samplers</h2>
<span style="font-weight: 400;">The Flownamics Sample-Mod 300 is an enhanced accessory that complements the popular Seg-Flow line of automated samplers.</span>

<span style="font-weight: 400;">Sample-Mod 300 allows for distribution of samples to a further 4 devices using a single-use fluid path via a zero dead volume syringe. It’s been engineered to deliver maximum precision.</span>

<span style="font-weight: 400;">The Sample-Mod enables sample dilution, including serial dilution, and allows for reagent addition for sample preparation. U</span><span style="font-weight: 400;">ltrasonic sensor for enhanced precision.</span>

Distributor of samples to different devices

<span style="font-weight: 400;">Automatic sampling of reactor vessels requires careful fluid management to achieve cell-free sampling. In high-density cultures or highly viscous media, this becomes even more important. A self-calibrating fluid control module can be added to sampling probes and automatic samplers that overcome these challenges and provides consistent sample quality.</span>
<h2>Increased fluid management for automatic samplers</h2>
<span style="font-weight: 400;">The Flownamics Seg-Mod 202 is a self-calibrating fluidic module for high cell density cultures.</span>

<span style="font-weight: 400;">Seg-Mod 202 mounts easily to the Flownamics FISP probes used with the trendy Seg-Flow line of automated samplers and uses ultrasonic sensors for increased accuracy and reliability.</span>

<span style="font-weight: 400;">The Seg-Mod calculates the fluidic pull on the probe to ensure accurate cell-free sampling. When it detects an increase in viscosity, it will decrease flow rates to maintain sample quality.</span>

<span style="font-weight: 400;">The unit is completely scale-independent, and it’s been designed to work with vessels from any manufacturer at scales from the lab through to full production.</span>

Fluid sample-taking module for high cell density cultures

Accurate sampling is a critical tool in the design and improvement of a large range of pharmaceutical bioprocesses. For maximum performance you need a robust and highly accurate automated sampling solution that delivers samples to your analysers 24/7 in real-time and can integrate with a large range of instrumentation.
<h2>Automated on-line sampler with increased reliability and ease of use</h2>
The Seg-Flow S3 from Flownamics is the latest generation in their line of automated samplers and has been built to deliver the perfect sampling solution for your most critical processes.

Designed for heavy-duty use, the Seg-Flow S3 has been engineered with increased robustness, featuring a highly durable powder-coated heavy-gauge steel construction. The integrated touchscreen GUI is bright and easy to use, with simple thumbnail navigation, and ideal for any lab environment. Bright LED lights offer “at a glance” status indication for easy monitoring.

Seg-Flow S3 offers complete flexibility to match your sampling needs. It can simultaneously sample from between one and eight vessels or process streams with cell-free or cell-containing samples, and then deliver to up to four analyzers or fraction collectors.

The S3 will automatically clean and/or sterilize the sample lines after every collection, removing cross-contamination risk entirely.

For process monitoring, the S3 can export data to any OPC-enabled DCS, PLC or PC, allowing easy performance data monitoring and analysis.

A wide range of feed control strategies can be programmed into the sampler, including setpoint and gravimetric. The S3 can control 2 feed pumps per vessel.

Fully Automated On-Line Sampling for Bioprocesses

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Getinge Applikon is the only company that can take you from the initial screening stage to full-scale production using the same platform. This minimizes scale-up risks and guarantees the shortest time to market for your new product development.

How can single use in biotech be sustainable, if you think of all the waste it creates? This might raise questions regarding the environmental impact. Let’s compare the complete life cycle of single-use systems such as tubing, capsule filters, chromatography devices, and bioreactors to their multi-use counterparts in glass or stainless steel and look at the outcome.

<h2>The end-of-life impact of single use tech</h2>
A product life cycle assessment compared single-use technologies to traditional multi use systems on points like resource extraction, processing, manufacturing, all through the end of the product life. Additionally environmental impact factors such as carbon, energy and water footprint were evaluated to paint a complete sustainable picture. Although disposal and waste remains a concern, the study found that this was actually only 1% of the total impact on the environment. Once put into use single use equipment presented a significantly lower impact resulting in <a href="https://cdn.cytivalifesciences.com/dmm3bwsv3/AssetStream.aspx?mediaformatid=10061&amp;destinationid=10016&amp;assetid=16801">a smaller overall end-of-life impact</a>.
<h2>Single use eliminates the need for cleaning in between batches</h2>
The most pressing finding is that the impact of chemicals, high purity waters and heat for cleaning and sterilization in between production batches is very high. Take for example a <a href="https://making.com/equipment/single-use-bioreactor">single use bioreactor</a> as shown in the video below; No need for extensive cleaning before the culture is started or after it’s finished and reducing the risk of cross contamination. Innovative technology such as 3D printing allows to create customizable products, while (re)creating exact replicas and keep desired process environments steady. Now officially stated as the more sustainable choice makes us understand why single systems are on the rise.

[embed]https://www.youtube.com/watch?v=RfPgrgw_wT8[/embed]

Is single use biotech equipment the more sustainable option?

Pharmaceutical

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Find production technology for Cell Culture Sampling, and connect directly with leading machine manufacturers worldwide

Cell Culture Sampling

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