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There are slight differences between human and animal pharmaceuticals, but that dissimilarity is enough to create new production challenges. Veterinary tablets formulation reflects the diversity of enzymes that different species use to break down substances. Although the methods involved are comparable to human drug manufacturing, equipment and processes need to adapt to a wider dosage variability in veterinary tablets.

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Veterinary pressing

Veterinary tablets drying

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Keep particle size of API above 10 μm for better flow

The geometric characteristics of the particles in your active pharmaceutical ingredients (API) mixture impact the tableting process. Reducing particle size is a double-edged sword. A smaller surface area favors solubility, but very fine particles become clumpy during manufacturing.

Size distribution of ≥250 μm typically achieves the desired free flow through the line. Ultra-fine API below 10 μm tend are more easily cohesive, resulting in a poor flow.

The ratio of flavorants must not be lower than one-fifth in veterinary tablets formulation.

Some ingredients have a bitter taste or a foul smell that produces an unpalatable aftertaste. The flavor of veterinary tablets is essential in manufacturing chewable dosages.

Flavorants such as sucrose, fructose, and aspartame offer a straightforward solution to offensive taste. But the ratio of the formulation is critical to mitigating intense aromas successfully. The concentration of flavorants needs to reach a minimum of 20% of the formulation.

Reduce processing time with a steam granulation technique

Granulation is a critical step in veterinary tablets formulation. Traditional wet and dry granulation techniques have different benefits depending on the properties of API particles.

Steam granulation is an alternative that combines the strengths of both methods and reduces processing time. A steam generator forms a water film around powder particles producing uniform agglomerates. The energy required to dry the granular matter is significantly lower than in the wet process. However, steam granulation is not suitable for thermolabile ingredients.

Use low-density excipients like iron in bolus formulations

The high ratio of active ingredients in a bolus compared to excipients makes its formulation more challenging. The composition of slow-release boluses, in particular, requires a higher concentration of drugs.

Excipients with a smaller density such as iron, clay, and dicalcium sulfate allow a greater API inclusion. The optimum range density of bolus formulation is 1.5 to 8.0.