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Insulin fermentation Equipment

The fermentation process stimulates enzymatic activity in organic substrates to transform their chemical composition. Fermentation is aided by storying the biomaterials in anaerobic environments, allowing the microorganisms to decompose their nutrient structures. The process is integral to some of the most popular products throughout time such as wine, beer, cheese, and kimchi. But besides the food sector, fermentation is also an important stage in the industrial manufacturing of chemicals, pharmaceuticals, and biofuels.

Fermentation

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

Sensitive bioprocess applications requires equipment that will not interfere with the chemical and biological processes being carried out.  At the same time, production bioprocesses, in particular those that involve peristaltic pumping, require robust tubing not prone to wear or mechanical failures.  Traditional transfer tubing for these more rigorous ans sensitive bioprocesses often proves inadequate.


<h2>A robust biocompatible tube designed for longevity in production peristaltic pumping applications</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company offers tubing solutions specifically designed for use in peristaltic pumps in bioprocess production environments. The tubes are of the PharMed BPT brand and are completely bio-compatible and less permeable to gasses and vapors than traditional silicone tubes.  This makes the PharMed BPT tubes ideal for protecting sensitive biological processes like cell culture, fermentation, separation, synthesis, and purification.  At the same time, they have been formulated for enhanced flex and wear characteristics allowing trouble free used in peristaltic pumping applications.  The combination of these qualities increases the efficiency of the bio-production process by reducing down time from tubing failure without making any sacrifices in bio compatibility.

Biocompatible tubing for peristaltic pumps

In pharmaceutical production, scaling up from laboratory research to commercial production involves specific equipment for microbial culture fermentation. This process requires strict regulatory compliance and the ability to handle various bacteria strains under controlled conditions.
<h2>Scale up microbial culture fermentation efficiently</h2>
The Biological Fermentation Tank by Austar addresses these needs with its comprehensive range, offering volumes from 5 to 30 kiloliters. This allows for smooth transitions from pilot-scale projects to commercial production. The tanks are designed in accordance with GMP regulations and ASME-BPE requirements, meeting pressure vessel standards worldwide, including ASME-U, GB150, and PED. The specialized, user-friendly, and modular design supports high oxygen-consuming bacteria such as E. coli and Pichia pastoris. This makes it suitable for the production of biological drugs like recombinant proteins (e.g., insulin) and vaccines (e.g., HPV, pneumococcal vaccine).

Biological fermentation tank for pharmaceutical production

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Insulin fermentation

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Insulin fermentation Equipment

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Biocompatible tubing for peristaltic pumps

Biological fermentation tank for pharmaceutical production

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