Let's make suppositories
Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.
What suppositories equipment do you need?
Granulation line for pharmaceutical solid dosage forms
Granulation is a common technique in production of pharmaceutical ...
Industrial scale tablet coater
During the coating process, tablets pass many stages that can make them wet and sticky or cra...
Fluid bed dryer for pharmaceutical solid dosage form
Fluid bed drying is a pharmaceutical process carried out to reduce t...
Industrial high shear mixer granulator for drug formation
It is rather difficult to successfully produce a pharmaceutica...
Tablet coater for laboratory scale
Tablet coating can be applied for adding colours or glosses, or based around sugar in or...
Automatic filling line for solid doses
For medium-scale production of solid doses such as tablets, capsules, and softgels t...
Automatic capsule loader
Capsules are a popular method of dosage delivery for a wide range of compounds. For anything other t...
Electronic capsule counter
For lab work or small batch production, hand counting of solid doses into dispensing containers i...
Suppository filling machine
Small-to-medium scale production of suppositories using pre-formed shells can be slow where manu...
Capsule checkweigher
The production of pharmaceutical capsules requires that individual doses are checked for accuracy. In a ...
Conical mill for drug formulation
The efficient size reduction of granular powders is a key step in many pharmaceutical pro...
Granulation line of mixer and fluid bed dryer
A complete granulation line allows for the mixing and granulation of pharmac...
Microencapsulation system for your drug delivery system
Whether you want to improve the stability of nutrients, protect a...
Rotary tablet press
For pharmaceutical tablet producers looking to reduce waste, costs and increase production volume, a hig...
Fluid bed dryer for production scale
Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for dryi...
High-shear mixer
For the efficient mixing of larger batches of pharmaceutical compounds and high-shear mixer provides the opti...
Entry-level high-shear mixer for drug formulation
For pilot and lab-scale pharmaceutical formulations, a high-shear granu...
Economic dispersing machine for emulsions and suspensions
For products of medium viscosity and relatively consistent par...
Ultra-fine dispersing machine for emulsions and suspensions
Producing the finest micro-emulsions and suspensions require...
Laboratory dispersing machine for low-viscous masses
Laboratory mixers have not always been easy to work with. Getting a...
High-speed blister machine
If you are looking for a compact machine that produces blisters with an output of up to 700 blist...
Horizontal intermittent motion cartoner
User-friendly cartooning solution with an intermittent motion for a wide range of p...
Horizontal continuous motion cartoner
An automatic cartoning machine designed for both high-speed operations and medium pac...
Entry-level blister machine
A start-up solution for contract packing and generics manufacturing with an easy-to-get upgrade ...
Compact blister machine
A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...
Case packer for cartons and bundles
Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...
Stretch bander
A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.
Vertical cartoner
A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...
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Manufacture suppositories by fusion molding or double casting
Most suppositories are produced by fusion molding. In this process, you melt the excipient base and mix in the active pharmaceutical ingredients. After the formula has cooled off, suppositories are ready for packing.
Double casting introduces a new approach to suppository manufacturing. To do this, you need to re-melt and re-form the original mixture of medication and excipient. The method ensures a more even distribution of the active ingredients and adjusts the composition according to the volume density of the drugs.
Calculate the temperature range of suppository excipients
The formulation of suppositories depends on your intended speed of drug delivery. To control the release of the medicinal, you need to consider the melting range at which the excipient material starts to melt and is completely dissolved.
The solidification point presents another crucial manufacturing factor and determines the storage and refrigeration conditions required to keep the finished product in optimum condition.
Cocoa butter for your suppository base
A majority of formulations use theobroma oil (cocoa butter) as a base for suppositories. It is relatively easy to form, melts at body temperature, and is nonreactive. Like other fat-based excipients, however, it may liquefy when combined with certain types of drugs.
Water-based alternatives do not depend on body temperature to release the active ingredients. Instead, materials such as glycerinated gelatin or polyethylene glycol (PEG) dissolve in body fluids.
Suppositories bypass the digestive system for higher effectiveness
Suppositories offer an effective way of treating the local areas where they are administered. But they can also be designed to deliver medicine to other parts of the body directly through the bloodstream.
This curing method is recommended by physicians to prevent active agents from breaking down too quickly in the gut or being altered in the gastrointestinal tract.
Processing steps involved in suppositories making
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