Let's make suppositories

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Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.

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Manufacture suppositories by fusion molding or double casting

Most suppositories are produced by fusion molding. In this process, you melt the excipient base and mix in the active pharmaceutical ingredients. After the formula has cooled off, suppositories are ready for packing.

Double casting introduces a new approach to suppository manufacturing. To do this, you need to re-melt and re-form the original mixture of medication and excipient. The method ensures a more even distribution of the active ingredients and adjusts the composition according to the volume density of the drugs.

Calculate the temperature range of suppository excipients

The formulation of suppositories depends on your intended speed of drug delivery. To control the release of the medicinal, you need to consider the melting range at which the excipient material starts to melt and is completely dissolved.

The solidification point presents another crucial manufacturing factor and determines the storage and refrigeration conditions required to keep the finished product in optimum condition.

Cocoa butter for your suppository base

A majority of formulations use theobroma oil (cocoa butter) as a base for suppositories. It is relatively easy to form, melts at body temperature, and is nonreactive. Like other fat-based excipients, however, it may liquefy when combined with certain types of drugs.

Water-based alternatives do not depend on body temperature to release the active ingredients. Instead, materials such as glycerinated gelatin or polyethylene glycol (PEG) dissolve in body fluids.

Suppositories bypass the digestive system for higher effectiveness

Suppositories offer an effective way of treating the local areas where they are administered. But they can also be designed to deliver medicine to other parts of the body directly through the bloodstream.

This curing method is recommended by physicians to prevent active agents from breaking down too quickly in the gut or being altered in the gastrointestinal tract.