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Cell Culture Purification Equipment

Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Purification

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

Sensitive bioprocess applications requires equipment that will not interfere with the chemical and biological processes being carried out.  At the same time, production bioprocesses, in particular those that involve peristaltic pumping, require robust tubing not prone to wear or mechanical failures.  Traditional transfer tubing for these more rigorous ans sensitive bioprocesses often proves inadequate.


<h2>A robust biocompatible tube designed for longevity in production peristaltic pumping applications</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company offers tubing solutions specifically designed for use in peristaltic pumps in bioprocess production environments. The tubes are of the PharMed BPT brand and are completely bio-compatible and less permeable to gasses and vapors than traditional silicone tubes.  This makes the PharMed BPT tubes ideal for protecting sensitive biological processes like cell culture, fermentation, separation, synthesis, and purification.  At the same time, they have been formulated for enhanced flex and wear characteristics allowing trouble free used in peristaltic pumping applications.  The combination of these qualities increases the efficiency of the bio-production process by reducing down time from tubing failure without making any sacrifices in bio compatibility.

Biocompatible tubing for peristaltic pumps

Single use bags for biopharmaceutical process containment and liquid storage are being used with increasing frequency in the industry due to their convenience, efficiency, and inherent cleanliness.  Integration of single use bags into biopharmaceutical processes is a great way to reduce required maintenance, and improve the versatility of equipment without increasing risk of cross contamination.
<h2>A mobile, vertical bag holder with integrated scale compatible with bags from any manufacturer</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs. The company’s WeighStation system is a wheeled bag stand that works with single use bags from any manufacturer.  The system includes integrated load cells and local display which allow it to be used as a stand-alone scale or to be integrated into other Scilog processing platforms for metered dispensing and purification.  The system has a minimized footprint and superior mobility when compared to a traditional floor scale.  The mobility and use of single use bags allow this piece of equipment to support several processes in your facility rather than being dedicated to just one.

Bag holder and weighing platform for bioprocesses

Chromatographic monolithic columns for working with large proteins, viruses, VLPs and pDNA require the high structural strength and contamination protection usually provided by expensive medical grade stainless steel.
<h2>Separate complex biomolecules using strong, versatile multi-use columns</h2>
CIMmultus™ disposable monolithic columns from BIA Separations have the structural integrity and leachable profile of medical grade stainless steel, but the process economics of a single or multi-use device.

With the introduction of composite materials into an epoxy-based housing and the application of USP Class VI Parylene C coating to the entire column surface, CIMmultus™ columns offer safety and high performance.

CIMmultus™ columns can be used at any step in the separation process and, with their 2 µm flow-through channels allowing convective mass transfer, make a perfect choice for the purification of viruses, VLPs, plasmids, antibodies, PEGylated proteins and other large biomolecules.

Disposable monolithic columns

Samples taken at various process steps need to be analysed quickly and accurate results delivered, without affecting the state or condition of the original sample.
<h2>Understand a bioprocess through real-time monitoring</h2>
CIMac™ Analytical Columns from BIA Separations are short bed, high performance monolithic columns offering all the advantages of CIM® monolithic technology. They are primarily intended for fast, efficient, and reproducible separations of biomolecules like large proteins, plasmid DNA, and viral particles.

Small volume and short column length allow operation at high volumetric flow rates (from 1 to 30 column volumes/min), enabling product quantity and purity information to be available in just a few minutes.

The CIMac™ Analytical Columns are pre-packed in dedicated stainless steel housings and allow user-friendly connections to HPLC equipment, hence they can be effectively used for both the in-process and final control of various samples from different purification processes.

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Short bed monolithic columns for analytics

When developing a pDNA purification process for eventual transfer into production, efficient examination and selection of protocols is critical.
<h2>Develop plasmid purification procedures quickly</h2>
BIA Separations' CIMmultus™ HiP2 Plasmid Process Pack™ is intended to help scientists easily develop their pDNA purification process and transfer it to production.

Allowing developers to select only the relevant parts of the recommended protocol that best fits their needs, the pack saves time and money on all scales.

The CIMmultus™ HiP2 Plasmid Process Pack™ contains one weak anion-exchange (DEAE) and one hydrophobic (C4 HLD) column and a protocol describing the purification procedure of specific plasmids.

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Plasmid process pack for your pDNA purification process

To purify a specific large biomolecule, for example IgM or a virus or virus-like particle, the first step is to screen the working conditions. Different mobile phases and column chemistries are then tested, according to the biochemical properties of that particular large molecule.
<h2>Efficiently identify, isolate and recover large biomolecules</h2>
The CIMmultus™ Purification Screening Kit from BIA Separations is intended to help scientists quickly discover the optimal stationary phase chemistry for their particular application.

The kit includes two different 1mL CIMmultus™ ion-exchange columns (QA and SO3) and one hydrophobic interaction chemistry column (OH).

By using one of the selected chemistries and applying proper working conditions, the user will be able to discover the combination that will result in appropriate purity and excellent recovery of their required large biomolecule.

Purification screening kit for large biomolecules

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Getinge Applikon is the only company that can take you from the initial screening stage to full-scale production using the same platform. This minimizes scale-up risks and guarantees the shortest time to market for your new product development.

How can single use in biotech be sustainable, if you think of all the waste it creates? This might raise questions regarding the environmental impact. Let’s compare the complete life cycle of single-use systems such as tubing, capsule filters, chromatography devices, and bioreactors to their multi-use counterparts in glass or stainless steel and look at the outcome.

<h2>The end-of-life impact of single use tech</h2>
A product life cycle assessment compared single-use technologies to traditional multi use systems on points like resource extraction, processing, manufacturing, all through the end of the product life. Additionally environmental impact factors such as carbon, energy and water footprint were evaluated to paint a complete sustainable picture. Although disposal and waste remains a concern, the study found that this was actually only 1% of the total impact on the environment. Once put into use single use equipment presented a significantly lower impact resulting in <a href="https://cdn.cytivalifesciences.com/dmm3bwsv3/AssetStream.aspx?mediaformatid=10061&amp;destinationid=10016&amp;assetid=16801">a smaller overall end-of-life impact</a>.
<h2>Single use eliminates the need for cleaning in between batches</h2>
The most pressing finding is that the impact of chemicals, high purity waters and heat for cleaning and sterilization in between production batches is very high. Take for example a <a href="https://making.com/equipment/single-use-bioreactor">single use bioreactor</a> as shown in the video below; No need for extensive cleaning before the culture is started or after it’s finished and reducing the risk of cross contamination. Innovative technology such as 3D printing allows to create customizable products, while (re)creating exact replicas and keep desired process environments steady. Now officially stated as the more sustainable choice makes us understand why single systems are on the rise.

[embed]https://www.youtube.com/watch?v=RfPgrgw_wT8[/embed]

Is single use biotech equipment the more sustainable option?

Pharmaceutical

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Find production technology for Cell Culture Purification, and connect directly with leading machine manufacturers worldwide