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Microtablets drying Equipment

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

It is not always possible to duct out the wet air from a dehumidifier servicing an enclosed facility. In such cases, the water is condensed out from the wet air flow and disposed off through a floor drain or a pump.


<h2>Dehumidify at sub-zero dew points with an air-chilled condensation dehumidifier</h2>
AQUASORB dehumidifiers from Seibu Giken function as a Consorb but condense the wet air flow in an air-chilled condensor instead of being lead out. These dehumidifiers have a high dry airflow, which improves the drying effect. It incorporates a next generation, washable, D-MAX silica gel dessicant rotor.

The chassis is made of stainless steel which is especially important in condensing units to prevent corrosion. Aquasorb can operate at dew points below 0°C. The fan for dry air and cool air helps accumulate the energy in the dry air.

Capacity
AQUASORB A-30B/BP: 0.5kg/h*, dry air flow rate: 400m3/h
* at 20°C and 60%RH

Sorption dehumidifier with air-chilled condenser

Water damaged areas require dehumidification to limit the damage and prepare the area for restoration. A handy, portable dehumidifier that is easy to setup and works silently is ideal for such applications. Dehumidifying can be particularly problematic in tropical conditions with high ambient humidity.


<h2>A small portable dehumidifier fit for climates with high humidity</h2>
The CONSORB CS series dehumidifiers from Seibu Giken use the Consorb principle. They are ideal for facilities with surplus heat or when dehumidifying very damp air. They are also useful when there is a large difference in moisture content between process and regeneration air inlets. Consorb CS dehumidifiers are fitted with a self regulating heater and a high quality, washable, D-MAX silica gel rotor.

The CONSORB CS has been designed as a very silent, compact and handy dehumidifier that can be easily placed indoors and in smaller areas. The corrosion resistant chassis is made of stainless steel. CS units deliver high performance in all climates.

Capacity
CS-5/-5L: 0.35 - 0.4kg/h*, dry air flow rate: 65 - 90m3/h
* at 20°C and 60%RH

Small portable dehumidifier

Small, humid areas can be difficult to dehumidify in humid ambient conditions such as those in tropical climates. A large difference in moisture content between process and regeneration air can be problematic during dehumidification. Processing and storage facilities that require deep drying can be especially difficult to dehumidify in these conditions.


<h2>Dehumidify areas with a large difference between incoming and required moisture content</h2>
The CONSORB DC series dehumidifiers from Seibu Giken use the Consorb principle. They are ideal for facilities with surplus heat or when dehumidifying very damp air. They are also useful when there is a large difference in moisture content between process and regeneration air inlets. DC dehumidifiers incorporate the new generation of high quality, washable, silica gel desiccant D-MAX rotor

DC series units are small, portable and light-weight with the smallest units weighing as little as 15Kgs. They have a maintenance-friendly, rust free, stainless steel chassis. The DC range offers a self-regulating heater and a protected control panel.

Capacity
DC-10: 0.6kg/h*, dry air flow rate 190m3/h
DC-20/30 T10, T16: 1.1 – 1.5kg/h*, dry air flow rate 310 - 400m3/h
* at 20°C and 60%RH

Sorption dehumidifier for large temperature differences

Humid ambient conditions such as those in tropical climates make dehumidification more challenging as there is a large difference in moisture content between process and regeneration air. Processing and storage facilities that require deep drying can be especially difficult to dehumidify in these conditions.


<h2>Dehumidify very damp air in tropical climates with deep drying</h2>
The CONSORB CZ series dehumidifiers from Seibu Giken use the Consorb principle. They are ideal for facilities with surplus heat or when dehumidifying very damp air. They are also useful when there is a large difference in moisture content between process and regeneration air inlets. CZ dehumidifiers incorporate the new generation of high quality, washable, silica gel desiccant D-MAX rotor

CZ series units can work with hot water for regeneration or with water in combination with an electric heater. In addition, electricity, steam and gas can also be used for regeneration. The CZ dehumidifiers are made with aluzinc and have an excellent deep drying ability. An ICE-version with higher process airflow, ideal for re-circulating installations, is also available.

Capacity: 22 – 69kg/h*,dry air flow rate 3,200 – 8,000m3/h
* at 20°C and 60%RH

Sorption dehumidifier for deep drying

Sealed rooms can be challenging to dehumidify with ordinary dehumidifiers. The wet air needs to be recycled and water removal must be by way of condensation. Condensing units can have high energy requirements if heat is not properly recycled.


<h2>Dehumidify sealed rooms and wet airflows efficiently</h2>
FRIGOSORB dehumidifiers from DST Seibu Giken are built on the patented Frigosorb sorption technology. These dehumidifiers are very energy efficient due to their heat pump function and use approximately one-third of the total energy consumption of regular sorption dehumidifiers. They incorporate the new generation of high quality, washable, silica gel desiccant D-MAX rotor

The F-31 unit works well at low temperatures. The chassis is made of stainless steel which prevents corrosion in condensing units. It is especially suited for sealed rooms as it condenses out the water. Applications include sealed pharmaceutical and health facilities, food processing and storage of sensitive goods.

Capacity:
F31: 1.1kg/h*, dry air flow rate 850– 400m3/h
* at 20°C and 60%RH

Dehumidifier for difficult wet airflows

Small humid spaces, used for processing or storage, often need a simple dehumidification solution. A single-phase powered dehumidifier with a compact, maintenance friendly design is ideally suited to these situations. Energy efficiency and low noise level operation are also important when working in small spaces.


<h2>Dehumidify small rooms with light weight &amp; efficient heat recycling technology</h2>
RECUSORB DR series dehumidifiers are built on the DR sorption technology from DST Seibu Giken. They incorporate the new generation of high quality, silica gel desiccant D-MAX rotor, a self regulating heater and integrated heat recycling technology. Heat is recycled, to pre-heat and partly dehumidify the incoming air. It uses a fan for both the dry airflow and the wet airflow making installation simpler in rooms with over pressure. They are also suitable for achieving very low dew points.

DR series dehumidifiers are suitable for small storage areas, archives, museums and other small spaces. The single-phase, compact DR-units have a stainless steel construction and offer a long life of robust performance.

They are available in the following capacities:
DR-31 T10: 1.6kg/h*, dry air flow rate 310m3/h
DR-40 T10/T16: 1.6-2.8kg/h*, dry air flow rate 550– 600m3/h
DR-010B: 0.5kg/h*, dry air flow rate 190m3/h
* at 20°C and 60%RH

Sorption dehumidifier for overpressured rooms

Facilities that handle large amounts of water can become very humid. High humidity may lead to corrosion in installed machinery and control systems. A dehumidifier is necessary to protect the installed machinery in these cases. The dehumidifier itself must have a robust construction to withstand these harsh conditions.


<h2>Dehumidify medium sized spaces with robust heat recycling technology</h2>
RECUSORB R series dehumidifiers are built on the Recusorb R sorption technology from DST Seibu Giken. They incorporate a washable, silica gel desiccant rotor and integrated heat recycling technology. Heat absorbed during rotor regeneration is recycled to pre-heat and partly dehumidify the incoming air.

The compact R-units have a stainless steel construction and offer a long life of robust performance in both indoor and outdoor settings. They are suitable for small to medium sized storage and processing facilities as well as museums, power plants and pumping stations.

The R series dehumidifiers are available in the following capacities:
R-060BR: 4.6kg/h*, dry air flow rate 1,000m3/h
R-51/61R: 7.3-10kg/h*, dry air flow rate 1,250– 1,450m3/h
* at 20°C and 60%RH

Heat recycling sorption dehumidifier

Dehumidification of medium sized manufacturing and processing facilities can be a daunting task considering the setup and maintenance effort associated with ordinary dehumidifiers. A compact dehumidifier, that's energy efficient and easy to setup and maintain, can greatly simplify the dehumidification process while lowering costs.


<h2>Dehumidify medium sized facilities with compact, service friendly, energy efficient technology</h2>
RECUSORB RL industrial dehumidifiers are built on the Recusorb R sorption technology from DST Seibu Giken. They incorporate the new generation of high quality, silica gel desiccant D-MAX rotor and integrated heat recycling technology. Heat absorbed during rotor regeneration is recycled to pre-heat and partly dehumidify the incoming air.

The compact RL-units are easy to service with easy access to filters, rotor and seals. Optional features include linear capacity control and frequency inverter to control airflows. They are suitable for extending life of stored products in small to medium sized warehouses, preventing condensation in cold stores &amp; ice rinks and ensuring desired ambient humidity in manufacturing facilities.

The RL series dehumidifiers are available in the following capacities:
RL-60R/LR : 4-5kg/h*, dry air flow rate 850– 1,000m3/h
RL-71R/ ICE/ LR: 13-17kg/h*, dry air flow rate 2,500– 3,200m3/h
* at 20°C and 60%RH

Industrial desiccant dehumidifier

Moisture sensitive processing and storage facilities need low humidity environments to safequard the quality of products. Large spaces require specialized dehumidifiers that have the necessary capacity and good energy efficiency to keep costs at a minimum. An industrial, automated humidity control system is best suited for these applications.


<h2>Dehumidify large facilities with high efficiency heat recycling technology</h2>
RECUSORB RZ industrial dehumidifiers are built on the Recusorb R sorption technology from DST Seibu Giken. They incorporate a silica gel desiccant rotor and integrated heat recycling technology. Heat absorbed during rotor regeneration is recycled to pre-heat and partly dehumidify the incoming air. They are available with electric, steam or gas reactivation.

RZ dehumidifiers have an aluzinc construction and offer multiple PLC control options. They are available in the capacity range 19 - 65kg/h (at 20°C / 60%RH) and dry air flow rate 2,800 – 10,500 m3/h. Some applications include preventing clumping of dried foods during processing, protecting hygroscopic materials in pharma manufacturing, excluding moisture during packaging, extending life of warehoused products and preventing condensation in cold stores and ice rinks. They are also available in an ICE-version with higher process airflow, ideal for re-circulating installations.

Large scale desiccant dehumidifier

Dehumidification needs can vary significantly from one project to another. Dehumidifiers with a fixed configuration therefore do not always fit your needs. A flexible dehumidification system that can be tailored to meet your requirements from basic desiccant dehumidification to a complete climate control system becomes useful in this situation.


<h2>Dehumidify with a customized solution that fits your processing needs</h2>
FLEXISORB from DST Seibu Giken is a versatile industrial dehumidifying system that can be configured to meet your particular needs. Flexisorb dehumidifiers use the Recusorb R sorption technology which incorporates a silica gel desiccant rotor and integrated heat recycling. Heat is absorbed during rotor regeneration and recycled in the “purge zone” where incoming air is pre-heated and partly dehumidified.

Flexisorb systems are available in the capacity range 19 - 300kg/h (at 20°C / 60%RH) and dry air flow rate of 900 – 61,100 m3/h. Options include pre-cooling, post-cooling and post-heating. Flexisorb has an anodized aluminum frame with a smooth interior design and external locks. Some applications include preventing clumping of dried or powdered foods during processing, protecting hygroscopic materials in pharma manufacturing, excluding moisture during packaging and extending life of warehoused products.

Customizable dehumidifier

<span style="font-weight: 400;">A complete granulation line allows for the mixing and granulation of pharmaceutical compounds for the production of tablets. By linking fully compatible milling, mixing and fluid bed machinery with vacuum conveying it provides a turnkey solution for preparation of powder doses ready for pressing into tablets.</span>
<h2>Complete solution for preparation of granular pharmaceutical compounds for tablets</h2>
<span style="font-weight: 400;">Sejong Pharmatech’s Granulation Line is the most cost-effective way to achieve a turn-key granulation solution for the manufacture of pharmaceutical compounds for tablet preparation.</span>

<span style="font-weight: 400;">The granulation line consists of the Sejong CM series production scale conical mill, the Sejong M series production-scale speed mixer, the Sejong D series production scale fluid bed dryer and an optional vacuum conveyor system for the creation of a completely closed line environment.</span>

<span style="font-weight: 400;">Designed for total compatibility, these devices work together seamlessly to provide the perfect input for tablet pressing machines. When buying as a line package, significant cost savings can be made compared to sourcing individual machines.</span>

<span style="font-weight: 400;">The optional vacuum conveyor removes the need for manual handling between processes, and ensure a clean and safe transfer of powders between process stages.</span>

<span style="font-weight: 400;">All the Sejong machinery is manufactured with ergonomics and ease of use in mind, and the touch screen HMI’s are fully 21CFR part 11 compliant.</span>

Granulation line of mixer and fluid bed dryer

Pharmaceutical industries employ several processes including drying, coating and granulation to create high-quality granules. Manufacturers can benefit from a single system that can complete all of these tasks simultaneously, increasing production yield without sacrificing the quality of the final product.


<h3>Coating, granulation, and drying granules by tangential fluid bed method</h3>
The Fluidized Bed System BFS from Bohle, is a system that can perform multiple processes such as coating, granulation, and drying to turn fine solids and dry powders into granules. The cone is equipped with a specially slotted air distributor plate which allows complete fluidization of particles while the tangential motion helps in achieving a uniform coating without the particles adhering to one another. Due to a relatively low fluidization height, the system does not require a high-volume expansion saving costs and production floor space.

The system can also be equipped with an online moisture measurement system using NIR technology to precisely identify moisture levels during the granulation and drying. The BFS has at least 6 filter elements that can be cleaned separately and ensure good uninterrupted airflow. To make it simple to use, the entire system is PLC controlled.

Fluidized bed system for the granulation and drying of pharmaceuticals

Pharmaceutical laboratories need compact equipment to handle and produce small amounts of granules from a mixture of wet and dry elements for R&amp;D applications. Furthermore, the granulation process requires short residence times in drying the products to easily identify and remove the defects without discarding the entire batch.


<h2>Automatic feeding, granulating, and quick drying of pharmaceutical  products</h2>
The QbCon 1 from L.B. Bohle is a continuous wet granulating and drying system for pharmaceutical laboratory scale applications. The system performs three processes: feeding, granulating, and drying. It features a twin screw granulator with a hinged barrel for easy access to its parts. The unit comes with a multi-position feeder and interchangeable ports, ensuring accurate gravimetric feeding of dry powder and using a pulsation-free pressurized feeder for granulation liquid.

The wet granules are gently dried by a moving fluid bed that provides short residence times and consistent product output. Its narrow residence time distribution allows easy traceability from the initial product to the final tablet or vice versa. The drying process parameters, such as airflow, temperature, and conveying speed, can be controlled and adjusted according to product requirements. The system allows for sampling wet and dry granulations without interrupting the ongoing processes. The system also has an innovative filter cleaning system to prevent clogging for longer hours of operation. The unit also features a complete WIP (Wash-in-Place) cleaning.

Continuous wet granulator and dryer for R&D

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

L.B. Bohle is a technology leader in machines, systems and processes for the pharmaceutical, chemical, food and nutraceutical industries. Our focus is on equipment for tablet manufacturing.

Continuous wet granulation and drying have been widely discussed in pharmaceutical research and development (R&amp;D) and industry. Daniel Emanuele from the Dortmund University of Applied Sciences and Robin Meier from L.B. Bohle set out to test if the QbCon® 1 from L.B. Bohle is suitable for extended process times and meets the quality standards of the market.


<h2>The research zoomed into three metrics</h2>
The research focused on measuring moisture content, residence time distribution, and granule size distribution of the granulator and dryer. The results indicate that the dryer achieves very precise and consistent residence time distributions, resulting in uniform drying of granules across different size categories. The process consistently produces granules with the desired moisture content and particle size over extended periods. By adjusting the conveying speed of the granules in the dryer while keeping other parameters constant, the researchers were able to determine the limits for specific process/formulation combinations, primarily influenced by the depth of the fluid bed.

The ability to monitor the process in real time makes the QbCon® 1 an ideal choice for introducing continuous wet granulation, especially with its innovative drying process.

See it in the video!

[embed]https://youtu.be/XRyCPRNM9jE[/embed]

&nbsp;

Scientifically tested continuous drying for your tablets

Pharmaceutical

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Manufacturing pharmaceutical solids like tablets requires using a proper blender to blend dry powders into a homogenous mixture. Having a blender that can accommodate various blending container sizes allows easy adjustment of the production volume.


<h3>Blending homogenously dry powder batches using a stationary blending device</h3>
The Container Blenders PM from Bohle is a blending system for fine solids and powders in pharmaceutical applications. The system features a wide variety of blending containers with various capacities that can handle square or round containers. Each blending container can be used to mix powders effectively at a range between 20% to 85% of its total container volume for densities ranging from 0.2 to 1.2 kg/L. The blending process is done in a closed system; each container has an inner lid for filling.

The blending system rotates at 6 rpm with an option to increase the speed depending on process requirements. It can be equipped with a chopper that operates at a speed of approximately 750 rpm to break solid lumps and chop small amounts of ingredients.

Product changeover can be done quickly by simply exchanging the blending container. The entire system can also be used as a milling station for bin-to-bin product transfer.

Container blender for pharmaceuticals

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

Whether you are making pharmaceuticals, chemicals, or nutraceuticals, you will need to blend your ingredients. Depending on your product and production needs, finding a suitable blender is the utmost priority, but it can prove to be a challenge. L.B. Bohle has tackled the need and come out with a wide array of blenders, adjustable for your processing needs and goals.


<h2>Five solutions to fit your needs</h2>
Their portfolio of blenders can be scaled up to 12,000 liters with standard exchangeable containers up to 2,400 liters. You can choose from five different pick-up systems.

First, you can request standard load arm and clamps, with containers docked using electronically monitored quick clamps for your blender. In this solution containers up to 1,200 liters, mounted on an undercarriage, can be adapted without additional lifting equipment. Additionally, you can opt for a chopper installation whose drive is integrated into the load arm.

Secondly, you can request a blender version where the system can be swiveled around its vertical axis. This design comes with a huge advantage: long service life and extremely low maintenance requirements!

Did this spark your interest and are you curious to find out about the other systems? <a href="https://lbbohle.com/pharma-whitepaper-pharma-product-brochures">Read more on the whitepapers from the L.B. Bohle team.</a>

Discover the best mix for your blending application

Chemical

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Producing the finest micro-emulsions and suspensions requires a mixing machine that generates extremely high shear.  Multi-staged rotor/stator dispersing machines work well for this purpose because of the high shear forces applied to the mixture at each rotor/stator stage.  A rotor /stator dispersing machine that also incorporates extremely fast rotation and resultant tip speeds for even greater shearing action will lead to the creation of super-fine emulsions and ensure the success of your process.
<h2>Top-of-the-line rotor/stator dispersion with utlra high shear for nano-scale particle emulsions and suspensions</h2>
The DISPAX-REACTOR® DRS from IKA is an inline ultra high shear dispersing machine used to achieve the finest micro-emulsions and suspensions. Extremely high shear rates (up to 190.000 1/s) combined with a fine generator geometry enable crushing of droplets and solids particles down to the nanoscale. The resulting product has long-term stability which reduces the need for emulsifying agents and thickeners. Because of the extremely high energy density, other dispersing aids can be reduced or possibly eliminated.

The DRS is usually equipped with a two-stage rotor-stator system (generators). The high tip speed of 40 m/s (10.000 fpm) often negates the need for a third stage. The ultra-fine dispersing machine, designed with the same high quality features as the ULTRA-TURRAX® UTL and the DISPAX-REACTOR® DR, is especially well suited for challenging pharmaceutical applications.  The units are designed for easy and reliable scalability and sizes are available with flow rates from 70 to 40.000 liters per hour.

Ultra-fine dispersing machine for emulsions and suspensions

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

Built upon its world-leading laboratory equipment, IKA Process is a game changing manufacturer of dispersing machines, homogenizers, stirrers, jet flow agitators, and kneading machines.

In the pharmaceutical industry, change often moves at a snail’s pace due to stringent regulations, but it does happen.



Traditionally, API manufacturers relied on the dry milling process, which begins with crystallization or precipitation within a liquid medium, where crystals form and grow. These crystals are separated using a centrifuge, dried, and finally subjected to dry milling before tableting.

As APIs became more potent, dry handling became problematic due to dust generation, causing cleaning issues and product loss. Furthermore, stricter ATEX regulations for handling hazardous powders have expedited the demand for change.

It’s not as simple as just mixing dry ingredients together, and voila, you have your API. APIs are always, and I mean always, synthesized within a liquid medium to form solid crystals. If liquid is always a part of the equation, why not control the growth of those crystals already in the crystallization step?

And this is where wet milling came into play. This approach allows early particle size control during precipitation, enhancing pharmaceutical manufacturers’ control over the API’s final particle size and distribution.
<h2>“<em>The value of an idea lies in the using of it</em>.” – The benefit of early particle size reduction</h2>
We had a chance to speak with Werner Kanzinger, <a href="https://www.ikaprocess.com/en/Products/Process-plants-cph-18/?gclid=Cj0KCQjwmICoBhDxARIsABXkXlLSTjoDkEyEOxqysB6am7wNW99asG4jDKpXJpsQO5pzSj_wv8ZdyHYaAlsvEALw_wcB">IKA</a> Vice President, one of the first to use wet milling for API production. Creating new pharmaceuticals requires starting from scratch and developing principles in the R&amp;D world. To address this need, IKA introduced an innovative three-stage inline dispersing technology called the <a href="https://www.ikaprocess.com/en/Products/Pilot-plants-cph-40/magic-LAB-csb-MLAB/">Magic Lab</a>.

“<em>We knocked on every door in the R&amp;D world and were surprised how the technology was well-received. The industry recognized its</em><em> potential to simplify production through early-stage particle size reduction,” </em>Werner explains.

According to Werner: “<em>Even at a half-liter batch, APIs are very valuable and pricey. As production scales up to 1000 liters per batch, the cost can be over 1 million, and nobody wants to take any risk.”</em>

To serve the industry across diverse production scales, IKA replicated Magic Lab’s success on a larger scale, ensuring consistent milling outcomes without compromising quality.
<h2>No dust, no fuss - Wet milling is here to simplify your life by shortening your production time</h2>
In dry milling, solid materials undergo high-speed impact and shearing forces, generating airborne dust particles. This dust settles on equipment, necessitating extensive cleaning to prevent cross-contamination.

“A w<em>et mill is already designed to create a high-turbulence environment, which helps with dust reduction</em>,” Werner continues.

Additionally, wet mills are easier to clean than dry mills due to their smaller and less complex internals, requiring less time and effort. Operating already during the crystallization step, wet milling allows for localized energy application. This reduces energy consumption compared to drum mills.

“<em>IKA three-stage inline technology allows for complete drainage after use. The product flows from the top to the bottom through a three-stage rotor-stator, progressively reducing particle size from coarse to fine. Since it’s vertically installed, no product remains inside, making cleaning straightforward,</em>” Werner concludes.

Just remember, it is better to move forward at a snail’s pace than backward at any pace.

Wet milling: The revolution in the API production

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

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What's new in pharmaceutical packaging?



During <a href="https://www.pharmapackeurope.com/en/home.html" target="_blank" rel="noopener">Pharmapack</a>, we met Chantal Younes, Key Account Manager at <a href="https://www.csptechnologies.com/" target="_blank" rel="noopener">Aptar CSP Technology</a>, who introduced us to the world of active packaging.

The pharmaceutical industry is subject to strict regulations, so that's why manufacturers are very meticulous when formulating their products but especially about their packaging, which must keep their products safe. Due to the formulation or active ingredient, pharmaceutical products can present significant stability issues if they come in contact with moisture or oxygen.

This is where Aptar CSP Technology comes in. Aptar CSP Technology has developed several active packaging solutions to protect pharmaceutical products and ensure extended shelf life.

The company has developed a new class of highly engineered polymer compounds that protect drug products, probiotics, and drug delivery systems from impurities, oxygen, and moisture. The polymer can be extruded into a film, injection molded, or blow molded.

#Changemaker: Ready to protect your pharmaceutical products from moisture?

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

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